IMP-Zn
IMP-Zn is a pyrazole-hydrazone Schiff base zinc (II) complex. IMP-Zn exhibits significant antiproliferative activity against human colorectal cancer cells and induces cell cycle arrest. IMP-Zn shows stronger binding affinity than its free ligand IMP towards three cancer-related protein targets: EGFR kinase 1M17, cytochrome P450 3RUK, and CDK inhibitor 6GUE. IMP-Zn can be used in studies related to colorectal cancer.
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- Fòrmula: C17H15Cl2N5OZn
- Peso molecular:441.62
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
IMP-Zn (10, 20, 30, 40, 50 μM; 24, 48, 72 h for HCT116, 48 h for HEK293) potently reduces viability of human colorectal carcinoma HCT116 cells with IC50 values of 28.62 μM (24 h), 24.56 μM (48 h), and 24.28 μM (72 h), while showing no cytotoxicity toward normal HEK293 cells at concentrations up to 50 μM after 48 h[1].
IMP-Zn (10, 20, 24.56 μM; 48 h treatment, followed by 10-day colony formation period) dose-dependently suppresses clonogenic growth of human colorectal carcinoma HCT116 cells, reducing both colony number and size[1].
IMP-Zn (24.56 μM; 48 h treatment) induces SubG0 phase accumulation in human colorectal carcinoma HCT116 cells, indicating apoptosis-associated cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human colorectal carcinoma HCT116 cells, normal human embryonic kidney HEK293 cells
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Concentration:10, 20, 30, 40, 50 μM (HCT116 cells); 10, 20, 30, 40, 50 μM (HEK293 cells)
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Incubation Time:24, 48, 72 h (HCT116 cells); 48 h (HEK293 cells)
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Result:Reduced HCT116 cell viability in a time- and dose-dependent manner, with IC50 values of 28.62 μM (24 h), 24.56 μM (48 h), and 24.28 μM (72 h).
Showed no significant effect on HEK293 cell viability at concentrations up to 50 μM after 48 h.
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Cell Line:human colorectal carcinoma HCT116 cells
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Concentration:24.56 μM
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Incubation Time:48 h
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Result:Increased the percentage of HCT116 cells in the SubG0 phase to 20.51% compared to 5.86% in control cells.
Chemical Information
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Peso molecular 441.62
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Fòrmula C17H15Cl2N5OZn
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SMILES
CC1=C(C(N2)=O[Zn]3(Cl)(Cl)[N]2=CC4=[N]3C=CC=C4)C=NN1C5=CC=CC=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IMP-Zn Related Classifications
HY-181923 Related Classifications
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