Referencia número: HY-N2117

Isoginkgetin

20 Cited Publications

Revisión del cliente

Based on 20 publication(s) in Google Scholar

Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy.

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Pureza: 99.91%
No. CAS: 548-19-6
Fòrmula: C₃₂H₂₂O₁₀
Peso molecular:566.51

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Isoginkgetin Chemical Structure

No. CAS: 548-19-6

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (20)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas MMP :

Ver todos los productos específicos de isoformas Akt :

Ver todos los productos específicos de isoformas NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
L6	IC₅₀	11 μM Compound: isoginkgetin	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 22989363]
PC-12	EC₅₀	5.18 μM Compound: 10	Neuroprotective activity against 0.1 uM amyloid beta 42-induced toxicity in rat PC12 cells assessed as cell viability after 24 hrs by MTT assay Neuroprotective activity against 0.1 uM amyloid beta 42-induced toxicity in rat PC12 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 26004578]

In Vitro

Isoginkgetin (0-20 μM, 24 h) inhibits cell invasion in a dose-dependent manner^[1].
Isoginkgetin (10 μM, 0-24 h) induces the accumulation of ubiquitinated protein cargo into perinuclear aggregates, activates autophagy and induces lysosomal swelling, repositioning, and acidification^[2].
Isoginkgetin (10 μM, 0-6 h) induces ER stress, impairs the unfolded protein response, and results in accumulation of ERAD substrates^[2].
Isoginkgetin directly inhibits the chymotrypsin-, trypsin-, and caspase-like activities of the 20S proteasome and impairs NF-κB signaling^[2].
Isoginkgetin (30 μM, 0-24 h) induces apoptosis in MM cell lines^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Invasion Assay^[1]

Cell Line:

MDA-MB-231 and B16F10
Concentration:

0, 5, 10 and 20 μM
Incubation Time:

24 h
Result:

Inhibited cell invasion in a dose-dependent manner.

Western Blot Analysis^[2]

Cell Line:

HeLa cells and MM cell lines (MM1S, 8826, OPM2, H929, JJN3 and U266)
Concentration:

10 μM in HeLa cells, 30 μM in MM cell lines
Incubation Time:

0-24 h
Result:

Induced the expression of cleaved PARP-1 and Casp-3. Increased the protein levels of both ATF4 and ATF3. Decreased the level of LC3 I. Increased TFEB activation. Prevented the degradation of IκBα in response to stimulation with TNF-α.

Cell Viability Assay^[2]

Cell Line:

MM1S, 8826, OPM2, H929, JJN3 and U266 cells
Concentration:
Incubation Time:

72 h
Result:

Inhibited cell viability with IC₅₀ values of 3.992, 3.716, 4.749, 2.564, 3.806 and 4.147 μM against MM1S, 8826, OPM2, H929, JJN3 and U266 cells, respectively.

In Vivo

Isoginkgetin (4 mg/kg; i.p.; daily for 14 days) shows anti-inflammatory effects^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male Kunming mice (age 8–10weeks, 30–50 g)^[3]
Dosage:

4 mg/kg
Administration:

Daily for 14 days by intraperitoneally (i.p.) prior to LPS (0.83mg/kg) administration.
Result:

Markedly suppressed the production of IL-1β, IL-6, tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide, and reactive oxygen species.

Chemical Information

No. CAS 548-19-6
Appearance Solid
Peso molecular 566.51
Fòrmula C₃₂H₂₂O₁₀
Color Light yellow to yellow
SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4OC)C(O)=CC(O)=C13
Structure Classification
- Flavonoids
- Biflavones
- Phenols
- Polyphenols
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (20)

All IFCell Proliferation/Viability Assay

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Journal Impact Factor

Mol Cell

ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition. [Abstract]

2025 Apr 17:S1097-2765(25)00307-7. PMID: 40267921
Acta Pharm Sin B

Chrysin serves as a novel inhibitor of DGK α/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC). [Abstract]

2021 Jan;11(1):143-155. PMID: 33532186
Autophagy

Isoginkgetin, a potential CDK6 inhibitor, suppresses SLC2A1/GLUT1 enhancer activity to induce AMPK-ULK1-mediated cytotoxic autophagy in hepatocellular carcinoma. [Abstract]

2023 Apr;19(4):1221-1238. PMID: 36048765
Theranostics

A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY. [Abstract]

2025 Mar 18;15(10):4325-4344. PMID: 40225566
Nucleic Acids Res

MEN1 is a regulator of alternative splicing and prevents R-loop-induced genome instability through suppression of RNA polymerase II elongation. [Abstract]

2023 Aug 25;51(15):7951-7971. PMID: 37395406
Nucleic Acids Res

BESST: a novel LncRNA knockout strategy with less genome perturbance. [Abstract]

2023 May 22;51(9):e49. PMID: 36938886
Nucleic Acids Res

TriTag: an integrative tool to correlate chromatin dynamics and gene expression in living cells. [Abstract]

2020 Dec 16;48(22):e127. PMID: 33104788
J Nanobiotechnology

Isoginkgetin-loaded reactive oxygen species scavenging nanoparticles ameliorate intervertebral disc degeneration via enhancing autophagy in nucleus pulposus cells. [Abstract]

2023 Mar 21;21(1):99. PMID: 36941611
J Hazard Mater

Identification of sanguinarine as a novel antagonist for perfluorooctanoate/perfluorooctane sulfonate-induced senescence of hepatocytes: An integrated computational and experimental analysis. [Abstract]

2024 Aug 22:478:135583. PMID: 39180998
Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
EMBO Mol Med

Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models via PINK1-Parkin-dependent mitophagy. [Abstract]

2025 Oct 15. PMID: 41094045
Cell Rep

circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis. [Abstract]

2025 Dec 5;44(12):116659. PMID: 41351835
J Ethnopharmacol

Cornus officinalis var. koreana Kitam extracts alleviate cadmium-induced renal fibrosis by targeting matrix metallopeptidase 9. [Abstract]

2024 May 10:325:117824. PMID: 38278375
RNA

Splicing efficiency of minor introns in a mouse model of SMA predominantly depends on their branchpoint sequence and can involve the contribution of major spliceosome components. [Abstract]

2022 Mar;28(3):303-319. PMID: 34893560
Molecules

Isoginkgetin-A Natural Compound to Control U87MG Glioblastoma Cell Growth and Migration Activating Apoptosis and Autophagy. [Abstract]

2022 Nov 29;27(23):8335. PMID: 36500428

Isoginkgetin purchased from MedChemExpress. Usage Cited in: Molecules. 2022 Nov 29;27(23):8335. [Abstract]

Isoginkgetin (Iso; 10, 15, 25 µM; 24, 48, 72 h) reduces the viability of U87MG in a time and dose-dependent manner.

Isoginkgetin purchased from MedChemExpress. Usage Cited in: Molecules. 2022 Nov 29;27(23):8335. [Abstract]

Isoginkgetin (Iso; 15, 25 µM; 48 h) determines a redistribution of vimentin, which no longer appears distributed in the extensions but are thickened in a roundish shape in U87MG cells.

Isoginkgetin purchased from MedChemExpress. Usage Cited in: Molecules. 2022 Nov 29;27(23):8335. [Abstract]

The number of colonies decreased by 38% and 57%, respectively, in U87MG treated with Isoginkgetin (Iso; 15, 25 µM; 12 days) compared to the control cells.
J Biol Chem

CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1. [Abstract]

2021 Aug;297(2):100994. PMID: 34298017
Chem Biol Drug Des

Isoginkgetin inhibits inflammatory response in the fibroblast-like synoviocytes of rheumatoid arthritis by suppressing matrix metallopeptidase 9 expression. [Abstract]

2022 Jun;99(6):923-929. PMID: 35353950
Biomed Res Int

Exploring the Antitumor Mechanisms of Zingiberis Rhizoma Combined with Coptidis Rhizoma Using a Network Pharmacology Approach. [Abstract]

2020 Dec 24:2020:8887982. PMID: 33426081
J Vis Exp

A Simple Protocol for the Isolation and Culture of Hepatocytes from MASLD Mice. [Abstract]

2025 Jul 18:(221). PMID: 40758599

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (176.52 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7652 mL

8.8260 mL

17.6519 mL

5 mM

0.3530 mL

1.7652 mL

3.5304 mL

10 mM

0.1765 mL

0.8826 mL

1.7652 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (3.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.08 mg/mL (3.67 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 1.67 mg/mL (2.95 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (288 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yoon SO, et al. Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression. Mol Cancer Ther. 2006 Nov;5(11):2666-75. [Content Brief]

[2]. Tsalikis J, et al. Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance. Mol Cell Biol. 2019 Apr 30;39(10):e00489-18. [Content Brief]

[3]. Li P, et al. Isoginkgetin treatment attenuated lipopolysaccharide-induced monoamine neurotransmitter deficiency and depression-like behaviors through downregulating p38/NF-κB signaling pathway and suppressing microglia-induced apoptosis. J Psychopharmacol. 2021 Oct;35(10):1285-1299. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7652 mL	8.8260 mL	17.6519 mL	44.1298 mL
	5 mM	0.3530 mL	1.7652 mL	3.5304 mL	8.8260 mL
	10 mM	0.1765 mL	0.8826 mL	1.7652 mL	4.4130 mL
	15 mM	0.1177 mL	0.5884 mL	1.1768 mL	2.9420 mL
	20 mM	0.0883 mL	0.4413 mL	0.8826 mL	2.2065 mL
	25 mM	0.0706 mL	0.3530 mL	0.7061 mL	1.7652 mL
	30 mM	0.0588 mL	0.2942 mL	0.5884 mL	1.4710 mL
	40 mM	0.0441 mL	0.2206 mL	0.4413 mL	1.1032 mL
	50 mM	0.0353 mL	0.1765 mL	0.3530 mL	0.8826 mL
	60 mM	0.0294 mL	0.1471 mL	0.2942 mL	0.7355 mL
	80 mM	0.0221 mL	0.1103 mL	0.2206 mL	0.5516 mL
	100 mM	0.0177 mL	0.0883 mL	0.1765 mL	0.4413 mL

Keywords

Isoginkgetin

20 Cited Publications

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Isoginkgetin

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Publications Citing Use of MedChemExpress (MCE) Isoginkgetin

Ver todos los productos específicos de isoformas MMP

Ver todos los productos específicos de isoformas Akt