CC-11
CC-11 is an orally active small molecule drug conjugate (SMDC) that links the PI3K/mTOR inhibitor with the extracellular heat shock protein 90 (EHSP90) targeting ligand through a cleavable linker. CC-11 exhibits strong HSP90 binding activity (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM). CC-11 has anti-proliferative activity against colon cancer cells. CC-11 shows significant efficacy in the HCT-116 xenograft tumor model. CC-11 can be used for research on colon cancer.
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- No. CAS: 3079942-94-9
- Fòrmula: C52H54F2N12O10S
- Peso molecular:1077.12
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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HSP90 15 nM (IC50) |
PI3Kα 0.54 nM (IC50) |
Chemical Information
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No. CAS 3079942-94-9
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Peso molecular 1077.12
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Fòrmula C52H54F2N12O10S
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SMILES
CC(C1=CC(C(N2C3=CC=C(NC(CCC(NCC(OC4CCCN(C4)CCCN5C=C(N=N5)C6=CN=C7N6N=C(C=C7)C8=CC(NS(C9=CC=C(F)C=C9F)(=O)=O)=C(N=C8)OC)=O)=O)=O)C=C3CC2)=O)=C(C=C1O)O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CC-11 Related Classifications
HY-179457 Related Classifications
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