Deltamethrin
Based on 2 publication(s) in Google Scholar
Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control.
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- Pureza: 99.96%
- No. CAS: 52918-63-5
- Fòrmula: C22H19Br2NO3
- Peso molecular:505.20
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Deltamethrin
MoreVer todos los productos específicos de isoformas Endogenous Metabolite
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Actividad biológica
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Caspase 3 |
Bcl-2 |
Bax |
IL-1β |
Deltamethrin (5-60 μM, 24 h) increases cytosolic free Ca2+ concentration and induces apoptosis in a concentration-dependent manner in OC2 human oral cancer cells[2].
Deltamethrin (0.5-100 μM, 24 h) inhibits thymocytes viability[3].
Deltamethrin (10-50 μM, 1-6 h) shows a concentration- and time-dependent enhancement in caspase-3 activity in murine thymocytes[3].
Deltamethrin (10-50 μM, 18 h) induces apoptosis in thymocytes[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Murine thymocytes
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Concentration:0.5 μM, 1 μM, 10 μM, 25 μM, 50 μM, 100 μM
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Incubation Time:6 h, 18 h
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Result:Caused 32% and 59% loss in cell viability at 25 μM and 100 μM at 6 h.
Caused 46% and 68% loss in cell viability at 25 μM and 100 μM at 18 h.
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Cell Line:Murine thymocytes
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Concentration:10 μM, 25 μM, 50 μM
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Incubation Time:18 h
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Result:Increased the number of apoptotic cells in a concentration-dependent manner.
Deltamethrin (60 mg/kg, Intraperitoneal injection, single dose) can increase the activity of Choline acetyltransferase (ChAT) in the striatum in rats[5].
Deltamethrin (15-45 mg/kg, Gavage, once a day for 12 weeks) promotes cardiomyocyte inflammation and apoptosis through inhibiting the Nrf2/HO-1 signaling pathway in quails[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino male mice[4]
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Dosage:5.6 mg/kg, 18 mg/kg
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Administration:Oral
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Result:Significantly induced lipid peroxidation (LPO) in liver and kidney.
Suppressed the activities of vital antioxidant enzymes such as glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT).
Decreased the glutathione (GSH) level.
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Animal Model:Male Sprague-Dawley rats[5]
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Dosage:60 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Modulated the hippocampal high-affinity choline uptake (HACU).
Increased the activity of ChAT in the hippocampus and cortex.
Increased the activity of striatal ChAT.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 52918-63-5
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Appearance Solid
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Peso molecular 505.20
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Fòrmula C22H19Br2NO3
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Color White to off-white
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SMILES
O=C([C@H]1C(C)(C)[C@H]1/C=C(Br)\Br)O[C@H](C#N)C2=CC=CC(OC3=CC=CC=C3)=C2
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Synonyms
Decamethrin
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Toxicol Appl Pharmacol
Pharmacological inhibition of USP7 attenuates deltamethrin-induced neuronal ferroptosis via GPX4 stabilization. [Abstract]2026 Mar:508:117716. PMID: 41539346 -
Toxicol In Vitro
MEK1 inhibition ameliorates mitochondrial-dependent apoptosis induced by deltamethrin in mouse hippocampal neuron HT22 cells. [Abstract]2025 Jun:106:106047. PMID: 40058615
Solvente y solubilidad
DMSO : 100 mg/mL (197.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (4.95 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (4.95 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Ficha de datos (283 KB)
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SDS (565 KB)
- English - EN (565 KB)
- Français - FR (565 KB)
- Deutsch - DE (565 KB)
- Norwegian - NO (565 KB)
- Español - ES (565 KB)
- Swedish - SV (565 KB)
- Italian - IT (565 KB)
- Korean - KR (565 KB)
- Portuguese - PT (565 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Lu Q, et al. Deltamethrin toxicity: A review of oxidative stress and metabolism [J]. Environmental research, 2019, 170: 260-281. [Content Brief]
[2]. Chi C C, et al. Effect of the pesticide, deltamethrin, on Ca2+ signaling and apoptosis in OC2 human oral cancer cells [J]. Drug and Chemical Toxicology, 2014, 37(1): 25-31. [Content Brief]
[3]. Kumar A, et al. Deltamethrin induced an apoptogenic signalling pathway in murine thymocytes: exploring the molecular mechanism [J]. Journal of Applied Toxicology, 2014, 34(12): 1303-1310. [Content Brief]
[4]. Rehman H, et al. The modulatory effect of deltamethrin on antioxidants in mice [J]. Clinica Chimica Acta, 2006, 369(1): 61-65. [Content Brief]
[5]. Hossain M M, et al. Neuromechanical effects of pyrethroids, allethrin, cyhalothrin and deltamethrin on the cholinergic processes in rat brain [J]. Life sciences, 2005, 77(7): 795-807 [Content Brief]
[6]. Yang X, et al. The heart as a target for deltamethrin toxicity: Inhibition of Nrf2/HO-1 pathway induces oxidative stress and results in inflammation and apoptosis [J]. Chemosphere, 2022, 300: 134479. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9794 mL | 9.8971 mL | 19.7941 mL | 49.4854 mL |
| 5 mM | 0.3959 mL | 1.9794 mL | 3.9588 mL | 9.8971 mL | |
| 10 mM | 0.1979 mL | 0.9897 mL | 1.9794 mL | 4.9485 mL | |
| 15 mM | 0.1320 mL | 0.6598 mL | 1.3196 mL | 3.2990 mL | |
| 20 mM | 0.0990 mL | 0.4949 mL | 0.9897 mL | 2.4743 mL | |
| 25 mM | 0.0792 mL | 0.3959 mL | 0.7918 mL | 1.9794 mL | |
| 30 mM | 0.0660 mL | 0.3299 mL | 0.6598 mL | 1.6495 mL | |
| 40 mM | 0.0495 mL | 0.2474 mL | 0.4949 mL | 1.2371 mL | |
| 50 mM | 0.0396 mL | 0.1979 mL | 0.3959 mL | 0.9897 mL | |
| 60 mM | 0.0330 mL | 0.1650 mL | 0.3299 mL | 0.8248 mL | |
| 80 mM | 0.0247 mL | 0.1237 mL | 0.2474 mL | 0.6186 mL | |
| 100 mM | 0.0198 mL | 0.0990 mL | 0.1979 mL | 0.4949 mL |
Deltamethrin Related Classifications
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