Longilactone
Longilactone is a quassinoid diterpenoid isolated from the roots of Eurycoma longifolia. Longilactone induces apoptosis in MCF-7 cells via the extrinsic caspase pathway, activating the cleavage of caspase-8, caspase-7 and PARP. Longilactone can be used in research related to breast cancer and human lung cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 129587-09-3
- Fòrmula: C19H26O7
- Peso molecular:366.41
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Caspase
More
Actividad biológica
|
Caspase-8 |
Caspase-7 |
PARP |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.53 μg/mL
|
Cytotoxic activity against human breast cancer MCF-7 cells assessed via Sulforhodamine B (SRB) assay following 72 hrs incubation.
Cytotoxic activity against human breast cancer MCF-7 cells assessed via Sulforhodamine B (SRB) assay following 72 hrs incubation.
|
article1379247682_Muhamad%20et%20al.pdf |
| A549 | ED50 |
4.6 μg/mL
|
Cytotoxicity against human lung cancer A-549 cells.
Cytotoxicity against human lung cancer A-549 cells.
|
14738962 |
| MCF7 | ED50 |
6.1 μg/mL
|
Cytotoxicity against human breast cancer MCF-7 cells.
Cytotoxicity against human breast cancer MCF-7 cells.
|
14738962 |
Longilactone (0.32-20 µg/mL; 72 h) potently inhibits the viability of human breast cancer MCF-7 cells, with an IC50 of 0.53 µg/mL after 72 h of treatment[1].
Longilactone (compound 36) exhibits cytotoxic activity against human lung cancer (A-549) cells with an ED50 value of 4.6 μg/mL; it also shows cytotoxic activity against human breast cancer (MCF-7) cells with an ED50 value of 6.1 μg/mL[3].
Longilactone (5 µg/mL; 12-72 h) induces time-dependent apoptosis in human breast cancer MCF-7 cells[1].
Longilactone (5 µg/mL; 72 h) induces apoptosis in human breast cancer MCF-7 cells[1].
Longilactone (5 µg/mL; 0-72 h) activates caspase-8 in a time-dependent manner in human breast cancer MCF-7 cells, but has no effect on the activity of caspase-9[1].
Longilactone (5 µg/mL; 0-72 h) upregulates the levels of activated caspase-8, activated caspase-7 and cleaved PARP in a time-dependent manner, activates the extrinsic apoptotic pathway in human breast cancer MCF-7 cells, and does not alter the expression of Bax and Bcl-2 or activate caspase-9[1].
Longilactone exhibits no significant anti-HIV activity in H9 lymphocytes[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:human breast cancer MCF-7 cells
-
Concentration:0.32, 0.16, 0.8, 4, 20 µg/mL
-
Incubation Time:72 h
-
Result:Exerted strong cytotoxic activity on MCF-7 cells, with an IC50 of 0.53 µg/mL.
-
Cell Line:human breast cancer MCF-7 cells
-
Concentration:5 µg/mL
-
Incubation Time:12, 24, 48, 72 h
-
Result:Induced typical apoptotic nuclear morphology changes including fragmentation, hypercondensation, and shrinkage after 48 h incubation.
Increased the percentage of apoptotic MCF-7 cells in a time-dependent manner, reaching 74.3% after 72 h.
-
Cell Line:human breast cancer MCF-7 cells
-
Concentration:5 µg/mL
-
Incubation Time:12, 24, 48, 72 h
-
Result:Increased levels of pro-caspase-8 (55 kDa), active caspase-8 (29 kDa), active caspase-7 (20 kDa), and cleaved poly (ADP-ribose) polymerase (PARP, 89 kDa) in a time-dependent manner.
Did not alter basal levels of Bax (20 kDa) and Bcl-2 (26 kDa), and active caspase-9 was not detected.
Chemical Information
-
No. CAS 129587-09-3
-
Peso molecular 366.41
-
Fòrmula C19H26O7
-
SMILES
C[C@]12[C@@]3([H])[C@@]4([C@@](C(C)=CC([C@H]4O)=O)([H])[C@H]([C@@]1([H])OC([C@@]2([H])[C@H]([C@H]([C@@H]3O)O)C)=O)O)C
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Longilactone Related Classifications
HY-N21972 Related Classifications
Powered by Bioz