Kdr - kinase insert domain protein receptor Gene

Also Known as orv; Flk1; Ly73; Flk-1; Krd-1; VEGFR2; VEGFR-2; sVEGFR-2; 6130401C07

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16542

About Kdr

Chromosome 5: 76,093,487-76,139,118 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 199 orthologues, 53 paralogues and is associated with 30 phenotypes. Broad expression in lung adult (RPKM 42.4), heart adult (RPKM 19.3) and 22 other tissues.

Summary

Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including circulatory system development; peptidyl-tyrosine autophosphorylation; and positive regulation of vasculogenesis. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and vasculature development. Located in several cellular components, including cell junction; endosome; and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including adhesions of uterus; artery disease (multiple); gastrointestinal system Cancer (multiple); macular degeneration (multiple); and pancreatic Cancer (multiple). Orthologous to human KDR (kinase insert domain receptor). [provided by Alliance of Genome Resources, Apr 2022]

Kdr Products (6)

mRNA	Protein	Name
NM_001403141.1	NP_001390070.1	vascular endothelial growth factor receptor 2 isoform 1 precursor
NM_001403144.1	NP_001390073.1	vascular endothelial growth factor receptor 2 isoform 5
NM_001363216.1	NP_001350145.1	vascular endothelial growth factor receptor 2 isoform 2 precursor
NM_001403143.1	NP_001390072.1	vascular endothelial growth factor receptor 2 isoform 4 precursor
NM_001403142.1	NP_001390071.1	vascular endothelial growth factor receptor 2 isoform 3 precursor
NM_010612.3	NP_034742.2	vascular endothelial growth factor receptor 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables coreceptor activity	IGI IGI: Inferred from genetic interaction	25985275	MGI
enables growth factor binding	IPI IPI: Inferred from physical interaction	7681362	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14977921	MGI
enables vascular endothelial growth factor receptor activity	IDA IDA: Inferred from direct assay	8356051	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within blood vessel endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	15644447	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	16375885	MGI
acts upstream of or within calcium ion homeostasis	IDA IDA: Inferred from direct assay	8356051	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	12569129	MGI
acts upstream of or within cell migration	IGI IGI: Inferred from genetic interaction	15601856	MGI
involved in cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	20660291	MGI
involved in embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	7596435	MGI
involved in endocardium development	IMP IMP: Inferred from mutant phenotype	7596435	MGI
acts upstream of or within endothelial cell differentiation	IDA IDA: Inferred from direct assay	12897140	MGI
acts upstream of or within endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	18772315	MGI
involved in endothelium development	IMP IMP: Inferred from mutant phenotype	7596435	MGI
acts upstream of or within epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	12053176	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16375885	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	15644447	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	12053176	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	16375885	MGI
acts upstream of or within lymph vessel development	IGI IGI: Inferred from genetic interaction	20439428	MGI
acts upstream of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	16375885	MGI
involved in negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	25985275	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	17050862	MGI
involved in peptidyl-tyrosine autophosphorylation	IDA IDA: Inferred from direct assay	20660291	MGI
involved in positive regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	20406889	MGI
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	20406889	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16375885	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	16375885	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	16375885	MGI
involved in positive regulation of vasculogenesis	IMP IMP: Inferred from mutant phenotype	19635461	MGI
acts upstream of or within post-embryonic camera-type eye morphogenesis	IGI IGI: Inferred from genetic interaction	22426483	MGI
acts upstream of or within regulation of bone development	IMP IMP: Inferred from mutant phenotype	22886301	MGI
acts upstream of or within regulation of hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	18772315	MGI
involved in semaphorin-plexin signaling pathway	IGI IGI: Inferred from genetic interaction	25985275	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	16375885	MGI
acts upstream of or within surfactant homeostasis	IMP IMP: Inferred from mutant phenotype	12053176	MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	8356051	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	15644447	MGI
involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	7596435	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell junction	IDA IDA: Inferred from direct assay	19635461	MGI
located in cell periphery	IDA IDA: Inferred from direct assay	16099728	MGI
located in cell surface	IDA IDA: Inferred from direct assay	22265737	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	22886301	MGI
located in early endosome	IDA IDA: Inferred from direct assay	20660291	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16455951	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22886301	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	20660291	MGI
located in sorting endosome	IDA IDA: Inferred from direct assay	23639442	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kdr Protein Structure

Ig_3

I-set

VEGFR-2_TMD

PTKc_VEGFR2

0
300
600
900
1200
1345 a.a.

Protein Preferred Names	Protein Names
vascular endothelial growth factor receptor 2	VEGF receptor-2 fetal liver kinase 1 kinase NYK protein-tyrosine kinase receptor flk-1 soluble vascular endothelial growth factor receptor 2 vascular endothelial growth factor receptor-3

Recombinant Kdr Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72429	VEGFR-2 Protein, Mouse (HEK293, Fc)	P35918 (A20-E762)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74471	VEGFR-2 Protein, Mouse (HEK293, His, solution)	P35918 (A20-E762)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74472	VEGFR-2 Protein, Mouse (Biotinylated, HEK293, His)	P35918 (A20-E762)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10260	Vandetanib		99.85%	Yes
HY-112306	Ripretinib		98.90%	Yes
HY-14914	Azilsartan		99.68%	Unkown
HY-10330A	Toceranib phosphate	Inhibitor	99.23%	Unkown
HY-10260B	Vandetanib hydrochloride		/	Unkown
HY-10260A	Vandetanib trifluoroacetate		/	Unkown

Clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50751	Linifanib		99.39%	Phase 3
HY-10205	Cediranib		99.87%	Phase 3
HY-10203	Vatalanib	Inhibitor	99.93%	Phase 3
HY-12018	Vatalanib dihydrochloride		99.68%	Phase 3
HY-13049	Cediranib maleate		99.95%	Phase 3
HY-12018A	Vatalanib hydrochloride	Inhibitor	/	Phase 3
HY-110272	Vatalanib succinate	Inhibitor	/	Phase 3
HY-10374	Semaxinib	Inhibitor	99.92%	Phase 2
HY-13024	Rebastinib		99.84%	Phase 2
HY-10338	Foretinib	Inhibitor	99.45%	Phase 2
HY-10987A	ENMD-2076		99.99%	Phase 2
HY-10987	ENMD-2076 Tartrate		99.66%	Phase 2
HY-10204	OSI-930		98.33%	Phase 1
HY-100315	XL 999	Inhibitor	99.01%	Phase 1

Bioactive MoleculesInhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99768	Olinvacimab	Inhibitor	95.00%	Phase 2
HY-P991419	MSB-0254	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (59)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12299	WH-4-023	Inhibitor	99.87%	Unkown
HY-151361	AMPK-IN-3	Inhibitor	98.51%	Unkown
HY-W062835	CGP77675	Inhibitor	99.46%	Unkown
HY-10330	Toceranib	Inhibitor	97.41%	Unkown
HY-144707	AK-778-XXMU		99.96%	Unkown
HY-P1663	ATWLPPR Peptide	Inhibitor	99.63%	Unkown
HY-18302	c-Kit-IN-5-1	Inhibitor	98.03%	Unkown
HY-W002616	5-Bromoindolin-2-one		99.50%	Unkown
HY-13838	PLX647	Inhibitor	99.74%	Unkown
HY-15814	HG-7-85-01		98.14%	Unkown
HY-13785	ZM 306416	Inhibitor	99.80%	Unkown
HY-P5438	Srctide	Substrate	99.71%	Unkown
HY-101219	VEGFR-IN-1	Inhibitor	99.07%	Unkown
HY-125741	GW768505A free base	Inhibitor	99.26%	Unkown
HY-10517A	(Z)-Orantinib	Inhibitor	99.44%	Unkown
HY-15769	WHI-P180	Inhibitor	99.84%	Unkown
HY-132135	(1E)-CFI-400437 dihydrochloride	Inhibitor	98.08%	Unkown
HY-133551	WF-47-JS03	Inhibitor	99.63%	Unkown
HY-119757	Tyrphostin AG1433	Inhibitor	99.08%	Unkown
HY-RS07226	KDR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-148742	RET-IN-21	Inhibitor	97.00%	Unkown
HY-RS07227	Kdr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-118105	RK-20448	Inhibitor	99.38%	Unkown
HY-50751G	Linifanib (GMP)	Inhibitor	/	Unkown
HY-100824	PP2 Analog	Inhibitor	/	Unkown
HY-10260S	Vandetanib-d6		/	Unkown
HY-10260S1	Vandetanib-d4		/	Unkown
HY-10260S2	Vandetanib-13C6		/	Unkown
HY-10330S	Toceranib-d8	Inhibitor	99.08%	Unkown
HY-116190	CFI-401870	Inhibitor	/	Unkown
HY-117733	Zerumin A	Inhibitor	/	Unkown
HY-120214	TAS05567	Inhibitor	/	Unkown
HY-123586	L-783277	Inhibitor	/	Unkown
HY-13838A	PLX647 dihydrochloride	Inhibitor	/	Unkown
HY-146369	PROTAC VEGFR-2 degrader-2	Degrader	/	Unkown
HY-14979	ML786	Inhibitor	/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-15334	CEP-5214	Inhibitor	/	Unkown
HY-168114	Multi-kinase inhibitor 3	Inhibitor	/	Unkown
HY-168115	Multi-kinase inhibitor 4	Inhibitor	/	Unkown
HY-172487	DSPE-PEG1000-K237		/	Unkown
HY-172488	DSPE-PEG2000-K237		/	Unkown
HY-172488A	DSPE-PEG3400-K237		/	Unkown
HY-172489	DSPE-PEG5000-K237		/	Unkown
HY-175477	UNC9750	Inhibitor	/	Unkown
HY-18318	Takeda-6D	Inhibitor	99.41%	Unkown
HY-18692	Multi-kinase-IN-12	Inhibitor	/	Unkown
HY-N16797	Sanggenol C		/	Unkown
HY-RS07228	Kdr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W062835A	CGP77675 hydrate	Inhibitor	/	Unkown
HY-W701071	Vatalanib-d4		/	Unkown
HY-110045	ZM-306416 hydrochloride	Inhibitor	/	Unkown
HY-119757A	Tyrphostin AG1433 hydrochloride	Inhibitor	/	Unkown
HY-149451	SYHA1815	Inhibitor	/	Unkown
HY-15769A	WHI-P180 hydrochloride	Inhibitor	/	Unkown
HY-174593	Human KDR mRNA		/	Unkown
HY-183616	VEGFR-2-IN-87	Inhibitor	/	Unkown
HY-N10379	19-epi-Scholaricine		99.14%	Unkown
HY-101628	VEGFR-2-IN-9	Inhibitor	/	Unkown

Bioactive MoleculesInhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991141	Inlecitug	Ligand	98.62%	Unkown
HY-P991689	Girancitug	Inhibitor	98.80%	Unkown
HY-P990318	Alacizumab	Inhibitor	/	Unkown
HY-P990542	Anti-VEGFR2/KDR/CD309 Antibody	Inhibitor	/	Unkown
HY-P990543	Anti-VEGFR2/KDR/CD309 Antibody (AT001)	Inhibitor	/	Unkown
HY-P991420	UB-925	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kdr	NCBI	NCBI:3791