2. Gene
  3. BRD2 - bromodomain containing 2 Gene

BRD2 - bromodomain containing 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ring3

Gene ID: 294276 | Gene type: protein coding

About BRD2

Primary_assembly 20: 4,728,151-4,735,388 forward strand.mRatBN7.2:CM026993.1

This gene has 3 transcripts (splice variants), 301 orthologues, 11 paralogues and is associated with 9 phenotypes. Biased expression in Thymus (RPKM 337.6), Testes (RPKM 264.7) and 9 other tissues.

Summary

Predicted to enable lysine-acetylated histone binding activity; nucleosomal histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in nucleosome assembly; protein phosphorylation; and regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

BRD2 Products(1)

mRNA Protein Name
NM_212495.1 NP_997660.1 bromodomain-containing protein 2

BRD2 Protein Structure

Bromo_Brdt_I_like

Bromo_Brdt_I_like: cd05497 (72 - 178)

PHA03247

PHA03247: cl33720 (214 - 331)

Bromo_Brdt_II_like

Bromo_Brdt_II_like: cd05498 (347 - 448)

BET

BET: pfam17035 (638 - 700)

  • 0
  • 200
  • 400
  • 600
  • 798 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 2

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
Pre-clinical Phase
Bioactive Molecules (25)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100972 ARV-771 Inhibitor 99.87% Unkown
HY-136570 GSK778 Inhibitor 98.93% Unkown
HY-136571 GSK046 Inhibitor 99.65% Unkown
HY-101519 BETd-260 Inhibitor 99.59% Unkown
HY-141438 SIM1 Inhibitor 99.72% Unkown
HY-120000 MS402 Inhibitor 99.62% Unkown
HY-112429 HJB97 Inhibitor 98.24% Unkown
HY-114504 RVX-297 Inhibitor 96.59% Unkown
HY-114416 GS-626510 Inhibitor 99.80% Unkown
HY-112610 CF53 Inhibitor 99.78% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.91% Unkown
HY-146208 BRD4 Inhibitor-20 Inhibitor 99.00% Unkown
HY-145264 OARV-771 Inhibitor 98.33% Unkown
HY-142520 I-BET567 Inhibitor 99.49% Unkown
HY-138563 GSK973 Inhibitor 99.46% Unkown
HY-130612 PROTAC BRD2/BRD4 degrader-1 Inhibitor / Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-149098 SJ1461 Inhibitor / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-121738 TC AC 28 Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-110215 XD14 Inhibitor 95.02% Unkown
HY-151972 BRD4 Inhibitor-25 Inhibitor / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown
HY-160528 IBG3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens BRD2 NCBI NCBI:6046