BRD2 - bromodomain containing 2 Gene
Also Known as Ring3
Species: Rattus norvegicus
About BRD2
This gene has 3 transcripts (splice variants), 301 orthologues, 11 paralogues and is associated with 9 phenotypes. Biased expression in Thymus (RPKM 337.6), Testes (RPKM 264.7) and 9 other tissues.
Summary
Predicted to enable lysine-acetylated histone binding activity; nucleosomal histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in nucleosome assembly; protein phosphorylation; and regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
BRD2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_212495.1 | NP_997660.1 | bromodomain-containing protein 2 |
BRD2 Protein Structure
Bromo_Brdt_I_like: cd05497 (72 - 178)
PHA03247: cl33720 (214 - 331)
Bromo_Brdt_II_like: cd05498 (347 - 448)
BET: pfam17035 (638 - 700)
- 0
- 200
- 400
- 600
- 798 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
bromodomain-containing protein 2 |
|
Related Agents
- Clinical Phase
- Pre-clinical Phase
Clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-100972 | ARV-771 | Degrader | 99.87% | Unkown |
| HY-78695 | JQ-1 carboxylic acid | Inhibitor | 99.69% | Unkown |
| HY-136570 | GSK778 | Inhibitor | 99.14% | Unkown |
| HY-162514 | BBC0403 | Inhibitor | 98.78% | Unkown |
| HY-136571 | GSK046 | Inhibitor | 99.70% | Unkown |
| HY-141438 | SIM1 | Degrader | 99.47% | Unkown |
| HY-160528 | IBG3 | Inhibitor | 98.53% | Unkown |
| HY-153385 | TMX1 | Degrader | 99.57% | Unkown |
| HY-153459 | IBG1 | Degrader | 99.88% | Unkown |
| HY-138563 | GSK973 | Inhibitor | 99.97% | Unkown |
| HY-101519 | BETd-260 | Inhibitor | 99.68% | Unkown |
| HY-103633 | PROTAC BET Degrader-1 | Inhibitor | 99.41% | Unkown |
| HY-112429 | HJB97 | Inhibitor | 99.12% | Unkown |
| HY-114504 | RVX-297 | Inhibitor | 95.00% | Unkown |
| HY-114416 | GS-626510 | Inhibitor | 99.46% | Unkown |
| HY-120000 | MS402 | Inhibitor | 98.36% | Unkown |
| HY-112610 | CF53 | Inhibitor | 99.81% | Unkown |
| HY-111875 | SNIPER(BRD)-1 | Degrader | 99.68% | Unkown |
| HY-130256 | β-NF-JQ1 | Degrader | 98.05% | Unkown |
| HY-131061 | BET bromodomain inhibitor 1 | Inhibitor | 99.67% | Unkown |
| HY-146208 | BRD4 Inhibitor-20 | Inhibitor | 99.24% | Unkown |
| HY-145264 | OARV-771 | Inhibitor | 98.77% | Unkown |
| HY-115568 | BETd-246 | Inhibitor | 98.34% | Unkown |
| HY-114228 | PROTAC BET degrader-2 | Inhibitor | 98.21% | Unkown |
| HY-110215 | XD14 | Inhibitor | 95.02% | Unkown |
| HY-142520 | I-BET567 | Inhibitor | 99.49% | Unkown |
| HY-130813 | BET-IN-6 | Inhibitor | / | Unkown |
| HY-126325 | BY27 | Inhibitor | / | Unkown |
| HY-155680 | BET BD2-IN-1 | Inhibitor | / | Unkown |
| HY-181003 | GSK785 | Inhibitor | / | Unkown |
| HY-155393 | PROTAC BRD4 Degrader-22 | Degrader | / | Unkown |
| HY-170390 | AB3067 | Degrader | / | Unkown |
| HY-181729 | PROTAC BET Degrader-15 | Degrader | / | Unkown |
| HY-152213 | BET-IN-13 | Inhibitor | / | Unkown |
| HY-182371 | BRD4 ligand 15 | Ligand | / | Unkown |
| HY-143471 | WNY0824 | Inhibitor | / | Unkown |
| HY-181495 | RAJQ14 | Degrader | / | Unkown |
| HY-181867 | PROTAC BET Degrader-16 | Degrader | / | Unkown |
| HY-182801 | PROTAC BRD4 Degrader-46 | Degrader | / | Unkown |
| HY-175679 | BRD2 BD1 ligand-1 | Ligand | / | Unkown |
| HY-121738 | TC AC 28 | Inhibitor | / | Unkown |
| HY-176535 | KB-0118 | Inhibitor | / | Unkown |
| HY-181869 | PROTAC BET Degrader-17 | Degrader | / | Unkown |
| HY-179588 | PROTAC BET Degrader-14 | Degrader | / | Unkown |
| HY-149098 | SJ1461 | Inhibitor | / | Unkown |
| HY-181735 | BET-IN-30 | Inhibitor | / | Unkown |
| HY-179589 | JQ-1 (carboxylic acid)-amine-PEG8-cyanogen | Degrader | / | Unkown |
| HY-173062 | BRD4 Inhibitor-40 | Inhibitor | / | Unkown |
| HY-180831 | BRD4 D1-IN-3 | Inhibitor | / | Unkown |
| HY-170900 | SJ44236 | Degrader | / | Unkown |
| HY-175678 | PROTAC BRD2 BD1 Degrader-1 | Degrader | / | Unkown |
| HY-168634 | SJ46421 | Inhibitor | / | Unkown |
| HY-184335 | PROTAC BET Degrader-18 | Degrader | / | Unkown |
| HY-169170 | PARP1/BRD4-IN-3 | Inhibitor | / | Unkown |
| HY-151972 | BRD4 Inhibitor-25 | Inhibitor | / | Unkown |
| HY-130612 | PROTAC BRD2/BRD4 degrader-1 | Inhibitor | / | Unkown |
| HY-180804 | CZL-077 | Inhibitor | / | Unkown |
| HY-136570A | GSK778 hydrochloride | Inhibitor | / | Unkown |
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