Nampt - nicotinamide phosphoribosyltransferase Gene

Also Known as Pbef; Pbef1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 297508

About Nampt

Primary_assembly 6: 49,424,332-49,462,100 forward strand.mRatBN7.2:CM026979.1

This gene has 4 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 20 phenotypes. Biased expression in Muscle (RPKM 673.5), Heart (RPKM 463.7) and 9 other tissues.

Summary

Enables several functions, including cytokine activity; identical protein binding activity; and nicotinamide phosphoribosyltransferase activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to oxygen-glucose deprivation; and negative regulation of cellular senescence. Located in cytoplasm; nucleus; and plasma membrane. Used to study middle cerebral artery infarction and transient cerebral ischemia. Biomarker of kidney failure; periodontitis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Nampt Products (1)

mRNA Protein Name
NM_177928.3 NP_808789.1 nicotinamide phosphoribosyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
18768589 RGD
enables heterocyclic compound binding IDA
IDA: Inferred from direct assay
16901503 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
16901503 RGD
enables nicotinamide phosphoribosyltransferase activity IDA
IDA: Inferred from direct assay
4402158 RGD
enables nucleotide binding IDA
IDA: Inferred from direct assay
16901503 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
28714019 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
28528966 RGD
involved in cellular response to ionizing radiation IEP
IEP: Inferred from expression pattern
27681750 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
26547053 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
17641280 RGD
involved in microglial cell activation IMP
IMP: Inferred from mutant phenotype
28528966 RGD
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
26601421 RGD
involved in negative regulation of cellular senescence IDA
IDA: Inferred from direct assay
28125705 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
18952695 RGD
involved in regulation of lung blood pressure IMP
IMP: Inferred from mutant phenotype
28438162 RGD
involved in response to D-galactose IEP
IEP: Inferred from expression pattern
28163205 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17418807 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nampt Protein Structure

PBEF_like

PBEF_like: cd01569 (27 - 436)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500 a.a.
Protein Preferred Names Protein Names

nicotinamide phosphoribosyltransferase

  • NAmPRTase

  • pre-B-cell colony enhancing factor 1

  • pre-B-cell colony-enhancing factor 1 homolog

  • visfatin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-50876 Daporinad Inhibitor 99.91% Phase 2
HY-12793 Padnarsertib Inhibitor 99.58% Phase 2
HY-10079 CHS-828 Inhibitor 99.28% Phase 1
HY-136241 OT-82 Inhibitor 99.95% Phase 1
HY-10080 Teglarinad chloride Inhibitor 99.67% Phase 1

Pre-clinical Phase

Bioactive Molecules (79)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126255 SBI-797812 Activator 99.88% Unkown
HY-152154 PROTAC NAMPT Degrader-30 Degrader 99.41% Unkown
HY-144776 NAT Activator 99.85% Unkown
HY-15766 GNE-617 Inhibitor 99.62% Unkown
HY-148948 Nampt activator-3 Activator 99.71% Unkown
HY-12808 STF-118804 Inhibitor 99.72% Unkown
HY-147193 Nampt-IN-10 TFA Inhibitor 98.63% Unkown
HY-12971 Nampt-IN-1 Inhibitor 99.48% Unkown
HY-112616 NAMPT inhibitor-linker 2 Inhibitor 99.35% Unkown
HY-402237 Nampt-IN-15 Inhibitor 99.55% Unkown
HY-12628 GNE-618 Inhibitor 99.89% Unkown
HY-148815 Nampt activator-1 Activator 98.63% Unkown
HY-148822 Nampt activator-2 Activator 98.79% Unkown
HY-14373 CB30865 Inhibitor 98.75% Unkown
HY-P2940 NADase / Unkown
HY-161515 BRD4/NAMPT-IN-1 Inhibitor 99.45% Unkown
HY-108701 Nampt-IN-3 Inhibitor 98.97% Unkown
HY-157421 Nampt activator-4 Activator 98.87% Unkown
HY-N3225 Myricanol Activator 98.93% Unkown
HY-15766A GNE-617 hydrochloride Inhibitor 99.16% Unkown
HY-14374 GPP78 Inhibitor 99.9% Unkown
HY-162537 LYP-8 Inhibitor 99.89% Unkown
HY-130606 Nampt-IN-5 Inhibitor 98.02% Unkown
HY-101280 LB-60-OF61 Inhibitor 99.39% Unkown
HY-14375 CB 300919 Inhibitor 99.10% Unkown
HY-179523 Carba1 Activator 98.23% Unkown
HY-125147 A-1293201 Inhibitor 99.82% Unkown
HY-101280A LB-60-OF61 hydrochloride Inhibitor / Unkown
HY-184918 NAMPT/PD-1/PD-L1-IN-1 Inhibitor / Unkown
HY-119159 AS1604498 Inhibitor / Unkown
HY-184467 Nampt-IN-20 Inhibitor / Unkown
HY-162519 LZFPN-90 Inhibitor / Unkown
HY-163280 JGB-1-155 Activator / Unkown
HY-181254 PARP1/NAMPT-IN-1 Inhibitor / Unkown
HY-187006 Nampt-IN-21 Inhibitor / Unkown
HY-147656 NAMPT degrader-1 Inhibitor / Unkown
HY-181880 PROTAC NAMPT Degrader-28 Degrader / Unkown
HY-182062 NAMPT activator-9 Activator / Unkown
HY-187347 PROTAC NAMPT Degrader-31 Degrader / Unkown
HY-170972 PARP1/NAMPT-IN-2 Inhibitor / Unkown
HY-163499 NAMPT activator-7 Activator / Unkown
HY-186105 P7C3-S243 / Unkown
HY-181911 L2-FK866 Inhibitor / Unkown
HY-163500 NAMPT activator-8 Activator / Unkown
HY-176237 Nampt-IN-16 Inhibitor / Unkown
HY-110319 (E/Z)-Daporinad hydrochloride Inhibitor / Unkown
HY-50876A Daporinad hydrochloride Inhibitor / Unkown
HY-172919 PDEδ/NAMPT IN-1 Inhibitor / Unkown
HY-181863 Nampt-IN-18 Inhibitor / Unkown
HY-148572 NAMPT/IDO1-IN-1 Inhibitor / Unkown
HY-181881 MV78-OH Ligand / Unkown
HY-181350 CAIX/XII/NAMPT-IN-1 Inhibitor / Unkown
HY-W1117786 Nampt-IN-10 Inhibitor / Unkown
HY-184650 SHP2/NAMPT-IN-1 Inhibitor / Unkown
HY-164759 Nampt-IN-13 Inhibitor / Unkown
HY-159009 MS7 Inhibitor / Unkown
HY-182567 Nampt-IN-19 Inhibitor / Unkown
HY-147838 Nampt-IN-9 Inhibitor / Unkown
HY-163445 NAMPT activator-6 Activator / Unkown
HY-162269 Nampt activator-5 Activator / Unkown
HY-187348 TT-03597 Inhibitor / Unkown
HY-147795 Nampt-IN-8 Inhibitor / Unkown
HY-155506 NAMPT degrader-3 Degrader / Unkown
HY-147756 Nampt-IN-7 Inhibitor / Unkown
HY-147193A Nampt-IN-10 trihydrochloride Inhibitor / Unkown
HY-175294 PD-L1/Nampt-IN-1 Inhibitor / Unkown
HY-162124 HDAC/NAMPT-IN-1 Inhibitor / Unkown
HY-158319 Mutant IDH1/NAMPT-IN-1 Inhibitor / Unkown
HY-184246 SR-34831 Activator / Unkown
HY-161051 Anticancer agent 177 Inhibitor / Unkown
HY-W587952 Gibberellin A34 Inhibitor / Unkown
HY-184247 SR-32685 Activator / Unkown
HY-163440 PROTAC NAMPT Degrader-1 Degrader / Unkown
HY-184396 GR2-128 Inhibitor / Unkown
HY-187336 Nampt-IN-22 Inhibitor / Unkown
HY-183148 NAMPT activator-10 Activator / Unkown
HY-10079A CHS-828 (nicotinate) Inhibitor / Unkown
HY-161180 Antitumor agent-136 Inhibitor / Unkown
HY-181578 Nampt-IN-17 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990319 ALT-100 (Human IgG4) Inhibitor ≥99.0% Unkown
HY-P991075 ALT-100 (Human IgG1) Inhibitor 99.90% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nampt NCBI NCBI:10135