Sirt2 - sirtuin 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 361532

About Sirt2

Primary_assembly 1: 84,052,903-84,076,975 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 187 orthologues, 6 paralogues and is associated with 3 phenotypes. Biased expression in Brain (RPKM 274.8), Muscle (RPKM 27.6) and 9 other tissues.

Summary

Enables NAD-dependent protein deacetylase activity and tubulin deacetylase activity. Involved in several processes, including nervous system development; regulation of nervous system development; and regulation of postsynaptic neurotransmitter receptor internalization. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Is active in glutamatergic synapse. Used to study high grade glioma and non-alcoholic fatty liver disease. Biomarker of intermittent claudication. Orthologous to human SIRT2 (Sirtuin 2). [provided by Alliance of Genome Resources, Apr 2022]

Sirt2 Products (2)

mRNA Protein Name
NM_001399631.1 NP_001386560.1 NAD-dependent protein deacetylase sirtuin-2 isoform 2
NM_001399630.1 NP_001386559.1 NAD-dependent protein deacetylase sirtuin-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
17344398 RGD
enables tubulin deacetylase activity IDA
IDA: Inferred from direct assay
17344398 RGD
Biological Process GO Annotation Evidence References Source
involved in myelination in peripheral nervous system IMP
IMP: Inferred from mutant phenotype
21949390 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
23522375 RGD
involved in negative regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17344398 RGD
involved in negative regulation of oligodendrocyte progenitor proliferation IMP
IMP: Inferred from mutant phenotype
17344398 RGD
involved in protein deacetylation IMP
IMP: Inferred from mutant phenotype
21949390 RGD
involved in regulation of myelination IMP
IMP: Inferred from mutant phenotype
21949390 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization EXP
EXP: Inferred from Experiment
28793258 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
28793258 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: Inferred from expression pattern
28793258 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
28793258 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
27664298 RGD
involved in tubulin deacetylation IDA
IDA: Inferred from direct assay
17344398 RGD
Cellular Component GO Annotation Evidence References Source
located in Schmidt-Lanterman incisure IDA
IDA: Inferred from direct assay
21949390 RGD
located in glial cell projection IDA
IDA: Inferred from direct assay
17344398 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
28793258 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28793258 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28793258 RGD
located in heterochromatin IDA
IDA: Inferred from direct assay
17344398 RGD
located in juxtaparanode region of axon IDA
IDA: Inferred from direct assay
17344398 RGD
located in lateral loop IDA
IDA: Inferred from direct assay
21949390 RGD
located in myelin sheath IDA
IDA: Inferred from direct assay
17344398 RGD
located in myelin sheath abaxonal region IDA
IDA: Inferred from direct assay
17344398 RGD
located in paranodal junction IDA
IDA: Inferred from direct assay
17344398 RGD
located in paranode region of axon IDA
IDA: Inferred from direct assay
17344398 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
17344398 RGD
located in terminal loop IDA
IDA: Inferred from direct assay
17344398 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sirt2 Protein Structure

SIRT1

SIRT1: cd01408 (105 - 431)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 489 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-2

  • 5E5 antigen

  • NAD-dependent deacetylase sirtuin-2

  • NAD-dependent protein defatty-acylase sirtuin-2

  • SIR2-like protein 2

  • regulatory protein SIR2 homolog 2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0150 Nicotinamide Inhibitor 99.98% Unkown
HY-B0879A Suramin sodium salt Inhibitor 99.98% Yes
HY-B0879 Suramin Inhibitor / Unkown
HY-B0150A Nicotinamide hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-B0150R Nicotinamide (Standard) Inhibitor 99.85% Phase 4

Pre-clinical Phase

Bioactive Molecules (59)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10532 SRT 1720 Activator 99.90% Unkown
HY-100578 AGK2 Inhibitor 99.43% Unkown
HY-107454 OSS_128167 Inhibitor 98.92% Unkown
HY-13515 Sirtinol Inhibitor 98.0% Unkown
HY-100591 SirReal2 Inhibitor 99.0% Unkown
HY-16691 AK-7 Inhibitor 99.63% Unkown
HY-100732 Cambinol Inhibitor 99.89% Unkown
HY-15510 Tenovin-6 Inhibitor 98.00% Unkown
HY-101278 Thiomyristoyl Inhibitor 98.23% Unkown
HY-15145 SRT 1720 monohydrochloride Activator 99.92% Unkown
HY-101073 Salermide Inhibitor 98.0% Unkown
HY-16616 SIRT-IN-2 Inhibitor 98.08% Unkown
HY-136199 SIRT1-IN-1 Inhibitor 98.15% Unkown
HY-103721 SIRT6-IN-2 Inhibitor 99.92% Unkown
HY-103636 PROTAC Sirt2 Degrader-1 Inhibitor 99.09% Unkown
HY-16605 SIRT6-IN-6 Inhibitor 98.59% Unkown
HY-N1926 Dihydrocoumarin Inhibitor 99.81% Unkown
HY-15510B Tenovin-6 Hydrochloride Inhibitor 98.88% Unkown
HY-101465 AK-1 Inhibitor 99.84% Unkown
HY-112427 Sirt2-IN-1 Inhibitor 98.71% Unkown
HY-111522 RK-9123016 Inhibitor 99.65% Unkown
HY-156027 SIRT6-IN-3 Inhibitor 98.19% Unkown
HY-107660 SIRT2-IN-8 Inhibitor 98.45% Unkown
HY-16615 SIRT-IN-1 Inhibitor 98.14% Unkown
HY-123653 SirReal-1 Inhibitor 99.82% Unkown
HY-146689 SIRT1-IN-2 Inhibitor 98.31% Unkown
HY-111329 JGB1741 Inhibitor 99.37% Unkown
HY-146690 SIRT1-IN-3 Inhibitor 99.12% Unkown
HY-163532 FLS-359 Modulator 95.41% Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor 98.37% Unkown
HY-151519 SIRT2-IN-9 Inhibitor 99.45% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-107453 SirReal1-O-propargyl Ligand / Unkown
HY-147233 MIND4-19 Inhibitor 99.93% Unkown
HY-148408 SIRT2-IN-11 Inhibitor 99.94% Unkown
HY-118343 AC-93253 Inhibitor 99.3% Unkown
HY-111303 CHIC35 Inhibitor / Unkown
HY-160617 SIRT2-IN-14 Inhibitor / Unkown
HY-160944 hsa62 Inhibitor / Unkown
HY-153509 Sirtuin-IN-1 Inhibitor / Unkown
HY-145958 Sirt2-IN-6 Inhibitor / Unkown
HY-149637 HSP70/SIRT2-IN-1 Inhibitor / Unkown
HY-W841840 SR94 Inhibitor / Unkown
HY-185682 NCO-141 Inhibitor / Unkown
HY-179388 PROTAC Sirt2 Degrader-2 Degrader / Unkown
HY-136713 Sirt1/2-IN-5 Inhibitor / Unkown
HY-150119 2'/3'-O-Acetyl-ADP-ribose sodium Substrate / Unkown
HY-114510 PRMT/HKMT-IN-1 / Unkown
HY-115979 Sirt2-IN-5 Inhibitor / Unkown
HY-114906 SIRT1/2/3-IN-2 Inhibitor / Unkown
HY-146013 Sirt1/2-IN-1 Inhibitor / Unkown
HY-W197205 SL010110 Inhibitor / Unkown
HY-183870 NCO-90 Inhibitor / Unkown
HY-182412 NH4-6 Inhibitor / Unkown
HY-170402 SIRT6-IN-4 Inhibitor / Unkown
HY-W109401 SIRT-IN-6 Inhibitor / Unkown
HY-119889 A1B11 Inhibitor / Unkown
HY-178773 SIRT2-IN-18 Inhibitor / Unkown
HY-117442 A2B57 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt2 NCBI NCBI:22933