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Angelicin

(別名: Isopsoralen; アンゲリシン)
11 Cited Publications
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Based on 11 publication(s) in Google Scholar

Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC50=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9 and caspase-3.

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  • 純度: 99.98%
  • CAS 番号: 523-50-2
  • 分子式: C11H6O3
  • 分子量:186.16
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Angelicin Chemical Structure
    Angelicin 構造式
  • Experimental Validation Results for Angelicin
  • Experimental Validation Results for Angelicin
  • Experimental Validation Results for Angelicin
  • Experimental Validation Results for Angelicin
  • Experimental Validation Results for Angelicin
CAS 番号: 523-50-2
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Cell Proliferation/Viability AssayApoptosis AnalysisWBRT-PCRELISA
  • Cell Proliferation/Viability Assay
  • Apoptosis Analysis
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  • Angelicin Chemical Structure
    Angelicin Chemical Structure
    1/16
  • 1/16

    Angelicin purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 Jun 9:12:669213. [Abstract]

    Customer Validation
     Effect of angelicin on the cell viability of BMM. The cytotoxic effects of Angelicin (10, 20, 30, 50, 100 μmol/L) were detected at the different concentrations for 24 and 48 h using CCK-8 assay.

  • 1/16

    Angelicin purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 Jun 9:12:669213. [Abstract]

    Customer Validation
     Representative image of apoptosis rate detected by flow cytometry treated with Angelicin (10, 20, 30, 50, 100 μmol/L).

  • 1/16

    Angelicin purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 Jun 9:12:669213. [Abstract]

    Customer Validation
     Western blot analysis of iNOS, Arg-1, STAT3, p-STAT3, and β-actin in BMMs treated with LPS, LPS + Angelicin (ANG) (30 μM), LPS + IL-4/IL-13 + Angelicin + AG490.

  • 1/16

    Angelicin purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 Jun 9:12:669213. [Abstract]

    Customer Validation
     qRT-PCR assay of IL-1β and TNF-α expression in BMMs treated with Angelicin (ANG).(30 μM).

  • 1/16

    Angelicin purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2021 Jun 9:12:669213. [Abstract]

    Customer Validation
     ELISA for IL-1β and TNF-α concentration from cellular supernatant treated with Angelicin (ANG).(30 μM).

  • Angelicin