CD00509
Based on 1 Customer Validation
CD00509 is a tyrosyl-DNA phosphodiesterase (PDE) Tdp1 inhibitor with an IC50 of 0.71 μM. CD00509 increases DNA damage and promotes apoptosis of MCF-7 cells. CD00509 can sensitize breast cancer cells and wild-type murine embryonic fibroblasts (MEFs) to Camptothecin (CPT) (HY-16560). CD00509 can be used for the study of cancers such as breast cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 27430-18-8
- 分子式: C9H6N2O3S
- 分子量:222.22
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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High-Throughput Bioactive Compound Library
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Covalent Fragment Library
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Apoptosis Compound Library
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Cell Cycle/DNA Damage Compound Library
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Metabolism/Protease Compound Library
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Anti-Cancer Compound Library
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Anti-Aging Compound Library
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生物活性
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PDEI 0.71 μM (IC50) |
Caspase-3 |
Caspase-7 |
CD00509 (30 μM, 1-2 h) increases γ-H2AX Foci and DNA breaks in CPT-treated MCF-7 Cells[2].
CD00509 (10 μM, 0-96 h) reduces the number of MCF-7 cells, has almost no effect on normal breast epithelial cells, and significantly increases the caspase-3/7 activation of MCF-7 cells and co-treatment with CPT or Rucaparib (HY-10617A) is more lethal[2].
CD00509 (10 μM) effectively restores the attenuated TPI activity of PGP-inactivated MEFs to wildtype levels[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 27430-18-8
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性状 Solid
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分子量 222.22
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分子式 C9H6N2O3S
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Color Light yellow to yellow
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SMILES
S=C1NC(=O)C(C(N1)=O)=CC2=CC=CO2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
DMSO : 12.5 mg/mL (56.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Laev SS, et al. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential. Bioorg Med Chem. 2016 Nov 1;24(21):5017-5027. [Content Brief]
[2]. Dean RA,et al. Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays. J Biomol Screen. 2014 Dec;19(10):1372-82. [Content Brief]
[3]. Dean RA, et al. Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays. J Biomol Screen. 2014 Dec;19(10):1372-82. [Content Brief]
[4]. Segerer G, et al. An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation. Sci Rep. 2016 Oct 12;6:35160. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5000 mL | 22.5002 mL | 45.0004 mL | 112.5011 mL |
| 5 mM | 0.9000 mL | 4.5000 mL | 9.0001 mL | 22.5002 mL | |
| 10 mM | 0.4500 mL | 2.2500 mL | 4.5000 mL | 11.2501 mL | |
| 15 mM | 0.3000 mL | 1.5000 mL | 3.0000 mL | 7.5001 mL | |
| 20 mM | 0.2250 mL | 1.1250 mL | 2.2500 mL | 5.6251 mL | |
| 25 mM | 0.1800 mL | 0.9000 mL | 1.8000 mL | 4.5000 mL | |
| 30 mM | 0.1500 mL | 0.7500 mL | 1.5000 mL | 3.7500 mL | |
| 40 mM | 0.1125 mL | 0.5625 mL | 1.1250 mL | 2.8125 mL | |
| 50 mM | 0.0900 mL | 0.4500 mL | 0.9000 mL | 2.2500 mL |
CD00509 関連分類
HY-W177546 関連分類
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