Quercimeritrin
Based on 2 publication(s) in Google Scholar
Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor (with an IC50 of 79.88 μM against the Saccharomyces cerevisiae enzyme) and a P-gp substrate, with anti-angiogenic and antioxidant activities. Quercimeritrin does not cross the blood-brain barrier and does not inhibit cytochrome P450 enzymes. Quercimeritrin precisely binds to and inhibits the active sites of c-Kit, MMP-2, Aurora-A kinases and α-glucosidase, thereby disrupting target functions. Quercimeritrin effectively regulates postprandial blood glucose and also exhibits significant anti-angiogenic activity, which inhibits endothelial cell proliferation and microvascular growth. Quercimeritrin can be used in the research of diabetes and breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.48%
- CAS 番号: 491-50-9
- 分子式: C21H20O12
- 分子量:464.38
-
保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-N1445
Isoquercitrin
-
HY-18085
Quercetin
-
HY-N6605
Kaempferol 3-O-β-D-galactopyranoside
-
HY-N0419R
Quercimeritrin (Standard)
-
HY-N4195
Resveratroloside
-
HY-N4285
Negletein
-
HY-N0455A
L-Arginine hydrochloride
-
HY-125740
Malvidin-3-glucoside chloride
-
HY-N0455AR
L-Arginine hydrochloride (Standard)
-
HY-W278582
Topoisomerase II inhibitor 14
-
HY-125740R
Malvidin-3-glucoside chloride (Standard)
MedChemExpress（MCE）の使用を引用している文献 Quercimeritrin
MoreVEGFR アイソフォーム固有の製品をすべて表示
MoreAurora Kinase アイソフォーム固有の製品をすべて表示
More
生物活性
|
VEGFR2 |
MMP-2 |
MMP-9 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| KB | ED50 |
28 μg/mL
Compound: NSC-115917
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 469554] |
Quercimeritrin has a high absorption rate in the human intestine, cannot cross the blood-brain barrier, and does not inhibit major CYPs. It is a substrate of P-gp, and fails to meet one of the Ghose rules due to its low lipophilicity[1].
Quercimeritrin (3.91-500 μM; 10-20 min) potently inhibits α-glucosidase isolated from Saccharomyces cerevisiae, with an IC50 of 79.88 μM, and exhibits a concentration-dependent inhibitory effect[2].
Quercimeritrin (3.91-500 μM; 10-20 min) weakly inhibits porcine pancreas-derived α-amylase, with an IC50 value greater than 250 μM[2].
Quercimeritrin (15.6-500 μM) competitively inhibits α-glucosidase from Saccharomyces cerevisiae and α-amylase from porcine pancreas, and exhibits higher binding affinity for α-glucosidase[2].
Quercimeritrin (10-100 μM; 72 h) inhibits the proliferation of human umbilical vein endothelial cells (HUVEC) in a dose-dependent manner, with a significant inhibitory effect observed at 100 μM[3].
Quercimeritrin (100 μM; 12 h) cannot effectively inhibit tube formation in human umbilical vein endothelial cells (HUVECs), with an inhibition rate of less than 20%[3].
Quercimeritrin (100 μM; 6 h) does not inhibit VEGF-induced HUVEC migration in Boyden chamber assays[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human umbilical vein endothelial cell (HUVEC)
-
Concentration:10, 100 μM
-
Incubation Time:72 h
-
Result:Suppressed HUVEC proliferation in a dose-dependent manner at 10-100 μM.
Significantly suppressed HUVEC proliferation at 100 μM.
-
Cell Line:Human umbilical vein endothelial cell (HUVEC)
-
Concentration:100 μM
-
Incubation Time:6 h
-
Result:Did not suppress VEGF-induced HUVEC migration, with migrated cell numbers similar to the positive control (VEGF alone).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:db/db mice[2]
-
Dosage:100 mg/kg; 200 mg/kg
-
Administration:oral; single dose
-
Result:Reduced postprandial glucose area under the curve (AUC) by 19.0% to 43.7 mmol/(L*h) compared to the model group (100 mg/kg dose).
Reduced postprandial glucose AUC by 24.5% to 40.7 mmol/(L*h) compared to the model group (200 mg/kg dose).
Resulted in a significantly lower postprandial blood glucose level at 120 minutes than the control and acarbose groups (200 mg/kg dose).
化学情報
-
CAS 番号 491-50-9
-
性状 Solid
-
分子量 464.38
-
分子式 C21H20O12
-
Color White to yellow
-
SMILES
OC1=CC=C(C(OC2=C3C(O)=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=C2)=C(O)C3=O)C=C1O
-
別名
Quercetin-7-O-β-D-glucopyranoside; クエルセチン 7-グルコシド
-
Structure Classification
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Food Chem
Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]2025 Dec 30:497:146992. PMID: 41285060 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530
溶剤 & 溶解度
DMSO : 33.33 mg/mL (71.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
-
データシート (281 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1534 mL | 10.7670 mL | 21.5341 mL | 53.8352 mL |
| 5 mM | 0.4307 mL | 2.1534 mL | 4.3068 mL | 10.7670 mL | |
| 10 mM | 0.2153 mL | 1.0767 mL | 2.1534 mL | 5.3835 mL | |
| 15 mM | 0.1436 mL | 0.7178 mL | 1.4356 mL | 3.5890 mL | |
| 20 mM | 0.1077 mL | 0.5384 mL | 1.0767 mL | 2.6918 mL | |
| 25 mM | 0.0861 mL | 0.4307 mL | 0.8614 mL | 2.1534 mL | |
| 30 mM | 0.0718 mL | 0.3589 mL | 0.7178 mL | 1.7945 mL | |
| 40 mM | 0.0538 mL | 0.2692 mL | 0.5384 mL | 1.3459 mL | |
| 50 mM | 0.0431 mL | 0.2153 mL | 0.4307 mL | 1.0767 mL | |
| 60 mM | 0.0359 mL | 0.1795 mL | 0.3589 mL | 0.8973 mL |
Quercimeritrin 関連分類
HY-N0419 関連分類
Powered by Bioz