ICAM1 - intercellular adhesion molecule 1 Gene
Also Known as BB2; CD54; P3.58
Species: Homo sapiens
About ICAM1
This gene has 5 transcripts (splice variants), 94 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 83.1), bone marrow (RPKM 40.5) and 20 other tissues.
Summary
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
ICAM1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000201.3 | NP_000192.2 | intercellular adhesion molecule 1 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables integrin binding |
IDA
IDA: Inferred from direct assay
|
23620790 | GOA |
| enables integrin binding |
IPI
IPI: Inferred from physical interaction
|
1448173 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
7822297 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
21276792 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
9290466 | GOA |
ICAM1 Protein Structure
ICAM_N: Intercellular adhesion molecule (ICAM), N-terminal domain (25 - 115)
Ig_2: Immunoglobulin domain (126 - 190)
Ig_2: Immunoglobulin domain (219 - 298)
Ig_2: Immunoglobulin domain (316 - 389)
Ig_2: Immunoglobulin domain (410 - 474)
- 0
- 100
- 200
- 300
- 400
- 500
- 532 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
intercellular adhesion molecule 1 |
|
ICAM1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ICAM1 | P05362 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
ICAM1 | P05362 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
ICAM1 | P05362 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
ICAM1 | P05362 | CIB1 | Homo sapiens | Q99828 | 32814053 | |
|
Intra
|
ICAM1 | P05362 | CIB1 | Homo sapiens | Q99828 | 32814053 | |
|
Intra
|
ICAM1 | P05362 | CIB1 | Homo sapiens | Q99828 | 32814053 | |
|
Intra
|
ICAM1 | P05362 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
ICAM1 | P05362 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
ICAM1 | P05362 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
ICAM1 | P05362 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
ICAM1 | P05362 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
ICAM1 | P05362 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
ICAM1 | P05362 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
ICAM1 | P05362 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
ICAM1 | P05362 | ITGAL | Homo sapiens | P20701 | 22956999 |
Recombinant ICAM1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72621 | ICAM-1/CD54 Protein, Human (HEK293, His) | P05362 (Q28-E480) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73910 | ICAM-1/CD54 Protein, Human (HEK293, Fc) | P05362/NP_000192.2 (Q28-E480) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73911 | ICAM-1/CD54 Protein, Human (HEK293) | P05362 (Q28-E480) | ≥ 95%, as determined by reducing SDS-PAGE. |
ICAM1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80502 | ICAM1/CD54 Antibody (YA725) | WB, IHC-P, ICC/IF, FC | Human |
| HY-P80716 | ICAM1/CD54 Antibody (YA352) | WB, IHC-P, IP | Human |
| HY-P80716A | ICAM1/CD54 Antibody (YA352)(PBS only) | WB, IHC-P, IP | Human |
| HY-P86708 | ICAM1/CD54 Antibody (YA6400) | IHC-P, IHC-F, IF-Tissue | Human |
| HY-P86708A | ICAM1/CD54 Antibody (YA6400)(PBS only) | IHC-P, IHC-F, IF-Tissue | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Malaria |
|
|
| Leukostasis |
|
|
| Hepatocellular Carcinoma |
|
|
| Erythema Multiforme |
|
|
| Lichen Planus |
|
|
| Amebiasis |
|
|
| Arteriosclerosis |
|
|
| Allergic Contact Dermatitis |
|
|
| Oral Lichen Planus |
|
|
| Endophthalmitis |
|
|
| Rheumatoid Vasculitis |
|
|
| Arteriosclerosis Obliterans |
|
|
| Alopecia Areata |
|
|
| Alcoholic Hepatitis |
|
|
| Arthus Reaction |
|
|
| Plasmodium Falciparum Malaria |
|
|
| Diabetic Macular Edema |
|
|
| Pulmonary Sarcoidosis |
|
|
| Chronic Venous Insufficiency |
|
|
| Allergic Rhinitis |
|
|
| Poliomyelitis |
|
|
| Vasculitis |
|
|
| Common Cold |
|
|
| Graves' Disease |
|
|
| Venous Insufficiency |
|
|
| Multiple Sclerosis |
|
|
| Plummer'S Disease |
|
|
| Relapsing-Remitting Multiple Sclerosis |
|
|
| Uveitis |
|
|
| Henoch-Schoenlein Purpura |
|
|
| Rhinitis |
|
|
| Erythema Nodosum |
|
|
| Hydrocele |
|
|
| Coronary Stenosis |
|
|
| Synovitis |
|
|
| Pulmonary Edema |
|
|
| Keratoconjunctivitis |
|
|
| Glomerulonephritis |
|
|
| Vaccinia |
|
|
| Rapidly Progressive Glomerulonephritis |
|
|
| Microvascular Complications Of Diabetes 1 |
|
|
| Smallpox |
|
|
| Leukocyte Adhesion Deficiency, Type I |
|
|
| Guillain-Barre Syndrome |
|
|
| Microvascular Complications Of Diabetes 5 |
|
|
| Polyarteritis Nodosa |
|
|
| Lymphadenitis |
|
|
| Conjunctivitis |
|
|
| Plasma Cell Leukemia |
|
|
| Toxicodendron Dermatitis |
|
|
| Allergic Asthma |
|
|
| Ischemia |
|
|
| Asthma |
|
|
| Atherosclerosis Susceptibility |
|
|
| Polymyositis |
|
|
| Carotid Stenosis |
|
|
| Angina Pectoris |
|
|
| Sleep Apnea |
|
|
| Graves Ophthalmopathy |
|
|
| Burkitt Lymphoma |
|
|
| Cholesteatoma Of Middle Ear |
|
|
| Ileus |
|
|
| Takayasu Arteritis |
|
|
| Heterophyiasis |
|
|
| Bronchiolitis |
|
|
| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
|
| Rheumatic Fever |
|
|
| Peritonitis |
|
|
| Acquired Immunodeficiency Syndrome |
|
|
| Leptospirosis |
|
|
| Gingivitis |
|
|
| Psoriasis |
|
|
| Sarcoma |
|
|
| Otitis Media |
|
|
| Rheumatoid Arthritis |
|
|
| Pre-Eclampsia |
|
|
| Meningitis |
|
|
| Mastitis |
|
|
| Interstitial Lung Disease |
|
|
| Systemic Lupus Erythematosus |
|
|
| Nodular Goiter |
|
|
| Allergic Disease |
|
|
| Varicose Veins |
|
|
| Fabry Disease |
|
|
| Inflammatory Bowel Disease |
|
|
| Retinal Detachment |
|
|
| Acute Pancreatitis |
|
|
| Periodontitis |
|
|
| Macular Retinal Edema |
|
|
| Pneumoconiosis |
|
|
| Viral Hepatitis |
|
|
| Myocarditis |
|
|
| Cholangitis |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Cardiovascular System Disease |
|
|
| Iga Glomerulonephritis |
|
|
| Gastroschisis |
|
|
| Sarcoidosis 1 |
|
|
| Buerger Disease |
|
|
| Hydronephrosis |
|
|
| Skin Disease |
|
|
| Hashimoto Thyroiditis |
|
|
| Inflammatory Bowel Disease 14 |
|
|
| Lung Disease |
|
|
| Dermatitis, Atopic |
|
|
| Background Diabetic Retinopathy |
|
|
| Vascular Disease |
|
|
| Aortic Atherosclerosis |
|
|
| Type 1 Diabetes Mellitus |
|
|
| Severe Nonproliferative Diabetic Retinopathy |
|
|
| Heart Disease |
|
|
| Shwartzman Phenomenon |
|
|
| Colorectal Cancer |
|
|
| Retinal Ischemia |
|
|
| Macular Degeneration, Age-Related, 9 |
|
|
| Acute Necrotizing Pancreatitis |
|
|
| Sjogren Syndrome |
|
|
| Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1 |
|
|
| Retinal Vascular Occlusion |
|
|
| Temporal Arteritis |
|
|
| Retinal Vascular Disease |
|
|
| Diabetic Angiopathy |
|
|
| Melanoma |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Myocardial Infarction |
|
|
| Viral Infectious Disease |
|
|
| Central Retinal Vein Occlusion |
|
|
| Follicular Lymphoma |
|
|
| Retinal Artery Occlusion |
|
|
| Vein Disease |
|
|
| Hypertension, Essential |
|
|
| Acute Asthma |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Hyperglobulinemic Purpura |
|
|
| Peripheral Artery Disease |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Cataract |
|
|
| Thrombocytopenia |
|
|
| Combined Immunodeficiency |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Autoimmune Disease |
|
|
| Diabetes Mellitus |
|
|
| Lacrimal Apparatus Disease |
|
|
| Peripheral Vascular Disease |
|
|
| Dry Eye Syndrome |
|
|
| Lichen Disease |
|
|
| Carotid Artery Disease |
|
|
| Bronchial Disease |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Cystic Fibrosis |
|
|
| Myeloma, Multiple |
|
|
| Apnea, Obstructive Sleep |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Nose Disease |
|
|
| Autoimmune Disease Of Skin And Connective Tissue |
|
|
| Osteoporosis |
|
|
| Extrinsic Cardiomyopathy |
|
|
| Lung Cancer |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Pancreatic Cancer |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Acute Hemorrhagic Encephalitis |
|
|
| Uveal Disease |
|
|
| Integumentary System Disease |
|
|
| Aortic Aneurysm, Familial Abdominal, 1 |
|
|
| Intracranial Berry Aneurysm |
|
|
| Exudative Vitreoretinopathy 1 |
|
|
| Prostate Cancer |
|
|
| Respiratory Failure |
|
|
| Lipid Metabolism Disorder |
|
|
| Breast Cancer |
|
|
| Sickle Cell Anemia |
|
|
| Behcet Syndrome |
|
|
| Diamond-Blackfan Anemia 1 |
|
|
| Eye Disease |
|
|
| Connective Tissue Disease |
|
|
| Interstitial Lung Disease 2 |
|
|
| Nervous System Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Dilated Cardiomyopathy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | ICAM1 | VGNC | VGNC:41856 |
| Felis catus | ICAM1 | VGNC | VGNC:67685 |
| Mus musculus | ICAM1 | MGD | MGI:96392 |
| Rattus norvegicus | ICAM1 | RGD | RGD:2857 |
| Bos taurus | ICAM1 | VGNC | VGNC:50197 |
| Others | ICAM1 | NCBI |