CC-11
CC-11 is an orally active small molecule drug conjugate (SMDC) that links the PI3K/mTOR inhibitor with the extracellular heat shock protein 90 (EHSP90) targeting ligand through a cleavable linker. CC-11 exhibits strong HSP90 binding activity (IC50 = 15 nM) and inhibits PI3Kα kinase activity (IC50 = 0.54 nM). CC-11 has anti-proliferative activity against colon cancer cells. CC-11 shows significant efficacy in the HCT-116 xenograft tumor model. CC-11 can be used for research on colon cancer.
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- CAS No.: 3079942-94-9
- 화학식: C52H54F2N12O10S
- 분자량:1077.12
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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HSP90 15 nM (IC50) |
PI3Kα 0.54 nM (IC50) |
Chemical Information
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CAS No. 3079942-94-9
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분자량 1077.12
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화학식 C52H54F2N12O10S
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SMILES
CC(C1=CC(C(N2C3=CC=C(NC(CCC(NCC(OC4CCCN(C4)CCCN5C=C(N=N5)C6=CN=C7N6N=C(C=C7)C8=CC(NS(C9=CC=C(F)C=C9F)(=O)=O)=C(N=C8)OC)=O)=O)=O)C=C3CC2)=O)=C(C=C1O)O)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CC-11 Related Classifications
HY-179457 Related Classifications
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