CD00509
Based on 1 Customer Validation
CD00509 is a tyrosyl-DNA phosphodiesterase (PDE) Tdp1 inhibitor with an IC50 of 0.71 μM. CD00509 increases DNA damage and promotes apoptosis of MCF-7 cells. CD00509 can sensitize breast cancer cells and wild-type murine embryonic fibroblasts (MEFs) to Camptothecin (CPT) (HY-16560). CD00509 can be used for the study of cancers such as breast cancer.
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- Purity: 98.0%
- CAS No.: 27430-18-8
- 화학식: C9H6N2O3S
- 분자량:222.22
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Covalent Screening Library
HY-L036
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Pyroptosis Compound Library
HY-L059
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Anti-Alzheimer's Disease Compound Library
HY-L069
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Anti-Breast Cancer Compound Library
HY-L074
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Neurodegenerative Disease-related Compound Library
HY-L086
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Anti-Colorectal Cancer Compound Library
HY-L103
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Metabolic Enzyme Compound Library
HY-L146
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Highly Selective Inhibitors Library
HY-L158
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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Covalent Screening Library Plus
HY-L036P
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Covalent Fragment Library
HY-L909
Biological Activity
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PDEI 0.71 μM (IC50) |
Caspase-3 |
Caspase-7 |
CD00509 (30 μM, 1-2 h) increases γ-H2AX Foci and DNA breaks in CPT-treated MCF-7 Cells[2].
CD00509 (10 μM, 0-96 h) reduces the number of MCF-7 cells, has almost no effect on normal breast epithelial cells, and significantly increases the caspase-3/7 activation of MCF-7 cells and co-treatment with CPT or Rucaparib (HY-10617A) is more lethal[2].
CD00509 (10 μM) effectively restores the attenuated TPI activity of PGP-inactivated MEFs to wildtype levels[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 27430-18-8
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Appearance Solid
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분자량 222.22
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화학식 C9H6N2O3S
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Color Light yellow to yellow
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SMILES
S=C1NC(=O)C(C(N1)=O)=CC2=CC=CO2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
DMSO : 12.5 mg/mL (56.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Laev SS, et al. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential. Bioorg Med Chem. 2016 Nov 1;24(21):5017-5027. [Content Brief]
[2]. Dean RA,et al. Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays. J Biomol Screen. 2014 Dec;19(10):1372-82. [Content Brief]
[3]. Dean RA, et al. Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays. J Biomol Screen. 2014 Dec;19(10):1372-82. [Content Brief]
[4]. Segerer G, et al. An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation. Sci Rep. 2016 Oct 12;6:35160. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5000 mL | 22.5002 mL | 45.0004 mL | 112.5011 mL |
| 5 mM | 0.9000 mL | 4.5000 mL | 9.0001 mL | 22.5002 mL | |
| 10 mM | 0.4500 mL | 2.2500 mL | 4.5000 mL | 11.2501 mL | |
| 15 mM | 0.3000 mL | 1.5000 mL | 3.0000 mL | 7.5001 mL | |
| 20 mM | 0.2250 mL | 1.1250 mL | 2.2500 mL | 5.6251 mL | |
| 25 mM | 0.1800 mL | 0.9000 mL | 1.8000 mL | 4.5000 mL | |
| 30 mM | 0.1500 mL | 0.7500 mL | 1.5000 mL | 3.7500 mL | |
| 40 mM | 0.1125 mL | 0.5625 mL | 1.1250 mL | 2.8125 mL | |
| 50 mM | 0.0900 mL | 0.4500 mL | 0.9000 mL | 2.2500 mL |
CD00509 Related Classifications
HY-W177546 Related Classifications
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