Cat. No.: HY-12708

Chlorpromazine

147 Cited Publications

고객리뷰

Based on 147 publication(s) in Google Scholar

Chlorpromazine is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT_2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine also blocks hNa_v1.7 channels (IC₅₀=25.9 μM; concentration-dependent) and HERG potassium channels (IC₅₀=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine also can inhibit clathrin-mediated endocytosis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.75%
CAS No.: 50-53-3
화학식: C₁₇H₁₉ClN₂S
분자량:318.86

보관:

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Chlorpromazine Chemical Structure

CAS No.: 50-53-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (147)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
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Biological Activity

제품 설명

IC₅₀ & Target

5-HT_2A Receptor

All Dopamine Receptor Isoforms :

All Cytochrome P450 Isoforms :

All 5-HT Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	3.4 μM Compound: chlorpromazine	Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits	[PMID: 23812503]
CHO-K1	IC₅₀	1 nM Compound: Chlorpromazine	Antagonist activity against human recombinant dopmaine D2L receptor expressed in CHOK1 cells assessed as reduction in apomorphine-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method Antagonist activity against human recombinant dopmaine D2L receptor expressed in CHOK1 cells assessed as reduction in apomorphine-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	[PMID: 25557493]
CHO-K1	IC₅₀	1 nM Compound: Chlorpromazine	Antagonist activity at human dopamine D2 receptor expressed in CHOK1 cells assessed as inhibition of apomorphine-induced calcium mobilization by radiometric and luminescence plate counting method Antagonist activity at human dopamine D2 receptor expressed in CHOK1 cells assessed as inhibition of apomorphine-induced calcium mobilization by radiometric and luminescence plate counting method	[PMID: 25557493]
Cortical neurone	IC₅₀	13.8 μM Compound: Chlorpromazine	Neurotoxicity in rat cortical neuron assessed as inhibition of neurite total length per neuron incubated for 72 hrs by Hoechst 33342 staining based ArrayScan analysis Neurotoxicity in rat cortical neuron assessed as inhibition of neurite total length per neuron incubated for 72 hrs by Hoechst 33342 staining based ArrayScan analysis	[PMID: 31841637]
Cortical neurone	IC₅₀	7.99 μM Compound: Chlorpromazine	Neurotoxicity in rat cortical neuron assessed as inhibition of valid neuron count incubated for 72 hrs by Hoechst 33342 staining based ArrayScan analysis Neurotoxicity in rat cortical neuron assessed as inhibition of valid neuron count incubated for 72 hrs by Hoechst 33342 staining based ArrayScan analysis	[PMID: 31841637]
Cortical neurone	IC₅₀	9.022 μM Compound: Chlorpromazine	Neurotoxicity in rat cortical neuron assessed as inhibition of neurite outgrowth by measuring mean neurite average length incubated for 72 hrs by Hoechst 33342 staining based ArrayScan analysis Neurotoxicity in rat cortical neuron assessed as inhibition of neurite outgrowth by measuring mean neurite average length incubated for 72 hrs by Hoechst 33342 staining based ArrayScan analysis	[PMID: 31841637]
HaCaT	IC₅₀	36.1 μM Compound: CPZ	Phototoxicity in human HaCaT cells assessed as reduction in cell viability preincubated for 60 mins followed by 7.5 J/cm2 UVA irradiation and measured after 24 hrs by neutral red uptake assay Phototoxicity in human HaCaT cells assessed as reduction in cell viability preincubated for 60 mins followed by 7.5 J/cm2 UVA irradiation and measured after 24 hrs by neutral red uptake assay	[PMID: 29604584]
HEK293	IC₅₀	27 μM Compound: chlorpromazine	Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy	[PMID: 18788725]
HeLa	IC₅₀	4.3 μM Compound: Chlorpromazine	TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing HeLa cells TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing HeLa cells	[PMID: 12606755]
Macrophage cell line	CC₅₀	22.24 μM Compound: CPZ	Cytotoxicity in human monocyte-derived macrophages assessed as reduction in cell viability incubated for 3 days by alamar blue dye based assay Cytotoxicity in human monocyte-derived macrophages assessed as reduction in cell viability incubated for 3 days by alamar blue dye based assay	[PMID: 28964936]
NCI-H1650	GI₅₀	30.3 μM Compound: Chlorpromazine	Cytotoxicity against human NCI-H1650 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human NCI-H1650 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26372073]
NHDF	IC₅₀	25.5 μM Compound: CPZ	Phototoxicity in human NHDF cells assessed as reduction in cell viability preincubated for 60 mins followed by 5 J/cm2 UVA irradiation and measured after 24 hrs by neutral red uptake assay Phototoxicity in human NHDF cells assessed as reduction in cell viability preincubated for 60 mins followed by 5 J/cm2 UVA irradiation and measured after 24 hrs by neutral red uptake assay	[PMID: 29604584]
NIH3T3	IC₅₀	0.93 μg/mL Compound: Chlorpromazine	Phototoxicity against BALB/c mouse 3T3 cells assessed as reduction in cell viability preincubated for 1 hr followed by 5 J/cm2 irradiation and subsequent replacement of medium without compound and measured after 24 hrs by neutral red dye based assay Phototoxicity against BALB/c mouse 3T3 cells assessed as reduction in cell viability preincubated for 1 hr followed by 5 J/cm2 irradiation and subsequent replacement of medium without compound and measured after 24 hrs by neutral red dye based assay	[PMID: 38128906]
NIH3T3	IC₅₀	45.08 μg/mL Compound: Chlorpromazine	Dark toxicity against BALB/c mouse 3T3 cells assessed as reduction in cell viability incubated for 1 hr by neutral red dye based assay Dark toxicity against BALB/c mouse 3T3 cells assessed as reduction in cell viability incubated for 1 hr by neutral red dye based assay	[PMID: 38128906]
ScN2a	EC₅₀	2 μM Compound: Chlorpromazine	Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells	[PMID: 12904059]
Sf21	IC₅₀	122.3 μM Compound: Chlorpromazine	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Sf21	IC₅₀	147.6 μM Compound: Chlorpromazine	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Vero	IC₅₀	26.52 μg/mL Compound: CPZ	Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability incubated for 72 hrs by resazurin assay Cytotoxicity against African green monkey Vero cells assessed as decrease in cell viability incubated for 72 hrs by resazurin assay	[PMID: 32526553]
WI-38	CC₅₀	10.34 μM Compound: Chlorpromazine	Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay	[PMID: 17893158]
WI-38	EC₅₀	7.6 μM Compound: Chlorpromazine	Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay	[PMID: 17893158]

In Vitro

Chlorpromazine (0, 10, 20, 40 μM; 0, 24, 48 h) inhibits growth of U-87MG glioma cells in a dose- and time- dependent manner^[2].
Chlorpromazine (20 μM; 0, 12, 24, 48 h) decreases the levels of cyclin A and cyclin B1 in U-87MG glioma cells, 12 h later^[2].
Chlorpromazine (20 μM) causes inhibition of cell cycle progression^[2].
Chlorpromazine (10 μM; 1 h) significantly suppresses the sEV internalization and dramatically reduces MDSCs in sEV-treated bone marrow cells (MDSCs can significantly suppress the immune cell response, causing immunosuppression in cancer cells)^[3].
Chlorpromazine (3, 10, 20, 40, 60 μM) blocks the hNa_v1.7 current in a concentration-dependent manner^[4].
Chlorpromazine blocks HERG potassium channels with an IC₅₀ value of 21.6 μM and a Hill coefficient of 1.11^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

U-87MG glioma cells
Concentration:

0, 10, 20, 40 μM
Incubation Time:

0, 24, 48 h
Result:

Showed anti-proliferative activity in a dose- and time-dependent manner.

Immunofluorescence^[3]

Cell Line:

Bone marrow cells (sEV-treated)
Concentration:

10 µM
Incubation Time:

1 h
Result:

Reduced MDSCs and suppressed the sEV internalization.

Western Blot Analysis^[2]

Cell Line:

U-87MG glioma cells
Concentration:

20 μM
Incubation Time:

0, 12, 24, 48 h
Result:

Decreased the levels of cyclin A and cyclin B1 12 h later, whereas levels of cyclin D1, proliferating cell nuclear antigen and GAPDH remained unchanged.

In Vivo

Chlorpromazine (20 mg/kg; i.p.; single daily for 7 days) inhibits xenograft tumor growth in nude mouse^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

5- to 6-week-old athymic nude mice bearing intracranial U-87MG xenograft tumors^[2].
Dosage:

20 mg/kg
Administration:

Injected intraperitoneally; single daily for 7 days
Result:

Inhibited tumor growth on day 17.

Chemical Information

CAS No. 50-53-3
Appearance Solid
분자량 318.86
화학식 C₁₇H₁₉ClN₂S
Color White to off-white
SMILES

CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Publications (147)

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Signal Transduct Target Ther

Disrupting SOX2 self-association and condensate formation to overcome chemotherapeutic drug resistance in lung squamous cell carcinoma. [Abstract]

2026 May 13;11(1):183. PMID: 42143069
Signal Transduct Target Ther

Condensate nanovaccine adjuvants augment CD8+ T-Cell-dependent antitumor immunity through mtDNA leakage-triggered cGAS-STING axis activation. [Abstract]

2025 Oct 21;10(1):349. PMID: 41115902

Chlorpromazine purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 21;10(1):349. [Abstract]

Analysis of the cellular uptake pathways of OVA PCD. Ethamilamiline (EIPA), genistein (GEN), and chlorpromazine (CPZ) (10 μM for 12 h）were used to inhibit macropinocytosis, caveolin-mediated endocytosis, and clathrin-mediated endocytosis, respectively.
Nat Nanotechnol

Metal-ion-chelating phenylalanine nanostructures reverse immune dysfunction and sensitize breast tumour to immune checkpoint blockade. [Abstract]

2024 Dec;19(12):1903-1913. PMID: 39187583
Cell Metab

Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer. [Abstract]

2024 Jun 18:S1550-4131(24)00189-X. PMID: 38897198

Chlorpromazine purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 Jun 18:S1550-4131(24)00189-X. [Abstract]

To clarify the possible pathways responsible for EV uptake by CAFs, BMDM-derived EVs were labeled with DiO, and m-CAFs were labeled with DiL. Chlorpromazine (50 μM, 1h) was used to block EV uptake by m-CAFs.
Cell Metab

Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production. [Abstract]

2022 Dec 6;34(12):2018-2035.e8. PMID: 36351432

Chlorpromazine purchased from MedChemExpress. Usage Cited in: Cell Metab. 2022 Dec 6;34(12):2018-2035.e8. [Abstract]

Bone marrow cells cultured in medium containing 10 ng/mL GM-CSF for 3 days were treated with 2 μg PKH67-labeled sEVs with or without Amiloride (10 μM), Chlorpromazine (10 μM), or EIPA (5 μM) for 1 h. The median fluorescence intensity (MFI) of PKH67 was assessed by flow cytometry.
Adv Mater

Self-Sustained Biophotocatalytic Nano-Organelle Reactors with Programmable DNA Switches for Combating Tumor Metastasis. [Abstract]

2025 Jan 10:e2415030. PMID: 39797479

Chlorpromazine purchased from MedChemExpress. Usage Cited in: Adv Mater. 2025 Jan 10:e2415030. [Abstract]

FCM analysis of F/G/H‐GNC internalization by 4T1 cells pre‐treated with various endocytosis inhibitors (n = 3). EIPA: 5‐(N‐ethyl‐N‐isopropyl)‐amiloride, 50 µM; Dyna: dynasore, 50 µg/mL; Me‐β‐CD: methyl‐β‐cyclodextrin, 2.5 mg/mL; CPZ: Chlorpromazine, 10 µg/mL; Cyto D: Cytochalasin D, 2.5 µg/mL; Noco: Nocodazole, 5 µM.
Nat Biomed Eng

Modular nucleic acid-based construct for delivery of immunostimulatory agonists and oncogene-silencing oligonucleotides in tumours. [Abstract]

2026 Jun 3. PMID: 42236980
Nat Biomed Eng

In situ formation of biomolecular condensates as intracellular drug reservoirs for augmenting chemotherapy. [Abstract]

2024 Nov;8(11):1469-1482. PMID: 39271933
Cancer Res

Targeting Sialylation Enhances the Therapeutic Efficacy of the Nectin-4-Targeted Antibody-Drug Conjugate Enfortumab Vedotin in Bladder Cancer. [Abstract]

2025 Oct 9. PMID: 41066596
J Extracell Vesicles

Extracellular Vesicles Coordinate Bacterial Cloaking in Lung Epithelial Cells to Alleviate Acute Inflammatory Injury. [Abstract]

2026 Feb;15(2):e70238. PMID: 41656978
J Extracell Vesicles

CD7-targeting pro-apoptotic extracellular vesicles: A novel approach for T-cell haematological malignancy therapy. [Abstract]

2024 Dec;13(12):e70025. PMID: 39676736
Adv Funct Mater

2024 Oct 31.
Adv Funct Mater

2023 Jan 15.
Adv Funct Mater

2020, 2004940.
Nat Commun

Supercharged ferritin nanocages enable universal cytosolic protein delivery. [Abstract]

2026 Jun 9. PMID: 42259798
Nat Commun

Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain. [Abstract]

2025 Dec 12;16(1):11314. PMID: 41387431
Nat Commun

Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats. [Abstract]

2025 Sep 26;16(1):8522. PMID: 41006301
Nat Commun

Microglial replacement in a Sandhoff disease mouse model reveals myeloid-derived β-hexosaminidase is necessary for neuronal health. [Abstract]

2025 Aug 27;16(1):7994. PMID: 40866328
Nat Commun

Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics. [Abstract]

2025 Mar 10;16(1):2368. PMID: 40064874
ACS Nano

Autophagy-Inducing and cfDNA-Scavenging Nanoparticles for Synergistic Atherosclerosis Therapy. [Abstract]

2026 Jun 26. PMID: 42361347
ACS Nano

Engineered Lysosome-Targeted Protein Degradation via Hijacking Macropinocytosis. [Abstract]

2026 Jun 30;20(25):18533-18544. PMID: 42304955
ACS Nano

Self-Assembling Enveloped Virus-Mimicking Particle for Extrahepatic Targeting mRNA Delivery. [Abstract]

2026 Apr 13. PMID: 41972484
ACS Nano

Deciphering the Hepatic Cellular Interactions of PEGylated Iron Oxide Nanoparticles. [Abstract]

2026 Feb 17;20(6):5157-5170. PMID: 41620948
ACS Nano

Redox-Responsive Peptide Coacervates for Enhanced mRNA Delivery and Intracellular Release. [Abstract]

2025 Dec 26. PMID: 41451635
ACS Nano

Enantioselective Degrader for Elimination of Extracellular Aggregation-Prone Proteins hIAPP Associated with Type 2 Diabetes. [Abstract]

2023 May 9;17(9):8141-8152. PMID: 37057955
ACS Nano

Modular Peptide Probe for Pre/Intra/Postoperative Therapeutic to Reduce Recurrence in Ovarian Cancer. [Abstract]

2020 Nov 24;14(11):14698-14714. PMID: 33174739
BMEmat

2026 Feb 11.
J Am Chem Soc

Potent Protein Delivery into Mammalian Cells via a Supercharged Polypeptide. [Abstract]

2018 Dec 12;140(49):17234-17240. PMID: 30398334
Nat Plants

An apoplastic fungal effector disrupts N-glycosylation of ZmLecRK1, inducing its degradation to suppress disease resistance in maize. [Abstract]

2025 Sep 12. PMID: 40940425
J Nanobiotechnology

Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer. [Abstract]

2025 Aug 6;23(1):554. PMID: 40770338
Theranostics

Adjuvant-free peptide vaccine targeting Clec9a on dendritic cells can induce robust antitumor immune response through Syk/IL-21 axis. [Abstract]

2021 May 24;11(15):7308-7321. PMID: 34158852
Theranostics

Proinflammatory macrophage-derived microvesicles exhibit tumor tropism dependent on CCL2/CCR2 signaling axis and promote drug delivery via SNARE-mediated membrane fusion. [Abstract]

2020 May 17;10(15):6581-6598. PMID: 32550891
Theranostics

A Multifunctional Nanotherapy for Targeted Treatment of Colon Cancer by Simultaneously Regulating Tumor Microenvironment. [Abstract]

2019 May 31;9(13):3732-3753. PMID: 31281510
Acta Pharm Sin B

Spatiotemporally delivery of Cas9 ribonucleoprotein/DNAzyme logic systems using near-infrared upconversion nanomachine for precise immunotherapy. [Abstract]

2025 Oct;15(10):5431-5443. PMID: 41132842
Acta Pharm Sin B

Cocrystal@protein-anchoring nanococktail for combinatorially treating multidrug-resistant cancer. [Abstract]

2024 Oct;14(10):4509-4525. PMID: 39525582
Interdiscip Med

2026 May 18.
Adv Sci (Weinh)

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis. [Abstract]

2026 Jun;13(34):e23189. PMID: 41933938
Adv Sci (Weinh)

Biomimetic Macrophage Cell Membrane-Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy. [Abstract]

2026 Jun 22:e76216. PMID: 42328759
Adv Sci (Weinh)

Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers. [Abstract]

2026 May 13:e75691. PMID: 42126794
Adv Sci (Weinh)

Biomimetic Nanomedicine for Senescence-Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma. [Abstract]

2025 Dec 23:e17792. PMID: 41432006
Adv Sci (Weinh)

Physiological pH Transition-Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles. [Abstract]

2025 Sep 3:e02788. PMID: 40902197
Adv Sci (Weinh)

Lipid Droplet-Derived Biomimetic Nanocarriers for the Enhancement of Porcine Intermuscular Fat Content. [Abstract]

2025 May 14:e2406150. PMID: 40365640
Adv Sci (Weinh)

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases. [Abstract]

2025 Apr 3:e2412356. PMID: 40178289
Adv Sci (Weinh)

CCR7 Mediated Mimetic Dendritic Cell Vaccine Homing in Lymph Node for Head and Neck Squamous Cell Carcinoma Therapy. [Abstract]

2023 Jun;10(17):e2207017. PMID: 37092579
Biomaterials

Biodegradable polymers with tertiary amines enhance mRNA delivery of lipid nanoparticles via improved endosomal escape. [Abstract]

2026 Jan:324:123541. PMID: 40644791
Biomaterials

Oral delivery of decanoic acid conjugated plant protein shell incorporating hybrid nanosystem leverage intestinal absorption of polyphenols. [Abstract]

2022 Feb:281:121373. PMID: 35063742
Carbohydr Polym

Premna microphylla Turcz pectin-modified diosmetin nanoparticles: A galectin-3 targeting strategy for precise colitis intervention. [Abstract]

2025 Nov 15;368(Pt 1):124067. PMID: 40912828
Chem Eng J

2025 Jul 1.
Chem Eng J

2024 Sep 1.
Chem Eng J

2024 Apr 15, 486 150125.
J Control Release

Intravitreal delivery of LATS1 mRNA by lipid nanoparticles as an effective strategy for uveal melanoma therapy. [Abstract]

2026 May 10:393:114784. PMID: 41786044
J Control Release

Bioswitchable intracellular delivery of small activating RNA by tetrahedral framework nucleic acid: Application to p21-mediated anti-tumor therapy. [Abstract]

2025 Nov 30:389:114488. PMID: 41330514
J Control Release

Cyclization and thermal modulation of a β-hairpin peptide for efficient cellular delivery. [Abstract]

2025 Dec 16:390:114551. PMID: 41412216
J Control Release

Inducing potent ferroptosis in cancer cells by manipulation of ferritinophagy with a ferritin-targeted ATTEC. [Abstract]

2025 Nov 20:389:114450. PMID: 41274571
J Control Release

Enzyme-instructed disassembly of phosphorylated temporin supramolecules enhances doxorubicin synergy for targeted cancer inhibition. [Abstract]

2025 Aug 29:387:114176. PMID: 40886776
J Control Release

Combating cisplatin-resistant lung cancer using a coiled-coil lipopeptides modified membrane fused drug delivery system. [Abstract]

2025 Jan 8:379:45-58. PMID: 39756686
J Control Release

A single molecule carrier for ocular posterior segment diseases. [Abstract]

2024 Oct 26:S0168-3659(24)00725-9. PMID: 39490420
J Control Release

A facile and smart strategy to enhance bone regeneration with efficient vitamin D3 delivery through sterosome technology. [Abstract]

2024 Jun:370:140-151. PMID: 38653347
Environ Sci Technol

Graphene Quantum Dots Disrupt Embryonic Stem Cell Differentiation by Interfering with the Methylation Level of Sox 2. [Abstract]

2021 Mar 2;55(5):3144-3155. PMID: 33569944
Small

Dynamically Reprograms Mitochondrial Respiration to Augment Cuproptosis in Cancer Therapy. [Abstract]

2026 Mar;22(18):e13435. PMID: 41653427
J Immunother Cancer

Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation. [Abstract]

2023 Jan;11(1):e005592. PMID: 36596591
Cell Commun Signal

Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy. [Abstract]

2023 May 4;21(1):99. PMID: 37143083
Cell Commun Signal

Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor. [Abstract]

2020 Nov 4;18(1):176. PMID: 33148272
Cell Commun Signal

A piggyBac-based TANGO GFP assay for high throughput screening of GPCR ligands in live cells. [Abstract]

2019 May 23;17(1):49 PMID: 31122241
J Pharm Anal

Effect of cholesterol on distribution, cell uptake, and protein corona of lipid microspheres at sites of cardiovascular inflammatory injury. [Abstract]

2025 Jul;15(7):101182. PMID: 40735031
Mater Today Bio

SLC7A11-independent disulfidptosis induced by a two-pronged delivery strategy for bladder cancer chemotherapy and cisplatin-resistance reverse. [Abstract]

2025 Nov 13:35:102547. PMID: 41322137
Mater Today Bio

Hyaluronic acid-anchored nanoparticles co-delivering emodin and siRNA confers protection against rheumatoid arthritis via macrophage polarization. [Abstract]

2025 Jul 10:33:102074. PMID: 40688667
Adv Healthc Mater

Lipoprotein-Based Nanocatalyst Enables Targeted Treatment of APAP-Induced Liver Injury via Enhanced Macropinocytosis. [Abstract]

2025 May 24:e2500507. PMID: 40411876
Mater Today Bio

Metal-organic framework-based delivery systems as nanovaccine for enhancing immunity against porcine circovirus type 2. [Abstract]

2025 Mar 27:32:101712. PMID: 40230641
Mater Today Bio

Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment. [Abstract]

2025 Apr 17:32:101778. PMID: 40290887
J Hazard Mater

Quantifying nanoplastic cellular interactions and uptake pathways by label-free plasmonic imaging. [Abstract]

2026 Jul 1:512:142290. PMID: 42114291
J Hazard Mater

CYP450 activation and mitophagy induction mediate Ti3C2 MXene detoxification in RAW 264.7 cells. [Abstract]

2025 Dec 5:500:140498. PMID: 41252987
Acta Biomater

Hydrogel system with growth cone-targeted hydroxyapatite nanorods: Regulating calcium signals for peripheral nerve injury repair. [Abstract]

2025 Jul 1:201:171-186. PMID: 40419070
Acta Biomater

A prodrug nanodevice co-delivering docetaxel and ROR1 siRNA for enhanced triple negative breast cancer therapy. [Abstract]

2025 Jan 24:193:498-513. PMID: 39730101
Sci China Life Sci

Receptor affinity-selective differential dynamics of membrane fusion initiation govern deltacoronavirus cross-species transmission. [Abstract]

2025 Oct 24. PMID: 41144156
J Colloid Interface Sci

Porphyrin-based supramolecular chiral assembly for enantioselective interaction and augmented photodynamic therapy. [Abstract]

2025 Jun 18;699(Pt 2):138235. PMID: 40544619
Sci China Life Sci

Bactericidal ability of target acidic phospholipids and phagocytosis of CDC42 GTPase-mediated cytoskeletal rearrangement underlie functional conservation of CXCL12 in vertebrates. [Abstract]

2024 Dec;67(12):2713-2729. PMID: 39279006
Sci China Life Sci

NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry. [Abstract]

2022 Feb;65(2):341-361. PMID: 34047913
Food Res Int

2025 Dec 20;226:118114.
Int J Biol Macromol

2026 Jan 7;340:150099.
Int J Nanomedicine

Dual-Spherical Multifunctional Nanomotors for Intravesical Bladder Cancer Therapy. [Abstract]

2025 Dec 6:20:14613-14628. PMID: 41383278
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용액&용해도

In Vitro:

DMSO : 100 mg/mL (313.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1362 mL

15.6809 mL

31.3617 mL

5 mM

0.6272 mL

3.1362 mL

6.2723 mL

10 mM

0.3136 mL

1.5681 mL

3.1362 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (7.84 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
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- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kamgar-Dayhoff P, et al. Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment. Oncotarget. 2021 Jul 6;12(14):1406-1426. [Content Brief]

[2]. Shin SY, et al. The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt/mTOR pathway in human U-87MG glioma cells. Carcinogenesis. 2013 Sep;34(9):2080-9. [Content Brief]

[3]. Yang Z, et al. Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production. Cell Metab. 2022 Nov 2:S1550-4131(22)00461-2. [Content Brief]

[4]. Lee SJ, et al. Mechanism of inhibition by chlorpromazine of the human pain threshold sodium channel, Nav1.7. Neurosci Lett. 2017 Feb 3;639:1-7. [Content Brief]

[5]. Thomas D, et al. The antipsychotic drug chlorpromazine inhibits HERG potassium channels. Br J Pharmacol. 2003 Jun;139(3):567-74. [Content Brief]

[6]. Suzuki H, et al. Comparison of the anti-dopamine D₂ and anti-serotonin 5-HT(2A) activities of chlorpromazine, bromperidol, haloperidol and second-generation antipsychotics parent compounds and metabolites thereof. J Psychopharmacol. 2013 Apr;27(4):396-400. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1362 mL	15.6809 mL	31.3617 mL	78.4043 mL
	5 mM	0.6272 mL	3.1362 mL	6.2723 mL	15.6809 mL
	10 mM	0.3136 mL	1.5681 mL	3.1362 mL	7.8404 mL
	15 mM	0.2091 mL	1.0454 mL	2.0908 mL	5.2270 mL
	20 mM	0.1568 mL	0.7840 mL	1.5681 mL	3.9202 mL
	25 mM	0.1254 mL	0.6272 mL	1.2545 mL	3.1362 mL
	30 mM	0.1045 mL	0.5227 mL	1.0454 mL	2.6135 mL
	40 mM	0.0784 mL	0.3920 mL	0.7840 mL	1.9601 mL
	50 mM	0.0627 mL	0.3136 mL	0.6272 mL	1.5681 mL
	60 mM	0.0523 mL	0.2613 mL	0.5227 mL	1.3067 mL
	80 mM	0.0392 mL	0.1960 mL	0.3920 mL	0.9801 mL
	100 mM	0.0314 mL	0.1568 mL	0.3136 mL	0.7840 mL

Keywords

Chlorpromazine

147 Cited Publications

100 mg 견적 받기

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Chlorpromazine

Publications Citing Use of MedChemExpress (MCE) Chlorpromazine

All Dopamine Receptor Isoforms

All Cytochrome P450 Isoforms

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Publications (147)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Chlorpromazine Related Classifications

HY-12708 Related Classifications