KIFC3 - kinesin family member C3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3801

About KIFC3

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,758,217-57,862,858 (from NCBI)

This gene has 35 transcripts (splice variants), 202 orthologues and 41 paralogues. Broad expression in kidney (RPKM 11.2), testis (RPKM 9.9) and 24 other tissues.

Summary

This gene encodes a member of the Kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the interphase cells. It may also be involved in the final stages of cytokinesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

KIFC3 Products (9)

mRNA	Protein	Name
NM_001130099.1	NP_001123571.1	kinesin-like protein KIFC3 isoform 3
NM_001130100.2	NP_001123572.1	kinesin-like protein KIFC3 isoform 2
NM_001318710.2	NP_001305639.1	kinesin-like protein KIFC3 isoform 4
NM_001318711.2	NP_001305640.1	kinesin-like protein KIFC3 isoform 5
NM_001318712.2	NP_001305641.1	kinesin-like protein KIFC3 isoform 6
NM_001318713.2	NP_001305642.1	kinesin-like protein KIFC3 isoform 7
NM_001318714.2	NP_001305643.1	kinesin-like protein KIFC3 isoform 3
NM_001318715.2	NP_001305644.1	kinesin-like protein KIFC3 isoform 3
NM_005550.4	NP_005541.3	kinesin-like protein KIFC3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20360068	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in epithelial cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	19041755	GOA
involved in zonula adherens maintenance	IMP IMP: Inferred from mutant phenotype	19041755	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	19041755	GOA
located in zonula adherens	IDA IDA: Inferred from direct assay	19041755	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIFC3 Protein Structure

Kinesin

0
200
400
600
833 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIFC3

KIFC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIFC3	Q9BVG8	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	ZNF572	Homo sapiens	Q7Z3I7	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	ZNF572	Homo sapiens	Q7Z3I7	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	ZNF572	Homo sapiens	Q7Z3I7	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	ITGB3BP	Homo sapiens	Q13352-5	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	ITGB3BP	Homo sapiens	Q13352-5	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	NEFL	Homo sapiens	I6L9F6	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	ZGPAT	Homo sapiens	Q8N5A5-2	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	TPM3	Homo sapiens	Q5VU62	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	TPM3	Homo sapiens	Q5VU62	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	CCDC28A	Homo sapiens	Q7Z6N9	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	ICA1L	Homo sapiens	Q8NDH6	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	CYTH4	Homo sapiens	Q8WWE8	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	CYTH4	Homo sapiens	Q8WWE8	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	ZNF180	Homo sapiens	Q9UJW8	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	ZNF180	Homo sapiens	Q9UJW8	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	MFAP1	Homo sapiens	P55081	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	MFAP1	Homo sapiens	P55081	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	MFAP1	Homo sapiens	P55081	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	RAD51D	Homo sapiens	O75771	Y2H Array	31515488
Intra	KIFC3	Q9BVG8	RAD51D	Homo sapiens	O75771	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	ATF2	Homo sapiens	P15336	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	ATF2	Homo sapiens	P15336	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	CDR2	Homo sapiens	Q01850	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	CDR2	Homo sapiens	Q01850	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	FCHSD2	Homo sapiens	O94868	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	FCHSD2	Homo sapiens	O94868	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	PRKAA2	Homo sapiens	P54646	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	PRKAA2	Homo sapiens	P54646	Y2H	21516116
Intra	KIFC3	Q9BVG8	PRKAA2	Homo sapiens	P54646	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	FANCL	Homo sapiens	Q9NW38	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	FANCL	Homo sapiens	Q9NW38	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	HAUS1	Homo sapiens	Q96CS2	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	KRT6C	Homo sapiens	P48668	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	KRT6C	Homo sapiens	P48668	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	ESRRG	Homo sapiens	P62508	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	ESRRG	Homo sapiens	P62508	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	ZGPAT	Homo sapiens	Q8N5A5	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	TSG101	Homo sapiens	Q99816	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	TSG101	Homo sapiens	Q99816	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	TSG101	Homo sapiens	Q99816	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	NUP62	Homo sapiens	P37198	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	CCDC28A	Homo sapiens	Q8IWP9	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	MCM7	Homo sapiens	P33993	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	MCM7	Homo sapiens	P33993	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	PSMB1	Homo sapiens	P20618	Y2H Array	31515488
Intra	KIFC3	Q9BVG8	MED4	Homo sapiens	Q9NPJ6	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	SMARCE1	Homo sapiens	Q969G3	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	SMARCE1	Homo sapiens	Q969G3	Y2H	21516116
Intra	KIFC3	Q9BVG8	SMARCE1	Homo sapiens	Q969G3	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	DTNBP1	Homo sapiens	Q96EV8	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	DTNBP1	Homo sapiens	Q96EV8	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	CLIP4	Homo sapiens	Q8N3C7	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	ZNF655	Homo sapiens	Q8N720	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	ZNF655	Homo sapiens	Q8N720	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	KRT5	Homo sapiens	P13647	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	KRT5	Homo sapiens	P13647	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	KRT6A	Homo sapiens	P02538	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	KRT6A	Homo sapiens	P02538	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	ITGB3BP	Homo sapiens	Q13352	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	CBX8	Homo sapiens	Q9HC52	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	CBX8	Homo sapiens	Q9HC52	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	PHC2	Homo sapiens	Q8IXK0	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	PHC2	Homo sapiens	Q8IXK0	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	PHC2	Homo sapiens	Q8IXK0	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	DCTN2	Homo sapiens	Q13561	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	ZNF20	Homo sapiens	P17024	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	ZNF20	Homo sapiens	P17024	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	LENG1	Homo sapiens	Q96BZ8	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	KRT15	Homo sapiens	P19012	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	KANSL1	Homo sapiens	Q7Z3B3	Y2H Array	31515488
Intra	KIFC3	Q9BVG8	KRT6B	Homo sapiens	P04259	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	KRT6B	Homo sapiens	P04259	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	CBY2	Homo sapiens	Q8NA61	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	CBY2	Homo sapiens	Q8NA61	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	KRT19	Homo sapiens	P08727	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	USP2	Homo sapiens	O75604	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	CEP170P1	Homo sapiens	Q96L14	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	CEP170P1	Homo sapiens	Q96L14	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	KIFC3	Q9BVG8	CDK18	Homo sapiens	Q07002	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	TSR2	Homo sapiens	Q969E8	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	TSR2	Homo sapiens	Q969E8	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	CEP55	Homo sapiens	Q53EZ4	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	RSPH14	Homo sapiens	Q9UHP6	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	RSPH14	Homo sapiens	Q9UHP6	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	DEUP1	Homo sapiens	Q05D60	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	DEUP1	Homo sapiens	Q05D60	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	HSBP1	Homo sapiens	O75506	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	LIN37	Homo sapiens	Q96GY3	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	LIN37	Homo sapiens	Q96GY3	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	SCEL	Homo sapiens	O95171	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	BCL6	Homo sapiens	P41182	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	BCL6	Homo sapiens	P41182	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	DCX	Homo sapiens	O43602	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	NDEL1	Homo sapiens	Q9GZM8	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	NDEL1	Homo sapiens	Q9GZM8	Y2H Prey Pooling	25416956
Intra	KIFC3	Q9BVG8	NDEL1	Homo sapiens	Q9GZM8	Y2H Array	25416956
Intra	KIFC3	Q9BVG8	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	KIFC3	Q9BVG8	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 63	RP63
Optic Atrophy 8	OPA8
Fanconi Anemia, Complementation Group C	Fanconi Anemia Complementation Group C FANCC Facc Fac Fa3 Fanconi Pancytopenia Type 3 Fanconi Pancytopenia, Type 3 Faces Syndrome Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies Friedman-Goodman Syndrome Abnormality Of The Face
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS07300	KIFC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20436	Kifc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26945	Kifc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KIFC3	VGNC	VGNC:42416
Rattus norvegicus	KIFC3	RGD	RGD:1307693
Felis catus	KIFC3	VGNC	VGNC:67947
Mus musculus	KIFC3	MGD	MGI:109202
Macaca mulatta	KIFC3	VGNC	VGNC:74022
Bos taurus	KIFC3	VGNC	VGNC:30613
Others	KIFC3	NCBI