Ossirene
Based on 2 publication(s) in Google Scholar
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits Caspase-1 and is used for the autoimmune diseases and certain malignancies.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.0%
- CAS No.: 106566-58-9
- 화학식: C2H8Cl3NO2Te
- 분자량:312.05
-
보관:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ossirene
More
Customer Validation & Images
-
RT-PCR
-
Histological Imaging/Staining
-
IHC
All Caspase Isoforms
More
Biological Activity
|
IL-1β |
IL-6 |
IL-8 |
IL-10 |
Caspase-1 |
Ossirene (AS101; 1 μg/mL; for 24 hours) almost completely abrogates expression of pStat3. Ossirene may reduce expression of Bcl-2 after inhibition of Stat3 activation via IL-10 inhibition[2].
AS101 (0.5, 5 mg/mL; 24 hours) inhibits IL-1β-induced mRNA expression of inflammatory mediators in the RPE in a dose-dependent manner. AS101 inhibits IL-1β-induced mRNA expression and protein production of IL-6 and IL-8 in RPE cells. AS101 (5 mg/mL; 1 hour) inhibits the phosphorylation of the p65 component of the NFκB complex activated by IL-1β[1].
Ossirene (0.1, 0.5, 1, 2.5 μg/mL) significantly decreases B16 melanoma, stomach adenocarcinoma, and human glioblastoma multiforme (GBM) cells proliferation[2].
AS101 (0.5 μg/mL; for 24 hours) sensitizes GBM tumor cells to paclitaxel in an IL-10-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:B16 melanoma cells
-
Concentration:1 μg/mL
-
Incubation Time:For 24 hours
-
Result:Almost completely abrogated expression of pStat3.
-
Cell Line:ARPE19 cells
-
Concentration:0.5, 5 mg/mL
-
Incubation Time:24 hours
-
Result:Inhibited IL-1β-induced mRNA expression of inflammatory mediators in the RPE in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:SCID mice with GBM cells[2]
-
Dosage:0.5 mg/kg
-
Administration:IP; daily; 25 days
-
Result:Significantly increased survival of GBM tumor-bearing mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 106566-58-9
-
Appearance Solid
-
분자량 312.05
-
화학식 C2H8Cl3NO2Te
-
Color White to off-white
-
SMILES
[Cl-][Te+4]1([Cl-])([Cl-])[O-]CC[O-]1.[NH4+]
-
Synonyms
AS101
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Cell Death Dis
Targeting miR-18a sensitizes chondrocytes to anticytokine therapy to prevent osteoarthritis progression. [Abstract]2020 Nov 3;11(11):947. PMID: 33144571
Ossirene purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 3;11(11):947. [Abstract]
qRT-PCR shows the effect of miR-18a ectopic expression on chondrocyte hypertrophy in cells treated with either AS101 or JSH23.
Ossirene purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 3;11(11):947. [Abstract]
AS101 (1 mg/kg) was intraperitoneal injected, and 10 μL antagomir of miR-18a (250 nM) were intra-articular injected in rat model of knee OA every 3 days, followed by dissociation of knee joint after 4 weeks. HE staining of p65, p-SMAD2/3, and RUNX2 were conducted.
Ossirene purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 3;11(11):947. [Abstract]
AS101 (1 mg/kg) was intraperitoneal injected, and 10 μL antagomir of miR-18a (250 nM) were intra-articular injected in rat model of knee OA every 3 days, followed by dissociation of knee joint after 4 weeks. IHC of p65, p-SMAD2/3, and RUNX2 were conducted.
-
Inflamm Res
Alpha-galactosylceramide pre-treatment attenuates clinical symptoms of LPS-induced acute neuroinflammation by converting pathogenic iNKT cells to anti-inflammatory iNKT10 cells in the brain. [Abstract]2024 Sep;73(9):1511-1527. PMID: 39028491
용액&용해도
DMSO : 12.5 mg/mL (40.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
-
Data Sheet (284 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Diamond Ling, et al. The Tellurium Redox Immunomodulating Compound AS101 Inhibits IL-1β-activated Inflammation in the Human Retinal Pigment Epithelium. Br J Ophthalmol. 2013 Jul;97(7):934-8. [Content Brief]
[2]. Sredni B, et al. Ammonium trichloro(dioxoethylene-o,o')tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop. Cancer Res. 2004 Mar 1;64(5):1843-52. [Content Brief]
[3]. Yona Kalechman, et al. Inhibition of interleukin-10 by the Immunomodulator AS101 Reduces Mesangial Cell Proliferation in Experimental Mesangioproliferative Glomerulonephritis: Association With Dephosphorylation of STAT3. J Biol Chem. 2004 Jun 4;279(23):24724-32. [Content Brief]
[4]. Yafit Hachmo, et al. The Small Tellurium Compound AS101 Ameliorates Rat Crescentic Glomerulonephritis: Association With Inhibition of Macrophage Caspase-1 Activity via Very Late Antigen-4 Inactivation. Front Immunol. 2017 Mar 7;8:240. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2046 mL | 16.0231 mL | 32.0461 mL | 80.1154 mL |
| 5 mM | 0.6409 mL | 3.2046 mL | 6.4092 mL | 16.0231 mL | |
| 10 mM | 0.3205 mL | 1.6023 mL | 3.2046 mL | 8.0115 mL | |
| 15 mM | 0.2136 mL | 1.0682 mL | 2.1364 mL | 5.3410 mL | |
| 20 mM | 0.1602 mL | 0.8012 mL | 1.6023 mL | 4.0058 mL | |
| 25 mM | 0.1282 mL | 0.6409 mL | 1.2818 mL | 3.2046 mL | |
| 30 mM | 0.1068 mL | 0.5341 mL | 1.0682 mL | 2.6705 mL | |
| 40 mM | 0.0801 mL | 0.4006 mL | 0.8012 mL | 2.0029 mL |
Ossirene Related Classifications
HY-101019 Related Classifications
Powered by Bioz