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Cat. No.: HY-N11784

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Triptolidenol

Triptolidenol, a traditional Chinese medicine, is an epoxy diterpene lactone that can be isolated from Tripterygium wilfordii. Triptolidenol has anti-inflammatory and anticancer activities. Triptolidenol significantly inhibits tumor cell proliferation and migration, arrests cell cycle arrest at S phase and induces apoptosis by activating the cytochrome c/caspase cascade signaling pathway. Triptolidenol disrupts NF-κB/COX-2 pathway by inhibiting IKKβ at ATP-binding sites. Triptolidenol can be used for chronic nephritis and kidney cancer like clear cell renal cell carcinoma (ccRCC) research.

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CAS No.: 99694-86-7
화학식: C₂₀H₂₄O₇
분자량:376.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Triptolidenol Chemical Structure

CAS No.: 99694-86-7

사이즈

가격

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

IKKβ

COX-2

p65

All Caspase Isoforms :

All NF-κB Isoforms :

All COX Isoforms :

All IKK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BGC-823	IC₅₀	0.2 μM Compound: 8c	Cytotoxicity against human BGC-823 cells by MTT assay Cytotoxicity against human BGC-823 cells by MTT assay	[PMID: 33289552]
HCT-116	IC₅₀	0.39 μM Compound: 8c	Cytotoxicity against human HCT-116 cells by MTT assay Cytotoxicity against human HCT-116 cells by MTT assay	[PMID: 33289552]
HepG2	IC₅₀	0.77 μM Compound: 8c	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 33289552]

Chemical Information

CAS No. 99694-86-7
분자량 376.40
화학식 C₂₀H₂₄O₇
SMILES

C[C@@]12[C@@]34[C@]5([C@@H]([C@@]6([C@](O6)([H])[C@]3([H])O4)C(C)(O)C)O)[C@@](C[C@@]1([H])C7=C(C(OC7)=O)CC2)([H])O5
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jin J, et al. Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ in clear cell renal cell carcinoma. Fitoterapia. 2021 Jan;148:104779. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
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Triptolidenol

All Caspase Isoforms

All NF-κB Isoforms

All COX Isoforms

All IKK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Triptolidenol Related Classifications

HY-N11784 Related Classifications