302 Results for "

IL-6 expression

" in MedChemExpress (MCE) Product Catalog:
Products (302)

302 Results for "IL-6 expression" in MCE Product Catalog:

3
Astegolimab
Astegolimab
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3 Cited Publications
Cat. No.: HY-P99444
CAS No.: 2173054-79-8
Synonyms: MSTT 1041A; RG 6149

Target:  

Interleukin Related MDM-2/p53 NF-κB

Domaines de recherche:  

Cardiovascular Disease Inflammation/Immunology

Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .
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Indole-3-pyruvic acid
Indole-3-pyruvic acid
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3 Cited Publications
Cat. No.: HY-W028393
CAS No.: 392-12-1
Category:  

Alkaloids Endogenous metabolite Disease Research Fields Inflammation/Immunology Indole Alkaloids

Target:  

Endogenous Metabolite Aryl Hydrocarbon Receptor Interleukin Related COX Bcl-2 Family

Indole-3-pyruvic acid is an orally active ketone analog of tryptophan, and is an aryl hydrocarbon receptor (AHR) agonist. Indole-3-pyruvic acid inhibits p38/MAPK phosphorylation, regulates the tryptophan metabolic pathway, and also possesses protective activities against skin photodamage, as well as anti-inflammatory and anti-anxiety bioactivities in the gut. Indole-3-pyruvic acid can downregulate the expression of IL-1β, IL-6, Cox-2, and Bax to alleviate UVB-induced keratinocyte toxicity. Indole-3-pyruvic acid can activate AHR to promote Tr1 cell differentiation, increase IL-10, and inhibit Th1 cytokine production. Indole-3-pyruvic acid can alter the levels of kynurenine metabolites in the brain, mediating central nervous system-related effects. Indole-3-pyruvic acid can be used in research on skin lesions, colitis, and anxiety .
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Taurohyodeoxycholic acid sodium
Taurohyodeoxycholic acid sodium
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2 Cited Publications
Cat. No.: HY-114360A
CAS No.: 38411-85-7
Pureté:  99.60%
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.
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Edpetiline
Edpetiline
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2 Cited Publications
Cat. No.: HY-N1921
CAS No.: 32685-93-1
Category:  

Triterpenes Terpenoids Plants Other Families Extract Disease Research Fields Inflammation/Immunology

Target:  

NF-κB p38 MAPK TNF Receptor Reactive Oxygen Species (ROS) COX Interleukin Related

Edpetiline is an anti-inflammatory agent. Edpetiline inhibits the phosphorylation of IκB, nuclear transcription/translocation of NF-κB p65, as well as the phosphorylation of p38 MAPK and ERK MAPK. Edpetiline reduces intracellular ROS levels, inhibits the expression of TNF-α, IL-6, iNOS, COX-2, and promotes the expression of IL-4. Edpetiline is applicable to the research of diseases associated with inflammation and oxidative stress .
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(±)-Stylopine
(±)-Stylopine
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2 Cited Publications
Cat. No.: HY-N0924
CAS No.: 4312-32-7
Synonyms: Tetrahydrocoptisine
Category:  

Alkaloids Chelidonium majus Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Papaveraceae Extract

Target:  

Interleukin Related NO Synthase p38 MAPK PERK NF-κB

(±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound. (±)-Stylopine can be isolated from the tubers of the plant Corydalis. (±)-Stylopine inhibits TNF-α, IL-6, and NO production, and attenuates phosphorylation of p38 MAPK, ERK1/2. (±)-Stylopine inhibits NF-κB expression. (±)-Stylopine exhibits anti-inflammatory activity. (±)-Stylopine has protective effects against foot edema, gastric ulcers, anxiety, depression, and acute lung injury .
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NecroX-7
NecroX-7
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2 Cited Publications
Cat. No.: HY-124750
CAS No.: 1120332-55-9
Pureté:  99.69%
Target:  

Free Radical Scavengers TNF Receptor Interleukin Related Toll-like Receptor (TLR) Reactive Oxygen Species (ROS)

Domaines de recherche:  

Cardiovascular Disease Inflammation/Immunology

NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research .
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Chikusetsusaponin Iva
Chikusetsusaponin Iva
0 Images
2 Cited Publications
Cat. No.: HY-N0818
CAS No.: 51415-02-2
Synonyms: Calenduloside F
Category:  

Triterpenes Terpenoids Amaranthaceae Extract Other Diseases Plants Alternanthera philoxeroides (Mart.) Griseb. Disease Research Fields

Target:  

Keap1-Nrf2

Chikusetsusaponin IVa is an orally active protein kinase activator. Chikusetsusaponin IVa binds to YAP with a KD value of 0.388 mM. Chikusetsusaponin IVa reduces inflammatory mediators (IL-6, IL-10, COX-2) expression, NO production, promotes ROS generation, induces Apoptosis, inhibits MAPK, TAZ, and regulates Nrf2, JAK/STAT. Chikusetsusaponin Iva has anti-H9N2 AIV and anti-endometrial cancer activities. Chikusetsusaponin Iva shows anti-inflammatory, hepatoprotective and osteoprotective effects .
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Brazilein
Brazilein
0 Images
2 Cited Publications
Cat. No.: HY-N10424
CAS No.: 600-76-0
Category:  

Caesalpinia sappan L. Pigments Phenols Polyphenols Leguminosae Extract Plants Disease Research Fields Inflammation/Immunology Food Research

Target:  

Na+/K+ ATPase Apoptosis Interleukin Related NO Synthase Bacterial Parasite

Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC50 of 500 μM against guinea pig Na +,K +-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases .
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HS-276
HS-276
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2 Cited Publications
Cat. No.: HY-147141
CAS No.: 2767422-72-8
Pureté:  98.93%
Target:  

IRAK TNF Receptor Casein Kinase Interleukin Related

Domaines de recherche:  

Inflammation/Immunology

HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 reduces the expression of TNF, IL-6, and IL-1β. HS-276 can be used for rheumatoid arthritis (RA) research .
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Phellodendrine chloride
Phellodendrine chloride
0 Images
2 Cited Publications
Cat. No.: HY-N0735
CAS No.: 104112-82-5
Category:  

Rutaceae Extract Alkaloids Phellodendron amurense Rupr. Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids Cancer

Target:  

Autophagy Apoptosis AMPK mTOR STAT Interleukin Related PKC p38 MAPK NF-κB COX Reactive Oxygen Species (ROS) PI3K Akt MMP

Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway .
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Valencene
Valencene
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1 Cited Publications
Cat. No.: HY-N6636
CAS No.: 4630-07-3
Category:  

Cyperaceae Extract Terpenoids Sesquiterpenes Cyperus rotundus L. Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Interleukin Related

Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model .
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Reticuline
Reticuline
0 Images
1 Cited Publications
Cat. No.: HY-N1356
CAS No.: 485-19-8
Category:  

Cardiovascular Disease Alkaloids Lauraceae Extract Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.

Target:  

JAK STAT NF-κB Endogenous Metabolite

Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3 . Reticuline exhibits cardiovascular effects .
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Coixol
Coixol
0 Images
1 Cited Publications
Cat. No.: HY-N0936
CAS No.: 532-91-2
Synonyms: 6-Methoxy-2-benzoxazolinone; 6-MBOA
Category:  

Infection Ketones, Aldehydes, Acids Marine natural products Coix lacryma-jobi Linn. Plants Gramineae Extract Disease Research Fields

Target:  

Others

Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level .
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Raspberry ketone glucoside
Raspberry ketone glucoside
0 Images
1 Cited Publications
Cat. No.: HY-N6069
CAS No.: 38963-94-9
Category:  

Ketones, Aldehydes, Acids Rosaceae Extract Plants Rubus corchorifolius Linn. f. Disease Research Fields Inflammation/Immunology

Target:  

Interleukin Related JAK STAT

Raspberry ketone glucoside is a melanogenesis inhibitor. Raspberry ketone glucoside inhibits melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes. Raspberry ketone glucoside shows remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo .
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Arecaidine
Arecaidine
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1 Cited Publications
Cat. No.: HY-N2368
CAS No.: 499-04-7
Category:  

Alkaloids Areca catechu L. Pyridine Alkaloids Plants Palmae Extract

Target:  

GABA Receptor Interleukin Related TGF-β Receptor TNF Receptor PPAR

Arecaidine is a GABA transport system inhibitor. Arecaidine inhibits the proliferation of oral mucosal fibroblasts, increases the secretion of IL-6, TGF-β and TNF-α in cells, downregulates the expression of PPAR-γ and PCK1 in cells, and upregulates the expression of TGF-β1 . Arecaidine inhibits the uptake of γ-aminobutyric acid and β-alanine by the central nervous system of cats . Arecaidine inhibits hPAT1-mediated L-[ 3H]proline uptake in cells. Arecaidine can be used in research related to neurological diseases .
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Arecaidine hydrochloride
Arecaidine hydrochloride
0 Images
1 Cited Publications
Cat. No.: HY-N2368A
CAS No.: 6018-28-6
Category:  

Alkaloids Areca catechu L. Pyridine Alkaloids Plants Palmae Extract

Target:  

GABA Receptor Interleukin Related TGF-β Receptor TNF Receptor PPAR

Arecaidine hydrochloride is a GABA transport system inhibitor. Arecaidine hydrochloride inhibits the proliferation of oral mucosal fibroblasts, increases the secretion of IL-6, TGF-β and TNF-α in cells, downregulates the expression of PPAR-γ and PCK1 in cells, and upregulates the expression of TGF-β1 . Arecaidine hydrochloride inhibits the uptake of γ-aminobutyric acid and β-alanine by the central nervous system of cats . Arecaidine hydrochloride inhibits hPAT1-mediated L-[ 3H]proline uptake in cells. Arecaidine hydrochloride can be used in research related to neurological diseases .
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Dazcapistat
Dazcapistat
0 Images
1 Cited Publications
Cat. No.: HY-132850
CAS No.: 2221010-42-8
Pureté:  ≥98.0%
Synonyms: BLD-2660
Target:  

Proteasome Interleukin Related

Domaines de recherche:  

Infection Inflammation/Immunology

Dazcapistat (BLD-2660) is an orally active small-molecule inhibitor of calpain 1, 2, and 9 (calpain 1, 2, 9). Dazcapistat reduces the expression/production level of IL-6 in injured lung tissue and alleviates fibrosis . Dazcapistat exerts anti-fibrotic effects in various animal models of fibrosis in the skin, liver and lung . Dazcapistat can be used in research related to coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis .
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iNOs-IN-1
iNOs-IN-1
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1 Cited Publications
Cat. No.: HY-145846
Pureté:  99.54%
Target:  

NO Synthase Interleukin Related

Domaines de recherche:  

Inflammation/Immunology

iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects .
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6-Demethoxytangeretin
6-Demethoxytangeretin
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1 Cited Publications
Cat. No.: HY-N4126
CAS No.: 6601-66-7
Category:  

Rutaceae Extract Neurological Disease Flavones Plants Other Families Extract Citrus reticulata Blanco Flavonoids Disease Research Fields Inflammation/Immunology Cancer

Target:  

Anaplastic lymphoma kinase (ALK) p38 MAPK Interleukin Related ERK JNK JAK STAT Akt

6-Demethoxytangeretin is a flavonoid compound that can be isolated from Citrus reticulata. 6-Demethoxytangeretin has anti-inflammatory and anti-allergic activities and can inhibit the production of IL-6 and the expression of related genes in human mast cells through the ALK and MAPK pathways. 6-Demethoxytangeretin can promote CRE-mediated transcription in hippocampal neurons .
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Gynostemma Extract
Gynostemma Extract
0 Images
1 Cited Publications
Cat. No.: HY-N0167
CAS No.: 80321-63-7
Synonyms: Ginsenoside C-Mx1; Gypenoside IX
Category:  

Triterpenes Terpenoids Cucurbitaceae Extract Plants Endogenous metabolite Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino Cancer

Target:  

p38 MAPK Akt NF-κB COX Interleukin Related NO Synthase

Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation .
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