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Anisomycin

(Synonyms: Flagecidin; Wuningmeisu C)
155 Cited Publications
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Based on 155 publication(s) in Google Scholar

Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is a JNK activator, which increases phospho-JNK. Anisomycin is a bacterial antibiotic.

For research use only. We do not sell to patients.

  • Purity: 99.82%
  • CAS No.: 22862-76-6
  • Formula: C14H19NO4
  • Molecular Weight:265.31
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Anisomycin Chemical Structure
    Anisomycin Chemical Structure
  • Experimental Validation Results for Anisomycin
  • Experimental Validation Results for Anisomycin
  • Experimental Validation Results for Anisomycin
  • Experimental Validation Results for Anisomycin
  • Experimental Validation Results for Anisomycin
  • Experimental Validation Results for Anisomycin
CAS No.: 22862-76-6
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  • Anisomycin Chemical Structure
    Anisomycin Chemical Structure
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    Anisomycin purchased from MedChemExpress. Usage Cited in: Am J Physiol Cell Physiol. 2018 Aug 1;315(2):C225-C235. [Abstract]

    Customer Validation
     Western blot analysis shows that inhibiting MAPK cannot completely reverse increased expression of RNF2 and CDDP resistance of OC cells.

  • 1/16

    Anisomycin purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2018 Sep 5:834:295-304. [Abstract]

    Customer Validation
     The protein levels of p-JNK by western blot following Anisomycin (4 μM) treatment for 24 h after Morroniside (100 μM) 12 h.

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    Anisomycin purchased from MedChemExpress. Usage Cited in: Sci Rep. 2018 Apr 23;8(1):6379. [Abstract]

    Customer Validation
     Immunoblot analysis of lysates from Anisomycin pre-treatment cells reveals an increase of CHIP protein compared with OGD treated only cells, contrasting with a decrease in RIPK3 and p-MLKL protei. Pre-treatment cells with SP600125 results in the expected attenuation in JNK phosphorylation levels.

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    Anisomycin purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 May 23;499(4):743-750. [Abstract]

    Customer Validation
     Astrocytes were cultured with p38 and JNK activator of DHC and ANS, respectively, at the indicated concentrations for 24 h. Then, all cells were harvested for western blot analysis of p-p38 and p-JNK. Astrocytes were pre-treated with DHC (500 nM) or ANS (10 μM) for 24 h, followed by Fru (5 mM) for an additional 24 h. Then, the following experiments were performed.

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    Anisomycin purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 5;503(2):467-473. [Abstract]

    Customer Validation
     The increase of Bcl-2 and decrease of Bax, cleaved Caspase-3 and PARP induced by Ulk1- inhibition in LPS-exposed AST are abrogated by the Dehydrocorydaline chloride (DHC) or Anisomycin (ANS) pre-treatment

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    Anisomycin purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2017 Nov 1:277:62-73. [Abstract]

    Customer Validation
     Effects of silencing p53 on colistin-induced ROS production and p-JNK expression level in PC-12 cells. The protein levels of p53. The protein levels of p-JNK by western blot.

  • Anisomycin