Art. -Nr.: HY-B1357

Digitoxin

10 Cited Publications

Kundenbewertung

Based on 10 publication(s) in Google Scholar

Digitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.18%
CAS. Nr.: 71-63-6
Formel: C₄₁H₆₄O₁₃
Molecular Weight:764.94

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Digitoxin Chemical Structure

CAS. Nr.: 71-63-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (10)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Bcl-2

Caspase-9

Caspase 3

Bax

HSV-1

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Alle Calcium Channel Isoform-spezifische Produkte anzeigen :

Alle HSV Isoform-spezifische Produkte anzeigen :

Alle Caspase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human A549 cells after 72 hrs by calcein AM assay Cytotoxicity against human A549 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
Cancer cell lines	IC₅₀	0.1 μM Compound: 2	Cytotoxicity against human colon cancer cells after 72 hrs by FMCA method Cytotoxicity against human colon cancer cells after 72 hrs by FMCA method	[PMID: 19894733]
DU-145	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human DU145 cells after 72 hrs by calcein AM assay Cytotoxicity against human DU145 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
HCT-116	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human HCT116 cells after 72 hrs by calcein AM assay Cytotoxicity against human HCT116 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
HCT-116	IC₅₀	0.74 μM Compound: 2	Cytotoxicity against human HCT116 cells after 72 hrs by FMCA method Cytotoxicity against human HCT116 cells after 72 hrs by FMCA method	[PMID: 19894733]
Hep 3B2	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human Hep3B cells after 72 hrs by calcein AM assay Cytotoxicity against human Hep3B cells after 72 hrs by calcein AM assay	[PMID: 16309329]
HFF	CC₅₀	2.8 μM Compound: 1	Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay	[PMID: 24900847]
HFF	CC₅₀	6 μM Compound: 1	Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay	[PMID: 24900847]
HT-29	IC₅₀	0.068 μM Compound: (+)-Digitoxin	Cytotoxicity against human HT-29 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay Cytotoxicity against human HT-29 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay	[PMID: 32096998]
HT-29	IC₅₀	4.07 μM Compound: 2	Cytotoxicity against human HT-29 cells after 72 hrs by FMCA method Cytotoxicity against human HT-29 cells after 72 hrs by FMCA method	[PMID: 19894733]
HT-29	IC₅₀	67.6 nM Compound: Digitoxin	Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
K562	IC₅₀	6.4 nM Compound: 1	Cytotoxicity against human K562 cells by XTT assay Cytotoxicity against human K562 cells by XTT assay	[PMID: 16309315]
KURAMOCHI	IC₅₀	5911 nM Compound: Digitoxin	Antiproliferative activity against human Kuramochi cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human Kuramochi cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
MCF7	IC₅₀	0.02 μM Compound: 1, DT	Antiproliferative activity against human MCF7 cells assessed as cell viability treated for 48 hrs followed by compound washout measured after 72 hrs by fluorometric CellTiter-Blue reagent assay Antiproliferative activity against human MCF7 cells assessed as cell viability treated for 48 hrs followed by compound washout measured after 72 hrs by fluorometric CellTiter-Blue reagent assay	[PMID: 21421322]
MCF7	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human MCF7 cells after 72 hrs by calcein AM assay Cytotoxicity against human MCF7 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
MCF7	IC₅₀	10.2 nM Compound: 1	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 16309315]
MDA-MB-231	IC₅₀	0.48 μM Compound: (+)-Digitoxin	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay	[PMID: 32096998]
MDA-MB-231	IC₅₀	482 nM Compound: Digitoxin	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
MDA-MB-435	IC₅₀	0.043 μM Compound: (+)-Digitoxin	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay	[PMID: 32096998]
MDA-MB-435	IC₅₀	43.3 nM Compound: Digitoxin	Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human MDA-MB-435 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
MDCK	IC₅₀	0.12 μM Compound: Digitoxin	TP_TRANSPORTER: inhibition of Digoxin uptake in OATP4C1-expressing MDCK cells TP_TRANSPORTER: inhibition of Digoxin uptake in OATP4C1-expressing MDCK cells	[PMID: 14993604]
NCI/ADR-RES	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human NCI/ADR-RES cells after 72 hrs by calcein AM assay Cytotoxicity against human NCI/ADR-RES cells after 72 hrs by calcein AM assay	[PMID: 16309329]
NCI-H460	GI₅₀	10.7 nM Compound: 1	Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 21643465]
NCI-H460	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human NCI-H460 cells after 72 hrs by calcein AM assay Cytotoxicity against human NCI-H460 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
NCI-H460	IC₅₀	357 nM Compound: 1	Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining	[PMID: 21643465]
OVCAR-3	IC₅₀	0.12 μM Compound: (+)-Digitoxin	Cytotoxicity against human OVCAR3 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay Cytotoxicity against human OVCAR3 cells after 72 hrs by CellTiter 96 Aqueous One Solution reagent based assay	[PMID: 32096998]
OVCAR-3	IC₅₀	117.1 nM Compound: Digitoxin	Antiproliferative activity against human OVCAR3 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human OVCAR3 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
OVCAR-4	IC₅₀	425.6 nM Compound: Digitoxin	Antiproliferative activity against human OVCAR4 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human OVCAR4 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
OVCAR-5	IC₅₀	321 nM Compound: Digitoxin	Antiproliferative activity against human OVCAR5 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human OVCAR5 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
OVCAR-8	IC₅₀	71.5 nM Compound: Digitoxin	Antiproliferative activity against human OVCAR8 cells after 72 hrs by CellTiter 96 aqueous one solution assay Antiproliferative activity against human OVCAR8 cells after 72 hrs by CellTiter 96 aqueous one solution assay	[PMID: 28234008]
SF-268	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human SF268 cells after 72 hrs by calcein AM assay Cytotoxicity against human SF268 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
SK-OV-3	IC₅₀	0.44 μM Compound: digitoxin	Cytotoxicity against human SKOV3 cells after 72 hrs by calcein AM assay Cytotoxicity against human SKOV3 cells after 72 hrs by calcein AM assay	[PMID: 16309329]
TK-10	IC₅₀	3.2 nM Compound: 1	Cytotoxicity against human TK10 cells after 48 hrs by SRB assay Cytotoxicity against human TK10 cells after 48 hrs by SRB assay	[PMID: 16309315]
UACC-62	IC₅₀	33.5 nM Compound: 1	Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay	[PMID: 16309315]
Vero	CC₅₀	>50 μM Compound: Digitoxin	Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr	10.1101/2020.03.20.999730
Vero	IC₅₀	<0.23 μM Compound: Digitoxin	Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr	10.1101/2020.03.20.999730

In Vitro

Digitoxin (0-80 nM, 72 h) compromised cell survival in PC12 cells^[1].
Digitoxin (4-1000 nM, 24-48 h) has an antitumor effects in MHCC97H, A549, HCT116 and HeLa cells^[3].
Digitoxin (4-100 nM, 24-48 h) disrupts the cell cycle in HeLa cells^[3].
Digitoxin (20-500 nM, 48 h) activates mitochondrial apoptosis in HeLa cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

MHCC97H, A549, HCT116 and HeLa cells
Concentration:

4-1000 nM
Incubation Time:

24 h, 48 h
Result:

Dcreased the viability of these cancer cells in a dose- and time-dependent manner, with the IC₅₀ values ranging from 0.075 to 0.395 µM following digitoxin treatment for 24 h and from 0.028 to 0.077 µM following digitoxin treatment for 48 h.

Cell Cycle Analysis^[3]

Cell Line:

HeLa cells
Concentration:

4 nM, 20 nM, 100 nM
Incubation Time:

24 h, 36 h, 48 h
Result:

Increased cell population in the G2/M phase from 16.27 to 18.36, 23.46 and 31.51% at concentrations of 20 nM for12, 24 and 36 h.
Increased average cell population in the G2/M phase from 16.27 to 28.07% at concentrations of 4, 20 and 100 nM for 24 h.
Significantly decreased the protein expression levels of total CDK1 and phosphorylated CDK1.

Apoptosis Analysis^[3]

Cell Line:

HeLa cells
Concentration:

20 nM, 100 nM, 500 nM
Incubation Time:

48 h
Result:

Upregulated Bax expression and unaltered Bcl-2 expression.
Significantly increased the expression of cytochrome c.

In Vivo

Digitoxin (1-2 mg/kg, Intraperitoneal injection, once a day for 19 days) has anticancer effects in nude mice^[3].
Digitoxin (0.3-3 μg/kg, Intraperitoneal injection, once a day for 4 days) blocks the host over-production of cytokines in the cotton rat lung^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

nude mice harboring HeLa tumor xenografts^[3]
Dosage:

1 mg/kg, 2 mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Decreased the tumor volume from 330.71±45.61 to 214.56.93±73.25 mm.
Strongly increased the protein levels of cleaved caspase-3.
Reduced the number of Ki-67-positive cells.

Animal Model:

cotton rats^[4]
Dosage:

0.3 μg/kg, 1 μg/kg, 3 μg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Blocked cytokine storm.
Differentially affected cytokine expression.
Left immune cell density intact in virus-infected lung.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 71-63-6
Appearance Solid
Molecular Weight 764.94
Formel C₄₁H₆₄O₁₃
Color White to off-white
SMILES

C[C@H]1O[C@](O[C@@H]2[C@@H](C)O[C@](O[C@H]3[C@@H](O)C[C@@](O[C@@H]4C[C@](CC[C@]5([H])[C@]6([H])CC[C@@]7(C)[C@]5(O)CC[C@@H]7C(CO8)=CC8=O)([H])[C@]6(C)CC4)([H])O[C@@H]3C)([H])C[C@@H]2O)([H])C[C@H](O)[C@@H]1O
Structure Classification
- Steroids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (10)

All Cell Proliferation/Viability AssayCell Migration/Invasion AssayWBFlow CytometryIn Vivo Efficacy Study

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Journal Impact Factor

Cancer Commun (Lond)

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3-dependent PDGFB signaling. [Abstract]

2025 Nov 10. PMID: 41212905
Nat Metab

Cardiac glycosides are broad-spectrum senolytics. [Abstract]

2019 Nov;1(11):1074-1088. PMID: 31799499
Int J Biol Macromol

Molecular interaction of abemaciclib with human serum albumin: Insights from spectroscopy, microscopy, and computational approaches. [Abstract]

2025 Dec 9;337(Pt 2):149613. PMID: 41380878
Foods

Unravelling the Interaction Mechanism Between Oryzanol and Human Serum Albumin: An Integrated Approach Using Multispectral Analysis and Molecular Simulations. [Abstract]

2026 Apr 18;15(8):1420. PMID: 42073308
Front Pharmacol

PFKFB3 deprivation attenuates the cisplatin resistance via blocking its autophagic elimination in colorectal cancer cells. [Abstract]

2024 Sep 4:15:1433137. PMID: 39295937

Digitoxin purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2024 Sep 4:15:1433137. [Abstract]

Cell viability was analyzed after indicated treatment for 24 h (Digitoxin (Dig): 1 μΜ; Oua: 1 μΜ).

Digitoxin purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2024 Sep 4:15:1433137. [Abstract]

Cell lysates were performed immunoblotting after DDP treatment in the presence or absence of Digitoxin (Dig)/Oua for 24 h.

Digitoxin purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2024 Sep 4:15:1433137. [Abstract]

The combination of 3-MA or Digitoxin (Dig) (3 mg/kg, i.p.) with DDP significantly reduced the tumor volume and tumor weight in the mouse xenograft model.
Gynecol Oncol

Preclinical 3D model screening reveals digoxin as an effective therapy for a rare and aggressive type of endometrial cancer. [Abstract]

2024 Jul 5:188:162-168. PMID: 38970843
Oncol Rep

Digitoxin inhibits ICC cell properties via the NF‑κB/ST6GAL1 signaling pathway. [Abstract]

2024 Aug;52(2):103. PMID: 38940341

Digitoxin purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2024 Aug;52(2):103. [Abstract]

Transwell assay detected the migration of HCCC9810 and HuCCT1 treated with Digitoxin (DT).

Digitoxin purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2024 Aug;52(2):103. [Abstract]

Digitoxin (DT) could reduce the α2,6 sialylation on the cell membrane, and the overexpression of ST6GAL1 was able to counteract the reduction effect induced by DT by Flow cytometry.
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Biochem Biophys Res Commun

Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]

2020 Feb 19;522(4):862-868. PMID: 31806372
University of Saskatchewan

2020 Jun 22.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (130.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3073 mL

6.5365 mL

13.0729 mL

5 mM

0.2615 mL

1.3073 mL

2.6146 mL

10 mM

0.1307 mL

0.6536 mL

1.3073 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (3.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (3.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (3.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Arispe N, et al. Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channels [J]. Proceedings of the National Academy of Sciences, 2008, 105(7): 2610-2615. [Content Brief]

[2]. Su C T, Hsu J T A, Hsieh H P, et al. Anti-HSV activity of digitoxin and its possible mechanisms [J]. Antiviral research, 2008, 79(1): 62-70.

[3]. Gan H, Qi M, Chan C, et al. Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arrest and apoptosis in vitro and in vivo [J]. International Journal of Oncology, 2020, 57(2): 562-573.

[4]. Pollard B S, Blanco J C, Pollard J R. Classical drug digitoxin inhibits influenza cytokine storm, with implications for COVID-19 therapy [J]. in vivo, 2020, 34(6): 3723-3730.

[5]. Haux J. Digitoxin is a potential anticancer agent for several types of cancer [J]. Medical hypotheses, 1999, 53(6): 543-548.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.3073 mL	6.5365 mL	13.0729 mL	32.6823 mL
	5 mM	0.2615 mL	1.3073 mL	2.6146 mL	6.5365 mL
	10 mM	0.1307 mL	0.6536 mL	1.3073 mL	3.2682 mL
	15 mM	0.0872 mL	0.4358 mL	0.8715 mL	2.1788 mL
	20 mM	0.0654 mL	0.3268 mL	0.6536 mL	1.6341 mL
	25 mM	0.0523 mL	0.2615 mL	0.5229 mL	1.3073 mL
	30 mM	0.0436 mL	0.2179 mL	0.4358 mL	1.0894 mL
	40 mM	0.0327 mL	0.1634 mL	0.3268 mL	0.8171 mL
	50 mM	0.0261 mL	0.1307 mL	0.2615 mL	0.6536 mL
	60 mM	0.0218 mL	0.1089 mL	0.2179 mL	0.5447 mL
	80 mM	0.0163 mL	0.0817 mL	0.1634 mL	0.4085 mL
	100 mM	0.0131 mL	0.0654 mL	0.1307 mL	0.3268 mL

Keywords

Digitoxin

10 Cited Publications

100 mg Angebot einholen

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Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Alle Calcium Channel Isoform-spezifische Produkte anzeigen

Alle HSV Isoform-spezifische Produkte anzeigen

Alle Caspase Isoform-spezifische Produkte anzeigen

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