Methyl ganoderate A
Methyl ganoderate A (Ganoderic acid A methyl ester) is a triterpenoid derivative. Methyl ganoderate A can be isolated from the fruiting bodies of G. lucidum. Methyl ganoderate A selectively inhibits CLK2 with an IC50 of 0.69 μM. Methyl ganoderate A inhibits the expression of ADAMTS5, MMP3, and MMP13, and reduces the levels of the cytokines IL-6, TNF-α, and IL-1β. Methyl ganoderate A can be used in research on knee osteoarthritis, Alzheimer's disease, and neuroinflammation.
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- CAS. Nr.: 81907-63-3
- Formel: C31H46O7
- Molecular Weight:530.69
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
MMP-3 |
MMP13 |
IL-6 |
IL-1β |
In Vitro
Methyl ganoderate A is a selective CLK2 inhibitor with an IC50 value of 0.69 μM[1].
Methyl ganoderate A (10 μM) inhibits cartilage degradation in rat chondrocytes and BMSCs by reducing the expression of ADAMTS5, MMP3, and MMP13[1].
Methyl ganoderate A competitively inhibits bovine testicular FPT with an IC50 of 38 μM and a Ki of 20 μM[2].
Methyl ganoderate A (200 μM) exhibits moderate inhibitory activity against AChE with an IC50 of 30.26 μM, and shows no inhibitory effect on BChE up to 200 μM[3].
Methyl ganoderate A (100 μM; 3 min preincubation, 30 min reaction) inhibits FAAH activity in vitro, with an inhibition rate of 61% at 100 μM[5].
Methyl ganoderate A (50 μM; 48 h) exhibits no cytotoxicity toward LOVO cells at 50 μM[5].
Methyl ganoderate A (50 μM; 48 h) exhibits no cytotoxicity toward MCF-7 cells at a concentration of 50 μM[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LOVO
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Concentration:50 μM
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Incubation Time:48 h
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Result:Displayed no cytotoxicity against LOVO human cancer cells.
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Cell Line:MCF-7
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Concentration:50 μM
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Incubation Time:48 h
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Result:Displayed no cytotoxicity against MCF-7 human cancer cells.
Chemical Information
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CAS. Nr. 81907-63-3
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Molecular Weight 530.69
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Formel C31H46O7
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SMILES
C[C@]12C3=C(C(C[C@@]1([C@@](C[C@@H]2O)([H])[C@H](C)CC(C[C@@H](C)C(OC)=O)=O)C)=O)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])C[C@@H]3O)C
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Synonyms
Ganoderic acid A methyl ester
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Structure Classification
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Initial Source
Ganoderma hainanense J. D. Zhao, L. W. Hsu et X. Q. Zhang
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[2]. Lee S, et al. Natural inhibitors for protein prenyltransferase. Planta medica. 1998 May;64(4):303-8.
[3]. Lee I, et al. Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum. Bioorganic & medicinal chemistry letters. 2011 Nov 01;21(21):6603-7. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Methyl ganoderate A Related Classifications
HY-N22053 Related Classifications
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