Cat. No.: HY-10108

LY294002

Name: LY294002
Brand: MedChemExpress
SKU: HY-10108
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LY294002 is a broad-spectrum inhibitor of PI3K with IC₅₀s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively. LY294002 also inhibits CK2 with an IC₅₀ of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC₅₀ of 1.4 μM. LY294002 is an apoptosis activator.

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Pureté: 99.90%
CAS No.: 154447-36-6
Formule: C₁₉H₁₇NO₃
Masse moléculaire:307.34

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Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

LY294002 Chemical Structure

CAS No.: 154447-36-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1219)
Solvant et solubilité
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Activité biologique

Description

LY294002 is a broad-spectrum inhibitor of PI3K with IC₅₀s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively^[1]. LY294002 also inhibits CK2 with an IC₅₀ of 98 nM^[2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC₅₀ of 1.4 μM. LY294002 is an apoptosis activator^[3].

IC₅₀ & Target

^[1]^[2]^[4]

p110α

0.5 μM (IC₅₀)

p110δ

0.57 μM (IC₅₀)

p110β

0.97 μM (IC₅₀)

human CK2

98 nM (IC₅₀)

human CK2α2

3.869 μM (IC₅₀)

DNA-PK

1.4 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform PI3K :

Voir tous les produits spécifiques à Isoform Casein Kinase :

Cellular Effect

Cell Line	Type	Value	Description	References
184B5	GI₅₀	29.37 μM Compound: 11, LY-294002	Cytotoxicity against human 184B5 cells at 20 uM chloroquine by SRB assay Cytotoxicity against human 184B5 cells at 20 uM chloroquine by SRB assay	[PMID: 18691894]
184B5	GI₅₀	32.37 μM Compound: 11, LY-294002	Cytotoxicity against human 184B5 cells at 10 uM chloroquine by SRB assay Cytotoxicity against human 184B5 cells at 10 uM chloroquine by SRB assay	[PMID: 18691894]
184B5	GI₅₀	39.37 μM Compound: 11, LY-294002	Cytotoxicity against human 184B5 cells by SRB assay Cytotoxicity against human 184B5 cells by SRB assay	[PMID: 18691894]
786-0	IC₅₀	18.1 μM Compound: 1, LY294002	Inhibition of human 786-O cell proliferation after 72 hrs by spectrophotometric analysis Inhibition of human 786-O cell proliferation after 72 hrs by spectrophotometric analysis	[PMID: 23410005]
A2780	GI₅₀	5.58 μM Compound: Chemical probe : LY294002	Antiproliferative activity against human A2780 cells harboring PI3KCA/PTEN mutant assessed as cell growth inhibition incubated for 96 hrs by SRB assay Antiproliferative activity against human A2780 cells harboring PI3KCA/PTEN mutant assessed as cell growth inhibition incubated for 96 hrs by SRB assay	[PMID: 17575152]
A-375	IC₅₀	8.4 μM Compound: LY-294002	Inhibition of serum-induced proliferation of human A375 cells Inhibition of serum-induced proliferation of human A375 cells	[PMID: 17601739]
A549	IC₅₀	790 nM Compound: LY294002	Inhibition of PI3K in human A549 cell lysate preincubated with compound for 5 mins followed by [gamma-32p]-ATP addition measured after 20 mins by immunoprecipitation based liquid scintillation spectroscopic analysis Inhibition of PI3K in human A549 cell lysate preincubated with compound for 5 mins followed by [gamma-32p]-ATP addition measured after 20 mins by immunoprecipitation based liquid scintillation spectroscopic analysis	[PMID: 16622124]
A549	IC₅₀	8.4 μM Compound: LY-294002	Antiproliferative activity against human A375 cells after 46 hrs Antiproliferative activity against human A375 cells after 46 hrs	[PMID: 17049248]
A549	GI₅₀	9 μM Compound: Chemical probe : LY294002	Antiproliferative activity against human A549 cells harboring AKT assessed as cell growth inhibition incubated for 96 hrs by SRB assay Antiproliferative activity against human A549 cells harboring AKT assessed as cell growth inhibition incubated for 96 hrs by SRB assay	[PMID: 17575152]
A549	IC₅₀	89.65 μM Compound: LY-294002	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 21945250]
A549	IC₅₀	89.65 μM Compound: 3, LY-294002	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 22480851]
A549	IC₅₀	82.32 μM Compound: LY294002	Antiproliferative activity against human A549 cells assessed as inhibition of absorbance after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of absorbance after 72 hrs by MTT assay	[PMID: 25693787]
A549	IC₅₀	82.32 μM Compound: LY294002	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31029551]
A549	IC₅₀	82.32 μM Compound: LY294002	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31446244]
A549	IC₅₀	89.65 μM Compound: LY294002	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	10.1039/C2MD00255H
A549	IC₅₀	17.7 μM Compound: Ly; LY294002	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay	10.1039/C5MD00603A
BT-474	IC₅₀	20.7 μM Compound: 1, LY294002	Inhibition of human BT474 cell proliferation after 72 hrs by spectrophotometric analysis Inhibition of human BT474 cell proliferation after 72 hrs by spectrophotometric analysis	[PMID: 23410005]
Detroit 562	GI₅₀	12.1 μM Compound: Chemical probe : LY294002	Antiproliferative activity against human Detroit 562 cells harboring PI3KCA mutant assessed as cell growth inhibition incubated for 96 hrs by SRB assay Antiproliferative activity against human Detroit 562 cells harboring PI3KCA mutant assessed as cell growth inhibition incubated for 96 hrs by SRB assay	[PMID: 17575152]
HCT-116	GI₅₀	10.5 μM Compound: Chemical probe : LY294002	Antiproliferative activity against human HCT-116 cells harboring PI3KCA mutant assessed as cell growth inhibition incubated for 96 hrs by SRB assay Antiproliferative activity against human HCT-116 cells harboring PI3KCA mutant assessed as cell growth inhibition incubated for 96 hrs by SRB assay	[PMID: 17575152]
HCT-116	IC₅₀	56.01 μM Compound: LY-294002	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 21945250]
HCT-116	IC₅₀	5.3 μM Compound: 1, LY-294002	Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay Growth inhibition of human HCT116 cells overexpressing PI3Kalpha H1047R mutant after 48 hrs by MTT assay	[PMID: 22212721]
HCT-116	IC₅₀	5.8 μM Compound: 1, LY-294002	Growth inhibition of human HCT116 cells after 48 hrs by MTT assay Growth inhibition of human HCT116 cells after 48 hrs by MTT assay	[PMID: 22212721]
HCT-116	IC₅₀	6.7 μM Compound: 1, LY-294002	Growth inhibition of human HCT116 cells overexpressing PI3Kalpha after 48 hrs by MTT assay Growth inhibition of human HCT116 cells overexpressing PI3Kalpha after 48 hrs by MTT assay	[PMID: 22212721]
HCT-116	IC₅₀	56.01 μM Compound: 3, LY-294002	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 22480851]
HCT-116	IC₅₀	51.82 μM Compound: LY294002	Antiproliferative activity against human HCT116 cells assessed as inhibition of absorbance after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as inhibition of absorbance after 72 hrs by MTT assay	[PMID: 25693787]
HCT-116	IC₅₀	51.82 μM Compound: LY294002	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31029551]
HCT-116	IC₅₀	51.82 μM Compound: LY294002	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31446244]
HCT-116	IC₅₀	56.01 μM Compound: LY294002	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	10.1039/C2MD00255H
HEK-293T	IC₅₀	0.42 μM Compound: LY294002	Inhibition of immobilized N-LY294002 bead binding to PI3Kbeta (unknown origin) expressed in HEK293T cells incubated for 1 hr by LC-MS/MS analysis Inhibition of immobilized N-LY294002 bead binding to PI3Kbeta (unknown origin) expressed in HEK293T cells incubated for 1 hr by LC-MS/MS analysis	[PMID: 28280261]
HEK-293T	IC₅₀	1.53 μM Compound: LY294002	Inhibition of immobilized N-LY294002 bead binding to PI3Kdelta (unknown origin) expressed in HEK293T cells incubated for 1 hr by LC-MS/MS analysis Inhibition of immobilized N-LY294002 bead binding to PI3Kdelta (unknown origin) expressed in HEK293T cells incubated for 1 hr by LC-MS/MS analysis	[PMID: 28280261]
HEK-293T	IC₅₀	10.3 μM Compound: LY294002	Inhibition of immobilized N-LY294002 bead binding to BRD2 (unknown origin) expressed in HEK293T cell nuclear extract incubated for 1 hr by LC-MS/MS analysis Inhibition of immobilized N-LY294002 bead binding to BRD2 (unknown origin) expressed in HEK293T cell nuclear extract incubated for 1 hr by LC-MS/MS analysis	[PMID: 28280261]
HEK-293T	IC₅₀	12.4 μM Compound: LY294002	Inhibition of immobilized N-LY294002 bead binding to C-terminal Flag-tagged BRD4 (unknown origin) expressed in HEK293T cell nuclear extract incubated for 1 hr by LC-MS/MS analysis Inhibition of immobilized N-LY294002 bead binding to C-terminal Flag-tagged BRD4 (unknown origin) expressed in HEK293T cell nuclear extract incubated for 1 hr by LC-MS/MS analysis	[PMID: 28280261]
HEK-293T	IC₅₀	13.7 μM Compound: LY294002	Inhibition of immobilized N-LY294002 bead binding to BRD3 (unknown origin) expressed in HEK293T cell nuclear extract incubated for 1 hr by LC-MS/MS analysis Inhibition of immobilized N-LY294002 bead binding to BRD3 (unknown origin) expressed in HEK293T cell nuclear extract incubated for 1 hr by LC-MS/MS analysis	[PMID: 28280261]
HEK-293T	IC₅₀	2.37 μM Compound: LY294002	Inhibition of immobilized N-LY294002 bead binding to PI3Kalpha (unknown origin) expressed in HEK293T cells incubated for 1 hr by LC-MS/MS analysis Inhibition of immobilized N-LY294002 bead binding to PI3Kalpha (unknown origin) expressed in HEK293T cells incubated for 1 hr by LC-MS/MS analysis	[PMID: 28280261]
HEK-293T	CC₅₀	>20 μM Compound: 95; LY294002	Cytotoxicity against HEK293T cells Cytotoxicity against HEK293T cells	[PMID: 33539089]
HeLa	IC₅₀	1.4 μM Compound: 2 (LY-294002)	Inhibition of DNA-dependent protein kinase (DNA-PK) of HeLa cell nuclear cell extract Inhibition of DNA-dependent protein kinase (DNA-PK) of HeLa cell nuclear cell extract	[PMID: 11597411]
HeLa	IC₅₀	1.4 μM Compound: 1	In vitro inhibition of DNA-dependent protein kinase(DNA-PK) from HeLa (human carcinoma) cells. In vitro inhibition of DNA-dependent protein kinase(DNA-PK) from HeLa (human carcinoma) cells.	[PMID: 12941339]
HeLa	IC₅₀	2.5 μM Compound: 2 (LY-294002)	Inhibition of mTOR protein isolated from HeLa cells Inhibition of mTOR protein isolated from HeLa cells	[PMID: 15658870]
HeLa	IC₅₀	1.47 μM Compound: 2 (LY-294002)	Inhibition of DNA dependent protein kinase isolated from HeLa cells Inhibition of DNA dependent protein kinase isolated from HeLa cells	[PMID: 15658870]
HeLa	IC₅₀	3 μM Compound: LY-294002	Inhibition of AX-7503 binding to recombinant Plk3 expressed in HeLa cells by Western blot Inhibition of AX-7503 binding to recombinant Plk3 expressed in HeLa cells by Western blot	[PMID: 17135248]
HeLa	EC₅₀	1.5 μM Compound: 15, LY-294002	Activity at PI3K in human HeLa cells by ELISA Activity at PI3K in human HeLa cells by ELISA	[PMID: 20092323]
HeLa	IC₅₀	20.5 μM Compound: Ly; LY294002	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay	10.1039/C5MD00603A
HL-60	IC₅₀	9.94 μM Compound: LY-294002	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 21945250]
HL-60	IC₅₀	9.94 μM Compound: 3, LY-294002	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 22480851]
HL-60	IC₅₀	18.43 μM Compound: LY294002	Antiproliferative activity against human HL60 cells assessed as inhibition of absorbance after 72 hrs by MTT assay Antiproliferative activity against human HL60 cells assessed as inhibition of absorbance after 72 hrs by MTT assay	[PMID: 25693787]
HL-60	IC₅₀	14 μM Compound: LY-294002	Antiproliferative activity against human HL60 cells measured after 3 days by MTS assay Antiproliferative activity against human HL60 cells measured after 3 days by MTS assay	[PMID: 26945110]
HL-60	IC₅₀	18.43 μM Compound: LY294002	Antiproliferative activity against human HL60 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HL60 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31029551]
HL-60	IC₅₀	18.43 μM Compound: LY294002	Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31446244]
HL-60	IC₅₀	9.94 μM Compound: LY294002	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	10.1039/C2MD00255H
Huh-7	IC₅₀	67.18 μM Compound: LY294002	Antiproliferative activity against human HuH7 cells assessed as inhibition of absorbance after 72 hrs by MTT assay Antiproliferative activity against human HuH7 cells assessed as inhibition of absorbance after 72 hrs by MTT assay	[PMID: 25693787]
Huh-7	IC₅₀	67.18 μM Compound: LY294002	Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31029551]
Huh-7	IC₅₀	67.18 μM Compound: LY294002	Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Antiproliferative activity against human HuH7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 31446244]
IGROV-1	GI₅₀	5.5 μM Compound: Chemical probe : LY294002	Antiproliferative activity against human IGROV-1 cells harboring PI3KCA/PTEN mutant assessed as cell growth inhibition incubated for 96 hrs by SRB assay Antiproliferative activity against human IGROV-1 cells harboring PI3KCA/PTEN mutant assessed as cell growth inhibition incubated for 96 hrs by SRB assay	[PMID: 17575152]
J774	IC₅₀	3.7 μM Compound: LY294002	Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA	[PMID: 29726680]
J774	IC₅₀	5.1 μM Compound: LY294002	Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA	[PMID: 29726680]
J774	IC₅₀	8.9 μM Compound: LY294002	Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 29726680]
Jurkat	IC₅₀	22 μM Compound: LY-294002	Antiproliferative activity against human Jurkat cells measured after 3 days by MTS assay Antiproliferative activity against human Jurkat cells measured after 3 days by MTS assay	[PMID: 26945110]
K562	IC₅₀	38 μM Compound: LY-294002	Antiproliferative activity against human K562 cells measured after 3 days by MTS assay Antiproliferative activity against human K562 cells measured after 3 days by MTS assay	[PMID: 26945110]
KB	IC₅₀	44.76 μM Compound: LY-294002	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 21945250]
KB	IC₅₀	44.76 μM Compound: 3, LY-294002	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 22480851]
MCF7	GI₅₀	2.63 μM Compound: 11, LY-294002	Cytotoxicity against human MCF7 cells in presence of 20 uM chloroquine by SRB assay Cytotoxicity against human MCF7 cells in presence of 20 uM chloroquine by SRB assay	[PMID: 18691894]
MCF7	GI₅₀	3.08 μM Compound: 11, LY-294002	Cytotoxicity against human MCF7 cells in presence of 10 uM chloroquine by SRB assay Cytotoxicity against human MCF7 cells in presence of 10 uM chloroquine by SRB assay	[PMID: 18691894]
MCF7	GI₅₀	3.16 μM Compound: 11, LY-294002	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 18691894]
MCF7	IC₅₀	29.1 μM Compound: Ly; LY294002	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay	10.1039/C5MD00603A
MDA-MB-231	GI₅₀	3.32 μM Compound: 11, LY-294002	Cytotoxicity against human MDA-MB-231 cells in presence of 20 uM chloroquine by SRB assay Cytotoxicity against human MDA-MB-231 cells in presence of 20 uM chloroquine by SRB assay	[PMID: 18691894]
MDA-MB-231	GI₅₀	4.35 μM Compound: 11, LY-294002	Cytotoxicity against human MDA-MB-231 cells in presence of 10 uM chloroquine by SRB assay Cytotoxicity against human MDA-MB-231 cells in presence of 10 uM chloroquine by SRB assay	[PMID: 18691894]
MDA-MB-231	GI₅₀	6.71 μM Compound: 11, LY-294002	Cytotoxicity against human MDA-MB-231 cells by SRB assay Cytotoxicity against human MDA-MB-231 cells by SRB assay	[PMID: 18691894]
MDA-MB-231	IC₅₀	0.38 μM Compound: LY-294002	Inhibition of epithelial growth factor-induced cell migration of human MDA-MB-231 cells pre-incubated for 24 hrs by cell invasion assay Inhibition of epithelial growth factor-induced cell migration of human MDA-MB-231 cells pre-incubated for 24 hrs by cell invasion assay	[PMID: 22804108]
MDA-MB-231	IC₅₀	0.38 μM Compound: LY294002	Antimigratory activity against EGF induced chemotaxis in human MDA-MB-231 cells preincubated for 24 hrs followed by EGF addition for 3.5 hrs by light microscopy Antimigratory activity against EGF induced chemotaxis in human MDA-MB-231 cells preincubated for 24 hrs followed by EGF addition for 3.5 hrs by light microscopy	[PMID: 27598237]
MDA-MB-231	IC₅₀	0.38 μM Compound: LY294002	Antiinvasive activity in human MDA-MB-231 cells assessed as inhibition of EGF-induced cell invasion after 3.5 hrs Antiinvasive activity in human MDA-MB-231 cells assessed as inhibition of EGF-induced cell invasion after 3.5 hrs	[PMID: 28009521]
MDA-MB-231	IC₅₀	0.38 μM Compound: LY294002	Inhibition of EGF-induced invasion of human MDA-MB-231 cells by MTT assay Inhibition of EGF-induced invasion of human MDA-MB-231 cells by MTT assay	[PMID: 28302401]
MDA-MB-231	IC₅₀	9.7 μM Compound: Ly; LY294002	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs by MTT assay	10.1039/C5MD00603A
MDA-MB-435	GI₅₀	15.28 μM Compound: Chemical probe : LY294002	Antiproliferative activity against human MDA-MB-435 cells harboring AKT assessed as cell growth inhibition incubated for 96 hrs by SRB assay Antiproliferative activity against human MDA-MB-435 cells harboring AKT assessed as cell growth inhibition incubated for 96 hrs by SRB assay	[PMID: 17575152]
MDA-MB-468	GI₅₀	6.5 μM Compound: Chemical probe : LY294002	Antiproliferative activity against human MDA-MB-468 cells harboring PTEN deletion assessed as cell growth inhibition incubated for 96 hrs by SRB assay Antiproliferative activity against human MDA-MB-468 cells harboring PTEN deletion assessed as cell growth inhibition incubated for 96 hrs by SRB assay	[PMID: 17575152]
MDA-MB-468	GI₅₀	10.4 μM Compound: 11, LY-294002	Cytotoxicity against human MDA-MB-468 cells by SRB assay Cytotoxicity against human MDA-MB-468 cells by SRB assay	[PMID: 18691894]
MDA-MB-468	GI₅₀	4.76 μM Compound: 11, LY-294002	Cytotoxicity against human MDA-MB-468 cells in presence of 20 uM chloroquine by SRB assay Cytotoxicity against human MDA-MB-468 cells in presence of 20 uM chloroquine by SRB assay	[PMID: 18691894]
MDA-MB-468	GI₅₀	8.2 μM Compound: 11, LY-294002	Cytotoxicity against human MDA-MB-468 cells in presence of 10 uM chloroquine by SRB assay Cytotoxicity against human MDA-MB-468 cells in presence of 10 uM chloroquine by SRB assay	[PMID: 18691894]
MG-63	IC₅₀	55.2 μM Compound: 22; LY294002	Antiproliferative activity against human MG63 cells after 48 hrs by MTT assay Antiproliferative activity against human MG63 cells after 48 hrs by MTT assay	[PMID: 28537720]
NCI-H1299	IC₅₀	11.1 μM Compound: 1, LY294002	Inhibition of human H1299 cell proliferation after 72 hrs by spectrophotometric analysis Inhibition of human H1299 cell proliferation after 72 hrs by spectrophotometric analysis	[PMID: 23410005]
Neutrophil	IC₅₀	1720 nM Compound: LY-294002	Inhibition of fMLP-induced superoxide production in human neutrophils Inhibition of fMLP-induced superoxide production in human neutrophils	[PMID: 17095227]
Neutrophil	IC₅₀	1.12 μM Compound: LY-294002	Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced superoxide anion generation by spectrophotometry	[PMID: 21316977]
Neutrophil	IC₅₀	1.92 μM Compound: LY-294002	Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced elastase release Antiinflammatory activity against human neutrophil assessed as inhibition of N-formyl-l-methionyl phenylalanine/cytochalasin B-induced elastase release	[PMID: 21316977]
Neutrophil	IC₅₀	1.09 μM Compound: LY-294002	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/cytochalasin B-induced superoxide anion production after 5 mins by spectrophotometer analysis Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/cytochalasin B-induced superoxide anion production after 5 mins by spectrophotometer analysis	[PMID: 21391659]
Neutrophil	IC₅₀	1.98 μM Compound: LY-294002	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/cytochalasin B-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate after 5 mins Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/cytochalasin B-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate after 5 mins	[PMID: 21391659]
Neutrophil	IC₅₀	1.18 μg/mL Compound: LY-294002	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation	[PMID: 21488654]
Neutrophil	IC₅₀	1.99 μg/mL Compound: LY-294002	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release	[PMID: 21488654]
Neutrophil	IC₅₀	3.84 μM Compound: LY-294002	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-indcued superoxide anion production Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-indcued superoxide anion production	[PMID: 21784631]
Neutrophil	IC₅₀	6.48 μM Compound: LY-294002	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release	[PMID: 21784631]
Neutrophil	IC₅₀	1.12 μM Compound: LY294002	Antiinflammatory activity in FMLP/CB activated human neutrophils assessed as inhibition of superoxide generation by ferricytochrome c reduction based spectrophotometry Antiinflammatory activity in FMLP/CB activated human neutrophils assessed as inhibition of superoxide generation by ferricytochrome c reduction based spectrophotometry	[PMID: 23347584]
Neutrophil	IC₅₀	1.92 μM Compound: LY294002	Antiinflammatory activity in FMLP/CB activated human neutrophils assessed as inhibition of elastase release Antiinflammatory activity in FMLP/CB activated human neutrophils assessed as inhibition of elastase release	[PMID: 23347584]
Neutrophil	IC₅₀	1 μM Compound: LY294002	Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced superoxide anion generation pretreated for 5 mins by spectrophotometry Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced superoxide anion generation pretreated for 5 mins by spectrophotometry	[PMID: 24798144]
Neutrophil	IC₅₀	1.5 μM Compound: LY294002	Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced elastase release for 5 mins Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced elastase release for 5 mins	[PMID: 24798144]
Neutrophil	IC₅₀	0.4 μg/mL Compound: LY294002	Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils by ferricytochrome c reduction method Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils by ferricytochrome c reduction method	[PMID: 24997688]
Neutrophil	IC₅₀	0.92 μg/mL Compound: LY294002	Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry	[PMID: 24997688]
Neutrophil	IC₅₀	0.6 μg/mL Compound: LY294002	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by fMLP/CB-induction measure Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by fMLP/CB-induction measure	[PMID: 25434002]
Neutrophil	IC₅₀	1.2 μg/mL Compound: LY294002	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction by spectroscopic analysis Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction by spectroscopic analysis	[PMID: 25434002]
Neutrophil	IC₅₀	0.4 μM Compound: LY294002	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation by spectrophotometry Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation by spectrophotometry	[PMID: 26575215]
Neutrophil	IC₅₀	1.5 μM Compound: LY294002	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release	[PMID: 26575215]
Neutrophil	IC₅₀	3.65 μM Compound: LY294002	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation after 5 mins by ferricytochrome c based spectrophotometric analysis Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation after 5 mins by ferricytochrome c based spectrophotometric analysis	[PMID: 27256910]
Neutrophil	IC₅₀	5.15 μM Compound: LY294002	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 5 mins by spectrofluorometric analysis Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate after 5 mins by spectrofluorometric analysis	[PMID: 27256910]
Neutrophil	IC₅₀	0.4 μM Compound: LY294002	Inhibition of fMLP/CB-induced superoxide anion production in human neutrophils assessed as SOD-based ferricytochrome c reduction assay Inhibition of fMLP/CB-induced superoxide anion production in human neutrophils assessed as SOD-based ferricytochrome c reduction assay	[PMID: 28398735]
Neutrophil	IC₅₀	1.5 μM Compound: LY294002	Inhibition of fMLP/CB-induced elastase release in human neutrophils Inhibition of fMLP/CB-induced elastase release in human neutrophils	[PMID: 28398735]
Neutrophil	IC₅₀	1.8 μM Compound: LY294002	Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLF/CB-induced superoxide anion generation preincubated for 5 mins followed by CB stimulation for 3 mins and subsequent fMLF stimulation for 10 mins by spectrophotometric method Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLF/CB-induced superoxide anion generation preincubated for 5 mins followed by CB stimulation for 3 mins and subsequent fMLF stimulation for 10 mins by spectrophotometric method	[PMID: 28445049]
Neutrophil	IC₅₀	3.3 μM Compound: LY294002	Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLF/CB-induced elastase release by measuring degranulation of azurophilic granules using MeOSuc-Ala-Ala-ProVal-p-nitroanilide as substrate preincubated for 5 mins followed by CB/fM Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLF/CB-induced elastase release by measuring degranulation of azurophilic granules using MeOSuc-Ala-Ala-ProVal-p-nitroanilide as substrate preincubated for 5 mins followed by CB/fM	[PMID: 28445049]
Neutrophil	IC₅₀	1.25 μM Compound: LY294002	Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase	[PMID: 29381070]
Neutrophil	IC₅₀	3.44 μM Compound: LY294002	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate	[PMID: 29381070]
Neutrophil	IC₅₀	2.1 μM Compound: LY294002	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation preincubated for 5 mins followed by cytochalasin B/fMLP addition for 3 mins by superoxide dismutase inhibitable reduction of ferricytochro Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation preincubated for 5 mins followed by cytochalasin B/fMLP addition for 3 mins by superoxide dismutase inhibitable reduction of ferricytochro	[PMID: 29975532]
Neutrophil	IC₅₀	5.1 μM Compound: LY294002	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release preincubated for 5 mins followed by fMLP/CB stimulation and measured for 10 mins using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release preincubated for 5 mins followed by fMLP/CB stimulation and measured for 10 mins using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate	[PMID: 29975532]
Neutrophil	IC₅₀	1.3 μM Compound: LY294002	Inhibition of fMLF/CB-induced superoxide anion generation in human neutrophil Inhibition of fMLF/CB-induced superoxide anion generation in human neutrophil	[PMID: 33508463]
Neutrophil	IC₅₀	1.1 μM Compound: LY294002	Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in superoxide anion Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in superoxide anion	[PMID: 37683361]
Neutrophil	IC₅₀	3.2 μM Compound: LY294002	Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in elastase release Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in elastase release	[PMID: 37683361]
OVCAR-3	IC₅₀	9.19 μM Compound: LY294002	Cytotoxicity against human OVCAR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Blue cell viability assay Cytotoxicity against human OVCAR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter-Blue cell viability assay	[PMID: 35100504]
PBMC	IC₅₀	>50 μM Compound: LY-294002	Cytotoxicity against PHA induced human PBMC after 3 days by MTS assay Cytotoxicity against PHA induced human PBMC after 3 days by MTS assay	[PMID: 26945110]
PC-3	GI₅₀	4.6 μM Compound: Chemical probe : LY294002	Antiproliferative activity against human PC-3 cells harboring PTEN deletion assessed as cell growth inhibition incubated for 96 hrs by SRB assay Antiproliferative activity against human PC-3 cells harboring PTEN deletion assessed as cell growth inhibition incubated for 96 hrs by SRB assay	[PMID: 17575152]
PC-3	IC₅₀	61.35 μM Compound: LY-294002	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 21945250]
PC-3	IC₅₀	61.35 μM Compound: 3, LY-294002	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 22480851]
PC-3	IC₅₀	1.3 μM Compound: 1, LY294002	Inhibition of PI3K in human PC3 cells assessed as decrease in AKT phosphorylation at serine 473 after 30 mins by ELISA Inhibition of PI3K in human PC3 cells assessed as decrease in AKT phosphorylation at serine 473 after 30 mins by ELISA	[PMID: 23410005]
PC-3	IC₅₀	12.1 μM Compound: 1, LY294002	Inhibition of human PC3 cell proliferation after 72 hrs by spectrophotometric analysis Inhibition of human PC3 cell proliferation after 72 hrs by spectrophotometric analysis	[PMID: 23410005]
PC-3	IC₅₀	61.35 μM Compound: LY294002	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	10.1039/C2MD00255H
RAW264.7	IC₅₀	10 μM Compound: LY-294002	Inhibition of C5a-mediated PKB/Akt phosphorylation in mouse Raw264 macrophage Inhibition of C5a-mediated PKB/Akt phosphorylation in mouse Raw264 macrophage	[PMID: 16789742]
Sf21	IC₅₀	0.5 μM Compound: LY-294002	Inhibition of mouse recombinant PI3Kalpha expressed in baculovirus-infected Sf21 cells Inhibition of mouse recombinant PI3Kalpha expressed in baculovirus-infected Sf21 cells	[PMID: 19748269]
Sf21	IC₅₀	0.5 μM Compound: LY-294002	Inhibition of recombinant PI3Kdelta expressed in baculovirus-infected Sf21 cells Inhibition of recombinant PI3Kdelta expressed in baculovirus-infected Sf21 cells	[PMID: 19748269]
Sf21	IC₅₀	0.9 μM Compound: LY-294002	Inhibition of human recombinant PI3Kbeta expressed in baculovirus-infected Sf21 cells Inhibition of human recombinant PI3Kbeta expressed in baculovirus-infected Sf21 cells	[PMID: 19748269]
Sf21	IC₅₀	7 μM Compound: LY-294002	Inhibition of bovine recombinant PI3Kgamma expressed in baculovirus-infected Sf21 cells Inhibition of bovine recombinant PI3Kgamma expressed in baculovirus-infected Sf21 cells	[PMID: 19748269]
Sf21	IC₅₀	0.5 μM Compound: LY-294002	Inhibition of mouse wild type PI3Kalpha expressed in Sf21 cells co-expressing N-terminal His-tagged human p85a using L-alpha-phosphatidylinositol substrate by TLC based phosphor imaging Inhibition of mouse wild type PI3Kalpha expressed in Sf21 cells co-expressing N-terminal His-tagged human p85a using L-alpha-phosphatidylinositol substrate by TLC based phosphor imaging	[PMID: 22520630]
Sf21	IC₅₀	0.97 μM Compound: LY-294002	Inhibition of human wild type PI3Kbeta expressed in Sf21 cells co-expressing N-terminal His-tagged human p85a using L-alpha-phosphatidylinositol substrate by TLC based phosphor imaging Inhibition of human wild type PI3Kbeta expressed in Sf21 cells co-expressing N-terminal His-tagged human p85a using L-alpha-phosphatidylinositol substrate by TLC based phosphor imaging	[PMID: 22520630]
Sf9	IC₅₀	10 μM Compound: LY-294002	Inhibition of His-tagged bovine PI3K expressed in Sf9 cells Inhibition of His-tagged bovine PI3K expressed in Sf9 cells	[PMID: 10998351]
Sf9	IC₅₀	6.9 μM Compound: LY-294002	Inhibition of His-tagged human CK2 expressed in Sf9 cells Inhibition of His-tagged human CK2 expressed in Sf9 cells	[PMID: 10998351]
Sf9	IC₅₀	0.34 μM Compound: LY-294002	Inhibition of GST-tagged human p110-beta expressed in SF9/Baculovirus system by SPA Inhibition of GST-tagged human p110-beta expressed in SF9/Baculovirus system by SPA	[PMID: 17601739]
Sf9	IC₅₀	0.63 μM Compound: LY-294002	Inhibition of GST-tagged bovine p110-alpha expressed in SF9/Baculovirus system by SPA Inhibition of GST-tagged bovine p110-alpha expressed in SF9/Baculovirus system by SPA	[PMID: 17601739]
Sf9	IC₅₀	1.6 μM Compound: LY-294002	Inhibition of His-tagged human p110gamma expressed in SF9/Baculovirus system by SPA Inhibition of His-tagged human p110gamma expressed in SF9/Baculovirus system by SPA	[PMID: 17601739]
Sf9	IC₅₀	2.1 μM Compound: LY-294002	Inhibition of glu-tagged PI3K C2-beta expressed in SF9/Baculovirus system by SPA Inhibition of glu-tagged PI3K C2-beta expressed in SF9/Baculovirus system by SPA	[PMID: 17601739]
Sf9	IC₅₀	6.9 μM Compound: 4, LY-294002	Inhibition of CK2 expressed in Sf9 cells Inhibition of CK2 expressed in Sf9 cells	[PMID: 18321716]
Sf9	IC₅₀	0.55 μM Compound: 3	Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assay Inhibition of human PI3Kalpha expressed in Sf9 cells by fluorescent polarization assay	[PMID: 21121631]
THP-1	IC₅₀	1.01 μM Compound: LY-294002	Inhibition of SCF1-induced PKB/Akt phosphorylation in THP1 cells Inhibition of SCF1-induced PKB/Akt phosphorylation in THP1 cells	[PMID: 16789742]
THP-1	IC₅₀	1.65 μM Compound: LY-294002	Inhibition of MCP1-induced PKB/Akt phosphorylation in THP1 cells Inhibition of MCP1-induced PKB/Akt phosphorylation in THP1 cells	[PMID: 16789742]
THP-1	IC₅₀	37 μM Compound: LY-294002	Inhibition of MCP1-induced chemotaxis of THP1 cells Inhibition of MCP1-induced chemotaxis of THP1 cells	[PMID: 16789742]
U-266	IC₅₀	46 μM Compound: LY-294002	Antiproliferative activity against human U266 cells measured after 3 days by MTS assay Antiproliferative activity against human U266 cells measured after 3 days by MTS assay	[PMID: 26945110]
U2OS	IC₅₀	62.96 μM Compound: 22; LY294002	Antiproliferative activity against human U2OS cells after 48 hrs by MTT assay Antiproliferative activity against human U2OS cells after 48 hrs by MTT assay	[PMID: 28537720]
U-87MG ATCC	GI₅₀	9.8 μM Compound: Chemical probe : LY294002	Antiproliferative activity against human U-87MG cells harboring PTEN deletion assessed as cell growth inhibition incubated for 96 hrs by SRB assay Antiproliferative activity against human U-87MG cells harboring PTEN deletion assessed as cell growth inhibition incubated for 96 hrs by SRB assay	[PMID: 17575152]
U-87MG ATCC	IC₅₀	8.1 μM Compound: LY-294002	Inhibition of GSK3-beta in human U87MG cells by ELISA Inhibition of GSK3-beta in human U87MG cells by ELISA	[PMID: 18345609]
U-937	IC₅₀	14 μM Compound: LY-294002	Antiproliferative activity against human U937 cells measured after 3 days by MTS assay Antiproliferative activity against human U937 cells measured after 3 days by MTS assay	[PMID: 26945110]

In Vitro

LY294002 (0-75 μM; 24 hours and 48 hours) remarkably decreases human nasopharyngeal carcinoma CNE-2Z cells in a dose-dependent fashion^[4].
LY294002 (0-75 μM; 24 hours and 48 hours ) induces CNE-2Z cells apoptosis rate in dose-dependent^[4].
LY294002 (10-75 μM) significantly decreases p-Akt (S473) expression levels and up-regulates caspase-9 activity in CNE-2Z cells. Total Akt protein level is not difference with different concentration^[4].
LY294002 (5, 10, 100 μM; for 2 hours) treatment partially suppresses Lysophosphatidic acid (LPA)-induced (20 μM; for 4 hours) nuclear translocation of YAP, accompanied by a reduction in p-AKT levels^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[4]

Cell Line:

CNE-2Z cells
Concentration:

0 μM, 10 μM, 25 μM, 50 μM, and 75 μM
Incubation Time:

24 hours and 48 hours
Result:

Decreased CNE-2Z cells in a dose-dependent fashion.

Apoptosis Analysis^[4]

Cell Line:

CNE-2Z cells
Concentration:

0 μM, 10 μM, 25 μM, 50 μM, and 75 μM
Incubation Time:

24 hours and 48 hours
Result:

Induced apoptosis rate in dose-dependent.

Western Blot Analysis^[4]

Cell Line:

CNE-2Z cells
Concentration:

10 μM, 25 μM, 50 μM, and 75 μM
Incubation Time:
Result:

Decreased phosphorylated Akt (S473) expression levels were significantly, up-regulated caspase-9 activity in CNE-2Z cells in treated group.

In Vivo

LY294002 (10, 25, 50, 75 mg/kg; i.p.; twice weekly; for 4 weeks) significantly reduces mean NPC tumor burden in a dose-dependent manner. LY294002 (10, 25 mg/kg) is less effective in decreasing tumor burden^[4].
LY294002 (1.2 mg/kg per day; i.p.; for 14 days) prevents Leptin (60 ug/kg)-induced adverse effects on spermatozoa in Sprague-Dawley rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Athymic nude mice (6-8 weeks) with CNE-2Z xenograft^[4]
Dosage:

10 mg/kg, 25 mg/kg, 50 mg/kg, and 75 mg/kg
Administration:

Intraperitoneal injection; twice weekly, for 4 weeks
Result:

Mean Nasopharyngeal carcinoma (NPC) tumor burden was remarkably decreased in a dose-dependent manner.

Chemical Information

CAS No. 154447-36-6
Appearance Solid
Masse moléculaire 307.34
Formule C₁₉H₁₇NO₃
Color White to yellow
SMILES

O=C1C=C(OC2=C1C=CC=C2C3=CC=CC=C3)N4CCOCC4
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1219)

All Bio/Physico-chemical AssayWBIHCIFCell Proliferation/Viability Assay

Sort by:

Journal Impact Factor

Signal Transduct Target Ther

A nanobody-based proteolysis-targeting chimera offers broad-spectrum protection against diverse influenza virus infections. [Abstract]

2026 May 15;11(1):182. PMID: 42140901
Signal Transduct Target Ther

p53 positively regulates the proliferation of hepatic progenitor cells promoted by laminin-521. [Abstract]

2022 Aug 31;7(1):290. PMID: 36042225
Signal Transduct Target Ther

M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity. [Abstract]

2021 Jun 18;6(1):234. PMID: 34140465
Cancer Cell

Stromal lipid species dictate melanoma metastasis and tropism. [Abstract]

2025 Apr 22:S1535-6108(25)00138-2. PMID: 40280124
Nature

Clinical functional proteomics of intercellular signalling in pancreatic cancer. [Abstract]

2025 Jan;637(8046):726-735. PMID: 39537929
Mol Cancer

Epithelial WNT secretion drives niche escape of developing gastric cancer. [Abstract]

2025 Dec 16;25(1):1. PMID: 41398956
Mol Cancer

Dynamic altruistic cooperation within breast tumors. [Abstract]

2023 Dec 14;22(1):206. PMID: 38093346

LY294002 purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2023 Dec 14;22(1):206. [Abstract]

Mi/EGFPHigh and Mi/EGFPLow cell from indicated cancer cell lines were exposed to indicated concentrations of the PI3K inhibitor Ly294002 (10-50 μM) or AKT inhibitor AKT IV for 12 h, and viability measured.
Mol Cancer

Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer. [Abstract]

2022 May 10;21(1):112. PMID: 35538494
Adv Mater

Engineered Perfusable Hepatic Fibrosis Model via Embedded Sacrificial Bioprinting Recapitulates Stiffness-Driven Fibrogenesis. [Abstract]

2026 Mar;38(13):e13401. PMID: 41568614
Adv Mater

Calcium Phosphate Nanoparticle-Immobilized Macrophage-Derived Extracellular Vesicle Nanohybrid Facilitates Diabetic Bone Regeneration. [Abstract]

2025 Oct 1:e09410. PMID: 41030201
Cancer Commun (Lond)

PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism. [Abstract]

2022 Sep;42(9):848-867. PMID: 35904817
Nat Metab

HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma. [Abstract]

2022 Oct;4(10):1306-1321. PMID: 36192599
Nat Immunol

The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity. [Abstract]

2023 Nov;24(11):1813-1824. PMID: 37813965
Cell Mol Immunol

ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome. [Abstract]

2020 Mar;17(3):261-271. PMID: 30911117
Blood

IGF-1 facilitates thrombopoiesis primarily through Akt activation. [Abstract]

2018 Jul 12;132(2):210-222. PMID: 29802222

LY294002 purchased from MedChemExpress. Usage Cited in: Blood. 2018 Jul 12;132(2):210-222. [Abstract]

Phosphorylation of p-ERK1/2 and p-Akt in MKs pretreated with 0.5 μM NVP-ADW742, 10 μM U0126 or 20 μM LY294002 followed by rhIGF-1 treatment for 15 minutes.
Bioact Mater

Non-electric bioelectrical analog strategy by a biophysical-driven nano-micro spatial anisotropic scaffold for regulating stem cell niche and tissue regeneration in a neuronal therapy. [Abstract]

2022 Jun 13:20:319-338. PMID: 36380746
Cancer Res

ACSL5 Mediates Adaptation to the Palmitic Acid-Enriched Pulmonary Microenvironment to Enhance Metastatic Breast Cancer Cell Survival and Lung Metastasis. [Abstract]

2026 Jan 22. PMID: 41570334
Cancer Res

Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate Cancer. [Abstract]

2022 Sep 2;82(17):3032-3044. PMID: 35767703

LY294002 purchased from MedChemExpress. Usage Cited in: Cancer Res. 2022 Sep 2;82(17):3032-3044. [Abstract]

Relative luciferase activities of indicated SQLE promoter reporters in C4-2 cells treated with 20 μM LY294002 or 10 μM Nutlin-3 for 12 h.
Cancer Res

GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors. [Abstract]

2022 Sep 16;82(18):3223-3235. PMID: 35895805
Cancer Res

ARID1A Hypermethylation Disrupts Transcriptional Homeostasis to Promote Squamous Cell Carcinoma Progression. [Abstract]

2020 Feb 1;80(3):406-417. PMID: 32015157
J Extracell Vesicles

Exomeres From Adventitial Fibroblasts of Spontaneously Hypertensive Rats Promote Vascular Remodelling via Transferring Osteopontin. [Abstract]

2025 Aug;14(8):e70146. PMID: 40767027
J Extracell Vesicles

CD7-targeting pro-apoptotic extracellular vesicles: A novel approach for T-cell haematological malignancy therapy. [Abstract]

2024 Dec;13(12):e70025. PMID: 39676736

LY294002 purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2024 Dec;13(12):e70025. [Abstract]

LY294002 (20 μM; 1h) effectively inhibits the endocytosis of both types of exosomes in Molt-4 cells, with a stronger inhibitory effect on Ctrl/EVs (control exosomes).
J Extracell Vesicles

Proton pump inhibitors enhance macropinocytosis-mediated extracellular vesicle endocytosis by inducing membrane v-ATPase assembly. [Abstract]

2024 Apr;13(4):e12426. PMID: 38532609

LY294002 purchased from MedChemExpress. Usage Cited in: J Extracell Vesicles. 2024 Apr;13(4):e12426. [Abstract]

Real-time fluorescence microscopy analysis of the uptake kinetics of TRITC-Dextran by PEMs treated with Rabe alone or combined with LY294002. Scale bar, 10 μm
Sci Bull

Genetically engineered MSCs overexpressing hepatocyte growth factor for the treatment of human refractory wounds. [Abstract]

2025 Nov 25:S2095-9273(25)01198-3. PMID: 41381331
Adv Funct Mater

2024 May 1.
Autophagy

Autophagic regulation of ferroportin 1 induces developmental ferroptosis in rice blast. [Abstract]

2025 Dec;21(12):2867-2882. PMID: 40774826
Autophagy

Apicoplast biogenesis mediated by ATG8 requires the ATG12-ATG5-ATG16L and SNAP29 complexes in Toxoplasma gondii. [Abstract]

2023 Apr;19(4):1258-1276. PMID: 36095096
Autophagy

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication. [Abstract]

2023 Feb;19(2):551-569. PMID: 35670302
Autophagy

Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. [Abstract]

2021 Nov;17(11):3592-3606. PMID: 33629929
Nat Commun

Human pluripotent stem cell-derived skin organoids enabled pathophysiological model of Mycobacterium tuberculosis infection. [Abstract]

2025 Dec 2;16(1):10831. PMID: 41331115
Nat Commun

Brd7 loss reawakens dormant metastasis initiating cells in lung by forging an immunosuppressive niche. [Abstract]

2025 Feb 5;16(1):1378. PMID: 39910049
Nat Commun

Small-molecule-induced ERBB4 activation to treat heart failure. [Abstract]

2025 Jan 10;16(1):576. PMID: 39794341
Nat Commun

An actin bracket-induced elastoplastic transition determines epithelial folding irreversibility. [Abstract]

2024 Dec 12;15(1):10476. PMID: 39668169
Nat Commun

Engineered model of heart tissue repair for exploring fibrotic processes and therapeutic interventions. [Abstract]

2024 Sep 12;15(1):7996. PMID: 39266508
Nat Commun

Bioelectric stimulation controls tissue shape and size. [Abstract]

2024 Apr 5;15(1):2938. PMID: 38580690
Nat Commun

Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion. [Abstract]

2024 Apr 11;15(1):3165. PMID: 38605010
Nat Commun

An injectable liposome-anchored teriparatide incorporated gallic acid-grafted gelatin hydrogel for osteoarthritis treatment. [Abstract]

2023 May 31;14(1):3159. PMID: 37258510
Nat Commun

PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis. [Abstract]

2021 Jun 8;12(1):3444. PMID: 34103528
Nat Commun

The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation. [Abstract]

2021 Mar 29;12(1):1940. PMID: 33782411
Nat Commun

Venous identity requires BMP signalling through ALK3. [Abstract]

2019 Jan 28;10(1):453. PMID: 30692543

LY294002 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Jan 28;10(1):453. [Abstract]

Protein levels of p53, p21 and MDM2 are upregulated in LNCaP cells after treatment with 2.0 μM concentration of RG7388.

LY294002 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Jan 28;10(1):453. [Abstract]

Apoptotic cell death in LNCaP cells shown by Fluorescence image obtained using the DEVD-amc. The results of cell death induced by SAHA and RG7388 treatment for 24 hrs are shown.

LY294002 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Jan 28;10(1):453. [Abstract]

Western blot analysis of BAX and PARP (full length and cleaved PARP) expressions in treated LNCaP cells with the treatment of SAHA or RG7388.
Exp Hematol Oncol

Combined inhibition of MET and VEGF enhances therapeutic efficacy of EGFR TKIs in EGFR-mutant non-small cell lung cancer with concomitant aberrant MET activation. [Abstract]

2024 Oct 1;13(1):97. PMID: 39354638
ACS Nano

Engineered Lysosome-Targeted Protein Degradation via Hijacking Macropinocytosis. [Abstract]

2026 Jun 30;20(25):18533-18544. PMID: 42304955
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Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments. [Abstract]

2025 Jun 16:S2090-1232(25)00442-4. PMID: 40533054
Cell Discov

ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression. [Abstract]

2026 Feb 24;12(1):13. PMID: 41730846
Sci Immunol

Radiotherapy enhances anticancer CD8 T cell responses by cGAMP transfer through LRRC8A/C volume-regulated anion channels. [Abstract]

2025 Jun 27;10(108):eadn1630. PMID: 40577443
Redox Biol

Heme: A link between hemorrhage and retinopathy of prematurity progression. [Abstract]

2024 Oct:76:103316. PMID: 39260060
Nat Chem Biol

Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans. [Abstract]

2021 May;17(5):576-584. PMID: 33664521
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PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]

2018 Jul 18;10(450):eaaq1093. PMID: 30021885
Adv Compos Hybrid Mater

2025 Dec 2.
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Inhalable targeted CD8 + T cell nanoparticles loaded ferroptosis inhibitor ferrostatin-1 alleviate acute lung injury. [Abstract]

2025 Nov 20;23(1):723. PMID: 41261431
J Nanobiotechnology

Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis. [Abstract]

2025 Apr 7;23(1):282. PMID: 40197477
J Nanobiotechnology

Ultrasound-triggered piezoelectric polyetheretherketone with boosted osteogenesis via regulating Akt/GSK3β/β-catenin pathway. [Abstract]

2024 Sep 5;22(1):539. PMID: 39237993
J Nanobiotechnology

Nanosilicates facilitate periodontal regeneration potential by activating the PI3K-AKT signaling pathway in periodontal ligament cells. [Abstract]

2024 Sep 3;22(1):532. PMID: 39223550
J Nanobiotechnology

3D nanofiber scaffolds from 2D electrospun membranes boost cell penetration and positive host response for regenerative medicine. [Abstract]

2024 Jun 8;22(1):322. PMID: 38849858
J Nanobiotechnology

Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K/Akt pathways. [Abstract]

2021 Jul 7;19(1):202. PMID: 34233694
Theranostics

Bone-Targeting Microspheres Enable Sustained Release of CD301b+ Macrophage-Derived Small Extracellular Vesicles to Promote Bone Repair. [Abstract]

2026 Jun 17;16(13):7514-7536. PMID: 42370173
Theranostics

Inactivating IL34 promotes regenerating muscle stem cell expansion and attenuates Duchenne muscular dystrophy in mouse models. [Abstract]

2023 Apr 23;13(8):2588-2604. PMID: 37215564
Theranostics

CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3. [Abstract]

2021 Jan 1;11(6):2612-2633. PMID: 33456563
Theranostics

FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity. [Abstract]

2020 Feb 3;10(6):2859-2871. PMID: 32194840
Genes Dis

2025 Nov 6.
Genes Dis

cTnIR193H restrictive cardiomyopathy mice satisfy high-energy metabolic demands through regulating glucose metabolism. [Abstract]

2025 Jul 25;13(2):101784. PMID: 41445980
Biomark Res

Lung cancer cell-intrinsic IL-15 promotes cell migration and sensitizes murine lung tumors to anti-PD-L1 therapy. [Abstract]

2024 Apr 19;12(1):40. PMID: 38637902
Genes Dis

PGRN exacerbates the progression of non-small cell lung cancer via PI3K/AKT/Bcl-2 antiapoptotic signaling. [Abstract]

2021 Jul 1;9(6):1650-1661. PMID: 36157487
Genes Dis

Sulfuretin exerts diversified functions in the processing of amyloid precursor protein. [Abstract]

2020 Nov 21;8(6):867-881. PMID: 34522714
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A novel FBW7/NFAT1 axis regulates cancer immunity in sunitinib-resistant renal cancer by inducing PD-L1 expression. [Abstract]

2022 Jan 26;41(1):38. PMID: 35081978
J Exp Clin Cancer Res

Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion. [Abstract]

2021 Jan 4;40(1):4. PMID: 33390170
J Exp Clin Cancer Res

MKRN2 inhibits migration and invasion of non-small-cell lung cancer by negatively regulating the PI3K/Akt pathway. [Abstract]

2018 Aug 13;37(1):189. PMID: 30103781

LY294002 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Aug 13;37(1):189. [Abstract]

H1299 cells transfected with si-MKRN2 are treated or not treated with the PI3K inhibitor LY294002 analyzed by western blot for the expression of proteins involved in cell migration and invasion.
J Exp Clin Cancer Res

Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling. [Abstract]

2018 Jun 25;37(1):122. PMID: 29940988

LY294002 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Jun 25;37(1):122. [Abstract]

MHCC97H cells are treated with either LY294002 (2.5, 5,10, 20, 40 μM) or ZSTK474 (0.5, 1, 2.5, 5, 10 μM) for 24 h. DMSO is used as the control. Cell lysates are subjected to western blot analysis with the indicated antibodies.
J Exp Clin Cancer Res

CADM2, as a new target of miR-10b, promotes tumor metastasis through FAK/AKT pathway in hepatocellular carcinoma. [Abstract]

2018 Mar 5;37(1):46. PMID: 29506532

LY294002 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Mar 5;37(1):46. [Abstract]

Treatment with LY294002 reverses Epithelial-mesenchymal transition (EMT) mediated by miR-10b overexpression. GAPDH is used as a loading control.
Adv Sci (Weinh)

pH/ROS-Responsive Injectable Hydrogel Co-Loaded with B7-H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy. [Abstract]

2026 Apr;13(20):e15431. PMID: 41684277
Adv Sci (Weinh)

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment. [Abstract]

2026 Mar 20:e16557. PMID: 41861091
Adv Sci (Weinh)

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα. [Abstract]

2026 Jan 20:e16355. PMID: 41560298
Adv Sci (Weinh)

GLUL Confers Perivascular Cancer-Associated Fibroblasts With Pro-Angiogenic Capacity to Promote Glioma Progression. [Abstract]

2025 Dec 8:e13184. PMID: 41355614
Adv Sci (Weinh)

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways. [Abstract]

2025 Nov 3:e09151. PMID: 41178446
MedComm (2020)

Gene Therapy Targeting Pkp2 Deficiency Attenuates Cardiac Fibrosis: Insights From Single-Cell Transcriptomics in Pkp2-Knockout Rats. [Abstract]

2025 Sep 18;6(10):e70392. PMID: 40979216
Adv Sci (Weinh)

Galectin-1-Induced Tumor Associated Macrophages Repress Antitumor Immunity in Hepatocellular Carcinoma Through Recruitment of Tregs. [Abstract]

2025 Mar;12(11):e2408788. PMID: 39853961
Adv Sci (Weinh)

Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro-Angiogenic Macrophage Polarization via Activation of the PI3K-Akt Signaling Pathway. [Abstract]

2025 Feb;12(8):e2414278. PMID: 39739591
Adv Sci (Weinh)

Localized COUP-TFII pDNA Delivery Modulates Stem/Progenitor Cell Differentiation to Enhance Endothelialization and Inhibit Calcification of Decellularized Allografts. [Abstract]

2025 Feb;12(5):e2409744. PMID: 39656938
Adv Sci (Weinh)

TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA-PKcs. [Abstract]

2024 Aug;11(29):e2400023. PMID: 38828688
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CCR7 Mediated Mimetic Dendritic Cell Vaccine Homing in Lymph Node for Head and Neck Squamous Cell Carcinoma Therapy. [Abstract]

2023 Jun;10(17):e2207017. PMID: 37092579
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RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy. [Abstract]

2023 Feb;10(5):e2203884. PMID: 36563124
Cell Rep Med

Therapeutic targeting of interleukin-17C signaling in carcinogenesis of endometriosis. [Abstract]

2025 Dec 16;6(12):102464. PMID: 41270735
Cell Rep Med

28 October 2021.
Sci Adv

BRD9 functions as a methylarginine reader to regulate AKT-EZH2 signaling. [Abstract]

2025 Apr 25;11(17):eads6385. PMID: 40279411
Biomaterials

Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration. [Abstract]

2021 Jul:274:120850. PMID: 33984637
Carbohydr Polym

Inulin with a low degree of polymerization protects human umbilical vein endothelial cells from hypoxia/reoxygenation-induced injury. [Abstract]

2019 Jul 15;216:97-106. PMID: 31047086
Neuro Oncol

2026 Jul 23:noag167. PMID: 42494116
Research (Wash D C)

Trabecular-Like Scaffold Dictates Osteogenesis via Fluid Shear Stress-Induced Metabolic Reprogramming through the CAV1-HIF-1α Axis. [Abstract]

2026 Jun 16:9:1307. PMID: 42312216
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2023 Jan 25, 217, 118617.
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2025 Dec 20.
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2025 Sep 7;522:168177.
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Targeting BRD4 and PI3K signaling pathways for the treatment of medulloblastoma. [Abstract]

2023 Feb:354:80-90. PMID: 36599397
Cell Death Dis

Targeting the LY6H-PI3K/AKT autophagy axis suppresses HCC malignancy and reveals a druggable vulnerability. [Abstract]

2026 Jun 15. PMID: 42297773
Cell Death Dis

Characterization of ADGRG6 as a potential molecular oncotarget of pancreatic cancer. [Abstract]

2026 May 6;17(1):604. PMID: 42091867
Cell Death Dis

Generation of proliferative hESC-derived grape-clustered hepatocyte organoids with multipolar architecture as regenerative counterpart via synergy of YAP and IGF2 pathways. [Abstract]

2026 Mar 26;17(1):381. PMID: 41888105
Cell Death Dis

ZC3H15 regulates the ubiquitination of PTEN via recruitment of TRIM56 and promotes malignant progression of non-small cell lung cancer. [Abstract]

2026 Jan 9;17(1):17. PMID: 41513632
Environ Sci Technol

Exposure to Sodium p-Perfluorous Nonenoxybenzenesulfonate Induces Renal Fibrosis in Mice by Disrupting Lysine Metabolism. [Abstract]

2025 Mar 21. PMID: 40116701
Cell Mol Biol Lett

Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)-anthrabenzoxocinone induces cell cycle arrest, apoptosis, and autophagy in non-small cell lung cancer. [Abstract]

2024 Apr 23;29(1):58. PMID: 38649803
Cell Death Dis

A potential strategy for bladder cancer treatment: inhibiting autophagy to enhance antitumor effects of Nectin-4-MMAE. [Abstract]

2024 Apr 25;15(4):293. PMID: 38664366
Cell Death Dis

USP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway. [Abstract]

2024 Mar 26;15(3):235. PMID: 38531846
Cell Death Dis

PRR15 deficiency facilitates malignant progression by mediating PI3K/Akt signaling and predicts clinical prognosis in triple-negative rather than non-triple-negative breast cancer. [Abstract]

2023 Apr 18;14(4):272. PMID: 37072408
Cell Death Dis

PLEKHH2 binds β-arrestin1 through its FERM domain, activates FAK/PI3K/AKT phosphorylation, and promotes the malignant phenotype of non-small cell lung cancer. [Abstract]

2022 Oct 8;13(10):858. PMID: 36209201
Pharmacol Res

Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin. [Abstract]

2022 Mar:177:106096. PMID: 35077844
Cell Death Dis

Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma. [Abstract]

2022 Feb 17;13(2):158. PMID: 35177591
Cell Death Dis

ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY. [Abstract]

2021 Nov 27;12(12):1113. PMID: 34839358
Cell Death Dis

TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression. [Abstract]

2021 Jun 23;12(7):642. PMID: 34162834
Cell Death Dis

SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells. [Abstract]

2021 Jun 2;12(6):570. PMID: 34108444
Cell Death Dis

Myeloid-derived suppressor cells regulate the immunosuppressive functions of PD-1-PD-L1+ Bregs through PD-L1/PI3K/AKT/NF-κB axis in breast cancer. [Abstract]

2021 May 9;12(5):465. PMID: 33967272
Cell Death Dis

METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial-mesenchymal transition of renal tubular cells in diabetic kidney disease. [Abstract]

2021 Jan 4;12(1):32. PMID: 33414476
Cell Death Dis

Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway. [Abstract]

2020 Jun 12;11(6):454. PMID: 32532964
Cell Death Dis

The therapeutic value of SC66 in human renal cell carcinoma cells. [Abstract]

2020 May 11;11(5):353. PMID: 32393791
Cell Death Dis

SIK2 enhances synthesis of fatty acid and cholesterol in ovarian cancer cells and tumor growth through PI3K/Akt signaling pathway. [Abstract]

2020 Jan 13;11(1):25. PMID: 31932581
Cell Death Dis

EGFR-PI3K-PDK1 pathway regulates YAP signaling in hepatocellular carcinoma: the mechanism and its implications in targeted therapy. [Abstract]

2018 Feb 15;9(3):269. PMID: 29449645

LY294002 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Feb 15;9(3):269. [Abstract]

WB is used to detect the effect of EGF treatment for 4 h on the expression of YAP with the inhibitors of EGFR or its downsream members, including ZD1839, LY294002, Wortmannin, GSK2334470, BX-795, MK-2206, GSK1120212, and U0126 in the Si RhoA transfected HepG2 and SMMC7721 cells for 48 h in HepG2 and SMMC7721 cells.
Cancer Lett

Forkhead box protein FOXK1 disrupts the circadian rhythm to promote breast tumorigenesis in response to insulin resistance. [Abstract]

2024 Sep 1:599:217147. PMID: 39094826
Cancer Lett

Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages. [Abstract]

2024 May 28:590:216801. PMID: 38479552
Cancer Lett

ETV4 promotes pancreatic ductal adenocarcinoma metastasis through activation of the CXCL13/CXCR5 signaling axis. [Abstract]

2022 Jan 1:524:42-56. PMID: 34582976
Int J Biol Sci

RNF2 Modulates Lipid Metabolism and Inflammation in Alcohol-associated Liver Disease by Interacting with USP7. [Abstract]

2025 Apr 28;21(7):3306-3323. PMID: 40384855
Int J Biol Sci

NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease. [Abstract]

2024 Mar 25;20(6):2219-2235. PMID: 38617542
Int J Biol Sci

Genistin: A Novel Estrogen Analogue Targeting ERβ to Alleviate Thrombocytopenia. [Abstract]

2024 Mar 25;20(6):2236-2260. PMID: 38617546
Int J Biol Sci

TGFβ Governs the Pleiotropic Activity of NDRG1 in Triple-Negative Breast Cancer Progression. [Abstract]

2023 Jan 1;19(1):204-224. PMID: 36594086
Int J Biol Sci

Long term usage of dexamethasone accelerating accelerates the initiation of osteoarthritis via enhancing chondrocyte apoptosis and the extracellular matrix calcification and apoptosis of chondrocytes. [Abstract]

2021 Oct 3;17(15):4140-4153. PMID: 34803488
J Immunother Cancer

Tumor-released autophagosomes induces CD4+ T cell-mediated immunosuppression via a TLR2-IL-6 cascade. [Abstract]

2019 Jul 12;7(1):178. PMID: 31300052
Int J Biol Sci

Ecological Trade-offs between Migration and Reproduction Are Mediated by the Nutrition-Sensitive Insulin-Signaling Pathway. [Abstract]

2016 Mar 30;12(5):607-16. PMID: 27143957
Cell Commun Signal

CDO1 phosphorylation is required for IL-6-induced tumor cell proliferation through governing cysteine availability. [Abstract]

2025 Apr 23;23(1):194. PMID: 40269955
Cell Commun Signal

BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation. [Abstract]

2025 Jan 6;23(1):7. PMID: 39762888
Cell Commun Signal

Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension. [Abstract]

2021 Oct 11;19(1):103. PMID: 34635097
J Exp Med

Modeling synovial sarcoma metastasis in the mouse: PI3'-lipid signaling and inflammation. [Abstract]

2016 Dec 12;213(13):2989-3005. PMID: 27956588
J Neuroinflammation

Ganglion cell-derived LysoPS induces retinal neovascularisation by activating the microglial GPR34-PI3K-AKT-NINJ1 axis. [Abstract]

2024 Oct 28;21(1):278. PMID: 39468551
J Neuroinflammation

Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain. [Abstract]

2020 Jul 14;17(1):211. PMID: 32665021
Phytomedicine

2026 Oct:160:158639. PMID: 42537464
Phytomedicine

2026 Sep:159:158511. PMID: 42419124
Phytomedicine

Narciclasine alleviates zearalenone-induced focal adhesion damage and anoikis in rat Sertoli cells through PI3K signaling pathway. [Abstract]

2026 Jul:156:158218. PMID: 42025009
Phytomedicine

Platycodin D alleviates idiopathic pulmonary fibrosis by targeting PPP2R1A and regulating the PP2A-mediated PI3K/Akt pathway to inhibit fibroblast transdifferentiation. [Abstract]

2026 Apr:153:158000. PMID: 41759424
Phytomedicine

Hydroalcoholic gel of Angelica sinensis polysaccharides promotes wound healing by suppressing ferroptosis through PI3K/AKT/Nrf2 signaling pathway. [Abstract]

2026 Apr:153:157962. PMID: 41724102
Phytomedicine

Paeoniflorin alleviates anxiety-like behaviors in sleep-deprived male mice by suppressing inflammation of the paraventricular nucleus of the hypothalamus. [Abstract]

2026 Jun:155:158111. PMID: 41931995
Phytomedicine

Asperosaponin VI enhances stress resilience by activating hippocampal neural stem cells. [Abstract]

2026 Mar:152:157874. PMID: 41619550
Phytomedicine

Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis. [Abstract]

2025 Nov 25:148:157378. PMID: 41106096
Phytomedicine

Shenfu injection inhibits myocardial fibrosis by regulating glycolysis through the PI3K-AKT/HIF-1α signaling pathway. [Abstract]

2025 Dec:149:157529. PMID: 41273867
Phytomedicine

Salvigenin mitigates neuronal ferroptosis by binding to PI3K and enhancing the interaction between VCP and PI3K in the repair of spinal cord injury. [Abstract]

2025 Nov:147:157181. PMID: 40865346
Phytomedicine

Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway. [Abstract]

2025 Jun:141:156701. PMID: 40220416
Phytomedicine

6'-O-caffeoylarbutin of Vaccinium dunalianum alleviated ischemic stroke through the PI3K/AKT/NF-κB pathway. [Abstract]

2025 Apr:139:156505. PMID: 39978278
Phytomedicine

Geniposide ameliorates atherosclerosis by restoring lipophagy via suppressing PARP1/PI3K/AKT signaling pathway. [Abstract]

2024 Jul:129:155617. PMID: 38614041
Phytomedicine

Modified Guo-Min decoction ameliorates PM2.5-induced lung injury by inhibition of PI3K-AKT and MAPK signaling pathways. [Abstract]

2024 Jan:123:155211. PMID: 38061286
Phytomedicine

Multi-omics analysis reveals the mechanism of action of ophiopogonin D against pulmonary fibrosis. [Abstract]

2023 Dec:121:155078. PMID: 37734252
Phytomedicine

Saikosaponin A and D attenuate skeletal muscle atrophy in chronic kidney disease by reducing oxidative stress through activation of PI3K/AKT/Nrf2 pathway. [Abstract]

2023 Jun:114:154766. PMID: 37002971
Phytomedicine

Hydroxysafflor yellow A regulates lymphangiogenesis and inflammation via the inhibition of PI3K on regulating AKT/mTOR and NF-κB pathway in macrophages to reduce atherosclerosis in ApoE-/- mice. [Abstract]

2023 Apr:112:154684. PMID: 36738477
Phytomedicine

Triterpenoid saponins from Ilex pubescens promote blood circulation in blood stasis syndrome by regulating sphingolipid metabolism and the PI3K/AKT/eNOS signaling pathway. [Abstract]

2022 Sep:104:154242. PMID: 35728385
Phytomedicine

The surface morphology of Platycodon grandiflorus polysaccharide and its anti-apoptotic effect by targeting autophagy. [Abstract]

2022 Aug:103:154212. PMID: 35665615
Phytomedicine

3'-Oxo-tabernaelegantine A (OTNA) selectively relaxes pulmonary arteries by inhibiting AhR. [Abstract]

2021 Nov:92:153751. PMID: 34563984
Phytomedicine

PSORI-CM02 ameliorates psoriasis in vivo and in vitro by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway. [Abstract]

2019 Nov:64:153054. PMID: 31401494
Phytomedicine

Vielanin P enhances the cytotoxicity of doxorubicin via the inhibition of PI3K/Nrf2-stimulated MRP1 expression in MCF-7 and K562 DOX-resistant cell lines. [Abstract]

2019 May:58:152885. PMID: 31009836
Adv Healthc Mater

Platelet Lysate-Enriched Human Induced Pluripotent Stem Cell-Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification. [Abstract]

2025 Nov 28:e03527. PMID: 41312909
J Hazard Mater

Diesel exhaust promoted diethylnitrosamine-induced hepatocarcinogenesis in mice. [Abstract]

2025 Jul 15:492:138219. PMID: 40220387
Acta Biomater

Functionalized layered double hydroxide coatings on biodegradable Zn-Mg alloy enhance osteogenesis via the Wnt/β-catenin and PI3K/Akt signaling pathways. [Abstract]

2026 Jan 26:S1742-7061(26)00061-9. PMID: 41605408
Cell Death Discov

CTDSPL2 promotes the progression of non-small lung cancer through PI3K/AKT signaling via JAK1. [Abstract]

2024 Aug 29;10(1):389. PMID: 39209829
Acta Pharmacol Sin

Protective effects of curcumin on desipramine-induced islet β-cell damage via AKAP150/PKA/PP2B complex. [Abstract]

2024 Feb;45(2):327-338. PMID: 37845344
Cell Death Discov

YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions. [Abstract]

2023 Oct 20;9(1):385. PMID: 37863897
Acta Pharmacol Sin

Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects. [Abstract]

2022 Oct;43(10):2573-2584. PMID: 35260820
Acta Biomater

Synergistic effects of mechanical stimulation and crimped topography to stimulate natural collagen development for tendon engineering. [Abstract]

2022 Jun;145:297-315. PMID: 35470072
Acta Pharmacol Sin

The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways. [Abstract]

2018 Nov;39(11):1787-1796. PMID: 30181579

LY294002 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2018 Nov;39(11):1787-1796. [Abstract]

Effects of LY294002 or AKT siRNA on the levels of total AKT, pAKT, phosphorylated PRAS40 and pMDM2 are examined by Western blot analysis in MCF-7 cells when HBXIP was overexpressed. Effects of MK-2206 or HBXIP siRNA on the levels of total AKT, pAKT, pPRAS40, and pMDM2 are examined by Western blot analysis in MCF-7-HBXIP cells.
J Cachexia Sarcopenia Muscle

C2C12-Derived ApoVs Promote Skeletal Muscle Development and Ameliorate Age-Related Muscle Loss Through Igf1r/PI3K/AKT/mTOR Pathway. [Abstract]

2025 Dec;16(6):e70159. PMID: 41344911
J Orthop Translat

Profibrotic macrophage-derived CXCL4 promotes pericyte-to-myofibroblast transition after spinal cord injury. [Abstract]

2026 Feb 11:56:101032. PMID: 41836554
J Orthop Translat

Cerebrospinal fluid-derived extracellular vesicles after spinal cord injury promote vascular regeneration via PI3K/AKT signaling pathway. [Abstract]

2023 Mar 4:39:124-134. PMID: 36909861
J Transl Med

Glutamine metabolism reprogramming promotes bladder cancer progression via PYCR1: a multi-omics and functional validation study. [Abstract]

2025 Nov 13;23(1):1277. PMID: 41233804
J Transl Med

DCST1-AS1 promotes renal cell carcinoma progression via regulating the miR-582-5p/HMGB2 axis. [Abstract]

2025 Nov 26;23(1):1352. PMID: 41299565
J Transl Med

Quercetin promotes angiogenesis and protects the blood-spinal cord barrier structure after spinal cord injury by targeting the PI3K/Akt signaling pathway. [Abstract]

2025 Aug 25;23(1):958. PMID: 40855559
J Transl Med

Apelin-13 attenuates optic nerve damage in glaucomatous mice by regulating glucose metabolism. [Abstract]

2025 Feb 18;23(1):200. PMID: 39966959
J Transl Med

Cholesterol overload in macrophages drives metabolic dysfunction-associated steatohepatitis via inhibiting 7-dehydrocholesterol reductase in mice. [Abstract]

2024 Nov 29;22(1):1085. PMID: 39614331
J Transl Med

MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and the PI3K-Akt-ROS pathway. [Abstract]

2024 Nov 22;22(1):1056. PMID: 39578795
J Transl Med

HOXD9/miR-451a/PSMB8 axis is implicated in the regulation of cell proliferation and metastasis via PI3K/AKT signaling pathway in human anaplastic thyroid carcinoma. [Abstract]

2023 Nov 16;21(1):817. PMID: 37974228
J Transl Med

CD58 acts as a tumor promotor in hepatocellular carcinoma via activating the AKT/GSK-3β/β-catenin pathway. [Abstract]

2023 Aug 12;21(1):539. PMID: 37573318
J Transl Med

The PI3K-Akt-mTOR pathway mediates renal pericyte-myofibroblast transition by enhancing glycolysis through HKII. [Abstract]

2023 May 13;21(1):323. PMID: 37179292
J Transl Med

Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin. [Abstract]

2023 Feb 2;21(1):72. PMID: 36732757
J Transl Med

MiR-30c-5p loss-induced PELI1 accumulation regulates cell proliferation and migration via activating PI3K/AKT pathway in papillary thyroid carcinoma. [Abstract]

2022 Jan 6;20(1):20. PMID: 34991623
J Transl Med

Delineation of colorectal cancer ligand-receptor interactions and their roles in the tumor microenvironment and prognosis. [Abstract]

2021 Dec 7;19(1):497. PMID: 34876143
J Transl Med

CHN1 promotes epithelial-mesenchymal transition via the Akt/GSK-3β/Snail pathway in cervical carcinoma. [Abstract]

2021 Jul 8;19(1):295. PMID: 34238315
Sci China Life Sci

Two sex pheromone receptors for sexual communication in the American cockroach. [Abstract]

2024 Jul;67(7):1455-1467. PMID: 38523236
Proc Natl Acad Sci U S A

2026 Jul 7;123(27):e2523789123. PMID: 42384696
Dev Cell

STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma. [Abstract]

2025 Jun 23;60(12):1751-1767.e9. PMID: 39933531
Food Chem X

Immunoregulatory activity of a low-molecular-weight heteropolysaccharide from Ganoderma leucocontextum fruiting bodies in vitro and in vivo. [Abstract]

2022 Apr 30;14:100321. PMID: 35571333
Food Chem X

Preparation, chemical structure, and immunostimulatory activity of a water-soluble heteropolysaccharide from Suillus granulatus fruiting bodies. [Abstract]

2022 Jan 15:13:100211. PMID: 35498979
J Eur Acad Dermatol Venereol

Recombinant Treponema pallidum protein Tp0136 promotes fibroblast migration by modulating MCP-1/CCR2 through TLR4. [Abstract]

2020 Apr;34(4):862-872. PMID: 31856347
Dev Cell

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung. [Abstract]

2016 Oct 24;39(2):239-253. PMID: 27720610
Oncogene

RBM39 promotes hepatocarcinogenesis by regulating RFX1's alternative splicing and subsequent activation of integrin signaling pathway. [Abstract]

2025 Jun;44(20):1488-1503. PMID: 40033026
Chin Med J (Engl)

Arsenic trioxide preconditioning attenuates hepatic ischemia- reperfusion injury in mice: Role of ERK/AKT and autophagy. [Abstract]

2025 Jan 17. PMID: 39820060
Chin Med J (Engl)

Fibroblast growth factor 5 overexpression ameliorated lipopolysaccharide-induced apoptosis of hepatocytes through regulation of the phosphoinositide-3-kinase/protein kinase B pathway. [Abstract]

2022 Dec 5;135(23):2859-2868. PMID: 36728504
Oncogene

NRG1 regulates Fra-1 transcription and metastasis of triple-negative breast cancer cells via the c-Myc ubiquitination as manipulated by ERK1/2-mediated Fbxw7 phosphorylation. [Abstract]

2022 Feb;41(6):907-919. PMID: 34992218
Oncogene

Circulating IGF-1 promotes prostate adenocarcinoma via FOXO3A/BIM signaling in a double-transgenic mouse model. [Abstract]

2019 Sep;38(36):6338-6353. PMID: 31312023
Apoptosis

PRELP inhibits colorectal cancer progression by suppressing epithelial-mesenchymal transition and angiogenesis via the inactivation of the FGF1/PI3K/AKT pathway. [Abstract]

2025 Feb;30(1-2):16-34. PMID: 39242474
Apoptosis

Honokiol induces paraptosis-like cell death of acute promyelocytic leukemia via mTOR & MAPK signaling pathways activation. [Abstract]

2021 Apr;26(3-4):195-208. PMID: 33550458
Apoptosis

Berberine mitigates IL-21/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17/Treg imbalance in rheumatoid arthritis. [Abstract]

2019 Aug;24(7-8):644-661. PMID: 31111379
Int J Nanomedicine

Royal Jelly-Derived Extracellular Vesicles: Key Bioactive Components Mediating Anti-Hepatocellular Carcinoma Activity. [Abstract]

2026 Jun 3:21:609268. PMID: 42261358
Int J Biol Macromol

RNA binding motif single-stranded interacting protein 1 drives renal fibrosis by stabilizing Annexin A8 mRNA to activate PI3K/AKT signaling. [Abstract]

2026 May 24:368:152687. PMID: 42184845
Int J Biol Macromol

Oncostatin M promotes immune escape, invasion, and metastasis of pancreatic cancer by upregulating PD-L1 via the PI3K/AKT pathway. [Abstract]

2026 May:363:152179. PMID: 42034135
Int J Nanomedicine

Layered Double Hydroxide-Loaded Dl-3-n-Butylphthalide Alleviates Renal Ischemia-Reperfusion Injury by Regulating the PI3K-AKT-Nrf2 Signaling Pathway. [Abstract]

2026 Apr 14:21:594110. PMID: 42016345
Int J Biol Macromol

Isolation, structural characterization and immunoregulatory activity of a novel acidic polysaccharide from Ganoderma sinense. [Abstract]

2026 Mar 3:151196. PMID: 41786176
Int J Biol Macromol

Genome-wide CRISPR screen identifies ALG5, ALG6, NF2, and FUT8 as key host proteins involved in transmissible gastroenteritis virus infection. [Abstract]

2025 Dec;333(Pt 2):148770. PMID: 41205942
Int J Biol Macromol

Aging impairs the Treg-related osteogenic induction process via the PGRN/EGFR/PI3K/AKT axis. [Abstract]

2025 Oct 11;331(Pt 2):148224. PMID: 41083091
Int J Biol Macromol

RPUSD1 enhances the expression of eIF4E through RluA catalytic domain, activates PI3K/AKT signaling pathway, and promotes the cell proliferation and invasion in non-small cell lung cancer. [Abstract]

2025 May;306(Pt 1):141410. PMID: 40010477
Int J Biol Macromol

Neuritin improves cognitive impairments in APP/PS1 Alzheimer's disease mice model by mitigating neuronal ferroptosis via PI3K/Akt activation. [Abstract]

2025 Apr:303:140662. PMID: 39914536
Int J Nanomedicine

Si-ITGA6-Loaded Liposomes Inhibit Capsule Fibrosis via the FAK/PI3K/Akt Signaling Pathway in Adhesive Capsulitis of Shoulder. [Abstract]

2025 Apr 5:20:4183-4200. PMID: 40207309
Int J Biol Macromol

Astrocyte-conditional knockout of MOB2 inhibits the phenotypic conversion of reactive astrocytes from A1 to A2 following spinal cord injury in mice. [Abstract]

2025 Apr:300:140289. PMID: 39863205
Int J Biol Macromol

Polysaccharides from Ostrea rivularis alleviate type II diabetes induced-retinopathy and VGEF165-induced angiogenesis via PI3K/AKT signaling pathway. [Abstract]

2024 Nov;279(Pt 4):135547. PMID: 39265902
Int J Biol Macromol

Type X collagen knockdown inactivate ITGB1/PI3K/AKT to suppress chronic unpredictable mild stress-stimulated triple-negative breast cancer progression. [Abstract]

2024 Jul;273(Pt 1):133074. PMID: 38866293
Int J Biol Macromol

Porcine TLR8 signaling and its anti-infection function are disturbed by immune checkpoint receptor TIM-3 via inhibition of P13K-AKT pathway. [Abstract]

2024 May 1;269(Pt 1):132018. PMID: 38702002
BMC Med

A novel 450-nm laser-mediated sinoporphyrin sodium-based photodynamic therapy induces autophagic cell death in gastric cancer through regulation of the ROS/PI3K/Akt/mTOR signaling pathway. [Abstract]

2022 Dec 8;20(1):475. PMID: 36482460
J Headache Pain

Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine. [Abstract]

2022 Aug 10;23(1):98. PMID: 35948867
Int J Biol Macromol

G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury. [Abstract]

2022 May 15:207:72-80. PMID: 35247425
Int J Biol Macromol

Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAMs and T lymphocytes. [Abstract]

2020 May 1:150:261-280. PMID: 32044366
Int J Mol Med

C3a/C3aR axis is involved in diabetic kidney injury by regulating podocyte mitophagy in diabetic nephropathy. [Abstract]

2025 Dec;56(6):223. PMID: 41104892
Int J Mol Med

Suppression of tumor growth by GMI, an edible fungal immunomodulatory protein, is associated with targeting GSK3β‑mediated proteasomal degradation of PD‑L1. [Abstract]

2025 Dec;56(6):217. PMID: 41070618
Int J Mol Med

Artesunate protects against a mouse model of cerulein and lipopolysaccharide‑induced acute pancreatitis by inhibiting TLR4‑dependent autophagy. [Abstract]

2025 Feb;55(2):25. PMID: 39635846
Int J Mol Med

Arctiin attenuates iron overload‑induced osteoporosis by regulating the PI3K/Akt pathway. [Abstract]

2023 Nov;52(5):108. PMID: 37800616
Neural Regen Res

Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury. [Abstract]

2022 May;17(5):1080-1087. PMID: 34558536
Int J Mol Med

Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer. [Abstract]

2021 Sep;48(3):172. PMID: 34278450
Mol Ther Oncolytics

Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas. [Abstract]

2021 Aug 19:22:114-128. PMID: 34514093
Int J Mol Med

Rosmarinic acid inhibits cell proliferation, migration, and invasion and induces apoptosis in human glioma cells. [Abstract]

2021 May;47(5):67. PMID: 33649774
Int J Mol Med

ADAM10 promotes the proliferation of ligamentum flavum cells by activating the PI3K/AKT pathway. [Abstract]

2021 Feb;47(2):688-698. PMID: 33416124
Int J Mol Med

Autophagy inhibition enhances the inhibitory effects of ursolic acid on lung cancer cells. [Abstract]

2020 Nov;46(5):1816-1826. PMID: 32901853
Int J Mol Med

Fibronectin 1 inhibits the apoptosis of human trophoblasts by activating the PI3K/Akt signaling pathway. [Abstract]

2020 Nov;46(5):1908-1922. PMID: 33000176
Neural Regen Res

The Akt/glycogen synthase kinase-3β pathway participates in the neuroprotective effect of interleukin-4 against cerebral ischemia/reperfusion injury. [Abstract]

2020 Sep;15(9):1716-1723. PMID: 32209778
Int J Mol Med

XPD inhibits cell growth and invasion and enhances chemosensitivity in esophageal squamous cell carcinoma by regulating the PI3K/AKT signaling pathway. [Abstract]

2020 Jul;46(1):201-210. PMID: 32377720
Int J Mol Med

Alantolactone enhances gemcitabine sensitivity of lung cancer cells through the reactive oxygen species-mediated endoplasmic reticulum stress and Akt/GSK3β pathway. [Abstract]

2019 Sep;44(3):1026-1038. PMID: 31524219
Int J Mol Med

Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes. [Abstract]

2019 Aug;44(2):447-456. PMID: 31173156
Int J Mol Med

Pristimerin enhances the effect of cisplatin by inhibiting the miR‑23a/Akt/GSK3β signaling pathway and suppressing autophagy in lung cancer cells. [Abstract]

2019 Mar;43(3):1382-1394. PMID: 30664149
EMBO J

RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis. [Abstract]

2025 Feb;44(4):1185-1219. PMID: 39762645
Mol Med

Berberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice. [Abstract]

2024 Dec 20;30(1):251. PMID: 39707173
Mater Des

2026 May 28;267:116302.
Arch Pharm Res

Osteogenic effect of an adiponectin-derived short peptide that rebalances bone remodeling: a potential disease-modifying approach for postmenopausal osteoporosis therapy. [Abstract]

2024 Sep;47(8-9):736-755. PMID: 39073743
Arch Pharm Res

Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways. [Abstract]

2024 Feb;47(2):127-145. PMID: 38267702
Mater Design

2023 Oct, 234, 112313.
Antioxidants (Basel)

Blue Light Alters the Composition of the Jejunal Microbiota and Promotes the Development of the Small Intestine by Reducing Oxidative Stress. [Abstract]

2022 Jan 29;11(2):274. PMID: 35204158
Cell Mol Gastroenterol Hepatol

Fibrinogen/AKT/Microfilament Axis Promotes Colitis by Enhancing Vascular Permeability. [Abstract]

2021;11(3):683-696. PMID: 33075564
Antioxidants (Basel)

Characterization of the Inducible and Slow-Releasing Hydrogen Sulfide and Persulfide Donor P*: Insights into Hydrogen Sulfide Signaling. [Abstract]

2021 Jun 29;10(7):1049. PMID: 34209813
Phytother Res

(+)-Matairesinol, Derived From Olive Oil, Enhanced T-Cell Anti-Tumor Immune via JAK3-STAT1 Signal and Synergized With Anti-PD-1 Efficacy. [Abstract]

2026 Apr 27. PMID: 42037203
Phytother Res

Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways. [Abstract]

2025 Sep 27. PMID: 41014201
Phytother Res

Silibinin attenuated pseudo-allergic reactions and mast cell degranulation via PLCγ and PI3K/Akt signaling pathway. [Abstract]

2023 Aug;37(8):3572-3582. PMID: 37115717
Phytother Res

Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease. [Abstract]

2023 Feb;37(2):611-626. PMID: 36325883
Phytother Res

Maltol mitigates cisplatin-evoked cardiotoxicity via inhibiting the PI3K/Akt signaling pathway in rodents in vivo and in vitro. [Abstract]

2022 Apr;36(4):1724-1735. PMID: 35174550
Phytother Res

A novel natural PPARγ agonist, Gypenoside LXXV, ameliorates cognitive deficits by enhancing brain glucose uptake via the activation of Akt/GLUT4 signaling in db/db mice. [Abstract]

2022 Apr;36(4):1770-1784. PMID: 35192202
Phytother Res

Resveratrol inhibits bile acid-induced gastric intestinal metaplasia via the PI3K/AKT/p-FoxO4 signalling pathway. [Abstract]

2021 Mar;35(3):1495-1507. PMID: 33103284
Fertil Steril

Protein kinase CK2 participates in estrogen-mediated endothelial progenitor cell homing to endometriotic lesions through stromal cells in a stromal cell-derived factor-1- CXCR4-dependent manner. [Abstract]

2020 May;113(5):1067-1079.e5. PMID: 32386617
Free Radic Biol Med

HIF-1α translation mediated by PKCδ facilitates RSV-induced production of innate inflammatory cytokines in vitro and in vivo. [Abstract]

2026 Mar 16:246:614-626. PMID: 41611036
Free Radic Biol Med

7,8-DHF inhibits BMSC oxidative stress via the TRKB/PI3K/AKT/NRF2 pathway to improve symptoms of postmenopausal osteoporosis. [Abstract]

2024 Oct:223:413-429. PMID: 39155025
Free Radic Biol Med

Sequestered SQSTM1/p62 crosstalk with Keap1/NRF2 axis in hPDLCs promotes oxidative stress injury induced by periodontitis. [Abstract]

2022 Sep:190:62-74. PMID: 35940517
Clin Transl Med

DDR2-mediated autophagy inhibition contributes to angiotensin II-induced adventitial remodeling. [Abstract]

2025 Jun;15(6):e70361. PMID: 40468620
Clin Transl Med

Regulatory roles of Osteopontin in lung epithelial inflammation and epithelial-telocyte interaction. [Abstract]

2023 Aug;13(8):e1381. PMID: 37605313
EMBO Mol Med

PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS-driven ELR+ CXC chemokine expression. [Abstract]

2023 Jan 11;15(1):e16373. PMID: 36511116
Am J Chin Med

Nephroprotective Effects of Formononetin in Diabetic Kidney Disease: Mechanistic Insights and Therapeutic Potential. [Abstract]

2025;53(7):2277-2305. PMID: 40947647
Br J Cancer

Transcriptome analysis of newly established carboplatin-resistant ovarian cancer cell model reveals genes shared by drug resistance and drug-induced EMT. [Abstract]

2023 Mar;128(7):1344-1359. PMID: 36717670
Stem Cell Res Ther

TNFα and IFNγ rapidly activate PI3K-AKT signaling to drive glycolysis that confers mesenchymal stem cells enhanced anti-inflammatory property. [Abstract]

2022 Oct 4;13(1):491. PMID: 36195887
Stem Cell Res Ther

Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2. [Abstract]

2022 Jun 7;13(1):241. PMID: 35672836
Stem Cell Res Ther

Engineered basic fibroblast growth factor-overexpressing human umbilical cord-derived mesenchymal stem cells improve the proliferation and neuronal differentiation of endogenous neural stem cells and functional recovery of spinal cord injury by activating the PI3K-Akt-GSK-3β signaling pathway. [Abstract]

2021 Aug 21;12(1):468. PMID: 34419172
Stem Cell Res Ther

Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis. [Abstract]

2021 May 20;12(1):295. PMID: 34016178
Stem Cell Res Ther

ELABELA ameliorates hypoxic/ischemic-induced bone mesenchymal stem cell apoptosis via alleviation of mitochondrial dysfunction and activation of PI3K/AKT and ERK1/2 pathways. [Abstract]

2020 Dec 14;11(1):541. PMID: 33317626
Stem Cell Res Ther

Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis. [Abstract]

2020 Jun 10;11(1):229. PMID: 32522231
Cell Rep

2026 Jul 28;45(7):117694. PMID: 42455679
World J Gastroenterol

2026 Mar 28;32(12).
Cell Rep

Liprin-α1 enhances PHLDB3 oncogenic function in colorectal cancer via activation of mTORC2-AKT1 pathway. [Abstract]

2025 Dec 16;45(1):116722. PMID: 41405991
Cell Rep

Neuropeptide adrenomedullin remodels stemness and macrophage dynamics in glioblastoma. [Abstract]

2025 Sep 24;44(10):116342. PMID: 41004340
Aging Cell

Role of PI3K/AKT/MAOA in glucocorticoid-induced oxidative stress and associated premature senescence of the trabecular meshwork. [Abstract]

2025 Apr;24(4):e14452. PMID: 39688282
Cell Rep

CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development. [Abstract]

2021 Nov 16;37(7):110007. PMID: 34788619
World J Gastroenterol

Y-box binding protein 1 augments sorafenib resistance via the PI3K/Akt signaling pathway in hepatocellular carcinoma. [Abstract]

2021 Jul 28;27(28):4667-4686. PMID: 34366628
Cell Rep

YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis. [Abstract]

2019 Apr 23;27(4):1176-1189.e5. PMID: 31018132
World J Gastroenterol

Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase. [Abstract]

2018 Feb 21;24(7):819-832. PMID: 29467552

LY294002 purchased from MedChemExpress. Usage Cited in: World J Gastroenterol. 2018 Feb 21;24(7):819-832. [Abstract]

HSCs are pretreated with AICAR (500 μM), LY294002 (20 μM), PD98059 (10 μM), or Rapamycin (100 nM) for 2 h and then incubated with or without CoCl₂ (150 μM) for 12 h. Expression levels of HIF-1α and VEGF are measured by Western blot analysis;
Cell Prolif

Expression and correlation of the Pi3k/Akt pathway and VEGF in oral submucous fibrosis. [Abstract]

2023 Nov;56(11):e13491. PMID: 37157945
Cell Prolif

p75NTR-/- mice exhibit an alveolar bone loss phenotype and inhibited PI3K/Akt/β-catenin pathway. [Abstract]

2020 Apr;53(4):e12800. PMID: 32215984
Br J Pharmacol

ATP release and metabolism by human and guinea pig airways and P2X receptor-dependent effects on bronchopulmonary vagal afferent nerve subtypes. [Abstract]

2025 Nov 2. PMID: 41178173
Brain Behav Immun

ERK1/2-dependent BDNF synthesis and signaling is required for the antidepressant effect of microglia stimulation. [Abstract]

2022 Nov:106:147-160. PMID: 35995236
Br J Pharmacol

Spinal heat shock protein 27 participates in PDGFRβ-mediated morphine tolerance through PI3K/Akt and p38 MAPK signalling pathways. [Abstract]

2020 Nov;177(22):5046-5062. PMID: 32559815
J Pineal Res

MicroRNA-7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland. [Abstract]

2019 Apr;66(3):e12552. PMID: 30618087
Cell Syst

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. [Abstract]

2018 Apr 25;6(4):424-443.e7. PMID: 29655704
Chin Med

2026 Jul 6;21(1):179. PMID: 42410650
Chin Med

2026 Jul 7;21(1):181. PMID: 42415127
Cell Mol Neurobiol

Inhibiting PI3K/Akt-Signaling Pathway Improves Neurobehavior Changes in Anti-NMDAR Encephalitis Mice by Ameliorating Blood-Brain Barrier Disruption and Neuronal Damage. [Abstract]

2023 Oct;43(7):3623-3637. PMID: 37314618
Neurotherapeutics

Inhibitions and Down-Regulation of Motor Protein Eg5 Expression in Primary Sensory Neurons Reveal a Novel Therapeutic Target for Pathological Pain. [Abstract]

2022 Jul;19(4):1401-1413. PMID: 35764763
Food Sci Hum Wellness

2026 Apr 29.
Food Sci Hum Wellness

2025.
Int J Oncol

FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway. [Abstract]

2019 Apr;54(4):1221-1232. PMID: 30968158
Int J Oncol

Valproic acid exhibits different cell growth arrest effect in three HPV-positive/negative cervical cancer cells and possibly via inducing Notch1 cleavage and E6 downregulation. [Abstract]

2016 Jul;49(1):422-30. PMID: 27176495
Environ Pollut

Integrative analysis of DEHP exposure and prostate cancer: Mechanistic insights and predictive modeling. [Abstract]

2026 Mar 1:392:127628. PMID: 41483848
Environ Pollut

Polystyrene nanoplastics induce ovarian injury by PI3K-Akt pathway-driven macrophage extracellular trap formation. [Abstract]

2025 Dec 1:386:127203. PMID: 41045980
J Agric Food Res

2025 Mar 25.
Environ Pollut

Thiophanate-methyl induces notochord toxicity by activating the PI3K-mTOR pathway in zebrafish (Danio rerio) embryos. [Abstract]

2023 Feb 1:318:120861. PMID: 36563988
Environ Pollut

Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis. [Abstract]

2017 Oct:229:964-975. PMID: 28765008

LY294002 purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2017 Oct:229:964-975. [Abstract]

Inhibition of PI3K/AKT blocks MC-LR-induced NF-κB activation. SC, LC, and GC are pretreated with the PI3K/AKT inhibitor LY294002 (LY) at 20 μM for 1 h followed by a 6-h treatment with MC-LR. Expression of phosphorylated NF-κB p65 (p-p65) and total p65 are detected by western blotting.
Cancer Cell Int

LncRNA AGAP2 antisense RNA 1 stabilized by insulin-like growth factor 2 mRNA binding protein 3 promotes macrophage M2 polarization in clear cell renal cell carcinoma through regulation of the microRNA-9-5p/THBS2/PI3K-Akt pathway. [Abstract]

2023 Dec 18;23(1):330. PMID: 38110984
Sci Signal

The Bacillus cereus toxin alveolysin disrupts the intestinal epithelial barrier by inducing microtubule disorganization through CFAP100. [Abstract]

2023 May 16;16(785):eade8111. PMID: 37192300
Front Immunol

Non-Structural Protein 3 of Duck Tembusu Virus Induces Autophagy via the ERK and PI3K-AKT-mTOR Signaling Pathways. [Abstract]

2022 Feb 3;13:746890. PMID: 35185869
J Invest Dermatol

Inhibition of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Cascade Limits Chlamydia trachomatis Infection. [Abstract]

2021 Apr;141(4):852-862.e6. PMID: 32918951
Cancer Cell Int

Phenyllactic acid promotes cell migration and invasion in cervical cancer via IKK/NF-κB-mediated MMP-9 activation. [Abstract]

2019 Sep 23:19:241. PMID: 31572058
Front Immunol

Distinct Functions of Bombyx mori Peptidoglycan Recognition Protein 2 in Immune Responses to Bacteria and Viruses. [Abstract]

2019 Apr 12:10:776. PMID: 31031766
Cancer Cell Int

Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway. [Abstract]

2019 Jan 8:19:9. PMID: 30636930
Lipids Health Dis

Knockdown of RASD1 improves MASLD progression by inhibiting the PI3K/AKT/mTOR pathway. [Abstract]

2024 Dec 27;23(1):424. PMID: 39731125
Redox Rep

The protective effect of proanthocyanidins on the psoriasis-like cell models via PI3K/AKT and HO-1. [Abstract]

2022 Dec;27(1):200-211. PMID: 36178125
J Ethnopharmacol

2027 Jan 10:372:122229. PMID: 42486453
Virulence

2026 Dec;17(1):2697518. PMID: 42397844
J Ethnopharmacol

"Shihu" promote T-cell immunity against breast cancer through bioactive constituent THMB enhancing JAK3-STAT1 signal. [Abstract]

2026 Oct 28:369:121888. PMID: 42202911
J Ethnopharmacol

Huangqi Guizhi Wuwu decoction promotes neuroprotection and functional recovery after ischemic stroke via activation of the PI3K/Akt/mTOR signaling pathway and modulation of microglial polarization. [Abstract]

2026 Jun 28:365:121563. PMID: 41887379
J Ethnopharmacol

Mechanistic investigation of RHEI FLOS extract against hepatocarcinoma via the PI3K/Akt signaling pathway In vitro and Invivo. [Abstract]

2026 Jun 28:365:121555. PMID: 41866007
J Ethnopharmacol

ShenRongGuBenHuanShao Pill ameliorates oligoasthenospermia by alleviating oxidative stress and DNA damage via activation of the PI3K/Akt/mTOR pathway. [Abstract]

2026 May 23:363:121439. PMID: 41747791
J Ethnopharmacol

Simo Tang mitigates mitochondria-dependent apoptosis via PI3K/AKT pathway activation in Chronic atrophic gastritis. [Abstract]

2026 May 23:363:121417. PMID: 41765119
J Ethnopharmacol

Methanol extract of Artemisia argyi against influenza a virus via inhibition of PI3K-AKT pathway activation. [Abstract]

2026 Mar 1:358:120973. PMID: 41317814
J Ethnopharmacol

Anti-inflammatory effects and mechanisms of Podophyllum hexandrum rhizomes and fruits in a chronic pelvic inflammatory disease rat model. [Abstract]

2026 Feb 28:357:120954. PMID: 41285229
J Ethnopharmacol

Integration of network pharmacology and transcriptomics to reveal the mechanism of Paeoniae Radix Alba Polysaccharide in alleviating hepatic fibrosis. [Abstract]

2025 Aug 5;353(Pt A):120357. PMID: 40759297
J Ethnopharmacol

Network pharmacology-based exploration of the mechanism of Wenweishu granule in treating chronic atrophic gastritis with spleen-stomach cold deficiency syndrome. [Abstract]

2025 Apr 9:345:119591. PMID: 40054637
J Ethnopharmacol

Osteoking inhibits apoptosis of BMSCs in osteoporotic rats via PI3K/AKT signaling pathway. [Abstract]

2025 Jan 31:340:118961. PMID: 39653105
Hum Reprod

CDC42 deficiency leads to endometrial stromal cell senescence in recurrent implantation failure. [Abstract]

2024 Dec 1;39(12):2768-2784. PMID: 39487595
J Ethnopharmacol

Huanglian Jiedu decoction inhibits vascular smooth muscle cell-derived foam cell formation by activating autophagy via suppressing P2RY12. [Abstract]

2024 Jun 28:328:118125. PMID: 38561055
J Ethnopharmacol

The Bufei Nashen pill inhibits the PI3K/AKT/HIF-1 signaling pathway to regulate extracellular matrix deposition and improve COPD progression. [Abstract]

2024 May 30:118390. PMID: 38823661
J Ethnopharmacol

Qi-Ju-Di-Huang-Pill delays the progression of diabetic retinopathy. [Abstract]

2024 Apr 6:323:117751. PMID: 38216102
J Ethnopharmacol

Study on the mechanism of action of Saposhnikovia divaricata and its key phytochemical on rheumatoid arthritis based on network pharmacology and bioinformatics. [Abstract]

2024 Mar 25:322:117586. PMID: 38104871
J Ethnopharmacol

Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-κB signaling pathway. [Abstract]

2023 Oct 26;319(Pt 3):117356. PMID: 37890803
J Ethnopharmacol

Paeoniae Radix Rubra extract attenuates cerebral ischemia injury by inhibiting ferroptosis and activating autophagy through the PI3K/Akt signalling pathway. [Abstract]

2023 Oct 28:315:116567. PMID: 37172921
J Ethnopharmacol

Jiedu-Quyu-Ziyin Fang (JQZF) inhibits the proliferation and activation of B cells in MRL/lpr mice via modulating the AKT/mTOR/c-Myc signaling pathway. [Abstract]

2023 Oct 28:315:116625. PMID: 37236380
J Ethnopharmacol

PI3K/AKT/mTOR, NF-κB and ERS pathway participated in the attenuation of H2O2-induced IPEC-J2 cell injury by koumine. [Abstract]

2023 Mar 25:304:116028. PMID: 36529250
J Ethnopharmacol

Protective effects of the Bupi Yishen formula on renal fibrosis through PI3K/AKT signaling inhibition. [Abstract]

2022 Jul 15;293:115242. PMID: 35367329
J Ethnopharmacol

Huang Bai Jian Pi decoction alleviates diarrhea and represses inflammatory injury via PI3K/Akt/NF-κB pathway: In vivo and in vitro studies. [Abstract]

2022 Jun 28:292:115212. PMID: 35331876
J Ethnopharmacol

Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro. [Abstract]

2021 Nov 15:280:114411. PMID: 34265380
J Ethnopharmacol

Guizhi Fuling Wan reduces autophagy of granulosa cell in rats with polycystic ovary syndrome via restoring the PI3K/AKT/mTOR signaling pathway. [Abstract]

2021 Apr 24:270:113821. PMID: 33460753
J Ethnopharmacol

The Chinese herbal prescription JZ-1 induces autophagy to protect against herpes simplex Virus-2 in human vaginal epithelial cells by inhibiting the PI3K/Akt/mTOR pathway. [Abstract]

2020 May 23:254:112611. PMID: 32088246
J Agric Food Chem

Hesperidin and Hesperetin from Orange Peel Water Extract Protect against NaIO3-Induced Oxidative Damage in Retinal Pigment Epithelial Cells by Modulating PI3K/Akt/HIF-1α/BNIP3 Signaling. [Abstract]

2025 Oct 22;73(42):26669-26682. PMID: 41082699
Biomater Adv

Brushite-coated Mg-Nd-Zn-Zr alloy promotes the osteogenesis of vertebral laminae through IGF2/PI3K/AKT signaling pathway. [Abstract]

2023 Sep:152:213505. PMID: 37327764
J Agric Food Chem

Pterostilbene Coupled with Physical Exercise Effectively Mitigates Collagen-Induced Articular Synovial by Correcting the PI3K/Akt/NF-κB Signal Pathway. [Abstract]

2021 Nov 24;69(46):13821-13830. PMID: 34752070
Ecotoxicol Environ Saf

Curcumin alleviates BPAF-induced ferroptosis in caprine endometrial epithelial cells through inhibition of endoplasmic reticulum stress and autophagy. [Abstract]

2026 May 14:318:120253. PMID: 42134007
CNS Neurosci Ther

Dl-3-n-Butylphthalide Promotes Cortical Angiogenesis via Akt/GSK-3β Signaling in Ischemic Stroke Mice. [Abstract]

2025 Dec;31(12):e70698. PMID: 41373119
CNS Neurosci Ther

Impaired WNT3/IGF-1 Signaling in Dorsal Dentate Gyrus Contributes to Chronic Pain-Related Cognitive Impairment. [Abstract]

2025 Dec;31(12):e70714. PMID: 41414737
Ecotoxicol Environ Saf

Downregulated NT-3 and PI3K/AKT signaling pathway mediates arsenic-induced apoptosis in hippocampal neurons in vivo and in vitro. [Abstract]

2025 Jul 1:299:118372. PMID: 40440981
Ecotoxicol Environ Saf

Endosulfan promotes cell growth, migration and invasion via CCL5/CCR5 axis in MCF-7 cells. [Abstract]

2024 Dec:288:117344. PMID: 39549571
CNS Neurosci Ther

Esketamine Provides Neuroprotection After Intracerebral Hemorrhage in Mice via the NTF3/PI3K/AKT Pathway. [Abstract]

2024 Dec;30(12):e70145. PMID: 39690816
Ecotoxicol Environ Saf

The ROS/AKT/S6K axis induces corneal epithelial dysfunctions under LED blue light exposure. [Abstract]

2024 Nov 15:287:117345. PMID: 39541698
Ecotoxicol Environ Saf

Hesperetin alleviates aflatoxin B1 induced liver toxicity in mice: Modulating lipid peroxidation and ferritin autophagy. [Abstract]

2024 Oct 1:284:116854. PMID: 39142113
CNS Neurosci Ther

LIPUS-SCs-Exo promotes peripheral nerve regeneration in cavernous nerve crush injury-induced ED rats via PI3K/Akt/FoxO signaling pathway. [Abstract]

2023 Nov;29(11):3239-3258. PMID: 37157936
CNS Neurosci Ther

Clinical and preclinical evaluation of miR-144-5p as a key target for major depressive disorder. [Abstract]

2023 Nov;29(11):3598-3611. PMID: 37308778
Ecotoxicol Environ Saf

Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice. [Abstract]

2023 Jan 15:250:114497. PMID: 36608565
Ecotoxicol Environ Saf

Chronic exposure to microcystin-leucine-arginine induces epithelial hyperplasia and inflammation in the mouse bladder. [Abstract]

2022 Oct 1:244:114033. PMID: 36075121
Ecotoxicol Environ Saf

Sulfamethoxazole induces brain capillaries toxicity in zebrafish by up-regulation of VEGF and chemokine signalling. [Abstract]

2022 Jun 15;238:113620. PMID: 35561544
Ecotoxicol Environ Saf

Bisphenol F suppresses insulin-stimulated glucose metabolism in adipocytes by inhibiting IRS-1/PI3K/AKT pathway. [Abstract]

2022 Feb:231:113201. PMID: 35051757
Ecotoxicol Environ Saf

Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs. [Abstract]

2020 Apr 1;192:110267. PMID: 32044604
Biochem Pharmacol

Bosentan confers cardioprotection against cisplatin toxicity: Involvement of β-arrestin-linked ETA receptor signaling. [Abstract]

2026 Aug;250(Pt 2):118027. PMID: 42069228
Biochem Pharmacol

UFM1 suppresses VSMCs phenotypic switching and attenuates atherosclerosis by inhibiting AKT phosphorylation. [Abstract]

2026 Aug;250(Pt 1):117957. PMID: 41974329
Biochem Pharmacol

Phosphatidylserine-Rich circulating extracellular vesicles activate TAM receptor signaling to promote skin wound repair. [Abstract]

2026 Jul:249:117941. PMID: 41921755
Biochem Pharmacol

Almonertinib inhibits liver cancer progression by triggering autophagy-dependent ferroptosis through inhibition of the PI3K/Akt1/mTOR pathway. [Abstract]

2026 Mar:245:117628. PMID: 41380804
Biochem Pharmacol

IL-18 potentiates platelet activation and thrombosis through IL-18Rα-dependent MAPKs and PI3K/Akt signaling. [Abstract]

2026 Mar:245:117656. PMID: 41421453
Biochem Pharmacol

ACOD1/Itaconate regulates trophoblast function through the PI3K/Akt/FOLR1 axis to participate in the pathogenesis of recurrent spontaneous abortion. [Abstract]

2025 Dec;242(Pt 3):117405. PMID: 41047036
Biochem Pharmacol

Circadian rhythm disturbance induces osteoarthritis in mice: Involvement of Clock and Bmal1 dysregulation and Pdgfa inhibition. [Abstract]

2025 Sep 17;242(Pt 3):117342. PMID: 40972737
Cell Mol Life Sci

SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1. [Abstract]

2025 Jun 30;82(1):266. PMID: 40586822
Biochem Pharmacol

SERPINA1 promotes the invasion, metastasis, and proliferation of pancreatic ductal adenocarcinoma via the PI3K/Akt/NF-κB pathway. [Abstract]

2024 Dec;230(Pt 2):116580. PMID: 39427920
Biochem Pharmacol

Columbianadin suppresses glioblastoma progression by inhibiting the PI3K-Akt signaling pathway. [Abstract]

2024 May:223:116112. PMID: 38458331
Biochem Pharmacol

S-adenosylmethionine attenuates angiotensin II-induced aortic dissection formation by inhibiting vascular smooth muscle cell phenotypic switch and autophagy. [Abstract]

2024 Jan:219:115967. PMID: 38065291
Biochem Pharmacol

Aucubin protects mouse cochlear hair cells from cisplatin-induced ototoxicity via activation of the PI3K/AKT/STAT3 pathway. [Abstract]

2023 Mar:209:115440. PMID: 36720354
Cell Biosci

Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase. [Abstract]

2022 Dec 30;12(1):210. PMID: 36585695
Mol Ther Nucleic Acids

Upregulation of miR-520c-3p via hepatitis B virus drives hepatocellular migration and invasion by the PTEN/AKT/NF-κB axis. [Abstract]

2022 May 20:29:47-63. PMID: 35795482
Mol Ther Nucleic Acids

Upregulation of long non-coding RNA SNHG16 promotes diabetes-related RMEC dysfunction via activating NF-κB and PI3K/AKT pathways. [Abstract]

2021 Feb 4:24:512-527. PMID: 33898104
Cell Biosci

KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity. [Abstract]

2020 Nov 27;10(1):139. PMID: 33292627
Cell Biosci

Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE-/- mice. [Abstract]

2019 Aug 27:9:68. PMID: 31467666
Cell Mol Life Sci

Microcystin-leucine-arginine causes blood-testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. [Abstract]

2018 Mar;75(6):1117-1132. PMID: 29071384

LY294002 purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2018 Mar;75(6):1117-1132. [Abstract]

Sertoli cells (SC) are pretreated with LY294002 at 20 μM for 1 h followed by a 24-h treatment with MC-LR. Expression levels of p-p65 and MMP-8 are detected by western blotting.
Life Sci

A bovine milk-derived peptide ameliorates alloxan-injured pancreatic β cells through IRS2/PI3K/Akt signaling. [Abstract]

2022 Nov 1:308:120907. PMID: 36037870
Life Sci

Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway. [Abstract]

2021 Jun 1:274:119354. PMID: 33737087
Life Sci

The anti-inflammatory effects of 15-HETE on osteoarthritis during treadmill exercise. [Abstract]

2021 May 15:273:119260. PMID: 33636171
Life Sci

Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro. [Abstract]

2020 Dec 15:263:118523. PMID: 33039386
Life Sci

Low SCRIB expression in fibroblasts promotes invasion of lung cancer cells. [Abstract]

2020 Sep 1:256:117955. PMID: 32534038
Life Sci

Euscaphic acid and Tormentic acid protect vascular endothelial cells against hypoxia-induced apoptosis via PI3K/AKT or ERK 1/2 signaling pathway. [Abstract]

2020 Jul 1:252:117666. PMID: 32298737
Life Sci

Anterior gradient 2-derived peptide upregulates major histocompatibility complex class I-related chains A/B in hepatocellular carcinoma cells. [Abstract]

2020 Apr 1:246:117396. PMID: 32035130
Life Sci

Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway. [Abstract]

2019 Jul 15:229:210-218. PMID: 31102746
Food Funct

Protective effects of a herbal combination (Dimocarpus longan and Orthosiphon stamineus) on metabolic-associated fatty liver disease via the ERα-PI3K-AKT pathway. [Abstract]

2026 Feb 23. PMID: 41729581
Food Front

2026 Feb 16;7(2):e70247.
Food Funct

Yolk extract-derived vitellogenin 2 ameliorates muscle atrophy in mice via the PI3K/AKT/mTOR pathway. [Abstract]

2025 Sep 29;16(19):7663-7677. PMID: 40910485
Food Front

2023 May 14.
Food Funct

Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. [Abstract]

2021 May 11;12(9):3898-3918. PMID: 33977953
Food Funct

Neuroprotective effect of apigenin against hypoxic-ischemic brain injury in neonatal rats via activation of the PI3K/Akt/Nrf2 signaling pathway. [Abstract]

2021 Mar 15;12(5):2270-2281. PMID: 33599218
Food Funct

Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo. [Abstract]

2019 Jul 17;10(7):4269-4279. PMID: 31259992
Inflamm Res

Methylmalonic acid as a ferroptosis-derived danger signal: activation of the PI3K-NF-κB pathway drives M1 macrophage polarization in renal ischemia-reperfusion injury. [Abstract]

2026 Jun 22;75(1):153. PMID: 42329408
Liver Int

Curcumin Targets Crispld2 to Suppress Hepatic Stellate Cell Activation via PI3K/AKT Pathway Inhibition in Hepatic Fibrosis. [Abstract]

2026 Jun;46(6):e70696. PMID: 42130159
Food Biosci

2025 Sep 23;73:107645.
J Mater Chem B

PI3K/AKT/mTOR signaling regulates BCP ceramic-induced osteogenesis. [Abstract]

2024 Aug 7;12(31):7591-7603. PMID: 38984467
Liver Int

Metformin synergistically enhances the antitumour activity of Lenvatinib in hepatocellular carcinoma by altering AKT-FOXO3 signalling pathway. [Abstract]

2023 Jul;43(7):1577-1592. PMID: 37208925
Food Biosci

7 May 2022, 101766.
Food Biosci

April 2022, 101571.
Drug Des Devel Ther

Diallyl Disulfide Mitigates LPS-Induced Inhibition of Osteogenic Differentiation and Alleviates Inflammatory Bone Loss via PI3K/AKT Signaling Pathway. [Abstract]

2026 Apr 14:20:590959. PMID: 42007397
RSC Adv

Sodium Danshensu promotes diabetic wound healing by targeting the EGFR-mediated PI3K-AKT pathway: a combined network pharmacology, machine learning, and in vitro approach. [Abstract]

2026 Mar 10;16(15):13394-13407. PMID: 41815389
RSC Adv

Integrating network pharmacology, molecular docking and experimental validation to explore therapeutic targets for alleviating allergic rhinitis with anxiety and depressive behaviors. [Abstract]

2025 Dec 9;15(57):48978-48993. PMID: 41377151
Drug Des Devel Ther

Astragaloside IV Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells via Activating PI3K/AKT/eNOS/NO Signaling Pathway: In vitro and in vivo Study. [Abstract]

2025 Jul 16:19:6073-6088. PMID: 40687900
Drug Des Devel Ther

Exploring the Therapeutic Potential of FSGTC for Osteoarthritis: A Comprehensive Study Combining Nested Case Analysis, Network Pharmacology, and Experimental Validation. [Abstract]

2025 Jun 17:19:5123-5141. PMID: 40546656
Drug Des Devel Ther

Remimazolam Suppresses Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury by Regulating AKT/GSK-3β/NRF2 Pathway. [Abstract]

2025 Jan 8:19:111-128. PMID: 39807342
Drug Des Devel Ther

Exploration of the Active Component and Mechanisms of Shengyu Decoction Against Myelosuppression Using Network Pharmacology and in vitro Experimental Validation. [Abstract]

2024 Jun 20:18:2405-2420. PMID: 38915868
Drug Des Devel Ther

ED-71 Improves Bone Mass in Ovariectomized Rats by Inhibiting Osteoclastogenesis Through EphrinB2-EphB4-RANKL/OPG Axis. [Abstract]

2024 May 6:18:1515-1528. PMID: 38716369
J Cell Biol

Membrane-bound SCF and VCAM-1 synergistically regulate the morphology of hematopoietic stem cells. [Abstract]

2021 Oct 4;220(10):e202010118. PMID: 34402812
Drug Des Devel Ther

Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways. [Abstract]

2021 Jul 16:15:3131-3150. PMID: 34295152
Drug Des Devel Ther

Hongjingtian Injection Inhibits Proliferation and Migration and Promotes Apoptosis in High Glucose-Induced Vascular Smooth Muscle Cells. [Abstract]

2019 Dec 5:13:4115-4126. PMID: 31827318
Drug Des Devel Ther

Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway. [Abstract]

2018 Jan 11:12:137-148. PMID: 29391778

LY294002 purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2018 Jan 11:12:137-148. [Abstract]

Effects of LY294002 on AKT and p-AKT expression of hPDLCs. (A) The increased expression of osteogenic marker proteins can be interdicted by PI3K pathway inhibitor LY294002 in hPDLCs. The expression level of ALP and Runx2 is tested by Western blot (B).
ACS Biomater Sci Eng

Sr-Incorporated Bioactive Glass Remodels the Immunological Microenvironment by Enhancing the Mitochondrial Function of Macrophage via the PI3K/AKT/mTOR Signaling Pathway. [Abstract]

2024 Jun 10;10(6):3923-3934. PMID: 38766805
J Am Heart Assoc

Liraglutide Accelerates Ischemia-Induced Angiogenesis in a Murine Diabetic Model. [Abstract]

2023 Feb 21;12(4):e026586. PMID: 36789853
Cells

Synergism of Feeding and Digestion Regulated by the Neuropeptide F System in Ostrinia furnacalis Larvae. [Abstract]

2023 Jan 3;12(1):194. PMID: 36611986
EMBO Rep

CIP2A deficiency promotes depression-like behaviors in mice through inhibition of dendritic arborization. [Abstract]

2022 Dec 6;23(12):e54911. PMID: 36305233
Cells

Follicle-Stimulating Hormone Alleviates Ovarian Aging by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism in Hens. [Abstract]

2022 Oct 18;11(20):3270. PMID: 36291137
EMBO Rep

Class IA PI3Ks regulate subcellular and functional dynamics of IDO1. [Abstract]

2020 Dec 3;21(12):e49756. PMID: 33159421
Nutrients

Betulinic Acid Reduces Intestinal Inflammation and Enhances Intestinal Tight Junctions by Modulating the PPAR-γ/NF-κB Signaling Pathway in Intestinal Cells and Organoids. [Abstract]

2025 Jun 20;17(13):2052. PMID: 40647158
Commun Biol

POT, an optogenetics-based endogenous protein degradation system. [Abstract]

2025 Mar 18;8(1):455. PMID: 40102608
J Integr Agric

2026 May 22.
Respir Res

Fibulin 5 mediates pulmonary artery smooth muscle cell dysfunction and vascular remodelling in congenital heart disease associated pulmonary arterial hypertension via TGF-β1/PI3K/AKT signalling. [Abstract]

2025 Sep 29;26(1):276. PMID: 41024156
Pharmaceuticals (Basel)

Puerarin Inhibits Proliferation, Migration and Invasion of Colon Cancer Cells and Induces Apoptosis via Suppression of the PI3K/AKT Signaling Pathway. [Abstract]

2025 Sep 16;18(9):1378. PMID: 41011246
J Affect Disord

Electroconvulsive therapy combined with esketamine improved depression through PI3K/AKT/GLT-1 pathway. [Abstract]

2025 Jan 1:368:282-294. PMID: 39265873
Eur J Pharmacol

Huperzine A protected against ferroptosis via activating PI3K/Akt signaling in lipopolysaccharide induced acute lung injury. [Abstract]

2024 Nov 15:983:177004. PMID: 39278310
Eur J Pharmacol

Nodakenin alleviates ovariectomy-induced osteoporosis by modulating osteoblastogenesis and osteoclastogenesis. [Abstract]

2023 Dec 5:960:176121. PMID: 37866743
Eur J Pharmacol

Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway. [Abstract]

2023 Oct 5:956:175985. PMID: 37572943
Clin Epigenetics

METTL3 exerts synergistic effects on m6A methylation and histone modification to regulate the function of VGF in lung adenocarcinoma. [Abstract]

2023 Sep 23;15(1):153. PMID: 37742030
Eur J Pharmacol

1,8-Cineole ameliorates endothelial injury and hypertension induced by L-NAME through regulation of autophagy via PI3K/mTOR signaling pathway. [Abstract]

2023 Sep 5:954:175863. PMID: 37380045
Eur J Pharmacol

The combination of machine learning and transcriptomics reveals a novel megakaryopoiesis inducer, MO-A, that promotes thrombopoiesis by activating FGF1/FGFR1/PI3K/Akt/NF-κB signaling. [Abstract]

2023 Apr 5:944:175604. PMID: 36804544
J Zhejiang Univ Sci B

AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer. [Abstract]

2023 Mar 15;24(3):232-247. PMID: 36915999
Respir Res

TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts. [Abstract]

2023 Jan 10;24(1):8. PMID: 36627645
Eur J Pharmacol

Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway. [Abstract]

2023 Jan 15:939:175476. PMID: 36539073
Respir Res

Protective effects of calcyclin-binding protein against pulmonary vascular remodeling in flow-associated pulmonary arterial hypertension. [Abstract]

2022 Aug 30;23(1):223. PMID: 36042446
Eur J Pharmacol

Estradiol reduced 5-HT reuptake by downregulating the gene expression of Plasma Membrane Monoamine Transporter (PMAT, Slc29a4) through estrogen receptor β and the MAPK/ERK signaling pathway. [Abstract]

2022 Jun 5;924:174939. PMID: 35398393
Schizophr Bull

Allosteric Modulation of the Sigma-1 Receptor Elicits Antipsychotic-like Effects. [Abstract]

2022 Mar 1;48(2):474-484. PMID: 34865170
Eur J Pharmacol

Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway. [Abstract]

2020 Nov 15:887:173557. PMID: 32946868
Eur J Pharmacol

Ginsenoside Rg1 promotes cerebral angiogenesis via the PI3K/Akt/mTOR signaling pathway in ischemic mice. [Abstract]

2019 Aug 5:856:172418. PMID: 31132356
Eur J Pharmacol

Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin-like growth factor-1 receptor/phosphatidylinositol-3-kinase signaling pathway. [Abstract]

2019 Jun 15:853:93-102. PMID: 30878387
Reprod Biol Endocrinol

Exogenous leptin affects sperm parameters and impairs blood testis barrier integrity in adult male mice. [Abstract]

2018 May 31;16(1):55. PMID: 29855380

LY294002 purchased from MedChemExpress. Usage Cited in: Reprod Biol Endocrinol. 2018 May 31;16(1):55. [Abstract]

Western blot analysis of claudin 5, occludin and ZO-1 in TM4 cells, cells are treated with 100 nM Leptin or pre-treated with different inhibitors following a 100 nM Leptin treatment.
Int Immunopharmacol

Rheumatoid arthritis synovial fibroblasts promote the glycolysis of myeloid-derived suppressor cells via TREM1/mTOR axis. [Abstract]

2026 Sep 1:184:116961. PMID: 42242136
Int Immunopharmacol

Targeting NBL1/PI3K/AKT axis to enhance the chemosensitivity and radiosensitivity of esophageal squamous cell carcinoma. [Abstract]

2026 Jul 1:180:116665. PMID: 42030890
Int Immunopharmacol

Cucurbitacin B attenuates bleomycin-induced pulmonary fibrosis by inhibiting M2 macrophage polarization via PI3K/AKT/mTOR signaling. [Abstract]

2026 Jun 13:185:116985. PMID: 42287958
Int Immunopharmacol

HO-1 relied on PI3K/mTOR signaling to alleviate inflammation by reducing the apoptosis and autophagy of bovine mammary epithelial cells. [Abstract]

2026 May 15:177:116545. PMID: 41875495
Int J Mol Sci

Hepatotoxic Mechanisms of Polyethylene Terephthalate Microplastics Revealed by Network Toxicology, Molecular Docking, and In Vivo Validation. [Abstract]

2026 Apr 3;27(7):3256. PMID: 41977435
Int Immunopharmacol

UBE2C-PI3K/AKT-mediated upregulation of MTHFD2 promotes tumor progression in hepatocellular carcinoma. [Abstract]

2026 Feb 1:170:116081. PMID: 41456492
Int Immunopharmacol

Dysregulated neutrophils contribute to bone loss in renal osteodystrophy by enhancing osteoclastogenesis: Insights from integrated bioinformatics and experimental validation. [Abstract]

2026 Jan 1;168(Pt 2):115947. PMID: 41314047
Int Immunopharmacol

PGK1 contributes to blood-brain barrier integrity via PI3K-AKT-mTOR pathway in early pneumococcal meningitis. [Abstract]

2026 Feb 15:171:116163. PMID: 41512793
Int Immunopharmacol

Higenamine alleviates abdominal aortic aneurysm by regulating oxidative stress and inflammation against VSMC apoptosis. [Abstract]

2026 Jan 1;168(Pt 1):115809. PMID: 41207100
Int Immunopharmacol

Glucocorticoid signaling mitigates colitis-associated visceral hypersensitivity by suppressing 5-HT release in enterochromaffin cells via a GR-PI3K-SGK1 axis. [Abstract]

2026 Mar 1:172:116207. PMID: 41554225
Int Immunopharmacol

Gasdermin D-dependent macrophage pyroptosis mediates polystyrene microplastics-induced pulmonary fibrosis. [Abstract]

2026 Mar 1:172:116189. PMID: 41539003
Int Immunopharmacol

TRIM21 knockdown suppresses ESCC progression and induces autophagy-mediated apoptosis via AKT/mTOR signaling pathway. [Abstract]

2025 Dec 10:167:115731. PMID: 41283348
Int J Mol Sci

Integrating Network Pharmacology, Machine Learning, and Experimental Validation to Elucidate the Mechanism of Cardamonin in Treating Idiopathic Pulmonary Fibrosis. [Abstract]

2025 Dec 25;27(1):249. PMID: 41516127
Int Immunopharmacol

VCPIP1 ameliorates sepsis-associated encephalopathy by promoting microglia autophagy via the PI3K/AKT/mTOR pathway. [Abstract]

2025 Oct 30:164:115417. PMID: 40865405
Int Immunopharmacol

1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons. [Abstract]

2025 Oct 30:164:115400. PMID: 40850199
Int Immunopharmacol

The BPIFA2 - LRP5 axis orchestrates mitochondrial dysfunction to mediate kidney injury in lupus nephritis. [Abstract]

2025 Sep 23:162:115114. PMID: 40543103
Int Immunopharmacol

Targeting CD161 inhibitory receptors enhances NK cell-mediated changes in synovial fibroblast function in rheumatoid arthritis. [Abstract]

2025 Sep 12:165:115528. PMID: 40945032
Int J Mol Sci

Direct and Indirect Downstream Pathways That Regulate Repulsive Guidance Effects of FGF3 on Developing Thalamocortical Axons. [Abstract]

2025 Jul 30;26(15):7361. PMID: 40806490
Int J Mol Sci

Molecular Mechanisms of Aminoglycoside-Induced Ototoxicity in Murine Auditory Cells: Implications for Otoprotective Drug Development. [Abstract]

2025 Jul 13;26(14):6720. PMID: 40724969
Cell Oncol (Dordr)

Enhanced ZBTB10 expression induced by betulinic acid inhibits gastric cancer progression by inactivating the ARRDC3/ITGB4/PI3K/AKT pathway. [Abstract]

2025 Jun;48(3):675-692. PMID: 39873948
Cell Oncol (Dordr)

UBE2Q2 promotes tumor progression and glycolysis of hepatocellular carcinoma through NF-κB/HIF1α signal pathway. [Abstract]

2025 Jun;48(3):637-654. PMID: 39833608
Int Immunopharmacol

Andrographolide attenuates PM2.5-induced blood-brain barrier damage via antioxidant and PI3K/AKT/mTOR/NRF2 pathways. [Abstract]

2025 Jun 5:157:114764. PMID: 40339493
Int Immunopharmacol

Phlorizin attenuates lupus nephritis via upregulating PI3K/Akt pathway-mediated Treg differentiation. [Abstract]

2025 May 8:154:114607. PMID: 40186900
Cell Oncol (Dordr)

TRPV4 drives the progression of leiomyosarcoma by promoting ECM1 generation and co-activating the FAK/PI3K/AKT/GSK3β pathway. [Abstract]

2025 Apr;48(2):455-470. PMID: 39612152
Int Immunopharmacol

TREM2 signaling in Parkinson's disease: Regulation of microglial function and α-synuclein pathology. [Abstract]

2024 Dec 25;143(Pt 2):113446. PMID: 39490141
Int J Mol Sci

Non-Structural Protein V of Canine Distemper Virus Induces Autophagy via PI3K/AKT/mTOR Pathway to Facilitate Viral Replication. [Abstract]

2024 Dec 25;26(1):84. PMID: 39795943
Int J Mol Sci

Ganglioside GM1 Alleviates Propofol-Induced Pyroptosis in the Hippocampus of Developing Rats via the PI3K/AKT/NF-κB Signaling Cascade. [Abstract]

2024 Nov 25;25(23):12662. PMID: 39684374
Int Immunopharmacol

The role of the PI3K/AKT/mTOR pathway in mediating PD-L1 upregulation during fibroblast transdifferentiation. [Abstract]

2024 Sep 18;142(Pt B):113186. PMID: 39298817
Int Immunopharmacol

Icaritin attenuates ischemia-reperfusion injury by anti-inflammation, anti-oxidative stress, and anti-autophagy in mouse liver. [Abstract]

2024 Sep 10:138:112533. PMID: 38924868
Int Immunopharmacol

Daphnetin alleviates silica-induced pulmonary inflammation and fibrosis by regulating the PI3K/AKT1 signaling pathway in mice. [Abstract]

2024 May 30:133:112004. PMID: 38613881
Int Immunopharmacol

Forsythiaside A suppresses renal fibrosis and partial epithelial-mesenchymal transition by targeting THBS1 through the PI3K/AKT signaling pathway. [Abstract]

2024 Mar 10:129:111650. PMID: 38342062
Int J Mol Sci

Lipid-Independent Regulation of PLIN5 via IL-6 through the JAK/STAT3 Axis in Hep3B Cells. [Abstract]

2023 Apr 13;24(8):7219. PMID: 37108378
Int J Mol Sci

Role of Berberine Thermosensitive Hydrogel in Periodontitis via PI3K/AKT Pathway In Vitro. [Abstract]

2023 Mar 28;24(7):6364. PMID: 37047340
Int Immunopharmacol

Anti-Na+/K+-ATPase DR antibody attenuates UUO-induced renal fibrosis through inhibition of Na+/K+-ATPase α1-dependent HMGB1 release. [Abstract]

2023 Mar:116:109826. PMID: 36764269
Cell Oncol (Dordr)

PKMYT1 inhibits lung adenocarcinoma progression by abrogating AKT1 activity. [Abstract]

2023 Feb;46(1):195-209. PMID: 36350496
Int J Mol Sci

Androgen-Responsive Oncogenic lncRNA RP11-1023L17.1 Enhances c-Myc Protein Stability in Prostate Cancer. [Abstract]

2022 Oct 13;23(20):12219. PMID: 36293081
J Hypertens

WNT1-inducible signalling pathway protein 1 stabilizes atherosclerotic plaques in apolipoprotein-E-deficient mice via the focal adhesion kinase/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase pathway. [Abstract]

2022 Sep 1;40(9):1666-1681. PMID: 35881419
Int J Mol Sci

β-Klotho Promotes the Development of Intrauterine Adhesions via the PI3K/AKT Signaling Pathway. [Abstract]

2022 Sep 25;23(19):11294. PMID: 36232594
Biomolecules

RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway. [Abstract]

2022 Feb 12;12(2):299. PMID: 35204799
Int Immunopharmacol

Topoisomerase 2 inhibitor etoposide promotes interleukin-10 production in LPS-induced macrophages via upregulating transcription factor Maf and activating PI3K/Akt pathway. [Abstract]

2021 Dec;101(Pt A):108264. PMID: 34715493
Int Immunopharmacol

Glial cell line-derived neurotrophic factor ameliorates dextran sulfate sodium-induced colitis in mice via a macrophage-mediated pathway. [Abstract]

2021 Nov:100:108143. PMID: 34543979
Int Immunopharmacol

Upregulation of FoxO3a expression through PI3K/Akt pathway attenuates the progression of lupus nephritis in MRL/lpr mice. [Abstract]

2020 Dec;89(Pt A):107027. PMID: 33039957
Int Immunopharmacol

Downregulating Akt/NF-κB signaling and its antioxidant activity with Loureirin A for alleviating the progression of osteoarthritis: In vitro and vivo studies. [Abstract]

2020 Jan:78:105953. PMID: 31784401
Artif Cells Nanomed Biotechnol

The efficacy and potential mechanism of cnidium lactone to inhibit osteoclast differentiation. [Abstract]

2019 Dec;47(1):3087-3093. PMID: 31343277
Int J Mol Sci

Inhibition of Phosphatidylinositol 3-kinase (PI3K) Signaling Synergistically Potentiates Antitumor Efficacy of Paclitaxel and Overcomes Paclitaxel-Mediated Resistance in Cervical Cancer. [Abstract]

2019 Jul 10;20(14):3383. PMID: 31295843
Int J Mol Sci

Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways. [Abstract]

2018 May 23;19(6):1556. PMID: 29882900

LY294002 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2018 May 23;19(6):1556. [Abstract]

E-cadherin, N-cadherin, Snail, and MMP-2 expression in HCC cells is examined by Western blot analysis. GAPDH is used as a loading control.
Phenomics

2026 Jul 9.
Mol Neurobiol

Inhibiting Caveolin-1-Related Akt/mTOR Signaling Pathway Protects Against N-methyl-D-Aspartate Receptor Activation-Mediated Dysfunction of Blood-Brain Barrier in vitro. [Abstract]

2024 Jul;61(7):4166-4177. PMID: 38066401
Biol Direct

Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis. [Abstract]

2023 Oct 24;18(1):67. PMID: 37875967
Mol Neurobiol

Mechanism of Molecular Activity of Yolkin-a Polypeptide Complex Derived from Hen Egg Yolk-in PC12 Cells and Immortalized Hippocampal Precursor Cells H19-7. [Abstract]

2023 May;60(5):2819-2831. PMID: 36735179
Mol Neurobiol

Cryptotanshinone Attenuates Amyloid-β42-induced Tau Phosphorylation by Regulating PI3K/Akt/GSK3β Pathway in HT22 Cells. [Abstract]

2022 Jul;59(7):4488-4500. PMID: 35575872
Mol Neurobiol

Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway. [Abstract]

2021 Jul;58(7):3471-3483. PMID: 33733293
Inflammation

FTO-dependent m6A Demethylation Activates Mxd1 To Enhance Vitamin D-induced Suppression of Neuroinflammation Via PTEN/AKT/PGC-1α Signaling Pathways in Microglia. [Abstract]

2026 Feb 3;49(1):77. PMID: 41632223
mBio

The swine acute diarrhea syndrome coronavirus spike protein promotes syncytial formation via upregulation of cellular cholesterol synthesis. [Abstract]

2025 Aug 13;16(8):e0097625. PMID: 40586601
Inflammation

Pharmacological Activation of GPR68 Attenuates Ferroptosis in Spinal Cord Ischemia/Reperfusion Injury Through PI3K/Akt-Mediated Nrf2 Antioxidant Pathway. [Abstract]

2025 Jun 18. PMID: 40528120
Inflammation

Evidence that a Novel Chalcone Derivative, Compound 27, Acts on the Epithelium Via the PI3K/AKT/Nrf2-Keap1 Signaling Pathway, to Mitigate LPS-Induced Acute Lung Injury in Mice. [Abstract]

2025 Apr;48(2):590-606. PMID: 38789816
Am J Physiol Cell Physiol

Inflammation-induced PFKFB3-mediated glycolysis promoting myometrium contraction through the PI3K-Akt-mTOR pathway in preterm birth mice. [Abstract]

2025 Feb 5. PMID: 39907705
Inflammation

Inhibition of Mitochondrial Succinate Dehydrogenase with Dimethyl Malonate Promotes M2 Macrophage Polarization by Enhancing STAT6 Activation. [Abstract]

2025 Jan 13. PMID: 39806091
Am J Respir Cell Mol Biol

Airway Epithelium-derived CXCL14 Promotes Eosinophil Accumulation in Allergic Airway Inflammation. [Abstract]

2025 Feb;72(2):145-157. PMID: 39141567
Front Pharmacol

Bioactive components and potential mechanisms of Biqi Capsule in the treatment of osteoarthritis: based on chondroprotective and anti-inflammatory activity. [Abstract]

2024 Apr 17:15:1347970. PMID: 38694911
mBio

PEDV inhibits HNRNPA3 expression by miR-218-5p to enhance cellular lipid accumulation and promote viral replication. [Abstract]

2024 Feb 14;15(2):e0319723. PMID: 38259103
mBio

Respiratory syncytial virus co-opts hypoxia-inducible factor-1α-mediated glycolysis to favor the production of infectious virus. [Abstract]

2023 Oct 31;14(5):e0211023. PMID: 37796013
Am J Respir Cell Mol Biol

Neuromedin U Induces Pulmonary ILC2 Activation via the NMUR1 Pathway During Acute RSV Infection. [Abstract]

2023 Mar;68(3):256-266. PMID: 36227802
Am J Physiol Cell Physiol

DOCK2 contributes to pulmonary fibrosis by promoting lung fibroblast to myofibroblast transition. [Abstract]

2022 Jul 1;323(1):C133-C144. PMID: 35584329
Inflammation

Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway. [Abstract]

2021 Oct;44(5):1993-2005. PMID: 33999329
Front Pharmacol

Extracellular HSP90α Interacts With ER Stress to Promote Fibroblasts Activation Through PI3K/AKT Pathway in Pulmonary Fibrosis. [Abstract]

2021 Aug 23;12:708462. PMID: 34497513
Inflammation

Insulin Exacerbates Inflammation in Fibroblast-Like Synoviocytes. [Abstract]

2020 Jun;43(3):916-936. PMID: 31981062
Front Pharmacol

Liraglutide Attenuates Non-Alcoholic Fatty Liver Disease in Mice by Regulating the Local Renin-Angiotensin System. [Abstract]

2020 Apr 8:11:432. PMID: 32322207
Front Pharmacol

Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells via PI3K/Akt/NF-κB Signaling Pathway. [Abstract]

2020 Feb 25:11:114. PMID: 32158391
Front Pharmacol

Shen-Yuan-Dan Capsule Attenuates Atherosclerosis and Foam Cell Formation by Enhancing Autophagy and Inhibiting the PI3K/Akt/mTORC1 Signaling Pathway. [Abstract]

2019 May 31:10:603. PMID: 31214032
Arthritis Res Ther

E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts. [Abstract]

2018 Oct 4;20(1):225. PMID: 30286793
Front Pharmacol

SCD1 Confers Temozolomide Resistance to Human Glioma Cells via the Akt/GSK3β/β-Catenin Signaling Axis. [Abstract]

2018 Jan 4:8:960. PMID: 29354058

LY294002 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jan 4:8:960. [Abstract]

Western blot for p-Akt (Ser-473), Akt, p-GSK3β (Ser-9), GSK3β, β-catenin, and SCD1 in T98G-R cells treated with DMSO, A939572, MK2206, A939572 plus MK2206, LY294002 and A939572 plus LY294002.

LY294002 purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jan 4:8:960. [Abstract]

Western blot for p-Akt (Ser-473), Akt, p-GSK3β (Ser-9), GSK3β, β-catenin, and SCD1 in U87-R cells treated with DMSO, A939572, MK2206, A939572 plus MK2206, LY294002 and A939572 plus LY294002.
J Ovarian Res

Vitamin B6 promotes the activation of primordial follicles through the PI3K/Akt signaling pathway. [Abstract]

2025 Dec 17;18(1):296. PMID: 41408298
Front Cell Dev Biol

SMARCC1 Suppresses Tumor Progression by Inhibiting the PI3K/AKT Signaling Pathway in Prostate Cancer. [Abstract]

2021 Jun 25:9:678967. PMID: 34249931
Front Cell Dev Biol

Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes. [Abstract]

2021 Mar 18:9:640667. PMID: 33816490
Toxicology

LGALS3 regulates endothelial-to-mesenchymal transition via PI3K/AKT signaling pathway in silica-induced pulmonary fibrosis. [Abstract]

2024 Dec:509:153962. PMID: 39353502
J Nutr Biochem

Protective effect of folic acid on MNNG-induced proliferation of esophageal epithelial cells via the PI3K/AKT/mTOR signaling pathway. [Abstract]

2024 Nov:133:109702. PMID: 39025456
Chem Biol Interact

Andrographolide inhibits the growth of human osteosarcoma cells by suppressing Wnt/β-catenin, PI3K/AKT and NF-κB signaling pathways. [Abstract]

2022 Sep 25:365:110068. PMID: 35917943
Toxicology

Low-dose arsenic trioxide enhances membrane-GLUT1 expression and glucose uptake via AKT activation to support L-02 cell aberrant proliferation. [Abstract]

2022 Jun 15:475:153237. PMID: 35714947
Chem Biol Interact

The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose. [Abstract]

2022 Feb 25:354:109843. PMID: 35122754
Toxicology

Cx43 overexpression is involved in the hyper-proliferation effect of trichloroethylene on human embryonic stem cells. [Abstract]

2022 Jan 15:465:153065. PMID: 34896440
J Thromb Haemost

Piezo1 initiates platelet hyperreactivity and accelerates thrombosis in hypertension. [Abstract]

2021 Dec;19(12):3113-3125. PMID: 34411418
Toxicology

1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells. [Abstract]

2021 Apr 30:454:152716. PMID: 33581215
Toxicology

Ginsenoside Rk1 induces cell cycle arrest and apoptosis in MDA-MB-231 triple negative breast cancer cells. [Abstract]

2019 Apr 15:418:22-31. PMID: 30797898
Chem Biol Interact

Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-κB signal pathways. [Abstract]

2018 Jun 25:290:44-51. PMID: 29782821
Bioorg Chem

Eupalinolide B prevents cerebral ischemia-reperfusion injury via the PI3K/Akt/GSK3β(Ser9) signaling pathway. [Abstract]

2026 Jun 5:173:109635. PMID: 41719922
World J Diabetes

Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis. [Abstract]

2026 Jan 15;17(1):112942. PMID: 41608090
World J Diabetes

RRM2 attenuates the renal tubular ferroptosis in diabetic kidney disease through PI3K/Akt/Nrf2 pathway. [Abstract]

2025 Nov 15;16(11):111223. PMID: 41278435
Clin Exp Ophthalmol

Novel Insight of Posterior Capsule Opacification: The Role of Lens Epithelial Cell Senescence. [Abstract]

2025 Jul 14. PMID: 40660668
Bioorg Chem

2β-methoxy-2-deethoxyphantomolin synergistically enhances epirubicin effect against triple-negative breast cancer via targeted inhibition of AKT and HR pathways. [Abstract]

2025 Jun 15:160:108453. PMID: 40253761
Bioorg Chem

Structure-based design and synthesis of anti-fibrotic compounds derived from para-positioned 3,4,5-trisubstituted benzene. [Abstract]

2024 Mar:144:107113. PMID: 38232685
Bioorg Chem

P-Y/G@NHs sensitizes non-small cell lung cancer cells to radiotherapy via blockage of the PI3K/AKT signaling pathway. [Abstract]

2023 Feb:131:106317. PMID: 36525920
Molecules

In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei. [Abstract]

2020 Apr 23;25(8):1980. PMID: 32340370
Molecules

Mytoxin B and Myrothecine A Induce Apoptosis in Human Hepatocarcinoma Cell Line SMMC-7721 via PI3K/Akt Signaling Pathway. [Abstract]

2019 Jun 20;24(12):2291. PMID: 31226773
Molecules

Screening of PI3K-Akt-targeting Drugs for Silkworm against Bombyx mori Nucleopolyhedrovirus. [Abstract]

2019 Apr 1;24(7):1260. PMID: 30939726
Molecules

Structure Identification of ViceninII Extracted from Dendrobium officinale and the Reversal of TGF-β1-Induced Epithelial⁻Mesenchymal Transition in Lung Adenocarcinoma Cells through TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways. [Abstract]

2019 Jan 2;24(1):144. PMID: 30609689
Exp Gerontol

Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway. [Abstract]

2017 Dec 15:100:77-86. PMID: 29079145

LY294002 purchased from MedChemExpress. Usage Cited in: Exp Gerontol. 2017 Dec 15:100:77-86. [Abstract]

Cells are treated with LY294002 5 μM for 2 h followed by treated with MANF 200 ng/mL for another 12 h, and then cell lysates are immunoblotted to assess the phosphorylation of Akt, GSK3β, and Nrf2.
Food Sci Nutr

Tetrandrine, a Major Alkaloid From Stephaniae Tetrandrae Radix, Ameliorates Non-Alcoholic Fatty Liver Disease in Zebrafish via the PI3K/AKT/STAT3 Pathway. [Abstract]

2026 May 12:14:e71814. PMID: 42137439
Mol Med Rep

Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis. [Abstract]

2026 Feb;33(2):57. PMID: 41347823
Mol Med Rep

Aberrant activation of the PI3K/AKT/HIF‑1α pathway promotes glycolysis and lenvatinib resistance in liver cancer. [Abstract]

2025 Nov;32(5):301. PMID: 40878941
Mol Med Rep

Dexmedetomidine mitigates oxidative stress in H9C2 cardiac myoblasts under a high‑glucose environment via the PI3K/AKT signaling pathway. [Abstract]

2025 Sep;32(3):251. PMID: 40641117
Mol Med Rep

Recombinant chromosome 6 open reading frame 120 protein promotes angiogenesis and endothelial‑to‑mesenchymal transition in human umbilical vein endothelial cells via the PI3K/Akt signaling pathway. [Abstract]

2025 Sep;32(3):231. PMID: 40539464
Food Sci Nutr

Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway. [Abstract]

2025 Apr 14;13(4):e70177. PMID: 40236832
Biochim Biophys Acta Mol Basis Dis

The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms. [Abstract]

2024 Mar 19;1870(4):167125. PMID: 38508477
Biochim Biophys Acta Mol Basis Dis

Senkyunolide I ameliorates thoracic aortic aneurysm and dissection in mice via inhibiting the oxidative stress and apoptosis of endothelial cells. [Abstract]

2023 Oct;1869(7):166819. PMID: 37499930
Aquaculture and Fisheries

2023 Sep 22.
Biochim Biophys Acta Mol Basis Dis

Immune response gene 1 deficiency aggravates high fat diet-induced nonalcoholic fatty liver disease via promotion of redox-sensitive AKT suppression. [Abstract]

2023 Apr;1869(4):166656. PMID: 36706797
Mol Med Rep

Notch1/Hes1‑PTEN/AKT/IL‑17A feedback loop regulates Th17 cell differentiation in mouse psoriasis‑like skin inflammation. [Abstract]

2022 Jul;26(1):223. PMID: 35582997
Mol Med Rep

Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease models via induction of Nrf2. [Abstract]

2022 Jun;25(6):215. PMID: 35543148
Mol Med Rep

FPR2 serves a role in recurrent spontaneous abortion by regulating trophoblast function via the PI3K/AKT signaling pathway. [Abstract]

2021 Dec;24(6):838. PMID: 34608500
Mol Med Rep

LY‑294002 enhances the chemosensitivity of liver cancer to oxaliplatin by blocking the PI3K/AKT/HIF‑1α pathway. [Abstract]

2021 Jul;24(1):508. PMID: 33982772
Mol Med Rep

FBXW7 mediates high glucose‑induced SREBP‑1 expression in renal tubular cells of diabetic nephropathy under PI3K/Akt pathway regulation. [Abstract]

2021 Apr;23(4):233. PMID: 33537812
Mol Med Rep

Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/β‑catenin signaling pathway. [Abstract]

2020 Dec;22(6):4868-4876. PMID: 33173974
Mol Med Rep

Laminin α5 modulates fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway. [Abstract]

2020 Mar;21(3):1491-1500. PMID: 32016453
Mol Med Rep

COX‑2 promotes epithelial‑mesenchymal transition and migration in osteosarcoma MG‑63 cells via PI3K/AKT/NF‑κB signaling. [Abstract]

2019 Oct;20(4):3811-3819. PMID: 31485669

LY294002 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Oct;20(4):3811-3819. [Abstract]

Expression of E-cadherin and vimentin is regulated by COX‑2. MG‑63 cells are infected with control or COX-2-overexpressing lentivirus, and treated with or without the COX‑2 inhibitor NS398 or the PI3K inhibitor LY294002. (A) The expression of E-cadherin (green) in each group was determined using immunofluorescence. (B) Quantification of E‑cadherin expression.

LY294002 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Oct;20(4):3811-3819. [Abstract]

Expression of E-cadherin and vimentin is regulated by COX‑2. MG‑63 cells are infected with control or COX-2-overexpressing lentivirus, and treated with or without the COX‑2 inhibitor NS398 or the PI3K inhibitor LY294002. (C) The expression of vimentin in each group. (D) Quantification of vimentin expression.

LY294002 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Oct;20(4):3811-3819. [Abstract]

Expression of NF‑κB p65 protein is regulated by COX‑2. MG‑63 cells were infected with control or COX‑2‑overexpressing lentivirus, and treated with or without the COX‑2 inhibitor NS398 or the PI3K inhibitor LY294002. (A)The expression of NF-κB p65 (green) in each group was determined by immunofluorescence. (B) Quantification of NF-κB p65 expression.
Mol Med Rep

Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas. [Abstract]

2019 Apr;19(4):2825-2830. PMID: 30720075
Mol Med Rep

Human adipose‑derived mesenchymal stem cells promote breast cancer MCF7 cell epithelial‑mesenchymal transition by cross interacting with the TGF‑β/Smad and PI3K/AKT signaling pathways. [Abstract]

2019 Jan;19(1):177-186. PMID: 30483746

LY294002 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Jan;19(1):177-186. [Abstract]

Western analysis of p-AKT1 and AKT1 in the treatment of MCF7 alone, MCF7 co-cultured, anti-TGF-β1 and LY29400
J Mol Med (Berl)

KIAA1199 promotes invasion and migration in non-small-cell lung cancer (NSCLC) via PI3K-Akt mediated EMT. [Abstract]

2019 Jan;97(1):127-140. PMID: 30478628
J Mol Med (Berl)

PHP14 regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-β1 signaling to PI3Kγ/AKT/Rac1 pathway. [Abstract]

2018 Feb;96(2):119-133. PMID: 29098317

LY294002 purchased from MedChemExpress. Usage Cited in: J Mol Med (Berl). 2018 Feb;96(2):119-133. [Abstract]

The regulation of PHP14 on Akt phosphorylation is possibly via PI3Kγ in LX-2 cells. Cells are serum starvation 24 h, then treated TGF-β1 (10 ng/mL) 2 h, then added LY294002 (5 μM) or AS252424 (10 μM) as indicated; after another 2 h incubation, Western blot is performed to assess the protein expression of p-Akt.
Mediators Inflamm

FGFR2 is a Candidate Immune-Associated Marker of Diabetic Foot Ulcer That Promotes Keratinocyte Function by Activating the PI3K/Akt and MAPK Pathways. [Abstract]

2026;2026(1):e3260549. PMID: 41983566
Sci Rep

Integrated UPLC, bioinformatics, and in vitro analyses reveal Yiqihuoxue decoction (GSC) alleviates vascular aging by promoting autophagy. [Abstract]

2026 Mar 13;16(1):13338. PMID: 41826643
Sci Rep

BDNF improves fracture healing through promoting osteoblasts proliferation and migration via trkb/akt regulated NUCKS1 expression. [Abstract]

2025 Jul 25;15(1):27107. PMID: 40715274
Sci Rep

Ring-finger protein RNF126 promotes prostate cancer progression via regulation of MBNL1. [Abstract]

2025 Jul 4;15(1):23847. PMID: 40615482
Sci Rep

Effects and mechanisms of trifolin on attenuating hypertension-induced vascular smooth muscle cell proliferation and collagen deposition in vivo and in vitro. [Abstract]

2025 May 9;15(1):16145. PMID: 40341164
Transplantation

Donor Variability and PD-1 Expression Limit BK Polyomavirus-specific T-cell Function and Therapy. [Abstract]

2025 Apr 9. PMID: 40200394
Diabetol Metab Syndr

Electroacupuncture modulates the gut-brain axis via the PI3K/Akt pathway to improve feeding behavior, body weight, glucolipid metabolism, and reduce insulin resistance in T2DM rats. [Abstract]

2025 Apr 9;17(1):122. PMID: 40205499
Sci Rep

Low intensity pulsed ultrasound alleviates synovial fibrosis in osteoarthritis via the PI3K/AKT pathway. [Abstract]

2025 Mar 20;15(1):9644. PMID: 40113833
Sci Rep

USP37-stabilized SALL4 promotes the keloid formation by PI3K/AKT pathway. [Abstract]

2025 Mar 4;15(1):7553. PMID: 40038378
Sci Rep

miR-21 regulates autophagy and apoptosis of ectopic endometrial stromal cells of adenomyosis via PI3K/ AKT/ mTOR pathway. [Abstract]

2025 Mar 4;15(1):7639. PMID: 40038429
World J Stem Cells

Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models. [Abstract]

2025 Jan 26;17(1):98349. PMID: 39866893
Sci Rep

Annexin A5 knockdown inhibits cardiomyocyte apoptosis and alleviates cardiac hypertrophy via activating the PI3K/AKT/Bcl-2 signaling pathway. [Abstract]

2024 Dec 30;14(1):31915. PMID: 39738388
Transplantation

Gas6/AXL Alleviates Hepatic Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the PI3K/AKT Pathway. [Abstract]

2024 Nov 1;108(11):e357-e369. PMID: 38725107
Sci Rep

KIFC3 promotes the proliferation, migration and invasion of non-small cell lung cancer through the PI3K/AKT signaling pathway. [Abstract]

2024 Sep 3;14(1):20471. PMID: 39227687
Sci Rep

Genipin promotes the apoptosis and autophagy of neuroblastoma cells by suppressing the PI3K/AKT/mTOR pathway. [Abstract]

2024 Aug 30;14(1):20231. PMID: 39215133
Sci Rep

The roles of autophagy, ferroptosis and pyroptosis in the anti-ovarian cancer mechanism of harmine and their crosstalk. [Abstract]

2024 Mar 18;14(1):6504. PMID: 38499622
PLoS Pathog

The NP protein of Newcastle disease virus dictates its oncolytic activity by regulating viral mRNA translation efficiency. [Abstract]

2024 Feb 20;20(2):e1012027. PMID: 38377149
Sci Rep

Trichostatin A enhances the titanium rods osseointegration in osteoporotic rats by the inhibition of oxidative stress through activating the AKT/Nrf2 pathway. [Abstract]

2023 Dec 27;13(1):22967. PMID: 38151509
APL Bioeng

Fluid shear stress enhances natural killer cell's cytotoxicity toward circulating tumor cells through NKG2D-mediated mechanosensing. [Abstract]

2023 Aug 11;7(3):036108. PMID: 37575881
PLoS Pathog

Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication. [Abstract]

2023 Feb 3;19(2):e1011126. PMID: 36735752
Sci Rep

Claudin-3 inhibits tumor-induced lymphangiogenesis via regulating the PI3K signaling pathway in lymphatic endothelial cells. [Abstract]

2022 Oct 19;12(1):17440. PMID: 36261482
Sci Rep

sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K-AKT signaling pathway. [Abstract]

2022 Apr 29;12(1):7047. PMID: 35487953
Cancer Sci

MZT2A promotes NSCLC viability and invasion by increasing Akt phosphorylation via the MOZART2 domain. [Abstract]

2021 Jun;112(6):2210-2222. PMID: 33754417
Am J Pathol

Su(var)3-9, Enhancer of Zeste, and Trithorax Domain-Containing 5 Facilitates Tumor Growth and Pulmonary Metastasis through Up-Regulation of AKT1 Signaling in Breast Cancer. [Abstract]

2021 Jan;191(1):180-193. PMID: 33129761
Mediators Inflamm

Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway. [Abstract]

2020 Oct 24:2020:1649453. PMID: 33162828
Sci Rep

Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells. [Abstract]

2020 May 7;10(1):7714. PMID: 32382009
Sci Rep

Sodium Selenate Ameliorates Cardiac Injury Developed from High-Fat Diet in Mice through Regulation of Autophagy Activity. [Abstract]

2019 Dec 10;9(1):18752. PMID: 31822702
Mediators Inflamm

Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs. [Abstract]

2019 Oct 7:2019:6168340. PMID: 31686985
Sci Rep

Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice. [Abstract]

2019 Feb 28;9(1):3041. PMID: 30816216
Eur J Med Res

DACT1 inhibits cuproptosis and promotes cell malignancy via activation of PI3K/AKT signaling in laryngeal squamous cell carcinoma. [Abstract]

2025 Dec 30;31(1):170. PMID: 41469752
Eur J Med Res

NDC80 promotes epithelial to mesenchymal transition of esophageal squamous cell carcinoma through macrophages polarization and PI3K/AKT pathway activation. [Abstract]

2025 Nov 10;30(1):1092. PMID: 41207896
Exp Neurol

Effect of activated autophagy on an animal model of vestibular migraine-like attacks. [Abstract]

2025 Oct:392:115366. PMID: 40602589
Cancers (Basel)

ITGA2 Mediates the Resistance of Hepatocellular Carcinoma to Lenvatinib by Activating the AKT/FOXO3A Signaling Pathway. [Abstract]

2025 Aug 29;17(17):2846. PMID: 40940943
Eur J Med Res

Peripheral Blood-Derived Mesenchymal Stem Cells Promote A2 Phenotype Polarization in Astrocytes via TGF-β-Mediated PI3K/Akt Pathway Activation. [Abstract]

2025 Jul 2;30(1):561. PMID: 40605103
Exp Neurol

Esculentoside H reduces the PANoptosis and protects the blood-brain barrier after cerebral ischemia/reperfusion through the TLE1/PI3K/AKT signaling pathway. [Abstract]

2024 Sep:379:114850. PMID: 38857750
Exp Neurol

Leptin combined with withaferin A boost posthemorrhagic neurogenesis via activation of STAT3/SOCS3 pathway. [Abstract]

2024 Jul:377:114809. PMID: 38714285
Exp Neurol

LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage. [Abstract]

2024 Jun:376:114776. PMID: 38609046
Exp Neurol

AAV-mediated VEGFA overexpression promotes angiogenesis and recovery of locomotor function following spinal cord injury via PI3K/Akt signaling. [Abstract]

2024 May:375:114739. PMID: 38401852
Cancers (Basel)

DKK1 Promotes Epithelial-Mesenchymal Transition and Cisplatin Resistance in Gastric Cancer via Activation of the PI3K/AKT Pathway. [Abstract]

2023 Sep 27;15(19):4756. PMID: 37835450
Exp Neurol

Neuregulin-1/PI3K signaling effects on oligodendrocyte proliferation, remyelination and behaviors deficit in a male mouse model of ischemic stroke. [Abstract]

2023 Apr:362:114323. PMID: 36690057
Cancers (Basel)

UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling. [Abstract]

2022 Nov 10;14(22):5538. PMID: 36428630
Neoplasia

ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma. [Abstract]

2021 Dec;23(12):1227-1239. PMID: 34768109
Mol Cell Biochem

Network pharmacology and experimental verification to explore the therapeutic mechanism of esketamine in postoperative cognitive dysfunction. [Abstract]

2026 Jun 23. PMID: 42334522
J Dairy Sci

Succinate/SUCNR1-mediated regulation of macrophage polarization reduces trophoblast apoptosis: A potential cause of retained placenta in peripartal dairy cows. [Abstract]

2026 Jun 8:S0022-0302(26)02907-3. PMID: 42264358
Oncol Rep

NF‑κB‑driven LUZP1 promotes metastasis and chemoresistance in head and neck squamous cell carcinoma. [Abstract]

2026 Jun;55(6):110. PMID: 41952496
Cell Signal

Puerarin protects against renal ischemia-reperfusion injury by restoring mitochondrial function and modulating the PI3K/AKT/NF-k B pathway and suppressing inflammatory responses. [Abstract]

2026 Mar:139:112350. PMID: 41482144
Cell Signal

ANXA1 regulates microglia polarization and autophagy via PI3K/Akt/mTOR pathway to reduce inflammatory injury after cerebral ischemia-reperfusion. [Abstract]

2026 Mar:139:112336. PMID: 41421718
Cell Signal

Anti-fibrotic activity of nobiletin and nintedanib: In vitro and in vivo evidence in pulmonary fibrosis models. [Abstract]

2026 May:141:112364. PMID: 41534678
Mol Cell Biochem

Bioelectric fields drive pulmonary epithelial proliferation through PI3K/AKT/GSK3β signaling. [Abstract]

2026 Jan 29. PMID: 41609898
Cell Signal

Biliverdin alleviates cerebral ischemia-reperfusion injury by regulating the P4hb/MAPK/mTOR pathway to inhibit autophagy. [Abstract]

2025 Aug:132:111815. PMID: 40258578
Neuropharmacology

Astragaloside Ⅳ improves neuroinflammation in Parkinson's disease by regulating amino acid metabolism and the PI3K-AKT signaling pathway. [Abstract]

2025 Aug 28:110661. PMID: 40882598
J Cell Mol Med

The Mechanosensitive Ion Channel Piezo1 Regulates Chondrocyte Homeostasis Through the PI3K/AKT/mTORC1 Pathway in Osteoarthritis. [Abstract]

2025 Aug;29(15):e70734. PMID: 40745673
J Cell Mol Med

Modified Qianghuo Shengshi Decoction Ameliorates Osteoarthritis via Inhibiting PI3K/Akt Pathway-Related Ferroptosis. [Abstract]

2025 Jul;29(13):e70691. PMID: 40586853
J Cell Mol Med

Exploring the Effect and Mechanism of Liraglutide in Treating Depression Based on Network Pharmacology and Experimental Analysis. [Abstract]

2025 Jun;29(11):e70630. PMID: 40461955
Cell Signal

Enhancement of Ndrg2 promotes hypertrophic scar fibrosis by regulating PI3K/AKT signaling pathway. [Abstract]

2025 May:129:111659. PMID: 39956247
Neuropharmacology

Baicalin ameliorates neuroinflammation by targeting TLR4/MD2 complex on microglia via PI3K/AKT/NF-κB signaling pathway. [Abstract]

2025 Apr 1:267:110296. PMID: 39798687
Neuropharmacology

Metformin activates the PI3K/AKT/BDNF axis to attenuate postoperative cognitive dysfunction. [Abstract]

2025 Mar 1:265:110262. PMID: 39662703
J Cell Mol Med

Foxk2 Enhances Adipogenic Differentiation by Relying on the Transcriptional Activation of Peroxisome Proliferator-Activated Receptor Gamma. [Abstract]

2025 Jan;29(1):e70332. PMID: 39789420
J Dairy Sci

Prolactin upregulates amino acids uptake in dairy cow mammary epithelial cells via LAT1. [Abstract]

2024 Nov;107(11):9948-9959. PMID: 38945262
Arch Gerontol Geriatr

GLP-2 ameliorates D-galactose induced muscle aging by IGF-1/Pi3k/Akt/FoxO3a signaling pathway in C2C12 cells and mice. [Abstract]

2024 Sep:124:105462. PMID: 38692155
Med Oncol

P4HA2 contributes to head and neck squamous cell carcinoma progression and EMT through PI3K/AKT signaling pathway. [Abstract]

2024 May 23;41(6):163. PMID: 38777998
Neuropharmacology

Microglial stimulation triggered by intranasal lipopolysaccharide administration produces antidepressant-like effect through ERK1/2-mediated BDNF synthesis in the hippocampus. [Abstract]

2023 Dec 1:240:109693. PMID: 37678448
Cell Signal

Effect of STK3 on proliferation and apoptosis of pancreatic cancer cells via PI3K/AKT/mTOR pathway. [Abstract]

2023 Jun:106:110642. PMID: 36871796
Med Oncol

Src inhibitor dasatinib sensitized gastric cancer cells to cisplatin. [Abstract]

2022 Dec 16;40(1):49. PMID: 36525117
Neuropharmacology

Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice. [Abstract]

2022 Nov 15:219:109231. PMID: 36041498
J Cell Mol Med

Soluble TREM-1, as a new ligand for the membrane receptor Robo2, promotes hepatic stellate cells activation and liver fibrosis. [Abstract]

2021 Dec;25(24):11113-11127. PMID: 34750987
Cell Signal

NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma cell growth through blocking the PI3K/AKT pathway. [Abstract]

2021 Oct:86:110074. PMID: 34229087
J Cell Mol Med

Puerarin attenuates intracerebral hemorrhage-induced early brain injury possibly by PI3K/Akt signal activation-mediated suppression of NF-κB pathway. [Abstract]

2021 Aug;25(16):7809-7824. PMID: 34180121
Oncol Rep

Interaction between CD9 and PI3K‑p85 activates the PI3K/AKT signaling pathway in B‑lineage acute lymphoblastic leukemia. [Abstract]

2021 Jul;46(1):140. PMID: 34036396
Cell Signal

Akt phosphorylation regulated by IKKε in response to low shear stress leads to endothelial inflammation via activating IRF3. [Abstract]

2021 Apr:80:109900. PMID: 33370582
J Cell Mol Med

Cardiomyocyte protective effects of thyroid hormone during hypoxia/reoxygenation injury through activating of IGF-1-mediated PI3K/Akt signalling. [Abstract]

2021 Apr;25(7):3205-3215. PMID: 33724692
J Cell Mol Med

M2 macrophage-derived G-CSF promotes trophoblasts EMT, invasion and migration via activating PI3K/Akt/Erk1/2 pathway to mediate normal pregnancy. [Abstract]

2021 Feb;25(4):2136-2147. PMID: 33393205
J Cell Mol Med

Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1-Foxo1 and PI3K-Akt signalling pathways. [Abstract]

2020 Nov;24(21):12355-12367. PMID: 32961025
J Cell Mol Med

Hydrogen exerts neuroprotection by activation of the miR-21/PI3K/AKT/GSK-3β pathway in an in vitro model of traumatic brain injury. [Abstract]

2020 Apr;24(7):4061-4071. PMID: 32108985
J Cell Mol Med

Inhibition of PHLPP1 ameliorates cardiac dysfunction via activation of the PI3K/Akt/mTOR signalling pathway in diabetic cardiomyopathy. [Abstract]

2020 Apr;24(8):4612-4623. PMID: 32150791
J Cell Mol Med

Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury. [Abstract]

2020 Apr;24(8):4736-4747. PMID: 32160403
Neuropharmacology

Hyperactive Akt-mTOR pathway as a therapeutic target for pain hypersensitivity in Cntnap2-deficient mice. [Abstract]

2020 Mar 15:165:107816. PMID: 31874168
Cell Signal

TRIM59 expression is regulated by Sp1 and Nrf1 in LPS-activated macrophages through JNK signaling pathway. [Abstract]

2020 Mar:67:109522. PMID: 31883458
J Cell Mol Med

Sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate ameliorates pressure overload-induced cardiac hypertrophy and dysfunction through inhibiting autophagy. [Abstract]

2019 Sep;23(9):6048-6059. PMID: 31222939
J Cell Mol Med

Heme oxygenase-1 induction mediates chemoresistance of breast cancer cells to pharmorubicin by promoting autophagy via PI3K/Akt pathway. [Abstract]

2018 Nov;22(11):5311-5321. PMID: 30216645

LY294002 purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2018 Nov;22(11):5311-5321. [Abstract]

The expression of PI3K, Akt, p-Akt, HO-1, LC3-II/LC3-I and Beclin-1 in LY294002 group after pharmorubicin treatment are examined by Western blot. The protein expression in LY294002 group is decreased.
J Cell Mol Med

Astragaloside IV modulates TGF-β1-dependent epithelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis. [Abstract]

2018 Sep;22(9):4354-4365. PMID: 29971947

LY294002 purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2018 Sep;22(9):4354-4365. [Abstract]

p-FOXO3a (Thr32), p-FOXO3a (Ser253), FOXO3a, p-Akt and Akt expression via western blot following treatment with PBS, ASV, TGF-b1, TGF-b1+ASV, TGF-b1+SB431542 or TGF-b1+LY294002.
Rheumatology (Oxford)

2-Methoxyestradiol inhibits hypoxia-induced scleroderma fibroblast collagen synthesis by phosphatidylinositol 3-kinase/Akt/mTOR signalling. [Abstract]

2018 Sep 1;57(9):1675-1684. PMID: 29905853

LY294002 purchased from MedChemExpress. Usage Cited in: Rheumatology (Oxford). 2018 Sep 1;57(9):1675-1684. [Abstract]

The hypoxia-aggravated phosphorylation of Akt and mTOR is inhibited by LY294002, a PI3K inhibitor (P<0.01), suggesting that hypoxia-induced Akt phosphorylation was through PI3K activation.

LY294002 purchased from MedChemExpress. Usage Cited in: Rheumatology (Oxford). 2018 Sep 1;57(9):1675-1684. [Abstract]

LY294002 and Rapamycin also down-regulates the HIF-1α expression under hypoxic condition (P<0.01) and inhibits hypoxia-induced expressions of CTGF (P<0.05) and collagen I (P<0.05 or P<0.01).
Neuropharmacology

GLP-1 receptor agonists downregulate aberrant GnT-III expression in Alzheimer's disease models through the Akt/GSK-3β/β-catenin signaling. [Abstract]

2018 Mar 15:131:190-199. PMID: 29223528

LY294002 purchased from MedChemExpress. Usage Cited in: Neuropharmacology. 2018 Mar 15:131:190-199. [Abstract]

LY294002 blocks the regulatory effects of GLP-1RA on Akt, GSK-3β and GnT-III. The inhibitor LY294002 (10 μM) is added to PC12 cells 1 h before Aβ_25-35 and GLP-1RA treatment. The levels of p-Akt、total Akt、p-GSK3β、 total GSK-3β and GnT-III are detected by Western blot (n=3 per group).
J Inflamm Res

Acupuncture Activates PI3K/Akt Pathway to Promote Spinal Microglial M2 Polarization and Alleviate Spastic Hemiplegia Following Ischemic Stroke. [Abstract]

2026 Apr 17:19:592917. PMID: 42022268
J Inflamm Res

The Effects of Da-Chai-Hu Decoction Alleviating Pancreatic Exocrine Dysfunction by Inhibiting Endoplasmic Reticulum Stress of Acinar Cell in Mice with Chronic Pancreatitis. [Abstract]

2025 Dec 22:18:18009-18024. PMID: 41458358
J Inflamm Res

Role of Autophagy Induced by Pmel17 in the Pathogenesis of Vitiligo. [Abstract]

2025 Oct 11:18:14185-14201. PMID: 41103279
J Inflamm Res

Long Non-Coding RNA lncTAF15:1-1 Promotes CCL5 Secretion and Cell Migration of Monocyte-Derived Dendritic Cells via PI3K/AKT/mTOR Pathway in Systemic Lupus Erythematosus. [Abstract]

2025 Aug 3:18:10389-10402. PMID: 40787263
J Inflamm Res

CCL20 Expression via AKT-ERK1/2-AP1 Pathway in Mycoplasma Pneumoniae Infection: Implications for EMT and Cell Migration. [Abstract]

2025 Apr 28:18:5727-5739. PMID: 40322529
J Dermatol Sci

Mechanical stiffness promotes skin fibrosis through FAPα-AKT signaling pathway. [Abstract]

2024 Feb;113(2):51-61. PMID: 38155020
J Neurochem

Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. [Abstract]

2022 Jun;161(6):478-491. PMID: 35583089
J Inflamm Res

Rosuvastatin Enhances Alveolar Fluid Clearance in Lipopolysaccharide-Induced Acute Lung Injury by Activating the Expression of Sodium Channel and Na,K-ATPase via the PI3K/AKT/Nedd4-2 Pathway. [Abstract]

2021 Apr 16:14:1537-1549. PMID: 33889010
Brain Res Bull

Identification and validation of growth hormone-reactive gene markers in brain tissue during the recovery period of stroke. [Abstract]

2026 Jun 4:243:111988. PMID: 42248536
Brain Res Bull

Multi-omics analysis identifies the miR-28a-5p/SerpinA3N/PI3K/AKT axis as a regulator of microglial neuroinflammation and cognitive decline in Alzheimer's disease. [Abstract]

2026 Jun 9:243:111994. PMID: 42263829
Brain Res Bull

Remimazolam alleviates blood-brain barrier damage by regulating the PI3K/AKT signaling pathway in sepsis-associated encephalopathy mice. [Abstract]

2026 Apr:237:111824. PMID: 41831795
ACS Infect Dis

Treponema pallidum Impairs Microglial Aβ1-42 Clearance by Hijacking TLR2/PI3K/AKT Immune Signaling. [Abstract]

2026 Apr 10;12(4):1329-1337. PMID: 41789731
Poult Sci

Quercetin attenuates deoxynivalenol-induced muscle developmental disorders in broilers by modulating the PI3K/Akt/mTOR pathway and reducing apoptosis. [Abstract]

2026 Mar 5;105(6):106740. PMID: 41850073
Poult Sci

Paeonol alleviates granulosa cell senescence in laying chickens via the PI3K/Akt/mTOR signaling pathway. [Abstract]

2026 Mar 8;105(6):106750. PMID: 41846081
iScience

Thrombospondin 1 aggravates cardiac remodeling in heart failure with preserved ejection fraction by inhibiting mitophagy. [Abstract]

2026 Jan 7;29(2):114639. PMID: 41623478
Neurochem Res

A Novel H2S Donor Suppresses Pilocarpine-Induced Seizures Through TREM2 Signaling. [Abstract]

2025 Nov 10;50(6):350. PMID: 41212272
ACS Infect Dis

Ebola Virus Glycoprotein Impairs Human Retinal Pigment Epithelial Barrier Function via the PI3K/Akt-Nrf2 Pathway. [Abstract]

2025 Apr 16. PMID: 40237321
Poult Sci

L-Theanine attenuates oxidative damage induced by heat stress through the PI3K/AKT/Nrf2 signaling pathway in skeletal muscle cells. [Abstract]

2025 Apr 4;104(6):105140. PMID: 40203618
ACS Infect Dis

Treponema pallidum Flagellin FlaB3 Activates Inflammation and Inhibits Autophagy in HMC3 Cells via the TLR4 Pathway. [Abstract]

2025 Mar 14;11(3):773-783. PMID: 40036177
Brain Res Bull

Electroacupuncture combined with trigonelline inhibits pyroptosis in cerebral ischemia-reperfusion by suppressing autophagy via the PI3K/AKT/mTOR signaling pathway. [Abstract]

2025 Feb:221:111200. PMID: 39788460
Neurochem Res

Naringenin Protected Against Blood Brain Barrier Breakdown after Ischemic Stroke through GSK-3β/ β-Catenin Pathway. [Abstract]

2024 Nov 18;50(1):17. PMID: 39556287
ACS Infect Dis

Pec 1 of Pseudomonas aeruginosa Inhibits Bacterial Clearance of Host by Blocking Autophagy in Macrophages. [Abstract]

2024 Aug 9;10(8):2741-2754. PMID: 39047963
Biomedicines

KDF1 Promoted Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells through Activating STAT3 and AKT Pathway. [Abstract]

2023 Dec 1;11(12):3194. PMID: 38137415
Biomedicines

Mechanisms Underlying the Suppression of IL-1β Expression by Magnesium Hydroxide Nanoparticles. [Abstract]

2023 Apr 27;11(5):1291. PMID: 37238962
Mol Oncol

NNK from tobacco smoking enhances pancreatic cancer cell stemness and chemoresistance by creating a β2AR-Akt feedback loop that activates autophagy. [Abstract]

2022 Aug;16(15):2881-2895. PMID: 35593085
J Periodontol

Connective tissue growth factor promotes cell-to-cell communication in human periodontal ligament stem cells via MAPK and PI3K pathway. [Abstract]

2022 Mar;93(3):e60-e72. PMID: 34532860
Neurochem Res

ACE2 Rescues Impaired Autophagic Flux Through the PI3K/AKT Pathway After Subarachnoid Hemorrhage. [Abstract]

2022 Mar;47(3):601-612. PMID: 34708340
Acta Biochim Biophys Sin (Shanghai)

PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway. [Abstract]

2021 Dec 8;53(12):1602-1613. PMID: 34718369
iScience

Excipient of paclitaxel induces metabolic dysregulation and unfolded protein response. [Abstract]

2021 Sep 25;24(10):103170. PMID: 34646996
Brain Res Bull

Progesterone Suppresses Cholesterol Esterification in APP/PS1 mice and a cell model of Alzheimer's Disease. [Abstract]

2021 Aug:173:162-173. PMID: 34044033
Acta Biochim Biophys Sin (Shanghai)

CCL26 is upregulated by nab-paclitaxel in pancreatic cancer-associated fibroblasts and promotes PDAC invasiveness through activation of the PI3K/AKT/mTOR pathway. [Abstract]

2021 Apr 15;53(5):612-619. PMID: 33764366
Mol Nutr Food Res

Quercetin-3-O-Glucuronide Alleviates Cognitive Deficit and Toxicity in Aβ1-42 -Induced AD-Like Mice and SH-SY5Y Cells. [Abstract]

2021 Mar;65(6):e2000660. PMID: 33141510
Neurochem Res

N-acetylserotonin Derivative Exerts a Neuroprotective Effect by Inhibiting the NLRP3 Inflammasome and Activating the PI3K/Akt/Nrf2 Pathway in the Model of Hypoxic-Ischemic Brain Damage. [Abstract]

2021 Feb;46(2):337-348. PMID: 33222058
Brain Res Bull

Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway. [Abstract]

2020 Oct:163:40-48. PMID: 32679060
Pharmacol Rep

A novel marine halophenol derivative attenuates lipopolysaccharide-induced inflammation in RAW264.7 cells via activating phosphoinositide 3-kinase/Akt pathway. [Abstract]

2020 Aug;72(4):1021-1031. PMID: 32112362
Biomed Environ Sci

Dexmedetomidine Attenuates High Glucose-induced HK-2 Epithelial-mesenchymal Transition by Inhibiting AKT and ERK. [Abstract]

2020 May 20;33(5):323-330. PMID: 32553076
Acta Biochim Biophys Sin (Shanghai)

Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells. [Abstract]

2019 Apr 1;51(4):365-374. PMID: 30877761
Food Nutr Res

3,5-Dicaffeoylquinic acid protects H9C2 cells against oxidative stress-induced apoptosis via activation of the PI3K/Akt signaling pathway. [Abstract]

2018 Oct 12:62. PMID: 30349447

LY294002 purchased from MedChemExpress. Usage Cited in: Food Nutr Res. 2018 Oct 12:62. [Abstract]

Western blotting of the PI3K/Akt signaling and the fold activation data analysis.
Brain Res Bull

Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways. [Abstract]

2017 Sep:134:236-245. PMID: 28843352
Aquaculture

2025 Sep 15.
J Endocr Soc

Thyroid Hormone Receptor Beta Inhibits PI3K-Akt-mTOR Signaling Axis in Anaplastic Thyroid Cancer via Genomic Mechanisms. [Abstract]

2021 Jun 1;5(8):bvab102. PMID: 34258492
BMC Complement Med Ther

Celastrol slows the progression of early diabetic nephropathy in rats via the PI3K/AKT pathway. [Abstract]

2020 Oct 23;20(1):321. PMID: 33097050
BMC Complement Med Ther

Overcoming cisplatin resistance by targeting the MTDH-PTEN interaction in ovarian cancer with sera derived from rats exposed to Guizhi Fuling wan extract. [Abstract]

2020 Feb 17;20(1):57. PMID: 32066429
J Pharmacol Exp Ther

2026 Jun 17;393(8):104968. PMID: 42442018
Lung

Mechanisms of Anti-Oxidants, N-Acetylcysteine and Elamipretide (SS-31), on Ozone-Induced Airway Hyperresponsiveness and Mucus Hypersecretion. [Abstract]

2026 Mar 9;204(1):12. PMID: 41801306
FASEB J

EM2, a Novel Elephantopus mollis H.B.K. Monomer, Enhances Radiosensitivity in Cervical Cancer Through Dual Inhibition of AKT and Autophagy. [Abstract]

2026 Jan 31;40(2):e71454. PMID: 41527777
FASEB J

EBV-LMP1 Promotes the Progression of Nasopharyngeal Carcinoma via TNC-Mediated Activation of PI3K/Akt Pathway. [Abstract]

2025 Dec 31;39(24):e71183. PMID: 41427845
FASEB J

Mechanical Stretch Prevents Senescence-Associated Osteogenic Impairment in Mesenchymal Stem Cells via CXCR4/PI3K/AKT Signaling. [Abstract]

2025 Nov 15;39(21):e71208. PMID: 41165551
FASEB J

Role of TRPV6-Mediated Calcium Signaling in High-Glucose-Inhibited Keratinocyte Migration. [Abstract]

2025 Nov 30;39(22):e71270. PMID: 41292236
FASEB J

Acute Exposure of Veterinary Antibiotic Tilmicosin Leads to Idiopathic Scoliosis-Like Vertebral Malformation Development Through Regulating PI3K-Akt Pathway in Zebrafish. [Abstract]

2025 Jul 31;39(14):e70765. PMID: 40641280
FASEB J

CD44 Deficiency Induces Combinatory NRF2 Inhibition and Endoplasmic Reticulum Stress-Associated Dyserythropoiesis. [Abstract]

2025 Jun 15;39(11):e70695. PMID: 40488748
Biol Trace Elem Res

Antagonizing Effects of Chromium Against Iron-Decreased Glucose Uptake by Regulating ROS-Mediated PI3K/Akt/GLUT4 Signaling Pathway in C2C12. [Abstract]

2024 Feb;202(2):701-712. PMID: 37156991
FASEB J

Amphiregulin improves ventricular remodeling after myocardial infarction by modulating autophagy and apoptosis. [Abstract]

2024 Feb 29;38(4):e23488. PMID: 38358359
FASEB J

Foxk1 stimulates adipogenic differentiation via a peroxisome proliferator-activated receptor gamma 2-dependent mechanism. [Abstract]

2023 Dec;37(12):e23266. PMID: 37889840
Biochim Biophys Acta Mol Cell Res

Treponema pallidum recombinant protein Tp47 enhanced interleukin-6 secretion in human dermal fibroblasts through the toll-like receptor 2 via the p38, PI3K/Akt, and NF-κB signalling pathways. [Abstract]

2023 Oct;1870(7):119540. PMID: 37468070
Biochim Biophys Acta Mol Cell Res

Sirt3 activates autophagy to prevent DOX-induced senescence by inactivating PI3K/AKT/mTOR pathway in A549 cells. [Abstract]

2023 Feb;1870(2):119411. PMID: 36521686
Biochim Biophys Acta Mol Cell Res

HMGB2 promotes chondrocyte proliferation under negative pressure through the phosphorylation of AKT. [Abstract]

2021 Oct;1868(11):119115. PMID: 34333060
FASEB J

Selective depletion of hepatic stellate cells-specific LOXL1 alleviates liver fibrosis. [Abstract]

2021 Oct;35(10):e21918. PMID: 34569648
Front Physiol

Downregulation of Interleukin-13 Receptor α2 Inhibits Angiogenic Formation Mediated by Chitinase 3-Like 1 in Late Atherosclerotic Lesions of apoE-/- Mice. [Abstract]

2021 Jul 19:12:690109. PMID: 34349665
Biochim Biophys Acta Mol Cell Res

Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC. [Abstract]

2020 Jul;1867(7):118713. PMID: 32246948
Wound Repair Regen

Down-regulation of mir-27b promotes angiogenesis and fibroblast activation through activating PI3K/AKT signaling pathway. [Abstract]

2020 Jan;28(1):39-48. PMID: 31587435
FASEB J

EphrinB2/ephB2-mediated myenteric synaptic plasticity: mechanisms underlying the persistent muscle hypercontractility and pain in postinfectious IBS. [Abstract]

2019 Dec;33(12):13644-13659. PMID: 31601124
Biol Trace Elem Res

Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway. [Abstract]

2019 Aug;190(2):327-335. PMID: 30421162

LY294002 purchased from MedChemExpress. Usage Cited in: Biol Trace Elem Res. 2019 Aug;190(2):327-335. [Abstract]

Number of cells stained positive for ALP increase significantly after stimulation with orthosilicic acid for 72 h and decrease after stimulation with LY294002 for the last 48 h of this period.
FASEB J

Transactivation domain of Krüppel-like factor 15 negatively regulates angiotensin II-induced adventitial inflammation and fibrosis. [Abstract]

2019 May;33(5):6254-6268. PMID: 30776250
FASEB J

Bile acids induce visceral hypersensitivity via mucosal mast cell-to-nociceptor signaling that involves the farnesoid X receptor/nerve growth factor/transient receptor potential vanilloid 1 axis. [Abstract]

2019 Feb;33(2):2435-2450. PMID: 30260705
Fish Shellfish Immunol

2026 Aug 17:178:111660. PMID: 42607971
Transl Stroke Res

Deacetylase SIRT2 Inhibition Promotes Microglial M2 Polarization Through Axl/PI3K/AKT to Alleviate White Matter Injury After Subarachnoid Hemorrhage. [Abstract]

2025 Aug;16(4):1075-1093. PMID: 39103659
FEBS J

Fusobacterium nucleatum promotes proliferation in oesophageal squamous cell carcinoma via AHR/CYP1A1 signalling. [Abstract]

2023 Feb;290(3):837-854. PMID: 36070107
Eur J Orthod

Effect of irisin on the expression of osteoclast-related genes in cementoblasts. [Abstract]

2022 Aug 16;44(4):420-426. PMID: 35290462
Fish Shellfish Immunol

PI3K/AKT/p53 pathway inhibits infectious spleen and kidney necrosis virus infection by regulating autophagy and immune responses. [Abstract]

2022 Jan:120:648-657. PMID: 34968710
Mol Hum Reprod

Excess fibronectin 1 participates in pathogenesis of pre-eclampsia by promoting apoptosis and autophagy in vascular endothelial cells. [Abstract]

2021 May 29;27(6):gaab030. PMID: 33881516
Antimicrob Agents Chemother

Inhibitory Effect of PIK-24 on Respiratory Syncytial Virus Entry by Blocking Phosphatidylinositol-3 Kinase Signaling. [Abstract]

2020 Sep 21;64(10):e00608-20. PMID: 32718963
Fish Shellfish Immunol

ROS induced by spring viraemia of carp virus activate the inflammatory response via the MAPK/AP-1 and PI3K signaling pathways. [Abstract]

2020 Jun:101:216-224. PMID: 32224280
J Virol

Coronavirus infectious bronchitis virus spike protein inhibits FUNDC1-mediated mitophagy to prevent nucleocapsid protein degradation. [Abstract]

2026 May 19;100(5):e0180025. PMID: 42007729
Curr Issues Mol Biol

Mechanistic Insights into Glycine's Regulation of Milk Protein Synthesis via PI3K-AKT-mTOR Signaling. [Abstract]

2026 May;48(5):453. PMID: 42193058
Curr Issues Mol Biol

Maresin-1 Alleviates Sepsis-Induced Liver Injury by Regulating Apoptosis and Autophagy via Activation of the PI3K/Akt Signaling Pathway in Mice. [Abstract]

2026 Mar 13;48(3):311. PMID: 41899462
J Biol Chem

Andrographolide targets syndecan4 to impair its interaction with syntenin and inhibits the biogenesis of small extracellular vesicles. [Abstract]

2026 Jan 20:111182. PMID: 41570990
Microbiol Spectr

PI3K/Akt/mTOR signaling pathway mediates energy metabolic reprogramming and regulates mitochondrial homeostasis in host cells exposed to Toxoplasma gondii. [Abstract]

2025 Dec 22:e0138525. PMID: 41427835
Clin Immunol

Glial-derived neurotrophic factor promotes aberrant basal cell hyperplasia in nasal polyps. [Abstract]

2025 Dec:281:110604. PMID: 41075855
J Virol

Dexamethasone disrupts intracellular pH homeostasis to delay coronavirus infectious bronchitis virus cell entry via sodium hydrogen exchanger 3 activation. [Abstract]

2025 Jun 17;99(6):e0189424. PMID: 40340398
J Virol

Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade. [Abstract]

2025 May 20;99(5):e0007825. PMID: 40304504
BMC Cancer

METTL16-dependent miR-146b-5p m6A modification remodeling sensitize NSCLC to osimertinib via activating PI3K/AKT signaling. [Abstract]

2025 Apr 8;25(1):641. PMID: 40200229
Front Biosci (Landmark Ed)

GRK2 Protein Mediates the ANRIL, a lncRNA, to Affect the Proliferation and Apoptosis of Kasumi-1 Cells. [Abstract]

2024 Oct 21;29(10):362. PMID: 39473411
Int J Chron Obstruct Pulmon Dis

Network Pharmacology Followed by Experimental Validation to Explore the Mechanism of Stigmasterol in Sangbaipi Decoction Regulating PI3K/Akt Signaling to Alleviate Acute Exacerbation of Chronic Obstructive Pulmonary Disease. [Abstract]

2024 Aug 8:19:1819-1834. PMID: 39140079
J Biol Chem

MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway. [Abstract]

2024 Aug;300(8):107530. PMID: 38971310
Clin Immunol

Eosinophil peroxidase promotes bronchial epithelial cells to secrete asthma-related factors and induces the early stage of airway remodeling. [Abstract]

2024 Jun:263:110228. PMID: 38663494
BMC Cancer

IKBIP promotes tumor development via the akt signaling pathway in esophageal squamous cell carcinoma. [Abstract]

2024 Jun 24;24(1):759. PMID: 38914958
J Biol Chem

Upregulation of CYR61 by TGF-β and YAP signaling exerts a counter-suppression of hepatocellular carcinoma. [Abstract]

2024 Apr;300(4):107208. PMID: 38521502
Lab Invest

Epigenetic modification-associated molecular classification of gastric cancer. [Abstract]

2023 Sep;103(9):100170. PMID: 37150296
J Biol Chem

Angiotensin-Converting Enzyme 2 improves hepatic insulin resistance by regulating GABAergic signaling in the liver. [Abstract]

2022 Dec;298(12):102603. PMID: 36265585
J Virol

PIK-24 Inhibits RSV-Induced Syncytium Formation via Direct Interaction with the p85α Subunit of PI3K. [Abstract]

2022 Dec 14;96(23):e0145322. PMID: 36416586
J Biol Chem

SARS-CoV-2 hijacks macropinocytosis to facilitate its entry and promote viral spike-mediated cell-to-cell fusion. [Abstract]

2022 Nov;298(11):102511. PMID: 36259516
J Virol

African Swine Fever Virus pI215L Inhibits Type I Interferon Signaling by Targeting Interferon Regulatory Factor 9 for Autophagic Degradation. [Abstract]

2022 Sep 14;96(17):e0094422. PMID: 35972295
Lab Invest

The CD146-HIF-1α axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia. [Abstract]

2022 Aug;102(8):794-804. PMID: 35306530
Lab Invest

TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway. [Abstract]

2021 Aug;101(8):983-997. PMID: 33854173
Exp Mol Pathol

SETD8 promotes stemness characteristics and is a potential prognostic biomarker of gastric adenocarcinoma. [Abstract]

2020 Dec:117:104560. PMID: 33127342
Exp Mol Pathol

MicroRNA-199a-3p inhibits angiogenesis by targeting the VEGF/PI3K/AKT signalling pathway in an in vitro model of diabetic retinopathy. [Abstract]

2020 Oct:116:104488. PMID: 32622012
Lab Invest

SPOCK1 overexpression induced by platelet-derived growth factor-BB promotes hepatic stellate cell activation and liver fibrosis through the integrin α5β1/PI3K/Akt signaling pathway. [Abstract]

2020 Aug;100(8):1042-1056. PMID: 32291390
J Virol

Axl Deficiency Promotes the Neuroinvasion of Japanese Encephalitis Virus by Enhancing IL-1α Production from Pyroptotic Macrophages. [Abstract]

2020 Aug 17;94(17):e00602-20. PMID: 32611752
J Biol Chem

The mTOR inhibitor manassantin B reveals a crucial role of mTORC2 signaling in Epstein-Barr virus reactivation. [Abstract]

2020 May 22;295(21):7431-7441. PMID: 32312752
J Trace Elem Med Biol

Ebselen rescues oxidative-stress-suppressed osteogenic differentiation of bone-marrow-derived mesenchymal stem cells via an antioxidant effect and the PI3K/Akt pathway. [Abstract]

2019 Sep:55:64-70. PMID: 31345368
Chem Res Toxicol

Bisdemethoxycurcumin Protection of Cardiomyocyte Mainly Depends on Nrf2/HO-1 Activation Mediated by the PI3K/AKT Pathway. [Abstract]

2019 Sep 16;32(9):1871-1879. PMID: 31402651
Naunyn Schmiedebergs Arch Pharmacol

2026 Jul 7. PMID: 42410225
Naunyn Schmiedebergs Arch Pharmacol

Naringenin ameliorates postmenopausal osteoporosis by inhibiting BMSC oxidative stress via the PI3K/AKT/NRF2 pathway. [Abstract]

2026 Jun 19. PMID: 42319419
Naunyn Schmiedebergs Arch Pharmacol

From network prediction to in vivo validation: luteolin attenuates cholestatic liver injury in association with PI3K/Akt/GSK-3β signalling modulation. [Abstract]

2026 Jun 23. PMID: 42331983
Naunyn Schmiedebergs Arch Pharmacol

Label-free cell phenotypic profiling of sphingosine-1-phosphate receptor 1 and discovery of its agonist from natural products. [Abstract]

2026 May 29. PMID: 42209736
Naunyn Schmiedebergs Arch Pharmacol

Resveratrol inhibits aerobic glycolysis and promotes cuproptosis in acute myeloid leukemia via the PI3K/AKT signaling pathway. [Abstract]

2026 Apr 30. PMID: 42056286
Funct Integr Genomics

GCSH promotes colorectal cancer progression by inhibiting Cuproptosis through the PI3K/AKT-FDX1 axis. [Abstract]

2026 Jan 27;26(1):32. PMID: 41591502
J Cell Commun Signal

Targeting the PI3K/Akt/NF-κB axis: Cluster of differentiation 5-like-mediated immunometabolic regulation of macrophage polarization in abdominal aortic aneurysm. [Abstract]

2025 Oct 1;19(4):e70048. PMID: 41040887
Differentiation

NONO regulates monocyte-macrophage lineage differentiation through a potential PI3K/AKT-dependent mechanism. [Abstract]

2025 Sep-Oct:145:100901. PMID: 40857758
Virol J

Estrogen protects against postpartum Concanavalin A-induced hepatitis by promoting intrahepatic CD4⁺CD25⁺ Treg expansion through activation of the PI3K/Akt signaling pathway in HBV-Tg mice. [Abstract]

2025 Jul 18;22(1):245. PMID: 40682191
J Cell Commun Signal

ELAVL1 promotes ferroptosis via the TRIM21/HOXD8 axis to inhibit osteogenic differentiation in congenital pseudoarticular tibia-derived mesenchymal stem cells. [Abstract]

2025 May 21;19(2):e70016. PMID: 40401147
Naunyn Schmiedebergs Arch Pharmacol

Combining network pharmacology and RNA sequencing to reveal the mechanism of emodin for the treatment of human neuroblastoma. [Abstract]

2025 Feb 13. PMID: 39945814
J Sci Food Agric

Total triterpenoids from apple peels exert pronounced anti-breast-cancer activity in vivo and in vitro. [Abstract]

2024 Dec;104(15):9228-9239. PMID: 39007208
J Cell Physiol

FNDC5 inhibits malignant growth of human cervical cancer cells via restraining PI3K/AKT pathway. [Abstract]

2024 Jun;239(6):e31267. PMID: 38558303
J Cell Commun Signal

Lactate drives CD38 signaling to promote Epithelial-Mesenchymal Transition through Snail induction in non-small cell lung cancer cells. [Abstract]

2024 Feb 14;18(1):e12018. PMID: 38545257
J Cell Physiol

BKCa channel participates in insulin-induced lipid deposition in adipocytes by increasing intracellular calcium. [Abstract]

2021 Aug;236(8):5818-5831. PMID: 33432604
J Cell Physiol

FoxO1a mediated cadmium-induced annulus fibrosus cells apoptosis contributes to intervertebral disc degeneration in smoking. [Abstract]

2021 Jan;236(1):677-687. PMID: 32654176
J Cell Physiol

PCTR1 improves pulmonary edema fluid clearance through activating the sodium channel and lymphatic drainage in lipopolysaccharide-induced ARDS. [Abstract]

2020 Dec;235(12):9510-9523. PMID: 32529661
Development

Insulin/IGF signaling and TORC1 promote vitellogenesis via inducing juvenile hormone biosynthesis in the American cockroach. [Abstract]

2020 Oct 23;147(20):dev188805. PMID: 33097549
Naunyn Schmiedebergs Arch Pharmacol

Salvianolic acid B protects against myocardial ischaemia-reperfusion injury in rats via inhibiting high mobility group box 1 protein expression through the PI3K/Akt signalling pathway. [Abstract]

2020 Aug;393(8):1527-1539. PMID: 31853618
J Cell Physiol

Wnt signaling associated small molecules improve the viability of pPSCs in a PI3K/Akt pathway dependent way. [Abstract]

2020 Jul;235(7-8):5811-5822. PMID: 32003013
J Cell Physiol

Scutellarin exerts protective effects against atherosclerosis in rats by regulating the Hippo-FOXO3A and PI3K/AKT signaling pathways. [Abstract]

2019 Aug;234(10):18131-18145. PMID: 30891776
J Cell Physiol

Knockdown of TRIM27 expression suppresses the dysfunction of mesangial cells in lupus nephritis by FoxO1 pathway. [Abstract]

2019 Jul;234(7):11555-11566. PMID: 30648253
J Cell Physiol

Gastrin-releasing peptide receptor gene silencing inhibits the development of the epithelial-mesenchymal transition and formation of a calcium oxalate crystal in renal tubular epithelial cells in mice with kidney stones via the PI3K/Akt signaling pathway. [Abstract]

2019 Feb;234(2):1567-1577. PMID: 30144073

LY294002 purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2019 Feb;234(2):1567-1577. [Abstract]

GRPR-1 gene silencing lowers the positive protein levels of GRPR in kidney tissues of mice detected by immunohistochemistry. The positive protein levels of GRPR by immunohistochemical staining (400×).
Toxins

The Effects of Autophagy and PI3K/AKT/m-TOR Signaling Pathway on the Cell-Cycle Arrest of Rats Primary Sertoli Cells Induced by Zearalenone. [Abstract]

2018 Sep 28;10(10):398. PMID: 30274213

LY294002 purchased from MedChemExpress. Usage Cited in: Toxins. 2018 Sep 28;10(10):398. [Abstract]

Expression levels of p-AKT/AKT, p-mTOR/mTOR, and LC3II/LC3I after adding PI3K inhibitors (LY294002) in the experiments.
J Hepatocell Carcinoma

GRB2 Promotes Sorafenib Resistance in Hepatocellular Carcinoma Cells Under Hypoxia by Activating the PI3K/AKT Signaling Pathway. [Abstract]

2026 May 6:13:581550. PMID: 42117089
Microb Pathog

Regulatory mechanism of quercitrin on oxidative stress and histone acetylation changes in PRV infected 3D4/2 cells. [Abstract]

2025 Aug 5:208:107958. PMID: 40769227
J Funct Foods

2025 Apr.
J Tradit Complement Med

2025 Mar 10.
Bone

Zoledronic acid relieves steroid-induced avascular necrosis of femoral head via inhibiting FOXD3 mediated ANXA2 transcriptional activation. [Abstract]

2024 Nov:188:117222. PMID: 39102974
J Hepatocell Carcinoma

ZDHHC20 Activates AKT Signaling Pathway to Promote Cell Proliferation in Hepatocellular Carcinoma. [Abstract]

2024 Sep 18:11:1763-1775. PMID: 39309302
Food Sci Biotechnol

Sinapine suppresses ROS-induced C2C12 myoblast cell death through MAPK and autophagy pathways. [Abstract]

2024 Sep 30;33(15):3629-3637. PMID: 39493388
J Funct Foods

2023 Nov, 110, 105821.
J Funct Foods

2023 Jun, 105, 105576.
Reprod Biomed Online

Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis. [Abstract]

2023 Mar;46(3):425-435. PMID: 36604215
J Funct Foods

2023 Mar 23.
J Funct Foods

2023 Apr.
Cell Cycle

N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K / AKT pathway. [Abstract]

2022 Nov;21(21):2268-2282. PMID: 35758219
J Funct Foods

July 2022, 105116.
Cell Cycle

miR-4677-3p participates proliferation and metastases of gastric cancer cell via CEMIP-PI3K/AKT signaling pathway. [Abstract]

2021 Oct;20(19):1978-1987. PMID: 34437815
J Funct Foods

57 (2019) 255-265.
J Trauma Acute Care Surg

Impact of a novel phosphoinositol-3 kinase inhibitor in preventing mitochondrial DNA damage and damage-associated molecular pattern accumulation: Results from the Biochronicity Project. [Abstract]

2017 Oct;83(4):683-689. PMID: 28930961
J Trauma Acute Care Surg

Inducing metabolic suppression in severe hemorrhagic shock: Pilot study results from the Biochronicity Project. [Abstract]

2016 Dec;81(6):1003-1011. PMID: 27537510
Ren Fail

Serum fibrinogen-like protein 2 is associated with diabetic nephropathy severity and modulates high glucose-induced tubular dysfunction via Akt-FoxO1 signaling. [Abstract]

2026 Dec;48(1):2672189. PMID: 42161877
Viruses

2026 Jan 1.
Am J Physiol Lung Cell Mol Physiol

Intrauterine inflammation-induced neonatal lung injury via succinic acid-mediated alveolar epithelial E-cadherin downregulation. [Abstract]

2025 Aug 1;329(2):L282-L295. PMID: 40643013
J Orthop Surg Res

miR-374-5p inhibits osteogenesis by targeting PTEN/PI3K/AKT signaling pathway. [Abstract]

2025 Mar 14;20(1):283. PMID: 40087681
J Orthop Surg Res

Mogroside V enhances bone marrow mesenchymal stem cells osteogenesis under hyperglycemic conditions through upregulating miR-10b-5p and PI3K/Akt signaling. [Abstract]

2025 Mar 14;20(1):278. PMID: 40082984
Viruses

Host DNA Demethylation Induced by DNMT1 Inhibition Up-Regulates Antiviral OASL Protein during Influenza a Virus Infection. [Abstract]

2023 Jul 28;15(8):1646. PMID: 37631988
Carcinogenesis

TCL1A acts as a tumour suppressor by modulating gastric cancer autophagy via miR-181a-5p-TCL1A-Akt/mTOR-c-MYC loop. [Abstract]

2023 May 15;44(1):29-37. PMID: 36317339
Ren Fail

Cinnamaldehyde attenuates kidney senescence and injury through PI3K/Akt pathway-mediated autophagy via downregulating miR-155. [Abstract]

2022 Dec;44(1):601-614. PMID: 35361048
Viruses

Inducible miR-150 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Targeting Viral Genome and Suppressor of Cytokine Signaling 1. [Abstract]

2022 Jul 7;14(7):1485. PMID: 35891465
J Orthop Surg Res

Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway. [Abstract]

2021 Oct 18;16(1):613. PMID: 34663382
Aquacult Rep

November 2021, 100838.
J Biomed Mater Res A

Immunomodulatory property and its regulatory mechanism of double network hydrogel on dendritic cells. [Abstract]

2021 Jun;109(6):1015-1026. PMID: 32856407
J Orthop Surg Res

Overexpression of CRABP2 inhibits dexamethasone-induced apoptosis in human osteoblast cells. [Abstract]

2021 Apr 20;16(1):272. PMID: 33879199
Viruses

The Role of Epidermal Growth Factor Receptor Signaling Pathway during Bovine Herpesvirus 1 Productive Infection in Cell Culture. [Abstract]

2020 Aug 24;12(9):927. PMID: 32846937
J Orthop Surg Res

PENK inhibits osteosarcoma cell migration by activating the PI3K/Akt signaling pathway. [Abstract]

2020 Apr 25;15(1):162. PMID: 32334633
Pathol Res Pract

Network pharmacology-based identification of cardamomin as a ferroptosis inhibitor in ischemic stroke via SP1/ALOX5 axis. [Abstract]

2026 May 24:286:156558. PMID: 42208355
Pathol Res Pract

Ndufa4l2 drives the pathological activation of Müller cells in ischemic retinopathy via the PI3K/AKT signaling pathway. [Abstract]

2026 May 30:286:156567. PMID: 42235340
Pathol Res Pract

Fucoxanthin alleviates secondary brain injury in mice following intracerebral hemorrhage via PI3K-mediated inhibition of NF-κB signaling pathway. [Abstract]

2025 Jun:270:155933. PMID: 40245673
Mol Immunol

Hypericin impedes M2 macrophage polarization and protects against Hepatocellular carcinoma. [Abstract]

2025 Mar 27:181:160-168. PMID: 40153953
J Pharm Pharmacol

Ethyl 2,2-difluoro-2-(2-oxo-2H-chromen-3-yl) acetate attenuates the malignant biological behaviors of non-small cell lung cancer via suppressing EGFR/PI3K/AKT/mTOR signaling pathway. [Abstract]

2024 Mar 4;76(3):269-282. PMID: 38241189
J Bioenerg Biomembr

Blockage of PHLPP1 protects against myocardial ischemia/reperfusion injury in diabetic mice via activation of STAT3 signaling. [Abstract]

2023 Oct;55(5):325-339. PMID: 37584737
Breast Cancer

Interleukin (IL)-17A in triple-negative breast cancer: a potent prognostic factor associated with intratumoral neutrophil infiltration. [Abstract]

2023 Sep;30(5):748-757. PMID: 37178415
Pathol Res Pract

Clinical importance and PI3K/Akt pathway-dependent anti-proliferative role of PALMD and DPT in breast cancer. [Abstract]

2023 Sep:249:154717. PMID: 37556876
Mol Immunol

IL-8 exacerbates CCl4-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway. [Abstract]

2022 Dec:152:111-122. PMID: 36327908
Pathol Res Pract

TSLP protects against sepsis-induced liver injury by inducing autophagy via activation of the PI3K/Akt/STAT3 pathway. [Abstract]

2022 Aug:236:153979. PMID: 35751928
J Pharm Pharmacol

PI3K/AKT/Nrf2 signalling pathway is involved in the ameliorative effects of xanthohumol on amyloid β-induced oxidative damage and bone loss. [Abstract]

2022 Jul 15;74(7):1017-1026. PMID: 35353176
Pathol Res Pract

SLC39A5 promotes lung adenocarcinoma cell proliferation by activating PI3K/AKT signaling. [Abstract]

2021 Aug:224:153541. PMID: 34252710
Int J Med Sci

Cobalt chloride-stimulated hypoxia promotes the proliferation of cholesteatoma keratinocytes via the PI3K/Akt signaling pathway. [Abstract]

2021 Aug 2;18(15):3403-3411. PMID: 34522167
Mol Immunol

Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264.7 macrophages. [Abstract]

2021 Mar:131:97-111. PMID: 33461765
Drug Metab Dispos

2026 Jun 29;54(8):100353. PMID: 42456276
J Dent Sci

2025 Nov 1.
J Biochem Mol Toxicol

Dihydroquercetin Ameliorates Neuronal Ferroptosis in Rats After Subarachnoid Hemorrhage via the PI3K/AKT/Nrf2/HO-1 Pathway. [Abstract]

2025 Jan;39(1):e70099. PMID: 39756058
Cytokine

Chrysin mitigated neuropathic pain and peripheral sensitization in knee osteoarthritis rats by repressing the RAGE/PI3K/AKT pathway regulated by HMGB1. [Abstract]

2024 Aug:180:156635. PMID: 38749277
Dis Model Mech

A Drosophila chemical screen reveals targeting MEK and DGKa mitigates Ras-driven polarity-impaired tumour growth. [Abstract]

2023 Mar 1;16(3):dmm049769. PMID: 36861754
J Bone Oncol

Indirect bilirubin impairs invasion of osteosarcoma cells via inhibiting the PI3K/AKT/MMP-2 signaling pathway by suppressing intracellular ROS. [Abstract]

2023 Feb 23:39:100472. PMID: 36876225
Stem Cells Int

Matricellular Protein SMOC2 Potentiates BMP9-Induced Osteogenic Differentiation in Mesenchymal Stem Cells through the Enhancement of FAK/PI3K/AKT Signaling. [Abstract]

2023 Jan 16:2023:5915988. PMID: 36698376
Stem Cells Int

Extracellular Vesicles Derived from Adipose Mesenchymal Stem Cells Promote Peritoneal Healing by Activating MAPK-ERK1/2 and PI3K-Akt to Alleviate Postoperative Abdominal Adhesion. [Abstract]

2022 May 5;2022:1940761 PMID: 35578661
Am J Physiol Renal Physiol

Soluble (pro)renin receptor promotes the fibrotic response in renal proximal tubule epithelial cells in vitro via the Akt/β-catenin/Snail signaling pathway. [Abstract]

2020 Nov 1;319(5):F941-F953. PMID: 32865015
Cytokine

PI3K mediates tumor necrosis factor induced-necroptosis through initiating RIP1-RIP3-MLKL signaling pathway activation. [Abstract]

2020 May;129:155046. PMID: 32114297
Cytokine

Effects of daphnetin on the autophagy signaling pathway of fibroblast-like synoviocytes in rats with collagen-induced arthritis (CIA) induced by TNF-α. [Abstract]

2020 Mar:127:154952. PMID: 31865066
Stem Cells Int

Puerarin Relieved Compression-Induced Apoptosis and Mitochondrial Dysfunction in Human Nucleus Pulposus Mesenchymal Stem Cells via the PI3K/Akt Pathway. [Abstract]

2020 Jan 11:2020:7126914. PMID: 32399049
Br J Haematol

S100A16 suppresses the growth and survival of leukaemia cells and correlates with relapse and relapse free survival in adults with Philadelphia chromosome-negative B-cell acute lymphoblastic leukaemia. [Abstract]

2019 Jun;185(5):836-851. PMID: 30916375
Cytokine

Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated osteoclastogenesis. [Abstract]

2018 Jun:106:54-66. PMID: 29549724

LY294002 purchased from MedChemExpress. Usage Cited in: Cytokine. 2018 Jun:106:54-66. [Abstract]

Effect of Berberine (BBR) (15-45 μM) on protein expression levels in IL-21 (20 ng/mL) stimulated AA-FLS cells. Western blot analysis of PI3K, mTOR, IL-23 and PTEN are estimated in whole cell lysates using densitometry analysis. Comparisons are made with: FLS versus AA-FLS+IL-21+BBR (15-45 μM)/LY294002 (20 μM).
Peptides

Tirzepatide improves angiogenesis after diabetic hindlimb ischemia through Akt/eNOS and ERK1/2 pathways. [Abstract]

2026 May:197:171489. PMID: 42002077
J Gastroenterol Hepatol

IKZF3 Promotes Gastric cancer Progression and Oxaliplatin Resistance via PI3K/AKT/mTOR Activation. [Abstract]

2026 Mar 12. PMID: 41820205
Exp Cell Res

TRPV4-dependent PI3K-Akt activation mediates hyperosmotic stress-induced cell contraction and myofibroblast differentiation in tubular epithelial cells. [Abstract]

2026 Mar 11:114984. PMID: 41825809
J Diabetes Res

Targeting Oxidative Stress and Apoptosis via PI3K/Akt/Nrf2 Pathway: The Therapeutic Role of Bletilla striata Polysaccharide in Diabetic Wound Repair. [Abstract]

2026 Jan 28:2026:5751331. PMID: 41613340
Peptides

FSTL1 silencing protects against lipopolysaccharide-induced ferroptosis in renal tubular cells by regulating the PI3K/Akt pathway. [Abstract]

2025 Dec:194:171454. PMID: 41297179
Exp Cell Res

SIRT1 rescues autophagic flux via PI3K/AKT/mTOR inactivation to suppress DOX-induced senescence in MCF-7 cells. [Abstract]

2025 Sep 15;452(1):114754. PMID: 40962168
Arch Biochem Biophys

Berberine triggers apoptosis through the PI3K/Akt pathways and Nrf2 by inducing ROS in papillary thyroid cancer. [Abstract]

2025 Sep:771:110481. PMID: 40436359
Arch Biochem Biophys

UCP2 attenuates neural apoptosis and inflammation in spinal cord injury by inducing the acetylation of ANXA1 and activating the PI3K/AKT pathway. [Abstract]

2025 Jun:768:110399. PMID: 40132777
J Reprod Immunol

LncRNA-THBS4 affects granulosa cell proliferation and apoptosis in diminished ovarian reserve by regulating PI3K/AKT/mTOR signaling pathway. [Abstract]

2025 Feb:167:104419. PMID: 39732055
BMC Pharmacol Toxicol

Analysis of the potential biological mechanisms of geniposide on renal fibrosis by network pharmacology and experimental verification. [Abstract]

2025 Jan 27;26(1):17. PMID: 39871379
Cancer Med

High glucose inhibits autophagy and promotes the proliferation and metastasis of colorectal cancer through the PI3K/AKT/mTOR pathway. [Abstract]

2024 Jun;13(11):e7382. PMID: 38872380
Mol Carcinog

LATS-regulated nuclear-cytoplasmic translocation of SREBP2 inhibits hepatocellular carcinoma cell migration and invasion via epithelial-mesenchymal transition. [Abstract]

2023 Jul;62(7):963-974. PMID: 37042569
Arch Biochem Biophys

Activation of Sestrin2 accelerates deep second-degree burn wound healing through PI3K/AKT pathway. [Abstract]

2023 Jul 15:743:109645. PMID: 37225009
Cell Biol Int

Crosstalk between myofibroblasts and macrophages: A regulative factor of valvular fibrosis in calcific aortic valve disease. [Abstract]

2023 Apr;47(4):754-767. PMID: 36542640
Peptides

Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor. [Abstract]

2022 Aug:154:170824. PMID: 35660638
Cell Biol Int

CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling. [Abstract]

2022 May;46(5):849-860. PMID: 35143104
Exp Cell Res

Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells. [Abstract]

2021 Nov 15;408(2):112862. PMID: 34626585
Cell Biol Int

MPP7 promotes the migration and invasion of breast cancer cells via EGFR/AKT signaling. [Abstract]

2021 May;45(5):948-956. PMID: 33377561
Exp Cell Res

PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway. [Abstract]

2021 Mar 15;400(2):112496. PMID: 33485844
Hum Exp Toxicol

Circular RNA has circ 0001591 promoted cell proliferation and metastasis of human melanoma via ROCK1/PI3K/AKT by targeting miR-431-5p. [Abstract]

2021 Feb;40(2):310-324. PMID: 32830578
Exp Cell Res

Plasminogen activator Inhibitor-2 inhibits pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension via PI3K/Akt and ERK signaling. [Abstract]

2021 Jan 1;398(1):112392. PMID: 33227315
Int J Biochem Cell Biol

Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer. [Abstract]

2020 Jun:123:105750. PMID: 32325280
Cell Biol Int

Reversing microtubule-directed chemotherapeutic drug resistance by co-delivering α2β1 inhibitor and paclitaxel with nanoparticles in ovarian cancer. [Abstract]

2020 Feb;44(2):610-620. PMID: 31743535
Cell Biol Int

LINC00462 is involved in high glucose-induced apoptosis of renal tubular epithelial cells via AKT pathway. [Abstract]

2020 Jan;44(1):286-294. PMID: 31489995
Exp Cell Res

The Akt/mTOR cascade mediates high glucose-induced reductions in BDNF via DNMT1 in Schwann cells in diabetic peripheral neuropathy. [Abstract]

2019 Oct 1;383(1):111502. PMID: 31323191
Cell Biol Int

TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling. [Abstract]

2019 Apr;43(4):360-372. PMID: 29663649
Arch Biochem Biophys

miR-19b-3p inhibits breast cancer cell proliferation and reverses saracatinib-resistance by regulating PI3K/Akt pathway. [Abstract]

2018 May 1:645:54-60. PMID: 29550144
Exp Cell Res

Bach2 regulates aberrant activation of B cell in systemic lupus erythematosus and can be negatively regulated by BCR-ABL/PI3K. [Abstract]

2018 Apr 1;365(1):138-144. PMID: 29501569
J Leukoc Biol

SHIP Blocks (MDP+LPS)-Induced Synergy in Macrophages Independent of Catalytic Activity. [Abstract]

2026 Jun 27:qiag090. PMID: 42364103
Virus Res

RAB25 promotes hepatitis B virus-induced liver fibrosis progression through activation of the PI3K/AKT signaling pathway. [Abstract]

2026 Mar:365:199698. PMID: 41651076
Reprod Toxicol

Protective effect of ginsenoside Rg3 on DBP-induced spermatogenesis injury via the Src/PI3K signaling pathway. [Abstract]

2025 Sep 8:109047. PMID: 40930195
Reprod Toxicol

Human umbilical cord mesenchymal stem cell-derived exosomes repair raloxifene-induced damage in endometrial stromal cells via autophagy activation. [Abstract]

2025 Jul 11:137:108997. PMID: 40652993
Andrology

Cellular mechanism underlying leptin-induced anion secretion of rat epididymal epithelial cells. [Abstract]

2025 Feb;13(2):371-381. PMID: 38778669
Br J Radiol

E2F3/CDCA2 reduces radiosensitivity in gastric adenocarcinoma by activating PI3K/AKT pathway. [Abstract]

2023 Dec;96(1152):20230477. PMID: 37750838
J Cancer

PLEKHG2 Promotes NSCLC Cell Growth by Increasing Glycolysis via Activated PI3K/AKT Pathway. [Abstract]

2023 Oct 30;14(18):3550-3560. PMID: 38021149
J Leukoc Biol

Transient receptor potential vanilloid 4 (TRPV4) in neutrophils enhances myocardial ischemia/reperfusion injury. [Abstract]

2023 Sep 1;114(3):266-279. PMID: 37232941
J Cancer

Role of DEP domain-containing protein 1B (DEPDC1B) in epithelial ovarian cancer. [Abstract]

2023 Mar 27;14(5):784-792. PMID: 37056386
Mol Cell Endocrinol

Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions. [Abstract]

2022 May 1:547:111598. PMID: 35157929
J Cancer

β-arrestin2 regulating β2-adrenergic receptor signaling in hepatic stellate cells contributes to hepatocellular carcinoma progression. [Abstract]

2021 Oct 28;12(24):7287-7299. PMID: 35003349
J Cancer

MST4 negatively regulates the EMT, invasion and metastasis of HCC cells by inactivating PI3K/AKT/Snail1 axis. [Abstract]

2021 May 27;12(15):4463-4477. PMID: 34149910
Front Oncol

Knockdown of SNORA47 Inhibits the Tumorigenesis of NSCLC via Mediation of PI3K/Akt Signaling Pathway. [Abstract]

2021 Mar 19:11:620213. PMID: 33816250
Front Oncol

High Iodine Induces the Proliferation of Papillary and Anaplastic Thyroid Cancer Cells via AKT/Wee1/CDK1 Axis. [Abstract]

2021 Mar 16:11:622085. PMID: 33796458
Mol Cell Endocrinol

ERO1α inhibits cell apoptosis and regulates steroidogenesis in mouse granulosa cells. [Abstract]

2020 Jul 1:511:110842. PMID: 32376276
Reproduction

miR-499 promotes immature porcine Sertoli cell growth through the PI3K/AKT pathway by targeting the PTEN gene. [Abstract]

2020 Feb;159(2):145-157. PMID: 31756167
J Cancer

Vasculogenic Mimicry in Prostate Cancer: The Roles of EphA2 and PI3K. [Abstract]

2016 Jun 5;7(9):1114-24. PMID: 27326255

LY294002 purchased from MedChemExpress. Usage Cited in: J Cancer. 2016 Jun 5;7(9):1114-24. [Abstract]

Effects of PI3K inhibition. (A) Protein levels of p-AKT^S473 . (B) Inhibition of PI3K dose-dependently decreased the levels of p-EphA2^S897 in vitro.
Biochem Biophys Rep

Salvianolic acid B mitigates senescence and promotes osteogenesis of senescent bone marrow mesenchymal stem cells via the PI3K/AKT pathway. [Abstract]

2026 Jun 4:46:102624. PMID: 42291502
Chem Biol Drug Des

Cepharanthine Reverses Gefitinib Resistance in NSCLC by Concurrently Inhibiting AKT/P70S6K Survival Signaling and Activating STING-Mediated Immune Response. [Abstract]

2026 May;107(5):e70298. PMID: 42059424
Int J Food Sci Tech

2024 Jul 18.
J Integr Neurosci

Tanshinone IIA Regulates Synaptic Plasticity in Mg2+-Free-Induced Epileptic Hippocampal Neurons via the PI3K/Akt Signaling Pathway. [Abstract]

2024 Mar 19;23(3):61. PMID: 38538223
J Neuropathol Exp Neurol

YTHDF2-regulated matrilin-3 mitigates post-reperfusion hemorrhagic transformation in ischemic stroke via the PI3K/AKT pathway. [Abstract]

2024 Feb 21;83(3):194-204. PMID: 38230623
Breast Cancer Res Treat

FOXO1-regulated lncRNA CYP1B1-AS1 suppresses breast cancer cell proliferation by inhibiting neddylation. [Abstract]

2023 Nov;202(2):397-408. PMID: 37640964
J Cancer Res Clin Oncol

Tumor-expressed B7-H3 promotes vasculogenic mimicry formation rather than angiogenesis in non-small cell lung cancer. [Abstract]

2023 Sep;149(11):8729-8741. PMID: 37129607
Cardiovasc Toxicol

Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway. [Abstract]

2023 Apr;23(3-4):161-175. PMID: 36934206
BMC Womens Health

Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency. [Abstract]

2022 Nov 24;22(1):474. PMID: 36434569
BMC Womens Health

Pentamidine inhibits proliferation, migration and invasion in endometrial cancer via the PI3K/AKT signaling pathway. [Abstract]

2022 Nov 24;22(1):470. PMID: 36434592
Psychopharmacology

Geniposide ameliorates chronic unpredictable mild stress induced depression-like behavior through inhibition of ceramide-PP2A signaling via the PI3K/Akt/GSK3β axis. [Abstract]

2021 Oct;238(10):2789-2800. PMID: 34142167
Neuroscience

The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3β Signaling. [Abstract]

2020 Aug 10:441:197-208. PMID: 32504794
Neuroscience

Peripheral FGFR1 Regulates Myofascial Pain in Rats via the PI3K/AKT Pathway. [Abstract]

2020 Jun 1:436:1-10. PMID: 32278061
J Neuropathol Exp Neurol

Neuroprotective Effects of Gabapentin Against Cerebral Ischemia Reperfusion-Induced Neuronal Autophagic Injury via Regulation of the PI3K/Akt/mTOR Signaling Pathways. [Abstract]

2019 Feb 1;78(2):157-171. PMID: 30597043

LY294002 purchased from MedChemExpress. Usage Cited in: J Neuropathol Exp Neurol. 2019 Feb 1;78(2):157-171. [Abstract]

Western analysis the protein expression of PI3K, p-mTOR, mTOR, p-AKT, AKT with or without the treatment of OGD, 450 μM GBP and 10 μM LY294002.
Immunol Cell Biol

Inflammatory compound lipopolysaccharide promotes the survival of GM-CSF cultured dendritic cell via PI3 kinase-dependent upregulation of Bcl-x. [Abstract]

2018 Oct;96(9):912-921. PMID: 29624724
Mol Biol Rep

2026 Jul 20;53(1):1218. PMID: 42474720
Adv Biol (Weinh)

MRC2 Links Collagen Turnover to Integrin/PI3K/AKT-Driven Fibrogenesis. [Abstract]

2026 Jun;10(6):e70133. PMID: 42253270
Mol Biol Rep

Hepatitis C virus inhibits the E2F2/PI3K/AKT signaling pathway through miR-378b and leads to glycolipid metabolism disorders in the liver. [Abstract]

2026 Jun 12;53(1):933. PMID: 42283974
Biol Reprod

Hypoxanthine is involved in promoting the activation of mouse primordial follicles†. [Abstract]

2026 Jan 12:ioag007. PMID: 41524735
Food Chem Toxicol

Bisphenol F promoted the differentiation of preadipocytes via ER-mediated PI3K/AKT pathway. [Abstract]

2025 Nov:205:115678. PMID: 40752664
Brain Res

Mitochonic acid 5, an ATP production accelerator, protects against neurological damage in ischemic stroke. [Abstract]

2025 Aug 1:1860:149664. PMID: 40339682
Biol Reprod

Activin A promotes bovine pituitary FSH synthesis and secretion through the cooperative action of the SMAD signaling pathway and FOXO3†. [Abstract]

2025 Aug 7:ioaf179. PMID: 40795281
Brain Res

Role of dexmedetomidine in postoperative cognitive dysfunction and sleep improvement in aged rats by regulating the PI3K/Akt signaling pathway and its mechanism. [Abstract]

2025 Apr 1:1852:149482. PMID: 39892804
Brain Res

TREM2 alleviates long-term cognitive dysfunction after subarachnoid hemorrhage in mice by attenuating hippocampal neuroinflammation via PI3K/Akt signaling pathway. [Abstract]

2025 Jan 1:1846:149235. PMID: 39270995
Biol Reprod

Fetal hypoxia exposure induces Hif1a activation and autophagy in adult ovarian granulosa cells†. [Abstract]

2024 Dec 12;111(6):1220-1234. PMID: 39361887
Neuropsychiatr Dis Treat

Shisandra Decoction Alleviates Parkinson's Disease Symptoms in a Mouse Model Through PI3K/AKT/mTOR Signalling Pathway. [Abstract]

2024 Oct 23:20:2011-2027. PMID: 39464379
Mol Biol Rep

Targeting myocardial inflammation: investigating the therapeutic potential of atrial natriuretic peptide in atrial fibrosis. [Abstract]

2024 Apr 15;51(1):506. PMID: 38622341
Brain Res

OXCT1 regulates hippocampal neurogenesis and alleviates cognitive impairment via the Akt/GSK-3β/β-catenin pathway after subarachnoid hemorrhage. [Abstract]

2024 Mar 15:1827:148758. PMID: 38199308
Biol Reprod

AQP9 causes recurrent spontaneous abortion by inhibiting trophoblast cell EMT and invasion through the PI3K/AKT pathway. [Abstract]

2023 Nov 15;109(5):736-748. PMID: 37602667
Mol Biol Rep

Mechanisms of autophagy and endoplasmic reticulum stress in the reversal of platinum resistance of epithelial ovarian cancer cells by naringin. [Abstract]

2023 Aug;50(8):6457-6468. PMID: 37326754
Immunol Lett

Mechanism of M2 macrophages modulating astrocyte polarization through the TGF-β/PI3K/Akt pathway. [Abstract]

2023 Jul:259:1-8. PMID: 37244460
Mol Biol Rep

Cannabinoid type 2 receptor activation inhibits MPP+-induced M1 differentiation of microglia through activating PI3K/Akt/Nrf2 signal pathway. [Abstract]

2023 May;50(5):4423-4433. PMID: 36977807
Mol Biol Rep

HMGB1 induces radioresistance through PI3K/AKT/ATM pathway in esophageal squamous cell carcinoma. [Abstract]

2022 Dec;49(12):11933-11945. PMID: 36260180
Food Chem Toxicol

Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network. [Abstract]

2022 Nov:169:113450. PMID: 36208653
Mol Biol Rep

Cholesterol inhibits autophagy in RANKL-induced osteoclast differentiation through activating the PI3K/AKT/mTOR signaling pathway. [Abstract]

2022 Oct;49(10):9217-9229. PMID: 35881223
Mol Biol Rep

PLEK2 promotes the proliferation and migration of non-small cell lung cancer cells in a BRD4-dependent manner. [Abstract]

2022 May;49(5):3693-3704. PMID: 35122599
Food Chem Toxicol

G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes. [Abstract]

2021 Feb:148:111925. PMID: 33359794
Mol Cell Probes

Ginsenoside Rb1 mitigates oxidative stress and apoptosis induced by methylglyoxal in SH-SY5Y cells via the PI3K/Akt pathway. [Abstract]

2019 Dec:48:101469. PMID: 31629029
J Neuroimmunol

Establishment of a passive-transfer mouse model of anti-NMDAR encephalitis and delineation of the PI3K-AKT-HIF-1α Axis in antibody-induced neuronal injury. [Abstract]

2026 Aug:417:578943. PMID: 42048740
Tissue Cell

BDNF alleviates senescence and enhances osteogenic differentiation in bone marrow mesenchymal stem cells via the TrkB/PI3K/AKT pathway. [Abstract]

2025 Oct:96:102972. PMID: 40367890
Mechanobiol Med

Piezo1 activates nitric oxide synthase in red blood cells via protein kinase C with increased activity in diabetes. [Abstract]

2025 Jul 28;3(3):100145. PMID: 40809083
Aging Med (Milton)

Effect of Bazi Bushen Capsule on D-Galactose-Induced Human Endothelial Cell Senescence Through PI3K/Akt/eNOS Signaling Pathway. [Abstract]

2025 Jun 11;8(3):258-266. PMID: 40620509
Tissue Cell

The role of HM13 expression and its relationship to PI3K/Akt and p53 signaling pathways in colorectal cancer. [Abstract]

2025 Apr:93:102702. PMID: 39755056
Immunobiology

APOE modulates ferroptosis to drive macrophage polarization toward the M2 type and enhance PTC migration and invasion. [Abstract]

2025 Apr 8;230(3):152900. PMID: 40245754
Exp Eye Res

Role of semaphorin7A in epithelial-mesenchymal transition and proliferative vitreoretinopathy. [Abstract]

2025 Jan:250:110153. PMID: 39566570
Placenta

Reduced syncytin-1 regulates trophoblast invasion and apoptosis in preeclampsia. [Abstract]

2024 Sep 26:155:32-41. PMID: 39121585
Exp Eye Res

Silibinin attenuates TGF-β2-induced fibrogenic changes in human trabecular meshwork cells by targeting JAK2/STAT3 and PI3K/AKT signaling pathways. [Abstract]

2024 Jul:244:109939. PMID: 38789021
Immunobiology

LncRNA SNHG1 overexpression alleviates osteoarthritis via activating PI3K/Akt signal pathway and suppressing autophagy. [Abstract]

2024 May;229(3):152799. PMID: 38636283
Placenta

OLFML3 suppresses trophoblast apoptosis via the PI3K/AKT pathway: A possible therapeutic target in preeclampsia. [Abstract]

2024 Mar 6:147:1-11. PMID: 38277999
Am J Cancer Res

miR-19a mediates the mechanism by which SPHK2 regulates hypopharyngeal squamous cell carcinoma progression through the PI3K/AKT axis. [Abstract]

2023 Jun 15;13(6):2342-2359. PMID: 37424828
Kaohsiung J Med Sci

Total saponins of Aralia elata (Miq.) Seem. alleviate myocardial ischemia-reperfusion injury by promoting NLRP3-inflammasome inactivation via PI3K/Akt signaling. [Abstract]

2023 Mar;39(3):290-301. PMID: 36408810
Kaohsiung J Med Sci

CST1 promotes the proliferation and migration of PDGF-BB-treated airway smooth muscle cells via the PI3K/AKT signaling pathway. [Abstract]

2023 Feb;39(2):145-153. PMID: 36354198
Kaohsiung J Med Sci

Capn4 regulates Snail to promote the epithelial-mesenchymal transition of nasopharyngeal carcinoma by mediating the transcriptional activity of claudin-11. [Abstract]

2023 Feb;39(2):134-144. PMID: 36354184
Kaohsiung J Med Sci

MiR-199a-5p promotes ferroptosis-induced cardiomyocyte death responding to oxygen-glucose deprivation/reperfusion injury via inhibiting Akt/eNOS signaling pathway. [Abstract]

2022 Nov;38(11):1093-1102. PMID: 36254861
Immunopharmacol Immunotoxicol

LY294002 attenuates inflammatory response in endotoxin-induced uveitis by downregulating JAK3 and inactivating the PI3K/Akt signaling. [Abstract]

2022 Aug;44(4):510-518. PMID: 35344456
Life Sci Alliance

ERK-Smurf1-RhoA signaling is critical for TGFβ-drived EMT and tumor metastasis. [Abstract]

2022 Jun 2;5(10):e202101330. PMID: 35654587
J Steroid Biochem Mol Biol

Dihydrotestosterone regulation of cyclooxygenase-2 expression in bovine endometrial epithelium cells by androgen receptor mediated EGFR/PI3K/Akt pathway. [Abstract]

2021 Nov:214:106001. PMID: 34547381
Genes (Basel)

Evaluation of Reference Genes for Transcriptional Profiling in Two Cockroach Models. [Abstract]

2021 Nov 25;12(12):1880. PMID: 34946836
Toxicol Lett

Bisphenol F promotes the secretion of pro-inflammatory cytokines in macrophages by enhanced glycolysis through PI3K-AKT signaling pathway. [Abstract]

2021 Oct 10:350:30-39. PMID: 34147605
Integr Cancer Ther

Electroacupuncture Attenuates Morphine Tolerance in Rats with Bone Cancer Pain by Inhibiting PI3K/Akt/JNK1/2 Signaling Pathway in the Spinal Dorsal Horn. [Abstract]

2021 Jan-Dec:20:1534735421995237. PMID: 33660537
Tissue Cell

Tectorigenin protect HUVECs from H2O2-induced oxidative stress injury by regulating PI3K/Akt pathway. [Abstract]

2021 Feb:68:101475. PMID: 33385639
Exp Eye Res

Transdifferentiation effects and related mechanisms of nerve growth factor and internal limiting membrane on Müller cells. [Abstract]

2019 Mar:180:146-154. PMID: 30578789
Cell Biochem Biophys

Sirt4 Overexpression Modulates the JAK2/STAT3 and PI3K/AKT/mTOR Axes to Alleviate Sepsis-Induced Acute Lung Injury. [Abstract]

2025 Jun;83(2):1785-1798. PMID: 39400781
Cell Biochem Biophys

Indoleamine 2, 3-dioxygenase Regulates the Differentiation of T Lymphocytes to Promote the Growth of Gastric Cancer Cells through the PI3K/Akt/mTOR Pathway. [Abstract]

2025 Jun;83(2):2289-2299. PMID: 39695014
Cell Biochem Biophys

Impairing Ferroptosis Through the PI3K/Akt/Nrf2 Pathway: The Way for Nerve Growth Factor to Mitigate Hypoxia-induced Cardiomyocyte Damage. [Abstract]

2025 Jun;83(2):2023-2033. PMID: 39549229
Cell Biochem Biophys

Isogarcinol Reduces MARS Levels and Deactivates the PI3K/AKT Pathway to Suppress the Malignant Properties of Breast Cancer Cells. [Abstract]

2025 Mar 22. PMID: 40120049
J Cell Biochem

Helicobacter pylori CagA protein induces gastric cancer stem cell-like properties through the Akt/FOXO3a axis. [Abstract]

2024 Mar;125(3):e30527. PMID: 38332574
Front Cardiovasc Med

Profilin 2 and Endothelial Exosomal Profilin 2 Promote Angiogenesis and Myocardial Infarction Repair in Mice. [Abstract]

2022 Apr 11;9:781753. PMID: 35479278
Neurogastroenterol Motil

Acute stress induces visceral hypersensitivity via glucocorticoid receptor-mediated membrane insertion of TRPM8: Involvement of a non-receptor tyrosine kinase Pyk2. [Abstract]

2020 Oct;32(10):1514-1528. PMID: 32391653
J Cell Biochem

Prolonged high-glucose exposure decreased SREBP-1/FASN/ACC in Schwann cells of diabetic mice via blocking PI3K/Akt pathway. [Abstract]

2019 Apr;120(4):5777-5789. PMID: 30362584
Appl Sci

2026 Jan;16(10):5132.
Fitoterapia

The potential of Humulus scandens in delaying non-small cell lung cancer: Targeting the PI3K/Akt signaling pathway to inhibit tumor growth and metastasis. [Abstract]

2026 May 25:192:107312. PMID: 42191034
IBRO Neurosci Rep

TNKS1 mediates the PTEN-PI3K/AKT pathway to regulate glycolysis and proliferation in gliomas. [Abstract]

2026 Jan 21:20:186-195. PMID: 41660562
Medicina (Kaunas)

The Synergistic Effect of Zuogui Pill and Eldecalcitol on Improving Bone Mass and Osteogenesis in Type 2 Diabetic Osteoporosis. [Abstract]

2023 Aug 3;59(8):1414. PMID: 37629706
Behav Brain Res

Inhibition of TREM-1 Ameliorates Lipopolysaccharide-induced Depressive-like Behaviors by Alleviating Neuroinflammation in the PFC via PI3K/Akt Signaling Pathway. [Abstract]

2023 Jul 9:449:114464. PMID: 37142164
Biomed Res Int

Effects of Baicalin on Alopecia and the Associated Mechanism. [Abstract]

2022 Nov 18:2022:3139123. PMID: 36440360
Biomed Res Int

Wenhua Juanbi Recipe Attenuates Rheumatoid Arthritis via Inhibiting miRNA-146a-Mediated Autophagy. [Abstract]

2022 Nov 16:2022:1768052. PMID: 36440364
PeerJ

Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways. [Abstract]

2022 Oct 25:10:e14192. PMID: 36312762
Acta Histochem

DRAM1 plays a tumor suppressor role in clear cell renal cell carcinoma through modulating Akt signaling. [Abstract]

2022 Apr;124(3):151874. PMID: 35299128
Theriogenology

Signaling pathways of Periplaneta americana peptide resist H2O2-induced apoptosis in pig-ovary granulosa cells through FoxO1. [Abstract]

2022 Apr 15:183:108-119. PMID: 35247848
BMC Immunol

Pharmacological activation of rev-erbα suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss. [Abstract]

2021 Aug 16;22(1):57. PMID: 34399700
Biomed Res Int

Role of PI3K/AKT Signaling Pathway in Nucleus Pulposus Cells. [Abstract]

2021 Jul 1:2021:9941253. PMID: 34307680
Biomed Res Int

Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta. [Abstract]

2021 May 14:2021:5565748. PMID: 34095301
Biomed Res Int

Remote Ischemic Postconditioning Protects against Myocardial Ischemia-Reperfusion Injury by Inhibition of the RAGE-HMGB1 Pathway. [Abstract]

2018 Jan 23:2018:4565630. PMID: 29789792
Hum Cell

2026 Jul 24;39(8):114. PMID: 42498884
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Dig Dis Sci

ABCG2 Upregulation Involving AKT/NF-κB Signaling Contributes to Intestinal Barrier Dysfunction in Inflammatory Bowel Disease. [Abstract]

2026 May 29. PMID: 42213380
Dose Response

4,8-Dicarboxyl-8,9-Iridoid-1-Glycoside Alleviates Cardiac Dysfunction After Myocardial Ischaemia-Reperfusion Injury by Activating the PI3K/AKT Pathway. [Abstract]

2026 Apr 18;24(2):15593258261444840. PMID: 42028182
PLoS One

Network pharmacology and experiments verify the effect of triptolide on extraocular muscle fibrosis. [Abstract]

2025 Nov 10;20(11):e0336487. PMID: 41212870
Dig Dis Sci

NCAPD2 Modulates MHC-I Antigen Presentation via the PI3K/AKT Axis to Drive Metastatic Progression in Gastric Cancer. [Abstract]

2025 Sep 26. PMID: 41004034
Toxicon

A Dendrobium chrysotoxum extract erianin induce AML cells death by activating PPARɑ and downregulating PI3K/AKT signaling pathways. [Abstract]

2025 Jul:261:108371. PMID: 40280444
Hum Cell

Heterophyllin B inhibits the malignant phenotypes of gastric cancer cells via CXCR4. [Abstract]

2023 Mar;36(2):676-688. PMID: 36539682
Vet Microbiol

PDZK1 upregulates nitric oxide production through the PI3K/ERK2 pathway to inhibit porcine circovirus type 2 replication. [Abstract]

2022 Sep:272:109514. PMID: 35917623
Genes Nutr

Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma. [Abstract]

2022 Feb 14;17(1):3. PMID: 35164673
Cardiovasc Ther

MicroRNA-325-3p Targets Human Epididymis Protein 4 to Relieve Right Ventricular Fibrosis in Rats with Pulmonary Arterial Hypertension. [Abstract]

2022 Jan 22:2022:4382999. PMID: 35136419
Tissue Eng Part A

Calcitonin Gene-Related Peptide Enhances Distraction Osteogenesis by Increasing Angiogenesis. [Abstract]

2021 Jan;27(1-2):87-102. PMID: 32375579
Vet Sci

BVDV NS5A Binds to CKAP2 and Activates the PI3K/AKT/mTOR Pathway to Facilitate Virus Transmission Through Tunneling Nanotubes. [Abstract]

2026 May 22;13(6):505. PMID: 42357703
Vet Sci

The HIF-Mediated PI3K-AKT Signaling Pathway Is a Key Signaling Pathway Triggering Testicular Spermatogenic Disorders in Yaks with Cryptorchidism. [Abstract]

2026 May 12;13(5):468. PMID: 42188938
FEBS Open Bio

Indoleamine 2,3-dioxygenase 1 inhibition reverses cancer-associated fibroblast-mediated immunosuppression in high-grade serous ovarian cancer. [Abstract]

2025 Oct 13. PMID: 41078340
Technol Cancer Res Treat

LncRNA NONHSAT227443.1 Confers Esophageal Squamous Cell Carcinoma Chemotherapy Resistance by Activating PI3K/AKT Signaling via Targeting MRTFB. [Abstract]

2024 Jan-Dec:23:15330338241274369. PMID: 39150441
Gene

Comparison of transcriptome profiles of mesenchymal stem cells derived from umbilical cord and bone marrow of giant panda (Ailuropoda melanoleuca). [Abstract]

2022 Dec 15:845:146854. PMID: 36055605
Photodiagnosis Photodyn Ther

Connexin 43 contributes to the sensitization of colorectal cancer cells to photodynamic therapy through Akt inhibition. [Abstract]

2022 Sep:39:103040. PMID: 35907621
Gene

Assessment of progesterone synthesis and its regulation role on dihydrotestosterone secretion in sheep epididymis. [Abstract]

2021 Jul 20:790:145699. PMID: 33964380
Toxicol In Vitro

YAN, a novel microtubule inhibitor, inhibits P-gp and MRP1 function and induces mitotic slippage followed by apoptosis in multidrug-resistant A549/Taxol cells. [Abstract]

2020 Dec:69:104971. PMID: 32805372
Technol Cancer Res Treat

Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer. [Abstract]

2020 Jan-Dec:19:1533033820926591. PMID: 32406319
Nutr Cancer

Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells. [Abstract]

2019;71(6):1007-1018. PMID: 31032633
Acta Trop

Ras-related protein Rab18 from hydatid cyst of Echinococcus granulosus induces apoptosis and autophagy in AML12 cells by inhibiting the PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 Jul 3:108213. PMID: 42398812
J Nat Med

Integrated network pharmacology and pharmacological evaluation to elucidate the effect and mechanism of the novel combination PMS in treatment of osteoporosis. [Abstract]

2026 May;80(3):555-564. PMID: 41927855
Mol Reprod Dev

Leucine Promotes Mouse Primordial Follicle Activation Via the PI3K/Akt Signaling Pathway. [Abstract]

2026 May;93(5):e70120. PMID: 42200771
World J Tradit Chin Med

2026 Feb 23.
J Mol Histol

Deficiency of METTL3 alleviates excessive autophagy and apoptosis in mice with slow transit constipation and glutamic acid-induced interstitial cells of Cajal via the activation of PI3K/AKT pathway. [Abstract]

2026 Jan 7;57(1):29. PMID: 41495570
J Cardiovasc Transl Res

Targeting KDM4C Prevents Heart Failure after Acute Myocardial Infarction Via Activation of SOS2. [Abstract]

2025 Jun;18(3):498-511. PMID: 39900886
Hereditas

Corynoxine suppresses lung adenocarcinoma proliferation and metastasis via inhibiting PI3K/AKT pathway and suppressing Cyclooxygenase-2 expression. [Abstract]

2024 Nov 7;161(1):41. PMID: 39511658
Virology

The ICAM-1 ligand HRV-A89 is internalized independently of clathrin-mediated endocytosis and its capsid reaches late endosomes. [Abstract]

2023 Jun:583:45-51. PMID: 37148647
Arch Gynecol Obstet

MiR-383-5p promotes apoptosis of ovarian granulosa cells by targeting CIRP through the PI3K/AKT signaling pathway. [Abstract]

2022 Aug;306(2):501-512. PMID: 35226160
Mol Reprod Dev

CD55 is upregulated by cAMP/PKA/AKT and modulates human decidualization via Src and ERK pathway and decidualization-related genes. [Abstract]

2022 May;89(5-6):256-268. PMID: 35474595
Anticancer Agents Med Chem

Anlotinib Overcomes Multiple Drug Resistant Colorectal Cancer Cells via Inactivating PI3K/AKT Pathway. [Abstract]

2021;21(15):1987-1995. PMID: 33438566
J Insect Physiol

Biosynthesis of aphid alarm pheromone is modulated in response to starvation stress under regulation by the insulin, glycolysis and isoprenoid pathways. [Abstract]

2021 Jan:128:104174. PMID: 33242454
Cancer Manag Res

TOP2A Promotes Cell Migration, Invasion and Epithelial-Mesenchymal Transition in Cervical Cancer via Activating the PI3K/AKT Signaling. [Abstract]

2020 May 21:12:3807-3814. PMID: 32547216
DNA Cell Biol

NUPR1 Silencing Induces Autophagy-Mediated Apoptosis in Multiple Myeloma Cells Through the PI3K/AKT/mTOR Pathway. [Abstract]

2020 Mar;39(3):368-378. PMID: 31971825
Cancer Manag Res

Silencing of Peroxiredoxin 1 Inhibits the Proliferation of Esophageal Cancer Cells and Promotes Apoptosis by Inhibiting the Activity of the PI3K/AKT Pathway. [Abstract]

2019 Dec 30:11:10883-10890. PMID: 31920397
Cancer Manag Res

NECTIN4 promotes papillary thyroid cancer cell proliferation, migration, and invasion and triggers EMT by activating AKT. [Abstract]

2019 Apr 2:11:2565-2578. PMID: 31114323
Biochem Biophys Res Commun

2026 Sep 10:830:154255. PMID: 42442088
Anal Cell Pathol

PYCR1 Downregulation Induces Autophagy Dependent Apoptosis Through Inhibiting PI3K/AKT/mTOR Axis in Human Hepatocellular Carcinoma Cells. [Abstract]

2026;2026(1):e3662809. PMID: 41810929
Biochem Biophys Res Commun

YBX1 contributes to lung adenocarcinoma progression and is associated with ferroptosis-related changes via the PI3K/AKT/mTOR pathway. [Abstract]

2026 Jan 8:795:153109. PMID: 41389617
Clin Exp Pharmacol Physiol

Indole-3-Propionic Acid Improves Vascular Function in High-Fat Diet-Induced Obese Mice via eNOS. [Abstract]

2025 Nov;52(11):e70081. PMID: 41057979
Biochem Biophys Res Commun

mTORC2/Akt axis promotes proteotoxic stress and mitochondrial Ca2+ overload during celastrol-induced paraptosis. [Abstract]

2025 Aug 11:781:152474. PMID: 40834605
Cancer Rep (Hoboken)

Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study. [Abstract]

2025 May;8(5):e70220. PMID: 40347062
Biochem Biophys Res Commun

Bradykinin attenuates NiSO4-induced autophagy in MIN6 cells and protects islet function in mice by regulating the PI3K/AKT/mTOR signaling pathway. [Abstract]

2025 Feb:746:151265. PMID: 39756208
Biochem Biophys Res Commun

Exploring the role of iNOS in HFpEF-Related myocardial fibrosis: Involvement of PTEN-PI3K/AKT signaling pathway. [Abstract]

2024 Nov 19:734:150589. PMID: 39245028
Clin Exp Pharmacol Physiol

AEBP1 restores osteoblastic differentiation under dexamethasone treatment by activating PI3K/AKT signalling. [Abstract]

2024 Nov;51(11):e13923. PMID: 39358837
Biochem Biophys Res Commun

Downregulation of Setdb2 promotes alternative activation of macrophages via the PI3K/Akt pathway to attenuate NAFLD after sleeve gastrectomy. [Abstract]

2024 Sep 24:726:150264. PMID: 38905784
Biomed Rep

Ethanol extract of Rubia yunnanensis inhibits carotid atherosclerosis via the PI3K/AKT signaling pathway. [Abstract]

2023 Dec 8;20(2):19. PMID: 38170026
Synapse

Neuroprotective mechanism of human umbilical cord mesenchymal stem cell-derived extracellular vesicles improving the phenotype polarization of microglia via the PI3K/AKT/Nrf2 pathway in vascular dementia. [Abstract]

2023 Jul;77(4):e22268. PMID: 36941024
Biochem Biophys Res Commun

Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia. [Abstract]

2023 Sep 3:671:246-254. PMID: 37307708
Neoplasma

Hypoxia-induced miR-9 expression promotes ovarian cancer progression via activating PI3K/AKT/mTOR/GSK3β signaling pathway. [Abstract]

2023 Apr;70(2):216-228. PMID: 36964721
Biochem Biophys Res Commun

Chromogranin A-derived peptide CGA47-66 protects against septic brain injury by reducing blood-brain barrier damage through the PI3K/AKT pathway. [Abstract]

2022 May 21;605:162-170. PMID: 35339012
Biochem Biophys Res Commun

LIGHT (TNFSF14) inhibits glucose uptake of adipocytes by downregulating GLUT4 expression via AKT signaling pathway. [Abstract]

2021 Oct 28:583:106-113. PMID: 34735871
Am J Reprod Immunol

Circadian rhythm-associated Rev-erbα modulates polarization of decidual macrophage via the PI3K/Akt signaling pathway. [Abstract]

2021 Sep;86(3):e13436. PMID: 33934423
Korean J Physiol Pharmacol

NOX4/Src regulates ANP secretion through activating ERK1/2 and Akt/GATA4 signaling in beating rat hypoxic atria. [Abstract]

2021 Mar 1;25(2):159-166. PMID: 33602886
J Cardiovasc Pharmacol

Danhong Injection Attenuates High-Fat-Induced Atherosclerosis and Macrophage Lipid Accumulation by Regulating the PI3K/AKT Insulin Pathway. [Abstract]

2019 Aug;74(2):152-161. PMID: 31306371
Biochem Biophys Res Commun

NIPA2 regulates osteoblast function via its effect on apoptosis pathways in type 2 diabetes osteoporosis. [Abstract]

2019 Jun 11;513(4):883-890. PMID: 31003774
Biochem Biophys Res Commun

Pyrroloquinoline quinine protects HK-2 cells against high glucose-induced oxidative stress and apoptosis through Sirt3 and PI3K/Akt/FoxO3a signaling pathway. [Abstract]

2019 Jan 8;508(2):398-404. PMID: 30502093

LY294002 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2019 Jan 8;508(2):398-404. [Abstract]

TUNEL staining shows green fluorescence of apoptosis HK-2 cells with the treatment of HG+PPQ or HG+PPQ+LY294002.
Cell Physiol Biochem

Peiminine Inhibits Glioblastoma in Vitro and in Vivo Through Cell Cycle Arrest and Autophagic Flux Blocking. [Abstract]

2018;51(4):1566-1583. PMID: 30497066

LY294002 purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2018;51(4):1566-1583. [Abstract]

The protein expressions of PI3K, p-PI3K, Akt, p-Akt, Bax, Bcl-2, Cleaved-caspase-3, Caspase-3, are measured by Western blotting with the treatment of LY294002, CDDP or Icariin.
Biochem Biophys Res Commun

Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway. [Abstract]

2018 Sep 18;503(4):3212-3218. PMID: 30149919

LY294002 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 18;503(4):3212-3218. [Abstract]

Western blot analysis for phospho-PI3K, total PI3K, phospho-Akt, total Akt, phospho-mTOR and total mTOR in control/Brg^fl/fl+NS, control/Brg^fl/fl+LY294002 group, SFTPC-Cre/Brg^fl/fl+LY294002 and SFTPC-Cre/Brg^fl/fl+NS group.
Biochem Biophys Res Commun

Rac1 signalling coordinates epiboly movement by differential regulation of actin cytoskeleton in zebrafish. [Abstract]

2017 Aug 26;490(3):1059-1065. PMID: 28668387
Cell Physiol Biochem

Sonodynamic Therapy Inhibits Fibrogenesis in Rat Cardiac Fibroblasts Induced by TGF-β1. [Abstract]

2016;40(3-4):579-588. PMID: 27889772

LY294002 purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2016;40(3-4):579-588. [Abstract]

LY294002, a highly selective AKT inhibitor, completely blocks GSK3β phosphorylation induced by SDT. Effect of SDT on the expression of p-SMAD3, p-AKT and p-GSK3β. Images of p-GSK3β, GSK3β and GAPDH protein and mean values of protein level (relative to GAPDH) in cells.
Sex Med

Angiotensin (1-7) decreases the fibrotic process by modulating the TGF-β1/AKT pathway in rat corpus cavernosum smooth muscle cells. [Abstract]

2025 Oct 14;13(5):qfaf080. PMID: 41103813
Sex Med

Hinokiflavone alleviates high-fat diet-induced erectile dysfunction via the EGFR/PI3K/Akt/eNOS signaling pathway. [Abstract]

2025 Aug 6;13(4):qfaf059. PMID: 40808867
FASEB Bioadv

NCAPD3-mediated AKT activation regulates prostate cancer progression. [Abstract]

2025 Jan 7;7(2):e1488. PMID: 39917394
Sleep Breath

Exogenous H2S targeting PI3K/AKT/mTOR pathway alleviates chronic intermittent hypoxia-induced myocardial damage through inhibiting oxidative stress and enhancing autophagy. [Abstract]

2024 Dec 3;29(1):43. PMID: 39627628
Radiat Res

Sea Buckthorn Oil Promotes the PI3K-Akt-ERK Signaling Pathway and Macrophage M2 Polarization to Reduce Radiation-induced Skin Injury. [Abstract]

2024 Nov 1;202(5):785-794. PMID: 39343736
Dev Comp Immunol

The interaction between 20-hydroxyecdysone and AMPK through PI3K activation in Chinese mitten crab, Eriocheir sinensis. [Abstract]

2024 Aug:157:105194. PMID: 38754572
Onco Targets Ther

Inhibition of PI3K-AKT Signaling Blocks PGE2-Induced COX-2 Expression in Lung Adenocarcinoma. [Abstract]

2020 Aug 18:13:8197-8208. PMID: 32904445
Onco Targets Ther

NCAPG Promotes The Proliferation Of Hepatocellular Carcinoma Through PI3K/AKT Signaling. [Abstract]

2019 Oct 16:12:8537-8552. PMID: 31802891
Exp Neurobiol

Developmental Exposure to Di-(2-ethylhexyl) Phthalate Induces Cerebellar Granule Cell Apoptosis via the PI3K/AKT Signaling Pathway. [Abstract]

2018 Dec;27(6):472-488. PMID: 30636900

LY294002 purchased from MedChemExpress. Usage Cited in: Exp Neurobiol. 2018 Dec;27(6):472-488. [Abstract]

LY294002 aggravates the suppression of PI3K/AKT signaling pathway induced by MEHP. CGCs are pre-treated with 5 μM of LY294002, an inhibitor of PI-3K/AKT pathway, for 2 h followed by treatment with 250 MEHP for 24 h.
Onco Targets Ther

Knockdown of RAI14 suppresses the progression of gastric cancer. [Abstract]

2018 Oct 9:11:6693-6703. PMID: 30349303

LY294002 purchased from MedChemExpress. Usage Cited in: Onco Targets Ther. 2018 Oct 9:11:6693-6703. [Abstract]

LY294002, an Akt inhibitor, is applied to the inhibition on prolifera¬tion.
J Oral Pathol Med

circMTO1/miR-30c-5p/SOCS3 axis alleviates oral submucous fibrosis through inhibiting fibroblast-myofibroblast transition. [Abstract]

2024 Aug;53(7):468-479. PMID: 38802299
J Food Biochem

Lutein attenuated methylglyoxal-induced oxidative damage and apoptosis in PC12 cells via the PI3K/Akt signaling pathway. [Abstract]

2022 Dec;46(12):e14382. PMID: 36017617
Immunol Invest

sRAGE Inhibits the Mucus Hypersecretion in a Mouse Model with Neutrophilic Asthma. [Abstract]

2022 Jul;51(5):1243-1256. PMID: 34018452
Arch Oral Biol

The polypeptide OP3-4 induced osteogenic differentiation of bone marrow mesenchymal stem cells via protein kinase B/glycogen synthase kinase 3β/β-catenin pathway and promoted mandibular defect bone regeneration. [Abstract]

2021 Oct:130:105243. PMID: 34416564
Mol Genet Genomics

WTAP-mediated m6A methylation of CEP55 promotes immune evasion in lung adenocarcinoma by activating the PI3K/AKT/mTOR pathway. [Abstract]

2026 Jun 16;301(1):138. PMID: 42298019
Histol Histopathol

Lysimachia christinae Hance aqueous extract ameliorates renal injury in kidney stone rats and calcium oxalate crystal-induced oxidative stress in HK-2 cells via inhibiting the PI3K/Akt/mTOR pathway. [Abstract]

2026 Mar;41(3):467-478. PMID: 40692330
Exp Ther Med

Tumor-associated macrophages suppress estrogen receptor-β expression in triple-negative breast cancer through the PI3K/AKT pathway. [Abstract]

2026 Jan 21;31(3):77. PMID: 41623312
J Ocul Pharmacol Ther

Qiming Granules Ameliorate Diabetic Retinopathy by Regulating the PI3K/Akt Signaling Pathway. [Abstract]

2025 Oct 24. PMID: 41134305
Neurosci Lett

Esketamine induces tripartite motif-containing protein 24 to improve cognitive dysfunction in Alzheimer's disease. [Abstract]

2024 Jun 21:834:137836. PMID: 38802052
Exp Ther Med

Bilobalide attenuates lipopolysaccharide‑induced HepG2 cell injury by inhibiting TLR4‑NF‑κB signaling via the PI3K/Akt pathway. [Abstract]

2023 Nov 22;27(1):24. PMID: 38125341
Int Urol Nephrol

Sufentanil inhibits Pin1 to attenuate renal tubular epithelial cell ischemia-reperfusion injury by activating the PI3K/AKT/FOXO1 pathway. [Abstract]

2023 Aug;55(8):1903-1916. PMID: 37300758
Exp Ther Med

FGF23 alleviates neuronal apoptosis and inflammation, and promotes locomotion recovery via activation of PI3K/AKT signalling in spinal cord injury. [Abstract]

2023 May 22;26(1):340. PMID: 37383378

LY294002 purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2023 May 22;26(1):340. [Abstract]

LY294002 (10 µM; 12 h) significantly inhibits the proliferation of primary neuronal cells.

LY294002 purchased from MedChemExpress. Usage Cited in: Exp Ther Med. 2023 May 22;26(1):340. [Abstract]

LY294002 (10 µM; 12 h) significantly increases the expression of C-caspase3 protein and decreases the expression of Bcl-2 protein in primary neuronal cells.
Exp Ther Med

Oxymatrine inhibits TGF‑β1‑mediated mitochondrial apoptotic signaling in alveolar epithelial cells via activation of PI3K/AKT signaling. [Abstract]

2023 Mar 20;25(5):198. PMID: 37090069
Exp Ther Med

LPS inhibits TRIM65 expression in macrophages and C57BL/6J mouse by activating the ERK1/2 signaling pathway. [Abstract]

2023 Mar 14;25(4):188. PMID: 37021067
Exp Ther Med

Protective effect of hydroxysafflor yellow A on renal ischemia‑-reperfusion injury by targeting the Akt‑Nrf2 axis in mice. [Abstract]

2022 Nov 3;24(6):741. PMID: 36478883
Biochem Cell Biol

SET8, a novel regulator to ameliorate vascular calcification via activating PI3K/Akt mediated anti-apoptotic effects. [Abstract]

2022 Apr;100(2):104-114. PMID: 34846946
Exp Ther Med

Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3β signaling pathway. [Abstract]

2021 Dec;22(6):1400. PMID: 34675994
Exp Ther Med

Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway-mediated inhibition of apoptosis, oxidative stress and autophagy. [Abstract]

2021 Aug;22(2):811. PMID: 34131434
Neurosci Lett

Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway. [Abstract]

2021 Apr 17:750:135793. PMID: 33667598
Exp Ther Med

PI3K inhibition sensitizes EGFR wild-type NSCLC cell lines to erlotinib chemotherapy. [Abstract]

2021 Jan;21(1):9. PMID: 33235618
Exp Ther Med

TRIM31 enhances chemoresistance in glioblastoma through activation of the PI3K/Akt signaling pathway. [Abstract]

2020 Aug;20(2):802-809. PMID: 32765650
Exp Ther Med

microRNA-mediated GAS1 downregulation promotes the proliferation of synovial fibroblasts by PI3K-Akt signaling in osteoarthritis. [Abstract]

2019 Dec;18(6):4273-4286. PMID: 31777535
Exp Ther Med

Insulin-like growth factor 2 promotes the adipogenesis of hemangioma-derived stem cells. [Abstract]

2019 Mar;17(3):1663-1669. PMID: 30867686
J Stroke Cerebrovasc Dis

Knockdown of programmed cell death 4 inhibits endoplasmic reticulum stress in male mice with intracerebral hemorrhage through the phosphoinositide 3-kinase/protein kinase B pathway. [Abstract]

2026 Feb;35(2):108554. PMID: 41513163
J Stroke Cerebrovasc Dis

Melatonin attenuates brain edema via the PI3K/Akt/Nrf2 pathway in rats with cerebral ischemia-reperfusion injury. [Abstract]

2025 Jun;34(6):108299. PMID: 40158783
J Reprod Dev

Role and action mechanisms of tPA in CRH-induced apoptosis of mouse oviductal epithelial and mural granulosa cells. [Abstract]

2024 Aug 7;70(4):238-246. PMID: 38910127
Oncol Lett

Hematoporphyrin derivative photodynamic therapy induces apoptosis and suppresses the migration of human esophageal squamous cell carcinoma cells by regulating the PI3K/AKT/mTOR signaling pathway. [Abstract]

2023 Nov 15;27(1):17. PMID: 38034489
Can Respir J

Effects of Different Intervention Factors on Vascular Endothelial Growth Factor-Induced Human Airway Smooth Muscle Cell Migration. [Abstract]

2022 Oct 10:2022:6879539. PMID: 36262381
Neuroreport

Inhibition of immunoproteasome subunit low molecular mass polypeptide 7 with ONX-0914 improves hypoxic-ischemic brain damage via PI3K/Akt signaling. [Abstract]

2021 Oct 6;32(14):1206-1215. PMID: 34406990
Leuk Lymphoma

miR-145-5p exerts anti-tumor effects in diffuse large B-cell lymphoma by regulating S1PR1/STAT3/AKT pathway. [Abstract]

2021 Aug;62(8):1884-1891. PMID: 33715582
Oncol Lett

PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway. [Abstract]

2021 Jul;22(1):534. PMID: 34084215
Neuroreport

Twisted gastrulation signaling modulator 1 promotes the ability of glioma cell through activating Akt pathway. [Abstract]

2021 Feb 3;32(3):198-205. PMID: 33534374
BMC Ophthalmol

Nerve growth factor promotes the proliferation of Müller cells co-cultured with internal limiting membrane by regulating cell cycle via Trk-A/PI3K/Akt pathway. [Abstract]

2019 Jun 17;19(1):130. PMID: 31208396
Oncol Lett

Triptolide suppresses the proliferation and induces the apoptosis of nasopharyngeal carcinoma cells via the PI3K/Akt pathway. [Abstract]

2019 Jan;17(1):1372-1378. PMID: 30655908

LY294002 purchased from MedChemExpress. Usage Cited in: Oncol Lett. 2019 Jan;17(1):1372-1378. [Abstract]

Pretreatment of C666-1 cells with the phosphatidylinositol 3-kinase/Akt inhibitor LY294002 counteracts the triptolide‑induced inhibition of proliferation and apoptosis.
Oncol Lett

S100A6 promotes the proliferation and migration of cervical cancer cells via the PI3K/Akt signaling pathway. [Abstract]

2018 Apr;15(4):5685-5693. PMID: 29552203

LY294002 purchased from MedChemExpress. Usage Cited in: Oncol Lett. 2018 Apr;15(4):5685-5693. [Abstract]

HeLa cells are treated with GST S100A6 and LY294002 for 72 h, and total Akt, total GSK3β, β catenin, p Akt and p GSK3β are detected using western blotting
Genes Genomics

2026 Jul 28. PMID: 42518168
Int J Genomics

Growth Hormone Alleviates Atherosclerosis Through Regulating the Activity of PI3K/AKT Pathway: Insights From Single-Cell Sequence and Mechanism Exploration. [Abstract]

2025 Oct 13:2025:9710652. PMID: 41089172
In Vitro Cell Dev Biol Anim

Radiotherapy promotes M2 polarization of macrophages through the regulation of the PTEN/PI3K/AKT signaling pathway through miR-616-3p in lung cancer cell-derived exosomes. [Abstract]

2025 Oct 27. PMID: 41143935
Curr Med Sci

ESE-1 Regulates CREB-Mediated PTEN Expression to Activate the PI3K/Akt Pathway and Promote High-Glucose-Induced Endothelial Cell Injury. [Abstract]

2025 Sep 16. PMID: 40956491
OMICS

Integrative Genomic and Immune Profiling to Identify and Characterize High-Risk Subgroups in Acute Myeloid Leukemia: Development of a 20-Gene Predictive Signature and Its Clinical Implications. [Abstract]

2025 Sep;29(9):458-472. PMID: 40844427
Curr Med Sci

FKBP5 Regulates the Osteogenesis of Human Adipose-derived Mesenchymal Stem Cells. [Abstract]

2024 Dec;44(6):1270-1279. PMID: 39586968
Genes Environ

Astaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-κB pathways via miR-29a-3p. [Abstract]

2024 Apr 22;46(1):10. PMID: 38649975
World Neurosurg

N-acetylserotonin protects rat nucleus pulposus cells against oxidative stress injury by activating the PI3K/AKT signaling pathway. [Abstract]

2023 Aug:176:e109-e124. PMID: 37169069
J Appl Anim Res

2023 May 11.
Exp Anim

Calcium and integrin binding protein 1 (CIB1) induces myocardial fibrosis in myocardial infarction via regulating the PI3K/Akt pathway. [Abstract]

2022 Feb 9;71(1):1-13. PMID: 34349085
In Vitro Cell Dev Biol Anim

Angiotensin II induces apoptosis of cardiac microvascular endothelial cells via regulating PTP1B/PI3K/Akt pathway. [Abstract]

2019 Dec;55(10):801-811. PMID: 31502193
Eur J Histochem

Electroacupuncture combined with rTMS promotes neuronal regeneration via DNMT1-mediated PI3K-AKT pathway in cerebral palsy model. [Abstract]

2026 Apr 20;70(2). PMID: 42007516
Mol Clin Oncol

A cascade via CD276/PI3K/SIRT1/E-Cad in overcoming contact inhibition of proliferation in hepatocellular carcinoma cells. [Abstract]

2026 Mar 13;24(5):32. PMID: 41929234
Neurol Res

AATF alleviates cerebral ischemia-reperfusion injury by suppressing endoplasmic reticulum stress-induced ferroptosis through upregulating the PI3K/Akt pathway. [Abstract]

2025 Nov 10:1-17. PMID: 41215590
Neurol Res

TPEN attenuates neuronal ferroptosis in ischemic brain injury via GPR39-mediated PI3K/AKT signaling activation. [Abstract]

2025 Oct 21:1-14. PMID: 41117931
Biochem Genet

GCNT3 Promotes Hepatocellular Carcinoma Progression and EMT by Activating the PI3K/AKT Pathway. [Abstract]

2025 Jun;63(3):2423-2437. PMID: 38789846
Braz J Med Biol Res

Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling. [Abstract]

2025 Mar 24:58:e14408. PMID: 40136230
J Investig Med

Propofol alleviates spinal cord ischemia-reperfusion injury by preserving PI3K/AKT/GIT1 axis. [Abstract]

2024 Oct;72(7):705-714. PMID: 38715211
Connect Tissue Res

Proanthocyanidins inhibit the apoptosis and aging of nucleus pulposus cells through the PI3K/Akt pathway delaying intervertebral disc degeneration. [Abstract]

2022 Nov;63(6):650-662. PMID: 35491814
Connect Tissue Res

Naringin alleviates H2O2-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells. [Abstract]

2020 Nov;61(6):554-567. PMID: 31294637
Respir Physiol Neurobiol

The Cosmc-mediated effects of neutrophil elastase on T antigen expression in BEAS-2B cells. [Abstract]

2020 Oct:281:103496. PMID: 32683071
J Interferon Cytokine Res

MCP-1/CCL2 Mediated by Autocrine Loop of PDGF-BB Promotes Invasion of Lung Cancer Cell by Recruitment of Macrophages Via CCL2-CCR2 Axis. [Abstract]

2019 Apr;39(4):224-232. PMID: 30730243
Cancer Biomark

Hsa_circ_0101308 adjusted by N6-methyladenosine (m6A) impacts chemo-resistance in cervical cancer via sponging miR-224. [Abstract]

2025 Jun;42(6):18758592251341157. PMID: 40534305
Am J Transl Res

LncRNA FGD5-AS1 reduces cardiomyocyte apoptosis and inflammation by modulating Akt and miR-223-3p expression. [Abstract]

2022 Sep 15;14(9):6175-6186. PMID: 36247255
Mol Vis

Ligustrazine protects against chronic hypertensive glaucoma in rats by inhibiting autophagy via the PI3K-Akt/mTOR pathway. [Abstract]

2021 Dec 12;27:725-733. PMID: 35035207
Am J Transl Res

Kinesin family member 2A promotes cancer cell viability, mobility, stemness, and chemoresistance to cisplatin by activating the PI3K/AKT/VEGF signaling pathway in non-small cell lung cancer. [Abstract]

2021 Apr 15;13(4):2060-2076. PMID: 34017375
Can J Physiol Pharmacol

Effects of inhibiting the PI3K/Akt/mTOR signaling pathway on the pain of sciatic endometriosis in a rat model. [Abstract]

2019 Oct;97(10):963-970. PMID: 31461309
Iran J Pharm Res

Amelioratory Effect of Melatonin on Cognition Dysfunction Induced by Sevoflurane Anesthesia in Aged Mice. [Abstract]

2023 Jan 24;21(1):e133971. PMID: 36896324
Reprod Domest Anim

Melatonin protects sheep endometrial epithelial cells against lipopolysaccharide-induced inflammation in vitro. [Abstract]

2022 Dec;57(12):1602-1614. PMID: 36018566
Genet Mol Biol

EPO activates PI3K-IKKα-CDK1 signaling pathway to promote the proliferation of Glial Cells under hypoxia environment. [Abstract]

2022 Feb 11;45(1):e20210249. PMID: 35167649
Reprod Domest Anim

Vitamin E regulates bovine granulosa cell apoptosis via NRF2-mediated defence mechanism by activating PI3K/AKT and ERK1/2 signalling pathways. [Abstract]

2021 Aug;56(8):1066-1084. PMID: 33978262
Lett Drug Des Discov

2026 Jan 16.
Tohoku J Exp Med

Mammalian Sterile 20-Like Kinase 1 Knockdown Reduces Sevoflurane-Induced Oxidative Stress in HT22 and SH-SY5Y Cells via AKT Phosphorylation and YAP1 Transcriptional Activity. [Abstract]

2026 Apr 23. PMID: 42021017
Chem Pharm Bull

Porcine Acellular Dermal Matrix Promotes Migration and Suppresses Inflammation of Keratinocytes by Mediating the AKT Signaling Pathway. [Abstract]

2023;71(12):852-858. PMID: 38044138
Nat Prod Commun

June 22, 2022.
Biomed Res

2017; 28 (8): 3383-3386

LY294002 purchased from MedChemExpress. Usage Cited in: Biomed Res. 2017; 28 (8): 3383-3386

Effects of various protease inhibitors on HO-1 and P-gp protein expressions.
Mol Cell Toxicol

2026 Feb 22.
J Cancer Res Ther

Proteomic analysis of the influence of CO2 pneumoperitoneum in cervical cancer cells. [Abstract]

2021 Nov;17(5):1253-1260. PMID: 34850775
Int J Clin Exp Pathol

TGF-β1/Smad3 signaling promotes collagen synthesis in pulmonary artery smooth muscle by down-regulating miR-29b. [Abstract]

2018 Dec 1;11(12):5592-5601. PMID: 31949646
Indiana University

2026.
Res Sq

2026 Jun 23.
Res Sq

2026 Jun 12.
Res Sq

2026 Jun 29.
Res Sq

2026 May 6.
SSRN

2026 Apr 16
Immun Inflamm

2026 Apr 14;2(1):20.
SSRN

2026 Mar 29.
bioRxiv

2026 Mar 29.
bioRxiv

Spatially Distinct Myosin II Architectures Regulate Protrusion Dynamics and Directional Persistence during Immune Cell Migration. [Abstract]

2026 Mar 16:2026.03.13.711384. PMID: 41889862
SSRN

2026 Mar 19.
bioRxiv

2026 Feb 10.
Res Sq

2026 Feb 20.
Res Sq

2026 Jan 15.
SSRN

2025 Dec 12.
bioRxiv

A human sensory neuron model for varicella-zoster virus latency and reactivation in vitro. [Abstract]

2025 Dec 12:2025.12.12.693952. PMID: 41415445
bioRxiv

2025 Nov 8.
Brain Mechanisms

2025 Nov 21.
bioRxiv

2025 Nov 12.
Hong Kong University of Science and Technology

2025.
SSRN

2025 Sep 30.
SSRN

2025 Oct 9.
Pediatr Discov

Succinate Promotes M1 Polarization of Intestinal Macrophages in Mice With Necrotizing Enterocolitis Through the PI3K/AKT Pathway. [Abstract]

2025 Sep 27;3(4):e70026. PMID: 41476733
Biomed Pharmacother

Soyasapogenol B prevents sarcopenia by increasing skeletal muscle mass and function through the Sirt1/PGC-1α and PI3K pathway. [Abstract]

2025 Aug:189:118316. PMID: 40618584
Res Sq

2025 Aug 20.
Princeton University

2025.
SSRN

2025 Jun 19.
SSRN

2025 May 2.
Authorea

2025 Apr 18.
SSRN

2025 Apr 18.
bioRxiv

Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition. [Abstract]

2025 Mar 19:2025.03.19.644113. PMID: 40166179
Patent

US20250025542A1.
University of Verona

2025.
University of Verona

2025.
Research Square Preprint

2024 Nov 18.
Heliyon

Small extracellular vesicles derived from miRNA-486 overexpressed dental pulp stem cells mitigate high altitude pulmonary edema through PTEN/PI3K/AKT/eNOS pathway. [Abstract]

2025 Jan 14;11(2):e41960. PMID: 39906863
University of Sheffield

2024 Nov 05.
bioRxiv

2024 November 03.
Res Sq

2024 Oct 29.
SSRN

2024 Oct 16.
Chemosphere

Early pregnancy exposure to Microcystin-LR compromises endometrial decidualization in mice via the PI3K/AKT/FOXO1 signaling pathway. [Abstract]

2024 Oct:366:143466. PMID: 39369752
bioRxiv

2024 September 22.
Heliyon

Leptin protects chondrocytes by inhibiting autophagy via phosphoinositide 3 kinase/protein kinase B/mammalian target of rapamycin signaling pathway. [Abstract]

2024 Aug 6;10(15):e35665. PMID: 39170379
Res Sq

2024 Jun 10.
bioRxiv

2024 June 03.
Res Sq

2024 May 9.
Biomed Pharmacother

Maximakinin reversed H2O2 induced oxidative damage in rat cardiac H9c2 cells through AMPK/Akt and AMPK/ERK1/2 signaling pathways. [Abstract]

2024 May:174:116489. PMID: 38513595
Research Square Preprint

2024 Apr 17.
Research Square Preprint

2024 Apr 19.
Research Square Preprint

2024 Apr 22.
Research Square Preprint

2024 Mar 25.
Sci Total Environ

TRPA1-PI3K/Akt-OPA1-ferroptosis axis in ozone-induced bronchial epithelial cell and lung injury. [Abstract]

2024 Mar 25:918:170668. PMID: 38320701
Elife

Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1. [Abstract]

2024 Feb 20:13:e85985. PMID: 38375778
Biomed Pharmacother

P-coumaric acid ameliorates Aβ25-35-induced brain damage in mice by modulating gut microbiota and serum metabolites. [Abstract]

2023 Dec:168:115825. PMID: 37924791
Environ Toxicol

1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/Akt pathway in vitro. [Abstract]

2023 Nov;38(11):2621-2631. PMID: 37466199
Research Square Preprint

2023 Oct 10.
SSRN

2023 Sep 13.
SSRN

2023 Jul 30.
Research Square Preprint

2023 May 25.
Heliyon

Activation of PPAR-γ prevents TERT-mediated pulmonary vascular remodeling in MCT-induced pulmonary hypertension. [Abstract]

2023 Mar 4;9(3):e14173. PMID: 36938425
Front Med

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma. [Abstract]

2023 Feb;17(1):119-131. PMID: 36525138
Heliyon

Konjac glucomannan defends against high-fat diet-induced atherosclerosis in rabbits by promoting the PI3K/Akt pathway. [Abstract]

2023 Feb 13;9(2):e13682. PMID: 36852043
Authorea

2023 Feb 2.
SSRN

2023 Feb 6.
SSRN

2023 Feb 2.
bioRxiv

2023 Feb 14.

LY294002 purchased from MedChemExpress. Usage Cited in: bioRxiv. 2023 Feb 14.

Both of LY294002 (LY; 30 μM) and Wortmannin (Wort; 50 nM) can downregulate the expression of ACE2 in HPAEpiC cells.
Research Square Print

January 3rd, 2023.
Research Square Print

Nov 2nd, 2022
Evid Based Complement Alternat Med

Arbutin Inhibited Heat Stress-Induced Apoptosis and Promoted Proliferation and Migration of Heat-Injured Dermal Fibroblasts and Keratinocytes by Activating PI3K/AKT Signaling Pathway. [Abstract]

2022 Sep 15;2022:8798861. PMID: 36159569
Oxid Med Cell Longev

KDM3A Attenuates Myocardial Ischemic and Reperfusion Injury by Ameliorating Cardiac Microvascular Endothelial Cell Pyroptosis. [Abstract]

2022 Sep 2:2022:4622520. PMID: 36092165
Research Square Print

2022 Aug.
Biomed Pharmacother

PPARγ activation inhibits PDGF-induced pulmonary artery smooth muscle cell proliferation and migration by modulating TERT. [Abstract]

2022 Aug:152:113233. PMID: 35689861
Research Square Print

2022 Jul.
Research Square Preprint

2022 Jun.
Oxid Med Cell Longev

Adipose Mesenchymal Stromal Cell-Derived Exosomes Prevent Testicular Torsion Injury via Activating PI3K/AKT and MAPK/ERK1/2 Pathways. [Abstract]

2022 Jun 16:2022:8065771. PMID: 35757503
Oxid Med Cell Longev

Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4-PGC-1 α-PPAR α/PPAR γ Signaling in Isolated Beating Rat Atria. [Abstract]

2022 Jun 20;2022:5905374. PMID: 35770043
Research Square Preprint

2022 May.
Biomed Pharmacother

Activation of α7nAChR preserves intestinal barrier integrity by enhancing the HO-1 / STAT3 signaling to inhibit NF-κB activation in mice. [Abstract]

2022 May:149:112733. PMID: 36068769
Research Square Print

2022 May.
Research Square Print

2022 May.
Research Square Preprint

2022 May.
Ann Transl Med

Fraxetin alleviates microglia-mediated neuroinflammation after ischemic stroke. [Abstract]

2022 Apr;10(8):439. PMID: 35571418
Dis Markers

Liraglutide Alleviates Diabetic Atherosclerosis through Regulating Calcification of Vascular Smooth Muscle Cells. [Abstract]

2022 Apr 25;2022:5013622. PMID: 35510038
Oxid Med Cell Longev

1,25(OH)2D3 Mitigates Oxidative Stress-Induced Damage to Nucleus Pulposus-Derived Mesenchymal Stem Cells through PI3K/Akt Pathway. [Abstract]

2022 Mar 18;2022:1427110. PMID: 35340208
Research Square Preprint

2022 Mar.
Research Square Preprint

2022 Feb.
Int J Biol Sci

Cancer-associated adipocytes promote the invasion and metastasis in breast cancer through LIF/CXCLs positive feedback loop. [Abstract]

2022 Jan 16;18(4):1363-1380. PMID: 35280694
Ann Transl Med

Activation of the AKT/GSK-3β/β-catenin pathway via photobiomodulation therapy promotes neural stem cell proliferation in neonatal rat models of hypoxic-ischemic brain damage. [Abstract]

2022 Jan;10(2):55. PMID: 35282079
Bioengineered

Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway. [Abstract]

2022 Jan;13(1):1320-1334. PMID: 35000528
Ann Transl Med

Asiaticoside alleviates cardiomyocyte apoptosis and oxidative stress in myocardial ischemia/reperfusion injury via activating the PI3K-AKT-GSK3β pathway in vivo and in vitro. [Abstract]

2022 Jan;10(2):69. PMID: 35282120
Bioengineered

miR-186-3p attenuates the tumorigenesis of cervical cancer via targeting insulin-like growth factor 1 to suppress PI3K-Akt signaling pathway. [Abstract]

2021 Dec;12(1):7079-7092. PMID: 34551673
Research Square Preprint

2021 Nov.
Ann Transl Med

Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/PPARγ signaling pathway. [Abstract]

2021 Oct;9(20):1547. PMID: 34790753
Research Square Preprint

2021 Oct.
Research Square Preprint

2021 Oct.
Oxid Med Cell Longev

Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGF β R Regulating TGF- β/Smad Pathway. [Abstract]

2021 Oct 18;2021:2337818. PMID: 34712379
Research Square Preprint

2021 Sep.
J Oncol

CWHM-1008 Induces Apoptosis and Protective Autophagy through the Akt/mTOR Axis in LUAD Cells. [Abstract]

2021 Sep 11:2021:5548128. PMID: 35096055
Ann Transl Med

Daidzein ameliorated concanavalin A-induced liver injury through the Akt/GSK-3β/Nrf2 pathway in mice. [Abstract]

2021 Aug;9(15):1228. PMID: 34532365
Oxid Med Cell Longev

Protective Activity of Aspirin Eugenol Ester on Paraquat-Induced Cell Damage in SH-SY5Y Cells. [Abstract]

2021 Aug 4:2021:6697872. PMID: 34394831
Oxid Med Cell Longev

Deficiency of ROS-Activated TRPM2 Channel Protects Neurons from Cerebral Ischemia-Reperfusion Injury through Upregulating Autophagy. [Abstract]

2021 Jul 27;2021:7356266. PMID: 34367466
Research Square Preprint

2021 Jul.
Research Square Preprint

2021 Jul.
Research Square Preprint

2021 Jul.
Aging (Albany NY)

Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway. [Abstract]

2021 Jun 11;13(12):16105-16123. PMID: 34118791
Oxid Med Cell Longev

The Protective Effect of Aspirin Eugenol Ester on Oxidative Stress to PC12 Cells Stimulated with H2O2 through Regulating PI3K/Akt Signal Pathway. [Abstract]

2021 Jun 24:2021:5527475. PMID: 34257805
Oxid Med Cell Longev

PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway. [Abstract]

2021 Jun 2:2021:9980444. PMID: 34285767
Research Square Preprint

2021 May.
Endocrinol Diabetes Nutr

Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic β-cells via the PI3K/Akt/FoxO1 signaling pathway. [Abstract]

2021 May;68(5):329-337. PMID: 33069631
Research Square Preprint

2021 Feb.
Aging (Albany NY)

Identification of novel candidate biomarkers for pancreatic adenocarcinoma based on TCGA cohort. [Abstract]

2021 Feb 11;13(4):5698-5717. PMID: 33591944
Aging (Albany NY)

The protective effects of memantine against inflammation and impairment of endothelial tube formation induced by oxygen-glucose deprivation/reperfusion. [Abstract]

2020 Nov 7;12(21):21469-21480. PMID: 33174867
Ann Transl Med

Cimetidine promotes STUB1-mediated degradation of tumoral FOXP3 by activating PI3K-Akt pathway in gastric cancer. [Abstract]

2020 Oct;8(20):1304. PMID: 33209884
Research Square Preprint

2020 Sep.
Universidad de Granada

2020 Sep.
Aging (Albany NY)

LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway. [Abstract]

2020 Sep 5;12(16):16142-16154. PMID: 32628130
Research Square Preprint

2020 Aug.
Research Square Preprint

2020 May.
Research Square Preprint

2020 May.
Preprints

2020 Apr.
Oxid Med Cell Longev

Kaji-Ichigoside F1 and Rosamultin Protect Vascular Endothelial Cells against Hypoxia-Induced Apoptosis via the PI3K/AKT or ERK1/2 Signaling Pathway. [Abstract]

2020 Apr 12:2020:6837982. PMID: 32318240
Oxid Med Cell Longev

NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling. [Abstract]

2019 Dec 4:2019:4286213. PMID: 31885790
Elife

Homeostasis of branched-chain amino acids is critical for the activity of TOR signaling in Arabidopsis. [Abstract]

2019 Dec 6:8:e50747. PMID: 31808741
Biomed Pharmacother

Platycodon grandiflorus enhances the effect of DDP against lung cancer by down regulating PI3K/Akt signaling pathway. [Abstract]

2019 Dec:120:109496. PMID: 31610427
Biomed Pharmacother

Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway. [Abstract]

2019 Jan:109:2309-2317. PMID: 30551489
Biomed Pharmacother

Down-regulation of Rictor enhances cell sensitivity to PI3K inhibitor LY294002 by blocking mTORC2-medicated phosphorylation of Akt/PRAS40 in esophageal squamous cell carcinoma. [Abstract]

2018 Oct:106:1348-1356. PMID: 30119206

LY294002 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Oct:106:1348-1356. [Abstract]

ECa109 and EC9706 cells are treated with various doses of LY294002 (0, 10, 20 μM) for 24 h. Total proteins are extracted for the analysis of key proteins in PI3K/Akt/ mTOR signaling pathway by Western blot.

LY294002 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Oct:106:1348-1356. [Abstract]

ECa109 and EC9706 cells are treated with 20 μM LY294002 for different time (0, 3, 6, 12, 24 h). Total proteins are extracted for the analysis of key proteins in PI3K/Akt/ mTOR signaling pathway by Western blot.
Eur Rev Med Pharmacol Sci

L-butyl phthalein improves neural function of vascular dementia mice by regulating the PI3K/AKT signaling pathway. [Abstract]

2018 Aug;22(16):5377-5384. PMID: 30178865

LY294002 purchased from MedChemExpress. Usage Cited in: Eur Rev Med Pharmacol Sci. 2018 Aug;22(16):5377-5384. [Abstract]

Western blot shows that L-NBP pretreatment significantly up-regulates p-AKT and Bcl2 protein contents in HT22 cells induced by I/R, whereas LY294002 intervention markedly alleviates the influence of L-NBP on p-AKT and Bcl-2 expressions.
Journal of Nanjing Agricultural University

2018, 41(4): 708-714.

LY294002 purchased from MedChemExpress. Usage Cited in: Journal of Nanjing Agricultural University. 2018, 41(4): 708-714.

Effects of PI3K inhibitors on the expression of Cdc2, Cdc25B and CyclinB1 in sertoli cells.
Biomed Pharmacother

Mitochondrial DNA content reduction induces aerobic glycolysis and reversible resistance to drug-induced apoptosis in SW480 colorectal cancer cells. [Abstract]

2018 Jul:103:729-737. PMID: 29684851

LY294002 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Jul:103:729-737. [Abstract]

Representative Western blots show the effect of PI3K inhibitor LY294002 treatment for 24 h on PI3K p110a, Akt phosphorylation (P-Akt) and mTOR phosphorylation (P-mTOR). Total Akt and GAPDH are also detected by Western blot.
Evid Based Complement Alternat Med

Xihuang Pill Induces Apoptosis of Human Glioblastoma U-87 MG Cells via Targeting ROS-Mediated Akt/mTOR/FOXO1 Pathway. [Abstract]

2018 Jun 26:2018:6049498. PMID: 30046342

LY294002 purchased from MedChemExpress. Usage Cited in: Evid Based Complement Alternat Med. 2018 Jun 26:2018:6049498. [Abstract]

Western blot analysis of AKT, p-Akt, mTOR, p-mTOR, FOXO1 and p-FOXO1 expression in U-87 MG cells after treatment with LY294002 (20 μM), Rapamycin (50 nM) or NAC (5 mM) with or without Xihuang pill (XHP).
Eur Rev Med Pharmacol Sci

Granulocyte colony-stimulating factor improves neurological function and angiogenesis in intracerebral hemorrhage rats. [Abstract]

2018 Apr;22(7):2005-2014. PMID: 29687856

LY294002 purchased from MedChemExpress. Usage Cited in: Eur Rev Med Pharmacol Sci. 2018 Apr;22(7):2005-2014. [Abstract]

Western blot detection of p-AKT and Bcl-2 protein expressions in brain tissue. LY294002 treatment apparently alleviates PI3K/AKT signaling pathway activity, Bcl-2, and VEGF protein expressions.
Oncotarget

Leucine mediates autophagosome-lysosome fusion and improves sperm motility by activating the PI3K/Akt pathway. [Abstract]

2017 Dec 4;8(67):111807-111818. PMID: 29340093
Biomed Pharmacother

Fusaric acid (FA) protects heart failure induced by isoproterenol (ISP) in mice through fibrosis prevention via TGF-β1/SMADs and PI3K/AKT signaling pathways. [Abstract]

2017 Sep:93:130-145. PMID: 28624424
Bosn J Basic Med Sci

Nitric oxide synthesis-promoting effects of valsartan in human umbilical vein endothelial cells via the Akt/adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway. [Abstract]

2017 May 20;17(2):132-137. PMID: 28178430

LY294002 purchased from MedChemExpress. Usage Cited in: Bosn J Basic Med Sci. 2017 May 20;17(2):132-137. [Abstract]

Effects of Akt/adenosine monophosphate-activated protein kinaseon CGP 48933 (VAL)-mediated endothelial nitric oxide (NO) synthase (eNOS) phosphorylation and NO production in human umbilical vein endothelial cells (HUVECs). (A) The variation of VAL (10 μM)-induced eNOS activation after HUVECs are incubated with LY294002 [LY] (10 μM), Compound C (1 μM), L-NAME (500 μM) for 3 hours. (B)The variation of VAL (10 μM)-induced nitric oxide (NO) productionafter HUVECs are incubated with LY294002 (10 μM),
Lingnan Modern Clinics in Surgery

2014,14(03):247-251.

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (162.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (162.69 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2537 mL

16.2686 mL

32.5373 mL

5 mM

0.6507 mL

3.2537 mL

6.5075 mL

10 mM

0.3254 mL

1.6269 mL

3.2537 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.25 mg/mL (7.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.25 mg/mL (7.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.25 mg/mL (7.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/saline water

Solubility: 15.71 mg/mL (51.12 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (285 KB)
SDS (393 KB)
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- Deutsch - DE (393 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chaussade C, et al. Evidence for functional redundancy of class IA PI3K isoforms. Biochem J. 2007 Jun 15;404(3):449-58. [Content Brief]

[2]. Gharbi SI, et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J. 2007 May 15;404(1):15-21. [Content Brief]

[3]. Davidson D, et al. Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond. Front Pharmacol. 2013 Jan 31;4:5. [Content Brief]

[4]. Jiang H, et al. Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma invitro and in vivo. J Exp Clin Cancer Res. 2010 Apr 22;29:34. [Content Brief]

[5]. Md Mokhtar AH, et al. LY294002, a PI3K pathway inhibitor, prevents leptin-induced adverse effects on spermatozoa in Sprague-Dawley rats. Andrologia. 2019 Apr;51(3):e13196. [Content Brief]

[6]. Yi-Jen Hsueh, et al. Lysophosphatidic acid induces YAP-promoted proliferation of human corneal endothelial cells via PI3K and ROCK pathways. Mol Ther Methods Clin Dev. 2015 Apr 29;2:15014. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / Ethanol	1 mM	3.2537 mL	16.2686 mL	32.5373 mL	81.3431 mL
	5 mM	0.6507 mL	3.2537 mL	6.5075 mL	16.2686 mL
	10 mM	0.3254 mL	1.6269 mL	3.2537 mL	8.1343 mL
	15 mM	0.2169 mL	1.0846 mL	2.1692 mL	5.4229 mL
	20 mM	0.1627 mL	0.8134 mL	1.6269 mL	4.0672 mL
	25 mM	0.1301 mL	0.6507 mL	1.3015 mL	3.2537 mL
	30 mM	0.1085 mL	0.5423 mL	1.0846 mL	2.7114 mL
	40 mM	0.0813 mL	0.4067 mL	0.8134 mL	2.0336 mL
	50 mM	0.0651 mL	0.3254 mL	0.6507 mL	1.6269 mL
	60 mM	0.0542 mL	0.2711 mL	0.5423 mL	1.3557 mL
	80 mM	0.0407 mL	0.2034 mL	0.4067 mL	1.0168 mL
	100 mM	0.0325 mL	0.1627 mL	0.3254 mL	0.8134 mL

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LY294002

1219 Cited Publications

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LY294002

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