Umckalin
Umckalin is Coumarin (HY-N0709) derivative that exhibits anti-inflammatory properties. Umckalin reduces phosphorylation of p38 MAPK, JNK, and ERK, lowers TNF-α, IL-6, IL-1β, NO, and PGE2 production. Umckalin can be used for the research of chronic inflammatory diseases.
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- CAS No.: 43053-62-9
- Formule: C11H10O5
- Masse moléculaire:222.19
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Umckalin (25-400 µM; 72 h) does not reduce viability of B16F10 murine melanoma cells at concentrations up to 200 µM[2].
Umckalin (50-200 µM; 72 h) dose-dependently increases intracellular melanin content in B16F10 murine melanoma cells[2].
Umckalin (50-200 µM; 72 h) dose-dependently enhances tyrosinase activity in B16F10 murine melanoma cells[2].
Umckalin (50-200 µM; 24 h) upregulates TRP-1 and MITF protein expression in B16F10 murine melanoma cells, while having minimal to no effect on tyrosinase and TRP-2 expression[2].
Umckalin (50-200 µM; 24 h) activates the GSK-3β/β-catenin pathway in B16F10 murine melanoma cells by increasing Ser9 phosphorylation of GSK-3β, reducing β-catenin phosphorylation, and increasing total β-catenin levels[2].
Umckalin (50-200 µM; 4 h) suppresses MAPK pathway activity in B16F10 murine melanoma cells by reducing ERK and JNK phosphorylation, while not affecting p38 phosphorylation[2].
Umckalin (50-200 µM; 4 h) activates the PI3K/AKT pathway in B16F10 murine melanoma cells by increasing PI3K and AKT phosphorylationn[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B16F10 murine melanoma cells
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Concentration:25; 50; 100; 200; 400 µM
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Incubation Time:72 h
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Result:Showed no cytotoxic effects at concentrations up to 200 µM.
Caused significant cytotoxicity at 400 µM.
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Cell Line:B16F10 murine melanoma cells
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Concentration:50; 100; 200 µM
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Incubation Time:24 h
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Result:Increased TRP-1 protein expression significantly in a dose-dependent manner (p < 0.001 at all concentrations).
Caused a small but significant increase in tyrosinase expression only at 200 µM.
Had no notable effect on TRP-2 expression.
Increased MITF protein expression significantly in a dose-dependent manner.
Increased Ser9 phosphorylation of GSK-3β significantly in a dose-dependent manner.
Increased total β-catenin levels significantly only at 200 µM.
Reduced β-catenin phosphorylation significantly at 200 µM.
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Cell Line:B16F10 murine melanoma cells
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Concentration:50-200 µM
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Incubation Time:4 h
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Result:Reduced ERK phosphorylation significantly in a dose-dependent manner.
Reduced JNK phosphorylation significantly in a dose-dependent manner.
Had no significant effect on p38 phosphorylation.\nIncreased PI3K phosphorylation significantly in a dose-dependent manner.
Increased AKT phosphorylation significantly in a dose-dependent manner.
Chemical Information
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CAS No. 43053-62-9
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Masse moléculaire 222.19
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Formule C11H10O5
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SMILES
O=C1C=CC2=C(OC)C(OC)=C(O)C=C2O1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Umckalin Related Classifications
HY-N8712 Related Classifications
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