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Art. -Nr.: HY-125142

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AP-24567

AP-24567 is a Ligands for Target Protein for PROTAC, which can be used for the synthesis of SB1-G-187 (HY-137342).

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CAS. Nr.: 943319-87-7
Formel: C₂₈H₂₅F₃N₆O
Molecular Weight:518.53

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AP-24567 Chemical Structure

CAS. Nr.: 943319-87-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AP-24567 is a Ligands for Target Protein for PROTAC, which can be used for the synthesis of SB1-G-187 (HY-137342)^[1].

IC₅₀ & Target

Lyn

Yes

IRAK1

Alle Src Isoform-spezifische Produkte anzeigen :

Alle VEGFR Isoform-spezifische Produkte anzeigen :

Alle Bcr-Abl Isoform-spezifische Produkte anzeigen :

Abl
Bcr-Abl

Alle PDGFR Isoform-spezifische Produkte anzeigen :

Alle IRAK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	34 nM Compound: 20j	Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	4 nM Compound: 20j	Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	915 nM Compound: 20j	Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay	[PMID: 20513156]

In Vitro

AP-24567 is a PROTAC-targeted protein ligand^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 943319-87-7
Molecular Weight 518.53
Formel C₂₈H₂₅F₃N₆O
SMILES

O=C(NC1=CC=C(CN2CCNCC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Art. -Nr.:
Menge:
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AP-24567

Alle Src Isoform-spezifische Produkte anzeigen

Alle VEGFR Isoform-spezifische Produkte anzeigen

Alle Bcr-Abl Isoform-spezifische Produkte anzeigen

Alle PDGFR Isoform-spezifische Produkte anzeigen

Alle IRAK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

AP-24567 Related Classifications

HY-125142 Related Classifications