IDO1 - indoleamine 2,3-dioxygenase 1 Gene
Also Known as IDO; INDO; IDO-1
Species: Homo sapiens
About IDO1
This gene has 9 transcripts (splice variants) and 98 orthologues. Biased expression in placenta (RPKM 49.9), lymph node (RPKM 25.9) and 9 other tissues.
Summary
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
IDO1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_002164.6 | NP_002155.1 | indoleamine 2,3-dioxygenase 1 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables indoleamine 2,3-dioxygenase activity |
IMP
IMP: Inferred from mutant phenotype
|
25310899 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| involved in positive regulation of T cell apoptotic process |
IMP
IMP: Inferred from mutant phenotype
|
25310899 | GOA |
| NOT involved in regulation of activated T cell proliferation |
IMP
IMP: Inferred from mutant phenotype
|
25310899 | GOA |
IDO1 Protein Structure
IDO: Indoleamine 2,3-dioxygenase (10 - 399)
- 0
- 100
- 200
- 300
- 403 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
indoleamine 2,3-dioxygenase 1 |
|
|
Recombinant IDO1 Proteins
| Art. -Nr. | Produktname | Accession | Reinheit |
|---|---|---|---|
| HY-P70679 | IDO-1 Protein, Human (His) | P14902 (A2-G403) | ≥ 90%, as determined by reducing SDS-PAGE. |
IDO1 Antibodies
| Art. -Nr. | Produktname | Anwendung | Reactivity |
|---|---|---|---|
| HY-P83355 | Indoleamine 2,3-dioxygenase Antibody (YA3100) | WB, IHC-F, IHC-P, ICC/IF, IP | Human |
| HY-P83355A | Indoleamine 2,3-dioxygenase Antibody (YA3100)(PBS only) | WB, IHC-F, IHC-P, ICC/IF, IP | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Granulomatous Endometritis |
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| Major Depressive Disorder |
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| Toxoplasmosis |
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| Psychotic Disorder |
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| Human Immunodeficiency Virus Infectious Disease |
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| Melanoma |
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| Mood Disorder |
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| Autoimmune Disease |
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| Pre-Eclampsia |
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| Schizophrenia |
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| Disease By Infectious Agent |
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| Renal Cell Carcinoma, Nonpapillary |
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| Craniopharyngioma |
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| Metatypical Basal Cell Carcinoma |
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| Colorectal Cancer |
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| Melanoma, Uveal |
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| Listeriosis |
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| Multiple Sclerosis |
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| Eosinophilia-Myalgia Syndrome |
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| Thrombocytopenia |
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| Aspergillosis |
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| Inflammatory Bowel Disease |
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| Malaria |
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| Ovarian Cancer |
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| Bladder Disease |
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| Pellagra |
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| Encephalitis |
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| Asthma |
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| Colitis |
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| Trypanosomiasis |
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| Influenza |
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| Scrub Typhus |
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| Trachoma |
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| Chlamydia |
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| Immune Deficiency Disease |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | IDO1 | VGNC | VGNC:41865 |
| Bos taurus | IDO1 | VGNC | VGNC:30035 |
| Rattus norvegicus | IDO1 | RGD | RGD:619989 |
| Mus musculus | IDO1 | MGD | MGI:96416 |
| Macaca mulatta | IDO1 | VGNC | VGNC:73580 |
| Felis catus | IDO1 | VGNC | VGNC:67802 |
| Others | IDO1 | NCBI |