Csf1r - colony stimulating factor 1 receptor Gene

Also Known as c-fms; mrfms; CSF-1R; CSF-1-R; M-CSF-R

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 307403

About Csf1r

Primary_assembly 18: 54,546,659-54,590,415 forward strand.mRatBN7.2:CM026991.1

This gene has 7 transcripts (splice variants), 273 orthologues, 54 paralogues and is associated with 81 phenotypes. Biased expression in Spleen (RPKM 534.2), Lung (RPKM 243.9) and 8 other tissues.

Summary

Predicted to enable several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein Phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of osteoclast differentiation; and regulation of bone resorption. Predicted to be located in cell surface; nucleoplasm; and plasma membrane. Predicted to be part of CSF1-CSF1R complex and receptor complex. Predicted to be integral component of plasma membrane. Used to study anti-basement membrane glomerulonephritis; bone development disease; infertility; and lymphopenia. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Csf1r Products (1)

mRNA Protein Name
NM_001029901.1 NP_001025072.1 macrophage colony-stimulating factor 1 receptor precursor

Csf1r Protein Structure

IG_like

IG_like: smart00410 (71 - 144)

Ig

Ig: cd00096 (81 - 85)

Ig

Ig: cd00096 (98 - 101)

Ig

Ig: cd00096 (109 - 113)

Ig

Ig: cd00096 (131 - 134)

IG_like

IG_like: smart00410 (156 - 238)

Ig

Ig: cl11960 (246 - 338)

Ig

Ig: cd00096 (263 - 267)

Ig

Ig: cd00096 (277 - 281)

Ig

Ig: cd00096 (302 - 306)

Ig

Ig: cd00096 (318 - 323)

Ig

Ig: cd00096 (331 - 334)

Ig

Ig: cl11960 (342 - 441)

Ig

Ig: cd00096 (362 - 366)

Ig

Ig: cd00096 (376 - 380)

Ig

Ig: cd00096 (405 - 409)

Ig

Ig: cd00096 (419 - 424)

Ig

Ig: cd00096 (432 - 435)

Ig_3

Ig_3: pfam13927 (442 - 530)

PTKc_CSF-1R

PTKc_CSF-1R: cd05106 (584 - 956)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1022 a.a.
Protein Preferred Names Protein Names

macrophage colony-stimulating factor 1 receptor

  • CSF-1 receptor

  • fms proto-oncogene

  • proto-oncogene c-Fms

  • proto-oncogene fms

Recombinant Csf1r Proteins

Cat. No. Product Name Accession Purity
HY-P72954 CSF1R Protein, Rat (HEK293, Fc) D4ACA7 (A64-E554) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72955 CSF1R Protein, Rat (HEK293, His, solution) D4ACA7 (A64-E554) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16749 Pexidartinib 99.64% Yes
HY-16749A Pexidartinib hydrochloride 99.82% Yes
HY-12297 Sulfatinib Inhibitor 99.52% Unkown

Clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-132166 Velzatinib Inhibitor 99.40% Phase 3
HY-109190 Seralutinib Inhibitor 99.94% Phase 3
HY-145601 Tinengotinib Inhibitor 99.57% Phase 3
HY-124526 Chiauranib Inhibitor 98.97% Phase 3
HY-153920A Pimicotinib hydrochloride Inhibitor / Phase 3
HY-12768 Sotuletinib Inhibitor 99.97% Phase 2
HY-109086 Edicotinib Inhibitor 99.68% Phase 2
HY-19772 GSK3117391 Inhibitor 99.40% Phase 2
HY-159838 Enrupatinib Inhibitor 98.90% Phase 2
HY-161025 SYHA1813 Inhibitor 99.46% Phase 2
HY-136362 ARRY-382 Inhibitor 99.95% Phase 2
HY-159503A Segigratinib hydrochloride Inhibitor / Phase 2
HY-114153A PLX5622 hemifumarate Inhibitor 99.93% Phase 1
HY-100491 H3B-6527 Inhibitor 98.0% Phase 1
HY-111787 Elzovantinib Inhibitor 99.93% Phase 1
HY-101768 PRN1371 Inhibitor 99.78% Phase 1
HY-10204 OSI-930 98.33% Phase 1
Inhibitory Antibodies (6)
Cat. No. Product Name Effect
Purity Phase
HY-P99245 Emactuzumab Inhibitor 97.60% Phase 3
HY-P990043 Iluzanebart 98.63% Phase 2
HY-P99452 Axatilimab Inhibitor 99.59% Phase 2
HY-P99259 Cabiralizumab Inhibitor 99.73% Phase 2
HY-P99368 Lacnotuzumab Inhibitor 99.9% Phase 2
HY-P991048 AMG-820 Inhibitor 98% Phase 2

Pre-clinical Phase

Bioactive Molecules (64)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114153 PLX5622 Inhibitor 99.95% Unkown
HY-114153C PLX5622 in AIN-76A Diet (1200 ppm) Inhibitor / Unkown
HY-50905 Dovitinib Inhibitor 99.88% Yes
HY-12768A Sotuletinib hydrochloride Inhibitor 99.43% Unkown
HY-153920 Pimicotinib Inhibitor 99.92% Unkown
HY-10408 Ki20227 Inhibitor 99.51% Unkown
HY-101774 CSF1R-IN-1 Inhibitor 98.04% Unkown
HY-159108 AZ683 Inhibitor 98.57% Unkown
HY-117244 AZD7507 Inhibitor 99.57% Unkown
HY-147615 CSF1R-IN-12 98.75% Unkown
HY-122906 JTE-952 Inhibitor 99.86% Unkown
HY-152830 Adrixetinib 99.55% Unkown
HY-126297 c-Fms-IN-10 Inhibitor 98.63% Unkown
HY-139990 CSF1R-IN-3 Inhibitor 98.10% Unkown
HY-112451 cFMS Receptor Inhibitor II Inhibitor 99.88% Unkown
HY-132935 BPR1R024 Inhibitor 98.50% Unkown
HY-160842 CSF1R-IN-24 Inhibitor 98.10% Unkown
HY-117273 AZ304 Inhibitor 99.77% Unkown
HY-119942 c-Fms-IN-8 Inhibitor 99.50% Unkown
HY-152830A Adrixetinib TFA 99.82% Unkown
HY-101526 GENZ-882706 Inhibitor / Unkown
HY-13075 c-Fms-IN-3 Inhibitor 98.83% Unkown
HY-132935A BPR1R024 mesylate Inhibitor / Unkown
HY-RS03228 CSF1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13493 AC710 Inhibitor 99.57% Unkown
HY-13496 JNJ-28312141 Inhibitor / Unkown
HY-101034 CHMFL-ABL/KIT-155 / Unkown
HY-12768B Sotuletinib dihydrochloride Inhibitor / Unkown
HY-174366 JMC14 Inhibitor / Unkown
HY-109086A Edicotinib hydrochloride Inhibitor / Unkown
HY-13496A JNJ-28312141 hydrochloride Inhibitor / Unkown
HY-144040 CSF1R-IN-4 / Unkown
HY-144041 CSF1R-IN-5 Inhibitor / Unkown
HY-144042 CSF1R-IN-6 / Unkown
HY-147608 CSF1R-IN-7 Inhibitor / Unkown
HY-147609 CSF1R-IN-8 Inhibitor / Unkown
HY-147610 CSF1R-IN-9 Inhibitor / Unkown
HY-147611 CSF1R-IN-10 Inhibitor / Unkown
HY-147616 CSF1R-IN-13 / Unkown
HY-147617 CSF1R-IN-14 / Unkown
HY-153012 Axl/Mer/CSF1R-IN-1 Inhibitor / Unkown
HY-153243 IACS-9439 Inhibitor / Unkown
HY-153277 Axl/Mer/CSF1R-IN-2 Inhibitor / Unkown
HY-155001 CSF1R-IN-15 Inhibitor / Unkown
HY-155550 CSF1R-IN-17 Antagonist / Unkown
HY-157422 CSF1R-IN-19 Inhibitor / Unkown
HY-157996 CSF1R-IN-21 Inhibitor / Unkown
HY-158050 PXB17 Inhibitor / Unkown
HY-158148 CSF1R-IN-23 Inhibitor / Unkown
HY-158363 CSF1R-IN-25 Inhibitor / Unkown
HY-161084 CSF1R-IN-18 Inhibitor / Unkown
HY-162309 CSF1R-IN-20 Inhibitor / Unkown
HY-162415 CSF1R-IN-22 / Unkown
HY-168954 CSF1R-IN-26 / Unkown
HY-176194 Antifibrotic agent 1 / Unkown
HY-183569 CSF1R-IN-27 Inhibitor / Unkown
HY-183931 NPA101.3 Inhibitor / Unkown
HY-187340 CSF1R/c-Kit-IN-1 / Unkown
HY-187341 CSF1R/c-Kit-IN-2 Inhibitor / Unkown
HY-RS03229 Csf1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03230 Csf1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13493A AC710 Mesylate Inhibitor / Unkown
HY-164529 SJ-C1044 Inhibitor 98.63% Unkown
HY-174606 Human IL34 mRNA / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990125 Anti-Mouse CSF1R/CD115 Antibody (AFS98) 99.38% Unkown
HY-P990849 Anti-CSF1R/CD115 Antibody (2-4A5-4) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Csf1r NCBI NCBI:1436