Csf1r - colony stimulating factor 1 receptor Gene

Rattus norvegicus

Also known as c-fms; mrfms; CSF-1R; CSF-1-R; M-CSF-R

Gene ID: 307403 | Gene type: protein coding

About Csf1r

Primary_assembly 18: 54,546,659-54,590,415 forward strand.mRatBN7.2:CM026991.1

This gene has 7 transcripts (splice variants), 273 orthologues, 54 paralogues and is associated with 81 phenotypes. Biased expression in Spleen (RPKM 534.2), Lung (RPKM 243.9) and 8 other tissues.

Summary

Predicted to enable several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein Phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of osteoclast differentiation; and regulation of bone resorption. Predicted to be located in cell surface; nucleoplasm; and plasma membrane. Predicted to be part of CSF1-CSF1R complex and receptor complex. Predicted to be integral component of plasma membrane. Used to study anti-basement membrane glomerulonephritis; bone development disease; infertility; and lymphopenia. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Csf1r Products(1)

mRNA	Protein	Name
NM_001029901.1	NP_001025072.1	macrophage colony-stimulating factor 1 receptor precursor

Csf1r Protein Structure

IG_like

Ig_3

PTKc_CSF-1R

0
200
400
600
800
1022 a.a.

Protein Preferred Names

Protein Names

macrophage colony-stimulating factor 1 receptor

CSF-1 receptor	fms proto-oncogene
proto-oncogene c-Fms	proto-oncogene fms

Recombinant Csf1r Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72954	CSF1R Protein, Rat (HEK293, Fc)	D4ACA7 (M1-E510)	≥95%
HY-P72955	CSF1R Protein, Rat (HEK293, His)	D4ACA7 (A64-E554)	≥95%

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16749	Pexidartinib		99.64%	Yes
HY-16749A	Pexidartinib hydrochloride		99.86%	Yes
HY-12297	Sulfatinib	Inhibitor	98.65%	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50905	Dovitinib	Inhibitor	99.94%	Phase 3
HY-124526	Chiauranib	Inhibitor	99.28%	Phase 3
HY-12768	Sotuletinib	Inhibitor	99.78%	Phase 2
HY-109086	Edicotinib	Inhibitor	98.78%	Phase 2
HY-111787	Elzovantinib	Inhibitor	99.97%	Phase 2
HY-109190	Seralutinib	Inhibitor	99.77%	Phase 2
HY-12768A	Sotuletinib hydrochloride	Inhibitor	98.84%	Phase 2
HY-114153	PLX5622	Inhibitor	99.95%	Phase 1
HY-114153A	PLX5622 hemifumarate	Inhibitor	99.64%	Phase 1
HY-101768	PRN1371	Inhibitor	99.43%	Phase 1
HY-10204	OSI-930		98.57%	Phase 1

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99245	Emactuzumab	Inhibitor	97.60%	Phase 3
HY-P99259	Cabiralizumab	Inhibitor	99.59%	Phase 2
HY-P99452	Axatilimab	Inhibitor	99.59%	Phase 2
HY-P99368	Lacnotuzumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (44)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10408	Ki20227	Inhibitor	99.17%	Unkown
HY-117244	AZD7507	Inhibitor	99.45%	Unkown
HY-132935	BPR1R024	Inhibitor	99.06%	Unkown
HY-101774	CSF1R-IN-1	Inhibitor	98.11%	Unkown
HY-117273	AZ304	Inhibitor	99.96%	Unkown
HY-153920	Pimicotinib	Inhibitor	99.69%	Unkown
HY-112451	cFMS Receptor Inhibitor II	Inhibitor	99.80%	Unkown
HY-136362	ARRY-382	Inhibitor	99.63%	Unkown
HY-139990	CSF1R-IN-3	Inhibitor	98.26%	Unkown
HY-13493	AC710	Inhibitor	98.56%	Unkown
HY-100491	H3B-6527	Inhibitor	≥98.0%	Unkown
HY-119942	c-Fms-IN-8	Inhibitor	99.47%	Unkown
HY-122906	JTE-952	Inhibitor	99.95%	Unkown
HY-101526	GENZ-882706	Inhibitor	/	Unkown
HY-126297	c-Fms-IN-10	Inhibitor	98.04%	Unkown
HY-132935A	BPR1R024 mesylate	Inhibitor	/	Unkown
HY-147615	CSF1R-IN-12		/	Unkown
HY-12768B	Sotuletinib dihydrochloride	Inhibitor	/	Unkown
HY-144040	CSF1R-IN-4		/	Unkown
HY-144041	CSF1R-IN-5	Inhibitor	/	Unkown
HY-144042	CSF1R-IN-6		/	Unkown
HY-147608	CSF1R-IN-7	Inhibitor	/	Unkown
HY-147609	CSF1R-IN-8	Inhibitor	/	Unkown
HY-147610	CSF1R-IN-9	Inhibitor	/	Unkown
HY-147611	CSF1R-IN-10	Inhibitor	/	Unkown
HY-147616	CSF1R-IN-13		/	Unkown
HY-147617	CSF1R-IN-14		/	Unkown
HY-153012	Axl/Mer/CSF1R-IN-1	Inhibitor	/	Unkown
HY-153243	IACS-9439	Inhibitor	/	Unkown
HY-153277	Axl/Mer/CSF1R-IN-2	Inhibitor	/	Unkown
HY-155001	CSF1R-IN-15	Inhibitor	/	Unkown
HY-155550	CSF1R-IN-17	Antagonist	/	Unkown
HY-157422	CSF1R-IN-19	Inhibitor	/	Unkown
HY-157996	CSF1R-IN-21	Inhibitor	/	Unkown
HY-158050	PXB17	Inhibitor	/	Unkown
HY-158148	CSF1R-IN-23	Inhibitor	/	Unkown
HY-161025	SYHA1813	Inhibitor	/	Unkown
HY-161084	CSF1R-IN-18	Inhibitor	/	Unkown
HY-162309	CSF1R-IN-20	Inhibitor	/	Unkown
HY-RS03228	CSF1R Human Pre-designed siRNA Set A		/	Unkown
HY-RS03229	Csf1r Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS03230	Csf1r Rat Pre-designed siRNA Set A		/	Unkown
HY-13493A	AC710 Mesylate	Inhibitor	/	Unkown
HY-101034	CHMFL-ABL/KIT-155		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Csf1r	NCBI	NCBI:1436
Macaca fascicularis	Csf1r	NCBI	NCBI:102124214
Mus musculus	Csf1r	NCBI	NCBI:12978
Macaca mulatta	Csf1r	NCBI	NCBI:711512

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