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クルクミン

(別名: Curcumin; Diferuloylmethane; Natural Yellow 3)
135 Cited Publications
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Based on 135 publication(s) in Google Scholar

Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

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  • 純度: 98.63%
  • CAS 番号: 458-37-7
  • 分子式: C21H20O6
  • 分子量:368.38
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Curcumin Chemical Structure
    Curcumin 構造式
  • Experimental Validation Results for Curcumin
  • Experimental Validation Results for Curcumin
  • Experimental Validation Results for Curcumin
  • Experimental Validation Results for Curcumin
  • Experimental Validation Results for Curcumin
  • Experimental Validation Results for Curcumin
  • Experimental Validation Results for Curcumin
  • Experimental Validation Results for Curcumin
  • Experimental Validation Results for Curcumin
  • Experimental Validation Results for Curcumin
CAS 番号: 458-37-7
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  • Curcumin Chemical Structure
    Curcumin Chemical Structure
    1/16
  • 1/16

    Curcumin purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2023 May 4.

    Customer Validation
     Curcumin (5, 10, 20, 40, 50 µM; 24 h) inhibits the viability of Hs578T cells in a concentration-dependent manner.

  • 1/16

    Curcumin purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2023 May 4.

    Customer Validation
     Curcumin (20 µM; 24 h) significantly inhibits the protein expression of Fibronectin, mTOR, β-Catenin, p-Akt, Akt, N-Cadherin, p-S6, and S6 in Hs578T cells.

  • 1/16

    Curcumin purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2019 Apr;120(4):6718-6728. [Abstract]

    Customer Validation
     Western analysis of the expression of NLRP3, pro-casp-1, casp-1, pro-1β, IL-1β in the treatment with or without Curcumin, DMSO, MSU and Colchicine.

  • 1/16

    Curcumin purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Oct 29;37(1):261. [Abstract]

    Customer Validation
     A375, A2058, and RPMI-7951 cells were treated with DMSO (control), Curcumin (25 μM), or Apigenin (30 μM) for 24 h. Apigenin and Curcumin induce apoptosis in melanoma cells.

  • 1/16

    Curcumin purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Oct 29;37(1):261. [Abstract]

    Customer Validation
     The protein expression levels of cleaved PARP are detected from Curcumin and Apigenin-treated A375, A2058, and RPMI-7951 cell lysates compared to control samples using Western blotting analyses.

  • 1/16

    Curcumin purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Oct 29;37(1):261. [Abstract]

    Customer Validation
     A375 cells are incubated with DMSO, curcumin (25 μM), or apigenin (30 μM) for 4 h and then treated with IFN-γ (10 ng/mL) for indicated times. The levels of STAT1 phosphorylation at Tyr701 and total STAT1 are detected by Western blot analysis.

  • 1/16

    Curcumin purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Oct 29;37(1):261. [Abstract]

    Customer Validation
     A375 cells are incubated with DMSO, curcumin (25 μM), or apigenin (30 μM) for 4 h and then treated with IFN-γ (10 ng/mL) for indicated times. The levels of STAT1 phosphorylation at Tyr701 and total STAT1 are detected by Western blot analysis.

  • 1/16

    Curcumin purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Oct 29;37(1):261. [Abstract]

    Customer Validation
     A375 cells are incubated with DMSO, curcumin (25 μM), or apigenin (30 μM) for 4 h and then treated with IFN-γ (10 ng/mL) for indicated times. The levels of STAT1 phosphorylation at Tyr701 and total STAT1 are detected by Western blot analysis.

  • 1/16

    Curcumin purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Oct 29;37(1):261. [Abstract]

    Customer Validation
     Western analysis of PD-L1 expression in A375, A2058, and RPMI-7951 cells treated with IFN-γ, curcumin, or apigenin.

  • 1/16

    Curcumin purchased from MedChemExpress. Usage Cited in: FASEB J. 2017 Sep;31(9):3800-3815. [Abstract]

    Customer Validation
     Expression of CFTR after treatment with Curcumin (10 μM) for 3 d is assayed by Western blotting. TDSCs from WT mice are treated with Curcumin (10 μM) for 3 d and results show that CFTR expression is increased at the protein level.

  • Curcumin