製品番号: HY-N2255

Crebanine

5 Cited Publications

カスタマーレビュー

Based on 5 publication(s) in Google Scholar

Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC₅₀ of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na⁺ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease.

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純度: 99.83%
CAS 番号: 25127-29-1
分子式: C₂₀H₂₁NO₄
分子量:339.39

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Crebanine 構造式

CAS 番号: 25127-29-1

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Amount: USD 0.00

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (5)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
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製品説明

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Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	5.26 μM Compound: 22	Inhibition of NO production in LPS-induced mouse BV-2 cells incubated for 24 hrs by Griess reagent based microplate reader analysis Inhibition of NO production in LPS-induced mouse BV-2 cells incubated for 24 hrs by Griess reagent based microplate reader analysis	[PMID: 37172474]
SH-SY5Y	IC₅₀	5.26 μM Compound: 22	Neuroprotective activity against human SH-SY5Y cells assessed as increase in BDNF level measured after 48 hrs Neuroprotective activity against human SH-SY5Y cells assessed as increase in BDNF level measured after 48 hrs	[PMID: 37172474]

体外実験

Crebanine (0-280 μM, 24-72 h) suppresses cell growth, reduces colony formation ability and inhibits migration and invasion of HepG2 cells^[1].
Crebanine (35-175 μM, 24 h) reduces mitochondrial membrane potential (MMP) and induces apoptosis rate in HepG2 cells^[1].
Crebanine (35-175 μM, 24 h) increases intracellular ROS levels, enhances MDA production, and decreases SOD and GSH-PX activities in HepG2 cells, an effect that can be reversed by Acetylcysteine (NAC) (HY-B0215) pretreatment^[1].
Crebanine (35-175 μM, 24 h) down-regulates p-AKT and p-FoxO3a (Ser253) in HepG2 cells in a dose-dependent manner without affecting total AKT and FoxO3a levels^[1].
Crebanine (1-20 μM, pretreated for 2 h, then co-treated with LPS for 24 h) inhibits NOX2 activation in BV-2 cells by reducing NADP⁺/NADPH levels, downregulating gp91^phox and p47^phox expression, and decreasing p47phox membrane translocation^[2].
Crebanine (1-20 μM, pretreated for 2 h, then co-treated with LPS (HY-D1056) for 24 h) reduces intracellular superoxide anion, ROS, and MDA levels, suppresses NO, iNOS, IL-1β, IL-6, and TNF-α expression, and inhibits NF-κB and MAPK signaling pathways^[2].
Crebanine (0-30 µg/mL, 48 h) inhibits proliferation of HL-60, U937, K562, HT1080, KB-3-1 and KB-V1 cells in a concentration-dependent manner with IC₅₀ values of 9, 12, 13, 20, 24 and 16 µg/mL respectively, and shows slight toxicity to normal fibroblast cells (72% survival at 30 µg/mL)^[3].
Crebanine (0-30 µg/mL, 24 h) induces G0/G1 phase arrest and induces apoptosis in HL-60 and U937 cells^[3].
Crebanine (20 µg/mL, 0-24 h) down-regulates the expression of cyclins A, D1, PCNA, Bcl-2 and Bcl-xl and enhances Bax expression in HL-60 cells, while cyclin E expression remains unchanged^[3].
Crebanine (0.0368-0.7366 mM) reversibly inhibits voltage-dependent Na⁺ current in guinea-pig ventricular myocytes in a concentration-dependent manner, with an IC₅₀ of 0.283 mM; the effect partially recovers after 5 min washout^[4].
Crebanine (10 μM) significantly inhibits the binding of (±)-[³H]-epibatidine to Ls-AChBP, Ac-AChBP and AcY55W-AChBP, with K_i values of 179 nM, 538 nM and >1000 nM respectively^[5].
Crebanine (10.3 μM) exhibits antagonistic effects on α7-nAChR, α4β2-nAChR, (α1)2β1δγ-nAChR and 5-HT3A receptor in mammalian cells, with inhibition percentages of 100.7%, 29.0%, 81.7% and 55.3% respectively^[5].
Crebanine exhibits high inhibitory activity against gram-positive animal pathogenic bacteria, with an MIC of 0.312 g/L against Micrococcus lysodeikticus, Bacillus megaterium, Bacillus subtilis and Staphylococcus aureus, and an MIC of 0.213 g/L against Bacillus cereus^[6].
Crebanine inhibits hyphal growth of these 5 plant pathogenic fungi (EC₅₀: 0.111 g/L for Cercospora kaki; 6.47×10^-2 g/L for Gymnosporangium haraeanum; 1.89×10^-2 g/L for Pyricularia oryzae; 4.25×10^-2 g/L for Rhizoctonia solani; 4.05×10^-2 g/L for Colletotrichum graminicola)^[6].
Crebanine (0.4 g/L) inhibits spore germination of Thielaviopsis paradoxa (94.96%), Fusarium oxysporum f. sp. niveum (100%), Sphaceloma fawcettii (100%) and Gymnosporangium haraeanum (100%)^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepG2 cells

Concentration:

0, 35, 70, 105, 140, 175, 280 µM

Incubation Time:

24, 48, 72 h

Result:

Inhibited viability of HepG2 cells in a dose- and time-dependent manner, with IC₅₀ values of 111.77 μM (24 h), 65.07 μM (48 h), and 23.68 μM (72 h).

Cell Invasion Assay^[1]

Cell Line:

HepG2 cells

Concentration:

35, 105, 175 µM

Incubation Time:

24 h

Result:

Inhibited invasion of HepG2 cells in a dose-dependent manner.

Cell Migration Assay ^[1]

Cell Line:

HepG2 cells

Concentration:

35, 105, 175 µM

Incubation Time:

24 h

Result:

Inhibited migration of HepG2 cells in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

HepG2 cells

Concentration:

35, 105, 175 µM

Incubation Time:

24 h

Result:

Increased apoptosis rate (up to 43.5% at highest dose) detected by flow cytometry with Annexin V-FITC/PI staining.

Western Blot Analysis^[1]

Cell Line:

HepG2 cells

Concentration:

35, 105, 175 µM

Incubation Time:

24 h

Result:

Up-regulated Bax, cleaved-PARP, cleaved-caspase-3, and cleaved-caspase-9.
Down-regulated Bcl-2, p-AKT and p-FoxO3a (Ser253).

ELISA Assay^[2]

Cell Line:

BV2 cells

Concentration:

1, 10, 20 μM

Incubation Time:

Pretreated for 2 h, then co-treated with LPS for 24 h

Result:

Suppressed IL-1β, IL-6, and TNF-α expression.

体内実験

Crebanine (250-500 μg/kg, after 2 h MCAO occlusion followed by 24 h reperfusion) ameliorates neurological deficits, reduces brain water content and infarct volume in MCAO/R rats^[2].
Crebanine (8.5 mg/kg (25 μmol/kg), i.p., single dose) significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult Sprague-Dawley (SD) rats were used to establish the middle cerebral artery occlusion and reperfusion (MCAO/R) model by a modified monofilament nylon suture embolism method^[1]

Dosage:

250-500 μg/kg

Administration:

After 2 h MCAO occlusion followed by 24 h reperfusion

Result:

Reduced brain water content and infarct volume in MCAO/R rats, with 500 μg/kg exhibiting obvious efficacy.
Up-regulated NeuN⁺ fluorescence density and down-regulated FJB⁺ cell count in the ischemic cortex of MCAO/R rats.
Mitigated synaptic damage induced by MCAO/R operation.
Attenuated NOX2 hyperactivation by reducing NADP⁺ and NADPH levels, suppressing gp91^phox and p47^phox expressions, and decreasing p47^phox membrane translocation in Iba-1⁺ cells of MCAO/R rats.
Reduced the quantity of Iba-1⁺ cells and protein expression in MCAO/R rats.
Exhibited antioxidant properties by down-regulating superoxide anion and intracellular ROS, and reducing lipid and DNA peroxidation in MCAO/R rats.
Exerted anti-inflammatory effects by reducing NO, IL-1β, TNF-α, IL-6, and iNOS expressions in MCAO/R rats.
Inhibited NF-κB and MAPK signaling pathways in MCAO/R rats, as evidenced by reduced NF-κB p65 promoter activity and nucleus translocation, suppressed IκBα phosphorylation and degradation, and inhibited phosphorylation of ERK, JNK, and p38 MAPKs.

Animal Model:

Male ICR mice, weighing 25-35 g and 8 weeks of age, were used to establish scopolamine-induced amnesic models^[5]

Dosage:

8.5 mg/kg (25 μmol/kg)

Administration:

i.p. 1 hour before Scopolamine (0.5 mg/kg, i.p.)

Result:

Improved scopolamine-induced cognitive deficits in male ICR mice.
Increased the time spent in the target quadrant (Q1) in the Morris water maze test.

化学情報

CAS 番号 25127-29-1

性状 Solid

分子量 339.39

分子式 C₂₀H₂₁NO₄

Color Off-white to light yellow

SMILES

CN1CCC(C2=C3C4=CC=C(OC)C(OC)=C4C[C@@]12[H])=CC5=C3OCO5

Structure Classification

Alkaloids

Other Alkaloids

Initial Source

Plants

Menispermaceae

Stephania venosa

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (5)

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Journal Impact Factor

Most Recent

J Pharm Anal

2025 Jul 31.

Cell Biol Toxicol

EZH2/DUSP1/Akt signaling axis mediates the inhibitory effect of crebanine on hepatocellular carcinoma progression. [Abstract]

2026 Jun 2. PMID: 42228265

Int J Mol Sci

Crebanine Induces Cell Death and Alters the Mitotic Process in Renal Cell Carcinoma In Vitro. [Abstract]

2025 Jul 18;26(14):6896. PMID: 40725144

Biomol Ther (Seoul)

Crebanine Protects HUVECs from LPS-Induced Inflammation and Oxidative Stress by Suppressing NF-κB Pathway. [Abstract]

2026 Mar 1;34(2):423-433. PMID: 41755781

J Cell Mol Med

Crebanine mitigates glucocorticoid-induced osteonecrosis of the femoral head by restoring bone remodelling homeostasis via attenuating oxidative stress. [Abstract]

2024 Aug;28(16):e70044. PMID: 39205463

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (294.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9465 mL

14.7323 mL

29.4646 mL

5 mM

0.5893 mL

2.9465 mL

5.8929 mL

10 mM

0.2946 mL

1.4732 mL

2.9465 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:

To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO    40% PEG300    5% Tween-80    45% Saline
Solubility: ≥ 2.5 mg/mL (7.37 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

Protocol 2

Add each solvent one by one: 10% DMSO    90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.37 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

Protocol 3

Add each solvent one by one: 10% DMSO    90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.37 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

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The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Method for preparing in vivo working solution for animal experiments:
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Saline .

Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

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参考文献

[1]. Tan J, et al. Crebanine induces ROS-dependent apoptosis in human hepatocellular carcinoma cells via the AKT/FoxO3a signaling pathway. Front Pharmacol. 2023 Feb 16;14:1069093. [Content Brief]

[2]. Yang Y, et al. Crebanine ameliorates ischemia-reperfusion brain damage by inhibiting oxidative stress and neuroinflammation mediated by NADPH oxidase 2 in microglia. Phytomedicine. 2023 Nov;120:155044. [Content Brief]

[3]. Wongsirisin P, et al. Induction of G1 arrest and apoptosis in human cancer cells by crebanine, an alkaloid from Stephania venosa. Chem Pharm Bull (Tokyo). 2012;60(10):1283-9. [Content Brief]

[4]. Xiao-Shan H, et al. Crebanine inhibits voltage-dependent Na+ current in guinea-pig ventricular myocytes. Chin J Nat Med. 2014 Jan;12(1):20-3. [Content Brief]

[5]. Rojsanga P, et al. The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor. Life Sci. 2012 Aug 21;91(3-4):107-14. [Content Brief]

[6]. Yecheng Deng, et al. Antimicrobial activity of extract and two alkaloids from traditional Chinesemedicinal plant Stephania dielsiana.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 2.9465 mL 14.7323 mL 29.4646 mL 73.6616 mL

5 mM 0.5893 mL 2.9465 mL 5.8929 mL 14.7323 mL

10 mM 0.2946 mL 1.4732 mL 2.9465 mL 7.3662 mL

15 mM 0.1964 mL 0.9822 mL 1.9643 mL 4.9108 mL

20 mM 0.1473 mL 0.7366 mL 1.4732 mL 3.6831 mL

25 mM 0.1179 mL 0.5893 mL 1.1786 mL 2.9465 mL

30 mM 0.0982 mL 0.4911 mL 0.9822 mL 2.4554 mL

40 mM 0.0737 mL 0.3683 mL 0.7366 mL 1.8415 mL

50 mM 0.0589 mL 0.2946 mL 0.5893 mL 1.4732 mL

60 mM 0.0491 mL 0.2455 mL 0.4911 mL 1.2277 mL

80 mM 0.0368 mL 0.1842 mL 0.3683 mL 0.9208 mL

100 mM 0.0295 mL 0.1473 mL 0.2946 mL 0.7366 mL

Crebanine 関連分類

HY-N2255 関連分類

PI3K/Akt/mTOR Apoptosis NF-κB Immunology/Inflammation Metabolic Enzyme/Protease MAPK/ERK Pathway Stem Cell/Wnt Neuronal Signaling Membrane Transporter/Ion Channel Anti-infection

Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial

疾患領域

Cancer Infection Neurological, Eye or Ear Disease Inflammation or Immune System Disease Blood or Cardio-cerebrovascular Disease Metabolic or Endocrine Disease Respiratory Disease Digestive System Disease Urogenital Disease Musculoskeletal and Skin Disease

Neurodegenerative Disease Lipid Metabolism Pulmonary Disease Autoimmune Disease Arthritis Lung Cancer Breast Cancer Colorectal Cancer Digestive System Cancer Prostate Cancer Urogenital Cancer Gastric Cancer Liver Cancer Leukemia/Lymphoma/Myeloma Blood Disease Pancreatic Cancer Ovarian Cancer Bacterial Infection Depression Pain Digestive System Inflammation Cardiovascular Disease

Alzheimer's Disease Parkinson's Disease Obesity Lung Fibrosis Rheumatoid Arthritis

天然物

Disease Research Fields Plants Alkaloids

Menispermaceae Cardiovascular Disease Inflammation/Immunology Other Alkaloids

Stephania venosa

標準物質

Natural Product Standards

Alkaloids

Cancer

Cancer Targeted Therapy Cancer Immunotherapy Cancer Stem Cells Cancer Metabolism and Metastasis

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Keywords

Crebanine
25127-29-1
Akt
Apoptosis
NF-κB
Reactive Oxygen Species (ROS)
p38 MAPK
ERK
Interleukin Related
TNF Receptor
NO Synthase
nAChR
Bacterial
hepatocellular carcinoma (HCC)
cerebral ischemia
AKT/FoxO3a
MAPK
Alzheimer's disease
bacteria
Inhibitor
inhibitor
inhibit

最近チェックした製品

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9465 mL	14.7323 mL	29.4646 mL	73.6616 mL
5 mM	0.5893 mL	2.9465 mL	5.8929 mL	14.7323 mL
10 mM	0.2946 mL	1.4732 mL	2.9465 mL	7.3662 mL
15 mM	0.1964 mL	0.9822 mL	1.9643 mL	4.9108 mL
20 mM	0.1473 mL	0.7366 mL	1.4732 mL	3.6831 mL
25 mM	0.1179 mL	0.5893 mL	1.1786 mL	2.9465 mL
30 mM	0.0982 mL	0.4911 mL	0.9822 mL	2.4554 mL
40 mM	0.0737 mL	0.3683 mL	0.7366 mL	1.8415 mL
50 mM	0.0589 mL	0.2946 mL	0.5893 mL	1.4732 mL
60 mM	0.0491 mL	0.2455 mL	0.4911 mL	1.2277 mL
80 mM	0.0368 mL	0.1842 mL	0.3683 mL	0.9208 mL
100 mM	0.0295 mL	0.1473 mL	0.2946 mL	0.7366 mL

Crebanine

5 Cited Publications

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Crebanine

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Anti-Fibrosis Compound Library

Miao Ethnicity Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library