N-Hydroxyphthalimide
Based on 1 Customer Validation
N-Hydroxyphthalimide is a blocking agent and catalyst. N-Hydroxyphthalimide promotes oxidation reactions by generating PINO free radicals and activating hydrogen atom transfer processes. N-Hydroxyphthalimide reduces the expression of anti-apoptotic proteins Survivin and Bcl-xL and activates caspase 9 and caspase 3. N-Hydroxyphthalimide induces Apoptosis. N-Hydroxyphthalimide inhibits the phosphorylation of mTOR (Ser2448, Ser2481) and Akt (Ser473). N-Hydroxyphthalimide has anticancer effects against breast and colon cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.63%
- CAS 番号: 524-38-9
- 分子式: C8H5NO3
- 分子量:163.13
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Caspase 9 |
Caspase 3 |
Bcl-xL |
N-Hydroxyphthalimide (2.5-40 μM; 24-72 h) selectively inhibits the proliferation of human breast carcinoma BT-20 cells, human colon adenocarcinoma LoVo and HT-29 cells by inducing G2/M phase arrest and apoptosis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Decreased the expressions of anti-apoptotic proteins survivin and Bcl-xL.
Activated caspase 9 and caspase 3.
BT-20, LoVo cells -
Concentration:2.5 μM, 5 μM, 10 μM, 20 μM
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Incubation Time:24 h
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Result:Decreased the expressions of anti-apoptotic proteins survivin and Bcl-xL.
Activated caspase 9 and caspase 3.
Suppressed the phosphorylation of mTOR (Ser2448, Ser2481).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Three-week old female BALB/c nude mice; human breast carcinoma BT-20 cell xenograft model[3]
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Dosage:40 mg/kg
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Administration:Intraperitoneal injection; 53 days (started when tumor volume reached approximately 100 mm3)
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Result:Significantly reduced tumor volume and tumor weight.
Achieved a 53% tumor growth inhibition rate.
Decreased the tumor weight by 45%.
Decreased the phosphorylation levels of mTOR at Ser2448, S6 at Ser235/236, 4E-BP1 at Ser65, and Akt at Ser473.
化学情報
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CAS 番号 524-38-9
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性状 Solid
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分子量 163.13
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分子式 C8H5NO3
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Color White to yellow
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SMILES
O=C1C2=C(C(N1O)=O)C=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (613.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.1301 mL | 30.6504 mL | 61.3008 mL | 153.2520 mL |
| 5 mM | 1.2260 mL | 6.1301 mL | 12.2602 mL | 30.6504 mL | |
| 10 mM | 0.6130 mL | 3.0650 mL | 6.1301 mL | 15.3252 mL | |
| 15 mM | 0.4087 mL | 2.0434 mL | 4.0867 mL | 10.2168 mL | |
| 20 mM | 0.3065 mL | 1.5325 mL | 3.0650 mL | 7.6626 mL | |
| 25 mM | 0.2452 mL | 1.2260 mL | 2.4520 mL | 6.1301 mL | |
| 30 mM | 0.2043 mL | 1.0217 mL | 2.0434 mL | 5.1084 mL | |
| 40 mM | 0.1533 mL | 0.7663 mL | 1.5325 mL | 3.8313 mL | |
| 50 mM | 0.1226 mL | 0.6130 mL | 1.2260 mL | 3.0650 mL | |
| 60 mM | 0.1022 mL | 0.5108 mL | 1.0217 mL | 2.5542 mL | |
| 80 mM | 0.0766 mL | 0.3831 mL | 0.7663 mL | 1.9157 mL | |
| 100 mM | 0.0613 mL | 0.3065 mL | 0.6130 mL | 1.5325 mL |
N-Hydroxyphthalimide 関連分類
HY-Y0396 関連分類
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