Oxychlororaphine
Based on 1 Customer Validation
Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.63%
- CAS 番号: 550-89-0
- 分子式: C13H9N3O
- 分子量:223.23
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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生物活性
Oxychloroaphine (1-256 μM; 24 h) has cytotoxicity with IC50 values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM[2].
Oxychloroaphine (1-150 μM; A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein[2].
Oxychloroaphine (32 μM; A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase[2].
Oxychloroaphine (48 h; A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, HeLa, and SW480 cancer cell lines
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Concentration:1, 2, 4, 8, 16, 32, 64, 128, and 256 μM
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Incubation Time:24 hours
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Result:Inhibited cell proliferative in a dose-dependent manner.
化学情報
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CAS 番号 550-89-0
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性状 Solid
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分子量 223.23
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分子式 C13H9N3O
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Color Light yellow to brown
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SMILES
O=C(C1=CC=CC2=NC3=CC=CC=C3N=C21)N
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Structure Classification
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Initial Source
Phytopathogenic bacteria
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 10 mg/mL (44.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
[1]. Li S, et, al. Comparative metabolomics and transcriptomics analyses provide insights into the high-yield mechanism of phenazines biosynthesis in Pseudomonas chlororaphis GP72. J Appl Microbiol. 2022 Nov;133(5):2790-2801. [Content Brief]
[2]. Ali HM, et, al. Isolation of Bioactive Phenazine-1-Carboxamide from the Soil Bacterium Pantoea agglomerans and Study of Its Anticancer Potency on Different Cancer Cell Lines. J AOAC Int. 2016 Sep;99(5):1233-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4797 mL | 22.3984 mL | 44.7968 mL | 111.9921 mL |
| 5 mM | 0.8959 mL | 4.4797 mL | 8.9594 mL | 22.3984 mL | |
| 10 mM | 0.4480 mL | 2.2398 mL | 4.4797 mL | 11.1992 mL | |
| 15 mM | 0.2986 mL | 1.4932 mL | 2.9865 mL | 7.4661 mL | |
| 20 mM | 0.2240 mL | 1.1199 mL | 2.2398 mL | 5.5996 mL | |
| 25 mM | 0.1792 mL | 0.8959 mL | 1.7919 mL | 4.4797 mL | |
| 30 mM | 0.1493 mL | 0.7466 mL | 1.4932 mL | 3.7331 mL | |
| 40 mM | 0.1120 mL | 0.5600 mL | 1.1199 mL | 2.7998 mL |
Oxychlororaphine 関連分類
HY-W042191 関連分類
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