512 Results for "

integrin

" in MedChemExpress (MCE) Product Catalog:
Products (512)

512 Results for "integrin" in MCE Product Catalog:

72
Cilengitide
Cilengitide
0 Images
72 Publications Verification
Cat. No.: HY-16141
CAS No.: 188968-51-6
Synonyms: EMD 121974
Target:  

Integrin Autophagy Apoptosis STAT PD-1/PD-L1

연구분야:  

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cilengitide (EMD 121974) is a BBB-permeable integrins antagonist with IC50s of 0.61 nM (ανβ3), 8.4 nM (ανβ5) and 14.9 nM (α5β1), respectively. Cilengitide inhibits the binding of ανβ3 and ανβ5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis, shows antiangiogenic effect in the research against glioblastoma and other cancers .
72
Cilengitide TFA
Cilengitide TFA
0 Images
72 Publications Verification
Cat. No.: HY-16143
CAS No.: 199807-35-7
Synonyms: EMD 121974 TFA
Target:  

Integrin Autophagy

연구분야:  

Cancer

Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively.
29
Cyclo(-RGDfK)
Cyclo(-RGDfK)
0 Images
29 Cited Publications
Cat. No.: HY-P0023
CAS No.: 161552-03-0
Target:  

Integrin

연구분야:  

Cancer

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
29
Cyclo(-RGDfK) TFA
Cyclo(-RGDfK) TFA
0 Images
29 Cited Publications
Cat. No.: HY-P0023A
CAS No.: 500577-51-5
Target:  

Integrin

연구분야:  

Cancer

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
18
GLPG0187
GLPG0187
0 Images
18 Cited Publications
Cat. No.: HY-100506
CAS No.: 1320346-97-1
Purity:  99.43%
Target:  

Integrin

연구분야:  

Cancer

GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM . GLPG0187 inhibits migrasome biogenesis without cytotoxicity .
16
PND-1186
PND-1186
0 Images
16 Cited Publications
Cat. No.: HY-13917
CAS No.: 1061353-68-1
Purity:  99.88%
Synonyms: VS-4718; SR-2516
Target:  

FAK Apoptosis

연구분야:  

Cancer

PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis .
16
PND-1186 hydrochloride
PND-1186 hydrochloride
0 Images
16 Cited Publications
Cat. No.: HY-13917A
CAS No.: 1356154-94-3
Purity:  99.92%
Synonyms: VS-4718 hydrochloride; SR-2516 hydrochloride
Target:  

FAK Apoptosis

연구분야:  

Cancer

PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis .
12
OSU-T315
OSU-T315
0 Images
12 Cited Publications
Cat. No.: HY-18676
CAS No.: 2070015-22-2
Target:  

Integrin Autophagy Apoptosis

연구분야:  

Cancer

OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain) . OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner . OSU-T315 causes cell death through apoptosis and autophagy .
11
Lifitegrast
Lifitegrast
0 Images
11 Cited Publications
Cat. No.: HY-19344
CAS No.: 1025967-78-5
Synonyms: SAR 1118; SHP-606
Target:  

Integrin

연구분야:  

Inflammation/Immunology

Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease .
11
Lifitegrast sodium
Lifitegrast sodium
0 Images
11 Cited Publications
Cat. No.: HY-19344A
CAS No.: 1119276-80-0
Synonyms: SAR 1118 sodium; SHP-606 sodium
Target:  

Integrin

연구분야:  

Inflammation/Immunology

Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease .
10
ATN-161
ATN-161
0 Images
10 Cited Publications
Cat. No.: HY-13535
CAS No.: 262438-43-7
Target:  

Integrin

연구분야:  

Cancer

ATN-161 is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
10
ATN-161 trifluoroacetate salt
ATN-161 trifluoroacetate salt
0 Images
10 Cited Publications
Cat. No.: HY-13535A
CAS No.: 904763-27-5
Purity:  99.04%
Synonyms: ATN-161 TFA salt
Target:  

Integrin

연구분야:  

Cancer

ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
10
CWHM-12
CWHM-12
0 Images
10 Cited Publications
Cat. No.: HY-18644
CAS No.: 1564286-55-0
Target:  

Integrin

연구분야:  

Cancer

CWHM-12 is a potent inhibitor of αV integrins with IC50s of 0.2, 0.8, 1.5, and 1.8 nM for αvβ8, αvβ3, αvβ6, and αvβ1.
9
Arg-Gly-Asp-Ser
Arg-Gly-Asp-Ser
0 Images
9 Cited Publications
Cat. No.: HY-12290
CAS No.: 91037-65-9
Purity:  99.93%
Synonyms: RGDS peptide; Fibronectin tetrapeptide
Target:  

Integrin

연구분야:  

Inflammation/Immunology

Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.
8
RGD
RGD
0 Images
8 Cited Publications
Cat. No.: HY-P0278
CAS No.: 99896-85-2
Target:  

Integrin

연구분야:  

Cancer

RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.
8
RGD Trifluoroacetate
RGD Trifluoroacetate
0 Images
8 Cited Publications
Cat. No.: HY-P0278A
CAS No.: 2378808-45-6
Target:  

Integrin

연구분야:  

Cancer

RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.
8
Fibronectin
Fibronectin
0 Images
8 Cited Publications
Cat. No.: HY-P3160
CAS No.: 86088-83-7
Category:  

Cardiovascular Disease Natural Products Endogenous metabolite Disease Research Fields

Target:  

Integrin

Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .
This product is a human Fibronectin obtained by recombinant expression in a rice expression system.
8
GW9508
GW9508
0 Images
8 Cited Publications
Cat. No.: HY-15589
CAS No.: 885101-89-3
Purity:  99.23%
Target:  

Free Fatty Acid Receptor Potassium Channel

연구분야:  

Cardiovascular Disease Metabolic Disease Inflammation/Immunology

GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities .
7
iRGD peptide
iRGD peptide
0 Images
7 Cited Publications
Cat. No.: HY-P0122
CAS No.: 1392278-76-0
Synonyms: c(CRGDKGPDC)
Target:  

Integrin

연구분야:  

Cancer

iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of agents by first binding to αv-integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties.
7
RGD peptide (GRGDNP)
RGD peptide (GRGDNP)
0 Images
7 Cited Publications
Cat. No.: HY-P1740
CAS No.: 114681-65-1
Target:  

Integrin Apoptosis Caspase

연구분야:  

Inflammation/Immunology

RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation .
Assay Types