TLE5 - TLE family member 5, transcriptional modulator Gene

Also Known as AES; GRG; ESP1; GRG5; AES-1; AES-2; Grg-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 166

About TLE5

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,052,910-3,062,966 (from NCBI)

This gene has 12 transcripts (splice variants), 255 orthologues and 6 paralogues. Ubiquitous expression in heart (RPKM 135.6), spleen (RPKM 116.8) and 25 other tissues.

Summary

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with Other family members to dominantly repress the expression of Other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TLE5 Products (3)

mRNA Protein Name
NM_001130.6 NP_001121.2 TLE family member 5 isoform b
NM_198969.1 NP_945320.1 TLE family member 5 isoform a
NM_198970.2 NP_945321.1 TLE family member 5 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
27107012 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10660609 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
19460168 GOA
enables transcription corepressor activity IPI
IPI: Inferred from physical interaction
10660609 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19460168 GOA
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
19460168 GOA
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
15006356 GOA
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
15489227 GOA
involved in negative regulation of response to cytokine stimulus IMP
IMP: Inferred from mutant phenotype
15489227 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10660609 GOA
involved in positive regulation of anoikis IMP
IMP: Inferred from mutant phenotype
15006356 GOA
involved in response to interleukin-1 IDA
IDA: Inferred from direct assay
15489227 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22952044 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLE5 Protein Structure

TLE_N

TLE_N: Groucho/TLE N-terminal Q-rich domain (2 - 134)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

TLE family member 5

  • amino-terminal enhancer of split

TLE5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TLE5 Q08117 KRT13 Homo sapiens A1A4E9
Validated Y2H
25416956
Intra
TLE5 Q08117 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
TLE5 Q08117 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
TLE5 Q08117 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
TLE5 Q08117 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
Intra
TLE5 Q08117 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
TLE5 Q08117 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
25416956
Intra
TLE5 Q08117 QARS1 Homo sapiens P47897-2
Y2H Array
25416956
Intra
TLE5 Q08117 QARS1 Homo sapiens P47897-2
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 OLIG3 Homo sapiens Q7RTU3
Validated Y2H
25416956
Intra
TLE5 Q08117 OLIG3 Homo sapiens Q7RTU3
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 OLIG3 Homo sapiens Q7RTU3
Y2H Array
25416956
Intra
TLE5 Q08117 MBNL1 Homo sapiens Q86VM6
Y2H Array
25416956
Intra
TLE5 Q08117 MBNL1 Homo sapiens Q86VM6
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 RNF31 Homo sapiens Q96EP0-3
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 RNF31 Homo sapiens Q96EP0-3
Validated Y2H
25416956
Intra
TLE5 Q08117 DIP2A Homo sapiens Q14689-6
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 DIP2A Homo sapiens Q14689-6
Validated Y2H
25416956
Intra
TLE5 Q08117 DIP2A Homo sapiens Q14689-6
Y2H Array
25416956
Intra
TLE5 Q08117 FBF1 Homo sapiens Q8TES7-6
Y2H Array
25416956
Intra
TLE5 Q08117 SNRPC Homo sapiens Q5TAL4
Validated Y2H
25416956
Intra
TLE5 Q08117 SNRPC Homo sapiens Q5TAL4
Y2H Array
25416956
Intra
TLE5 Q08117 LINC00526 Homo sapiens Q96FQ7
Validated Y2H
25416956
Intra
TLE5 Q08117 LINC00526 Homo sapiens Q96FQ7
Y2H Array
25416956
Intra
TLE5 Q08117 NUDT22 Homo sapiens Q9BRQ3
Validated Y2H
25416956
Intra
TLE5 Q08117 NUDT22 Homo sapiens Q9BRQ3
Y2H Array
31515488
Intra
TLE5 Q08117 MFAP1 Homo sapiens P55081
Validated Y2H
25416956
Intra
TLE5 Q08117 MIA2 Homo sapiens Q96PC5
Y2H Array
25416956
Intra
TLE5 Q08117 MIA2 Homo sapiens Q96PC5
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 NCDN Homo sapiens Q9UBB6
Y2H Array
25416956
Intra
TLE5 Q08117 NCDN Homo sapiens Q9UBB6
Validated Y2H
25416956
Intra
TLE5 Q08117 NCDN Homo sapiens Q9UBB6
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 PTRH2 Homo sapiens Q9Y3E5
Anti Tag CoIP
15006356
Intra
TLE5 Q08117 PTRH2 Homo sapiens Q9Y3E5
Anti Tag CoIP
22952044
Intra
TLE5 Q08117 PTRH2 Homo sapiens Q9Y3E5
Y2H
15006356
Intra
TLE5 Q08117 PRKAA1 Homo sapiens Q13131
Validated Y2H
25416956
Intra
TLE5 Q08117 PRKAA2 Homo sapiens P54646
Y2H Array
25416956
Intra
TLE5 Q08117 PRPF31 Homo sapiens Q8WWY3
Y2H Array
25416956
Intra
TLE5 Q08117 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra
TLE5 Q08117 KIFC3 Homo sapiens Q9BVG8
Y2H Array
25416956
Intra
TLE5 Q08117 CCNJL Homo sapiens Q8IV13
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 TRIM26 Homo sapiens Q12899
Y2H Array
25416956
Intra
TLE5 Q08117 TRIM26 Homo sapiens Q12899
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 KANK2 Homo sapiens Q63ZY3
Validated Y2H
25416956
Intra
TLE5 Q08117 VPS37C Homo sapiens A5D8V6
Validated Y2H
25416956
Intra
TLE5 Q08117 VPS37C Homo sapiens A5D8V6
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 VPS37C Homo sapiens A5D8V6
Y2H Array
25416956
Intra
TLE5 Q08117 PRR3 Homo sapiens P79522
Y2H Array
25416956
Intra
TLE5 Q08117 PRR3 Homo sapiens P79522
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 CCDC57 Homo sapiens Q2TAC2
Validated Y2H
25416956
Intra
TLE5 Q08117 SKIL Homo sapiens P12757
Y2H Array
25416956
Intra
TLE5 Q08117 SKIL Homo sapiens P12757
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
TLE5 Q08117 ARHGAP32 Homo sapiens A7KAX9
Validated Y2H
25416956
Intra
TLE5 Q08117 ZGPAT Homo sapiens Q8N5A5
Y2H Array
31515488
Intra
TLE5 Q08117 TBX3 Homo sapiens O15119
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 SMAD3 Homo sapiens P84022
Y2H Array
31515488
Intra
TLE5 Q08117 SMAD3 Homo sapiens P84022
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 SMAD3 Homo sapiens P84022
Validated Y2H
25416956
Intra
TLE5 Q08117 LSM2 Homo sapiens Q9Y333
Y2H Array
25416956
Intra
TLE5 Q08117 QARS1 Homo sapiens P47897
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 DDX6 Homo sapiens P26196
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 HNRNPF Homo sapiens P52597
Y2H Array
25416956
Intra
TLE5 Q08117 HNRNPF Homo sapiens P52597
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra
TLE5 Q08117 BYSL Homo sapiens Q13895
Validated Y2H
25416956
Intra
TLE5 Q08117 TSSK3 Homo sapiens Q96PN8
Validated Y2H
25416956
Intra
TLE5 Q08117 TSSK3 Homo sapiens Q96PN8
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 ZNF576 Homo sapiens Q9H609
Y2H Array
25416956
Intra
TLE5 Q08117 PARVG Homo sapiens Q9HBI0
Y2H Array
25416956
Intra
TLE5 Q08117 EIF4E2 Homo sapiens O60573
Validated Y2H
25416956
Intra
TLE5 Q08117 EIF4E2 Homo sapiens O60573
Y2H Array
25416956
Intra
TLE5 Q08117 MORF4L2 Homo sapiens Q15014
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 GRB2 Homo sapiens P62993
Validated Y2H
25416956
Intra
TLE5 Q08117 GRB2 Homo sapiens P62993
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 VPS37B Homo sapiens Q9H9H4
Y2H Array
25416956
Intra
TLE5 Q08117 BIRC7 Homo sapiens Q96CA5
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 BIRC7 Homo sapiens Q96CA5
Y2H Array
31515488
Intra
TLE5 Q08117 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
TLE5 Q08117 FSD2 Homo sapiens A1L4K1
Y2H Array
31515488
Intra
TLE5 Q08117 FSD2 Homo sapiens A1L4K1
Y2H Array
25416956
Intra
TLE5 Q08117 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
TLE5 Q08117 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
TLE5 Q08117 PPP1R16A Homo sapiens Q96I34
Validated Y2H
25416956
Intra
TLE5 Q08117 BHLHE40 Homo sapiens O14503
Validated Y2H
25416956
Intra
TLE5 Q08117 BHLHE40 Homo sapiens O14503
Y2H Array
25416956
Intra
TLE5 Q08117 BHLHE40 Homo sapiens O14503
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 TRIM27 Homo sapiens P14373
Y2H Array
31515488
Intra
TLE5 Q08117 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
TLE5 Q08117 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
TLE5 Q08117 RBM10 Homo sapiens P98175
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 RBM10 Homo sapiens P98175
Validated Y2H
25416956
Intra
TLE5 Q08117 FRS3 Homo sapiens O43559
Y2H Array
25416956
Intra
TLE5 Q08117 FRS3 Homo sapiens O43559
Validated Y2H
25416956
Intra
TLE5 Q08117 TRIM41 Homo sapiens Q8WV44
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 TRIM41 Homo sapiens Q8WV44
Validated Y2H
25416956
Intra
TLE5 Q08117 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
29892012
Intra
TLE5 Q08117 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Intra
TLE5 Q08117 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
25416956
Intra
TLE5 Q08117 KRT15 Homo sapiens P19012
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra
TLE5 Q08117 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
TLE5 Q08117 CRACR2A Homo sapiens Q9BSW2
Y2H Array
31515488
Intra
TLE5 Q08117 CRACR2A Homo sapiens Q9BSW2
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 CRACR2A Homo sapiens Q9BSW2
Y2H Array
25416956
Intra
TLE5 Q08117 CCNK Homo sapiens O75909
Y2H Array
25416956
Intra
TLE5 Q08117 CCNK Homo sapiens O75909
Validated Y2H
25416956
Intra
TLE5 Q08117 L3MBTL2 Homo sapiens Q969R5
Y2H Array
25416956
Intra
TLE5 Q08117 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra
TLE5 Q08117 NEK6 Homo sapiens Q9HC98
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 LDOC1 Homo sapiens O95751
Y2H Array
25416956
Intra
TLE5 Q08117 MLX Homo sapiens Q9UH92
Y2H Array
31515488
Intra
TLE5 Q08117 FAM124B Homo sapiens Q9H5Z6
Validated Y2H
25416956
Intra
TLE5 Q08117 U2AF2 Homo sapiens P26368
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 U2AF2 Homo sapiens P26368
Y2H Array
25416956
Intra
TLE5 Q08117 BAHD1 Homo sapiens Q8TBE0
Validated Y2H
25416956
Intra
TLE5 Q08117 BAHD1 Homo sapiens Q8TBE0
Y2H Array
25416956
Intra
TLE5 Q08117 BAHD1 Homo sapiens Q8TBE0
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
TLE5 Q08117 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
Intra
TLE5 Q08117 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
Intra
TLE5 Q08117 SIX1 Homo sapiens Q15475
Validated Y2H
25416956
Intra
TLE5 Q08117 SIX1 Homo sapiens Q15475
Y2H Array
25416956
Intra
TLE5 Q08117 GFAP Homo sapiens P14136
Validated Y2H
25416956
Intra
TLE5 Q08117 GFAP Homo sapiens P14136
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 GFAP Homo sapiens P14136
Y2H Array
25416956
Intra
TLE5 Q08117 ZBTB24 Homo sapiens O43167
Validated Y2H
25416956
Intra
TLE5 Q08117 ZBTB24 Homo sapiens O43167
Y2H Array
25416956
Intra
TLE5 Q08117 ZBTB24 Homo sapiens O43167
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 FAM124A Homo sapiens Q86V42
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 FAM124A Homo sapiens Q86V42
Validated Y2H
25416956
Intra
TLE5 Q08117 TSGA10 Homo sapiens Q9BZW7
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 TSGA10 Homo sapiens Q9BZW7
Y2H Array
25416956
Intra
TLE5 Q08117 UBXN11 Homo sapiens Q5T124
Y2H Array
25416956
Intra
TLE5 Q08117 RFX6 Homo sapiens Q8HWS3
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 RFX6 Homo sapiens Q8HWS3
Validated Y2H
25416956
Intra
TLE5 Q08117 MAGOHB Homo sapiens Q96A72
Validated Y2H
25416956
Intra
TLE5 Q08117 MAGOHB Homo sapiens Q96A72
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 CPSF7 Homo sapiens Q8N684
Validated Y2H
25416956
Intra
TLE5 Q08117 CPSF7 Homo sapiens Q8N684
Y2H Array
25416956
Intra
TLE5 Q08117 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Intra
TLE5 Q08117 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
25416956
Intra
TLE5 Q08117 C1orf216 Homo sapiens Q8TAB5
Y2H Array
25416956
Intra
TLE5 Q08117 C1orf216 Homo sapiens Q8TAB5
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 CRX Homo sapiens O43186
Validated Y2H
25416956
Intra
TLE5 Q08117 SCNM1 Homo sapiens Q9BWG6
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 CFAP206 Homo sapiens Q8IYR0
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 CFAP206 Homo sapiens Q8IYR0
Validated Y2H
25416956
Intra
TLE5 Q08117 STK16 Homo sapiens O75716
Y2H Array
25416956
Intra
TLE5 Q08117 CARD9 Homo sapiens Q9H257
Y2H Array
31515488
Intra
TLE5 Q08117 CARD9 Homo sapiens Q9H257
Y2H Array
25416956
Intra
TLE5 Q08117 BCL6 Homo sapiens P41182
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 BCL6 Homo sapiens P41182
Validated Y2H
25416956
Intra
TLE5 Q08117 EAF1 Homo sapiens Q96JC9
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 EAF1 Homo sapiens Q96JC9
Validated Y2H
25416956
Intra
TLE5 Q08117 EAF1 Homo sapiens Q96JC9
Lumier
32814053
Intra
TLE5 Q08117 AEN Homo sapiens Q8WTP8
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 AEN Homo sapiens Q8WTP8
Validated Y2H
25416956
Intra
TLE5 Q08117 LMO1 Homo sapiens P25800
Y2H Array
25416956
Intra
TLE5 Q08117 LMO1 Homo sapiens P25800
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 NAB2 Homo sapiens Q15742
Y2H Array
25416956
Intra
TLE5 Q08117 NAB2 Homo sapiens Q15742
Validated Y2H
25416956
Intra
TLE5 Q08117 AIRIM Homo sapiens Q9NX04
Y2H Array
25416956
Intra
TLE5 Q08117 AIRIM Homo sapiens Q9NX04
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 PROP1 Homo sapiens O75360
Anti Tag CoIP
23732115
Intra
TLE5 Q08117 OSGIN1 Homo sapiens Q9UJX0
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 C1orf94 Homo sapiens Q6P1W5
Validated Y2H
25416956
Intra
TLE5 Q08117 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra
TLE5 Q08117 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra
TLE5 Q08117 FOXP2 Homo sapiens O15409
Y2H Prey Pooling
25416956
Intra
TLE5 Q08117 FOXP2 Homo sapiens O15409
Validated Y2H
25416956
Intra
TLE5 Q08117 FOXP2 Homo sapiens O15409
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

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Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14567 TLE5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TLE5 RGD RGD:2731
Mus musculus TLE5 MGD MGI:95806
Others TLE5 NCBI