PIM1 - Pim-1 proto-oncogene, serine/threonine kinase Gene

Also Known as PIM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5292

About PIM1

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:37,170,152-37,175,428 (from NCBI)

This gene has 3 transcripts (splice variants), 245 orthologues, 2 paralogues and is associated with 63 phenotypes. Broad expression in bone marrow (RPKM 89.3), esophagus (RPKM 60.8) and 21 other tissues.

Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and Pim subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate Cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

PIM1 Products (2)

mRNA	Protein	Name
NM_001243186.2	NP_001230115.1	serine/threonine-protein kinase pim-1 isoform 1
NM_002648.4	NP_002639.1	serine/threonine-protein kinase pim-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ATP binding	IDA IDA: Inferred from direct assay	1825810	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	1825810	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16186805	GOA
enables protein serine/threonine kinase activator activity	IMP IMP: Inferred from mutant phenotype	16186805	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	1825810	GOA
enables ribosomal small subunit binding	IPI IPI: Inferred from physical interaction	16266891	GOA
enables transcription factor binding	IPI IPI: Inferred from physical interaction	18593906	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular detoxification	IMP IMP: Inferred from mutant phenotype	18056989	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	37797010	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18593906	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	16186805	GOA
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	37797010	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	31548394	GOA
involved in positive regulation of cardiac muscle cell proliferation	IDA IDA: Inferred from direct assay	21474815	GOA
involved in positive regulation of cardioblast proliferation	IDA IDA: Inferred from direct assay	21474815	GOA
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18593906	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	16186805	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	16266891	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	18593906	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	1825810	GOA
involved in regulation of transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	18056989	GOA
involved in vitamin D receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22720752	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	1825810	GOA
located in cytosol	IDA IDA: Inferred from direct assay	16186805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16186805	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16186805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIM1 Protein Structure

Pkinase

0
100
200
313 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase pim-1	Oncogene PIM1 pim-1 oncogene (proviral integration site 1) proto-oncogene serine/threonine-protein kinase pim-1

PIM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PIM1	P11309	TFPT	Homo sapiens	P0C1Z6-2	Validated Y2H	25416956
Intra	PIM1	P11309	TFPT	Homo sapiens	P0C1Z6-2	Y2H Array	25416956
Intra	PIM1	P11309	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	25416956
Intra	PIM1	P11309	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	25416956
Intra	PIM1	P11309	NHLH1	Homo sapiens	Q5T203	Validated Y2H	25416956
Intra	PIM1	P11309	FH	Homo sapiens	P07954	Y2H Prey Pooling	25416956
Intra	PIM1	P11309	FH	Homo sapiens	P07954	Validated Y2H	25416956
Intra	PIM1	P11309	ZBTB1	Homo sapiens	Q9Y2K1	Y2H Prey Pooling	25416956
Intra	PIM1	P11309	ZBTB1	Homo sapiens	Q9Y2K1	Validated Y2H	25416956
Intra	PIM1	P11309	RPS19	Homo sapiens	P39019	Y2H	16266891
Intra	PIM1	P11309	RPS19	Homo sapiens	P39019	Pull Down	16266891
Intra	PIM1	P11309	HEXIM2	Homo sapiens	Q96MH2	Y2H Prey Pooling	25416956
Intra	PIM1	P11309	HEXIM2	Homo sapiens	Q96MH2	Validated Y2H	25416956
Intra	PIM1	P11309	BMX	Homo sapiens	P51813	Anti Bait CoIP	16186805
Intra	PIM1	P11309	FXR2	Homo sapiens	P51116	Validated Y2H	25416956
Intra	PIM1	P11309	FXR2	Homo sapiens	P51116	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

PIM1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82757	PIM1 Antibody (YA2502)	WB, IHC-P	Human
HY-P82757A	PIM1 Antibody (YA2502)(PBS only)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Primary Central Nervous System Lymphoma	Pcnsl Primary Cns Lymphoma Primary Brain Lymphoma Primary Lymphoma, Cns Primary Cerebral Lymphoma
Plasma Protein Metabolism Disease
Dressler'S Syndrome	Dressler Syndrome Postmyocardial Infarction Syndrome Donath-Landsteiner Hemolytic Anemia Post-Myocardial Infarction Syndrome Postmyocardial Infarction Pericarditis
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Polyploidy	Polyploid Polyploidy Syndrome
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-101870B	Uzansertib phosphate	Inhibitor	99.77%	Phase 2
HY-101870	Uzansertib	Inhibitor	99.45%	Phase 2
HY-19322	PIM447	Inhibitor	99.52%	Phase 1
HY-19322B	PIM-447 dihydrochloride	Inhibitor	99.82%	Phase 1

Pre-clinical Phase

Bioactive Molecules (41)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-10371	Pim1/AAK1-IN-1	Inhibitor	98.40%	Unkown
HY-16576A	SMI-4a	Inhibitor	99.85%	Unkown
HY-N4149	Quercetagetin	Inhibitor	99.94%	Unkown
HY-18086	TCS PIM-1 1	Inhibitor	98.40%	Unkown
HY-16976	GDC-0339	Inhibitor	99.87%	Unkown
HY-135906	CK2/ERK8-IN-1	Inhibitor	99.0%	Unkown
HY-101947	SMI-16a	Inhibitor	98.0%	Unkown
HY-120758	SEL24-B489	Inhibitor	99.02%	Unkown
HY-122665	HTH-01-091	Inhibitor	99.81%	Unkown
HY-142696A	CDK6/PIM1-IN-1 hydrochloride	Inhibitor	99.38%	Unkown
HY-147785	Pim-1 kinase inhibitor 2	Inhibitor	99.91%	Unkown
HY-108605	PIM1-IN-2	Inhibitor	99.0%	Unkown
HY-111552	PIM1-IN-1	Inhibitor	99.83%	Unkown
HY-149054	GSK-3β inhibitor 13	Inhibitor	99.74%	Unkown
HY-164460	AZD1897	Inhibitor	99.69%	Unkown
HY-123983	HS56	Inhibitor	99.6%	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-101783	GNE-955	Inhibitor	/	Unkown
HY-186146	SGI-1776-VHL-02	Degrader	96.67%	Unkown
HY-147920	PIM1-IN-6	Inhibitor	/	Unkown
HY-147921	PIM1-IN-7	Inhibitor	/	Unkown
HY-179098	Multi-target kinase-IN-8	Inhibitor	/	Unkown
HY-135816	CK2/PIM1-IN-1	Inhibitor	/	Unkown
HY-143898	PIM1-IN-4	Inhibitor	/	Unkown
HY-143897	PIM1-IN-3	Inhibitor	/	Unkown
HY-178443	Pim-1 kinase-IN-15	Inhibitor	/	Unkown
HY-181925	FD2024	Inhibitor	/	Unkown
HY-163119	Pim-1 kinase inhibitor 9	Inhibitor	/	Unkown
HY-168071	Pim-1 kinase inhibitor 11	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-156470	Multi-kinase-IN-6	Inhibitor	/	Unkown
HY-185446	KZ-02	Inhibitor	/	Unkown
HY-150731	Pim-1 kinase inhibitor 3	Inhibitor	/	Unkown
HY-174302	PIM-1/HDAC-IN-2	Inhibitor	/	Unkown
HY-168517	PIM-1/CK2-IN-2	Inhibitor	/	Unkown
HY-178133	Pim-1 kinase-IN-14	Inhibitor	/	Unkown
HY-168479	VB1080	Inhibitor	/	Unkown
HY-173224	CDK2/PIM1-IN-1	Inhibitor	/	Unkown
HY-122670	VS-II-173	Inhibitor	/	Unkown
HY-157404	Pim-1/2 kinase inhibitor 2	Inhibitor	/	Unkown
HY-181125	Pim-1 kinase-IN-16	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PIM1	VGNC	VGNC:32899
Rattus norvegicus	PIM1	RGD	RGD:3330
Felis catus	PIM1	VGNC	VGNC:102483
Mus musculus	PIM1	MGD	MGI:97584
Others	PIM1	NCBI