PP129
PP129 is a multi-kinase inhibitor targeting the PI3K catalytic subunits p110α (IC50 32 μM), p110β (100 μM), p110δ (3.4 μM), and p110γ (100 μM); mTOR serine/threonine kinase (2.2 μM); DNAPK DNA-dependent protein kinase (2.7 μM); and the tyrosine kinases Abl (12 μM), Hck (100 μM), Src (0.8 μM), mutant Src T/I (100 μM), VEGFR (49 μM), EGFR (25 μM), and EphB4 (12 μM).
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- CAS. Nr.: 1092788-76-5
- Formel: C17H16N6
- Molecular Weight:304.36
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
p110α 32 μM (IC50) |
p110β 100 μM (IC50) |
p110δ 3.4 μM (IC50) |
p110γ 100 μM (IC50) |
mTOR 2.2 μM (IC50) |
Abl 12 μM (IC50) |
Hck 100 μM (IC50) |
In Vitro
Chemical Information
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CAS. Nr. 1092788-76-5
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Molecular Weight 304.36
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Formel C17H16N6
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SMILES
N=1C=CC=2C=CC(=CC2C1)C3=NN(C=4N=CN=C(N)C34)C(C)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PP129 Related Classifications
HY-134474 Related Classifications
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Keywords
- PP129
- 1092788-76-5
- PP 129
- PP-129
- PI3K
- mTOR
- DNA-PK
- Bcr-Abl
- Src
- VEGFR
- EGFR
- Ephrin Receptor
- Phosphoinositide 3-kinase
- Mammalian target of Rapamycin
- DNA-dependent protein kinase
- Vascular endothelial growth factor receptor
- Epidermal growth factor receptor
- ErbB-1
- HER1
- DNAPK
- mTOR serine/threonine kinase
- p110α
- p110β
- p110γ
- p110δ
- Inhibitor
- inhibitor
- inhibit