GEM - GTP binding protein overexpressed in skeletal muscle Gene

Also Known as KIR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2669

About GEM

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:94,249,253-94,262,319 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 35 paralogues. Broad expression in gall bladder (RPKM 114.4), urinary bladder (RPKM 36.5) and 15 other tissues.

Summary

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GEM Products (2)

mRNA	Protein	Name
NM_005261.4	NP_005252.1	GTP-binding protein GEM
NM_181702.3	NP_859053.1	GTP-binding protein GEM

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables GDP binding	IDA IDA: Inferred from direct assay	17052716	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	17107948	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	17107948	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	17107948	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12093360	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in chromosome organization	IMP IMP: Inferred from mutant phenotype	22964304	GOA
involved in metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	22964304	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22964304	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	7912851	GOA
located in midbody	IDA IDA: Inferred from direct assay	22964304	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	22964304	GOA
located in spindle midzone	IDA IDA: Inferred from direct assay	22964304	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GEM Protein Structure

Ras

0
100
200
296 a.a.

Protein Preferred Names	Protein Names
GTP-binding protein GEM	GTP-binding mitogen-induced T-cell protein

GEM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	GEM	P55040	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	GEM	P55040	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	25416956
Intra	GEM	P55040	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	GEM	P55040	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	GEM	P55040	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	GEM	P55040	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	GEM	P55040	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	GEM	P55040	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	32296183
Intra	GEM	P55040	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	GEM	P55040	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	GEM	P55040	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	GEM	P55040	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	GEM	P55040	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	GEM	P55040	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	GEM	P55040	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	30886144
Intra	GEM	P55040	KRT83	Homo sapiens	P78385	Y2H Prey Pooling	32296183
Intra	GEM	P55040	KRT83	Homo sapiens	P78385	Validated Y2H	32296183
Intra	GEM	P55040	KRT83	Homo sapiens	P78385	Y2H Array	32296183
Intra	GEM	P55040	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
Intra	GEM	P55040	ZNF774	Homo sapiens	Q6NX45	Validated Y2H	32296183
Intra	GEM	P55040	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
Intra	GEM	P55040	ISCA2	Homo sapiens	Q86U28	Validated Y2H	32296183
Intra	GEM	P55040	ISCA2	Homo sapiens	Q86U28	Y2H Array	32296183
Intra	GEM	P55040	ISCA2	Homo sapiens	Q86U28	Y2H Prey Pooling	32296183
Intra	GEM	P55040	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	GEM	P55040	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	GEM	P55040	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	GEM	P55040	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	GEM	P55040	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	GEM	P55040	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	GEM	P55040	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	GEM	P55040	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	HOOK2	Homo sapiens	Q96ED9-2	Validated Y2H	32296183
Intra	GEM	P55040	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	GEM	P55040	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	GEM	P55040	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	GEM	P55040	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	GEM	P55040	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	GEM	P55040	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	GEM	P55040	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	GEM	P55040	GOPC	Homo sapiens	Q9HD26-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	GOPC	Homo sapiens	Q9HD26-2	Validated Y2H	32296183
Intra	GEM	P55040	GOPC	Homo sapiens	Q9HD26-2	Y2H Array	32296183
Intra	GEM	P55040	PRDM6	Homo sapiens	Q9NQX0	Y2H Array	32296183
Intra	GEM	P55040	PRDM6	Homo sapiens	Q9NQX0	Validated Y2H	32296183
Intra	GEM	P55040	PRDM6	Homo sapiens	Q9NQX0	Y2H Prey Pooling	32296183
Intra	GEM	P55040	GPRASP3	Homo sapiens	Q6PI77	Validated Y2H	32296183
Intra	GEM	P55040	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	GEM	P55040	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	GEM	P55040	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	GEM	P55040	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	GEM	P55040	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	30886144
Intra	GEM	P55040	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	GEM	P55040	TRIM69	Homo sapiens	Q86WT6-2	Validated Y2H	32296183
Intra	GEM	P55040	TRIM69	Homo sapiens	Q86WT6-2	Y2H Array	32296183
Intra	GEM	P55040	TRIM69	Homo sapiens	Q86WT6-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	CARD9	Homo sapiens	Q9H257-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	CARD9	Homo sapiens	Q9H257-2	Y2H Array	32296183
Intra	GEM	P55040	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	GEM	P55040	MSS51	Homo sapiens	Q4VC12	Y2H Prey Pooling	32296183
Intra	GEM	P55040	MSS51	Homo sapiens	Q4VC12	Validated Y2H	32296183
Intra	GEM	P55040	MSS51	Homo sapiens	Q4VC12	Y2H Array	32296183
Intra	GEM	P55040	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	GEM	P55040	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	GEM	P55040	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	CDR2	Homo sapiens	Q01850	Validated Y2H	32296183
Intra	GEM	P55040	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
Intra	GEM	P55040	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
Intra	GEM	P55040	CACNB3	Homo sapiens	P54284	MAPPIT	32296183
Intra	GEM	P55040	CACNB3	Homo sapiens	P54284	Y2H Array	32296183
Intra	GEM	P55040	CACNB3	Homo sapiens	P54284	Y2H Prey Pooling	32296183
Intra	GEM	P55040	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	GEM	P55040	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	32296183
Intra	GEM	P55040	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	GEM	P55040	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	GEM	P55040	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	CCDC125	Homo sapiens	Q86Z20	Validated Y2H	32296183
Intra	GEM	P55040	CCDC125	Homo sapiens	Q86Z20	Y2H Prey Pooling	32296183
Intra	GEM	P55040	CCDC125	Homo sapiens	Q86Z20	Y2H Array	32296183
Intra	GEM	P55040	TRIM10	Homo sapiens	Q9UDY6-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	TRIM10	Homo sapiens	Q9UDY6-2	Validated Y2H	32296183
Intra	GEM	P55040	TRIM10	Homo sapiens	Q9UDY6-2	Y2H Array	32296183
Intra	GEM	P55040	POF1B	Homo sapiens	Q8WVV4-1	Y2H Prey Pooling	32296183
Intra	GEM	P55040	POF1B	Homo sapiens	Q8WVV4-1	Validated Y2H	32296183
Intra	GEM	P55040	POF1B	Homo sapiens	Q8WVV4-1	Y2H Array	32296183
Intra	GEM	P55040	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	GEM	P55040	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	GEM	P55040	TGM7	Homo sapiens	Q96PF1	Validated Y2H	32296183
Intra	GEM	P55040	TGM7	Homo sapiens	Q96PF1	Y2H Array	32296183
Intra	GEM	P55040	TGM7	Homo sapiens	Q96PF1	Y2H Prey Pooling	32296183
Intra	GEM	P55040	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	GEM	P55040	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	GEM	P55040	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	GEM	P55040	INSC	Homo sapiens	Q1MX18	Y2H Prey Pooling	32296183
Intra	GEM	P55040	INSC	Homo sapiens	Q1MX18	Y2H Array	32296183
Intra	GEM	P55040	INSC	Homo sapiens	Q1MX18	Validated Y2H	32296183
Intra	GEM	P55040	VPS28	Homo sapiens	Q9UK41-2	Validated Y2H	32296183
Intra	GEM	P55040	VPS28	Homo sapiens	Q9UK41-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	VPS28	Homo sapiens	Q9UK41-2	Y2H Array	32296183
Intra	GEM	P55040	ANKRD36B	Homo sapiens	Q8N2N9-4	Validated Y2H	32296183
Intra	GEM	P55040	ANKRD36B	Homo sapiens	Q8N2N9-4	Y2H Array	32296183
Intra	GEM	P55040	ANKRD36B	Homo sapiens	Q8N2N9-4	Y2H Prey Pooling	32296183
Intra	GEM	P55040	DBF4B	Homo sapiens	Q8NFT6-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	DBF4B	Homo sapiens	Q8NFT6-2	Validated Y2H	32296183
Intra	GEM	P55040	DBF4B	Homo sapiens	Q8NFT6-2	Y2H Array	32296183
Intra	GEM	P55040	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	GEM	P55040	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	GEM	P55040	NDUFB7	Homo sapiens	P17568	Y2H Prey Pooling	32296183
Intra	GEM	P55040	NDUFB7	Homo sapiens	P17568	Y2H Array	32296183
Intra	GEM	P55040	ASB15	Homo sapiens	Q8WXK1	Y2H Prey Pooling	32296183
Intra	GEM	P55040	ASB15	Homo sapiens	Q8WXK1	Y2H Array	32296183
Intra	GEM	P55040	ASB15	Homo sapiens	Q8WXK1	Validated Y2H	32296183
Intra	GEM	P55040	SNAP91	Homo sapiens	O60641-3	Y2H Prey Pooling	32296183
Intra	GEM	P55040	SNAP91	Homo sapiens	O60641-3	Y2H Array	32296183
Intra	GEM	P55040	LIMS1	Homo sapiens	P48059-3	Y2H Prey Pooling	32296183
Intra	GEM	P55040	LIMS1	Homo sapiens	P48059-3	Y2H Array	32296183
Intra	GEM	P55040	MGLL	Homo sapiens	A0A0C4DFN3	Y2H Array	32296183
Intra	GEM	P55040	MGLL	Homo sapiens	A0A0C4DFN3	Y2H Prey Pooling	32296183
Intra	GEM	P55040	TBC1D3G	Homo sapiens	Q6DHY5	Y2H Prey Pooling	32296183
Intra	GEM	P55040	TBC1D3G	Homo sapiens	Q6DHY5	Y2H Array	32296183
Intra	GEM	P55040	TBC1D3G	Homo sapiens	Q6DHY5	Validated Y2H	32296183
Intra	GEM	P55040	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	GEM	P55040	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	GEM	P55040	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	GEM	P55040	C1orf131	Homo sapiens	Q8NDD1-6	Validated Y2H	32296183
Intra	GEM	P55040	C1orf131	Homo sapiens	Q8NDD1-6	Y2H Array	32296183
Intra	GEM	P55040	C1orf131	Homo sapiens	Q8NDD1-6	Y2H Prey Pooling	32296183
Intra	GEM	P55040	SPATA6	Homo sapiens	Q9NWH7-2	Validated Y2H	32296183
Intra	GEM	P55040	SPATA6	Homo sapiens	Q9NWH7-2	Y2H Array	32296183
Intra	GEM	P55040	SPATA6	Homo sapiens	Q9NWH7-2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	LRP2BP	Homo sapiens	Q9P2M1	Y2H Array	32296183
Intra	GEM	P55040	LRP2BP	Homo sapiens	Q9P2M1	Validated Y2H	32296183
Intra	GEM	P55040	LRP2BP	Homo sapiens	Q9P2M1	Y2H Prey Pooling	32296183
Intra	GEM	P55040	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	GEM	P55040	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	GEM	P55040	MKRN3	Homo sapiens	Q13064	Y2H Prey Pooling	32296183
Intra	GEM	P55040	MKRN3	Homo sapiens	Q13064	Y2H Array	32296183
Intra	GEM	P55040	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
Intra	GEM	P55040	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	GEM	P55040	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Intra	GEM	P55040	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	GEM	P55040	AHCYL1	Homo sapiens	O43865	Y2H Prey Pooling	32296183
Intra	GEM	P55040	AHCYL1	Homo sapiens	O43865	Y2H Array	32296183
Intra	GEM	P55040	AHCYL1	Homo sapiens	O43865	Y2H Prey Pooling	25416956
Intra	GEM	P55040	AHCYL1	Homo sapiens	O43865	Validated Y2H	25416956
Intra	GEM	P55040	TFAP4	Homo sapiens	Q01664	Anti Bait CoIP	16924111
Intra	GEM	P55040	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	GEM	P55040	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	GEM	P55040	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	25416956
Intra	GEM	P55040	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	25416956
Intra	GEM	P55040	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	GEM	P55040	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	32296183
Intra	GEM	P55040	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	32296183
Intra	GEM	P55040	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	32296183
Intra	GEM	P55040	ZNF552	Homo sapiens	Q9H707	Y2H Prey Pooling	32296183
Intra	GEM	P55040	ZNF552	Homo sapiens	Q9H707	Validated Y2H	32296183
Intra	GEM	P55040	ZNF552	Homo sapiens	Q9H707	Y2H Array	32296183
Intra	GEM	P55040	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	32296183
Intra	GEM	P55040	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	GEM	P55040	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	GEM	P55040	PLAGL2	Homo sapiens	Q9UPG8	Y2H Array	32296183
Intra	GEM	P55040	PLAGL2	Homo sapiens	Q9UPG8	Y2H Prey Pooling	32296183
Intra	GEM	P55040	PLAGL2	Homo sapiens	Q9UPG8	Validated Y2H	32296183
Intra	GEM	P55040	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	GEM	P55040	PNMA1	Homo sapiens	Q8ND90	Y2H Array	25416956
Intra	GEM	P55040	CCDC88B	Homo sapiens	A6NC98	Y2H Array	32296183
Intra	GEM	P55040	CCDC88B	Homo sapiens	A6NC98	Y2H Prey Pooling	32296183
Intra	GEM	P55040	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	32296183
Intra	GEM	P55040	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	GEM	P55040	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	32296183
Intra	GEM	P55040	PDLIM7	Homo sapiens	Q9NR12	Y2H Pooling	16189514
Intra	GEM	P55040	PDLIM7	Homo sapiens	Q9NR12	Y2H Prey Pooling	32296183
Intra	GEM	P55040	PDLIM7	Homo sapiens	Q9NR12	Validated Y2H	32296183
Intra	GEM	P55040	PDLIM7	Homo sapiens	Q9NR12	Y2H Array	32296183
Intra	GEM	P55040	VIM	Homo sapiens	P08670	Y2H Prey Pooling	32296183
Intra	GEM	P55040	VIM	Homo sapiens	P08670	Y2H Array	32296183
Intra	GEM	P55040	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	GEM	P55040	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	GEM	P55040	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	GEM	P55040	PIH1D1	Homo sapiens	Q9NWS0	Y2H Prey Pooling	32296183
Intra	GEM	P55040	PIH1D1	Homo sapiens	Q9NWS0	Validated Y2H	32296183
Intra	GEM	P55040	PIH1D1	Homo sapiens	Q9NWS0	Y2H Array	32296183
Intra	GEM	P55040	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	GEM	P55040	TRAF1	Homo sapiens	Q13077	Validated Y2H	32296183
Intra	GEM	P55040	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	GEM	P55040	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	GEM	P55040	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	GEM	P55040	YWHAB	Homo sapiens	P31946	CoIP	14701738
Intra	GEM	P55040	YWHAB	Homo sapiens	P31946	Pull Down	30833792
Intra	GEM	P55040	EXOSC8	Homo sapiens	Q96B26	Validated Y2H	32296183
Intra	GEM	P55040	EXOSC8	Homo sapiens	Q96B26	Y2H Array	32296183
Intra	GEM	P55040	EXOSC8	Homo sapiens	Q96B26	Y2H Prey Pooling	32296183
Intra	GEM	P55040	GADD45GIP1	Homo sapiens	Q8TAE8	Y2H Array	32296183
Intra	GEM	P55040	GADD45GIP1	Homo sapiens	Q8TAE8	Y2H Prey Pooling	32296183
Intra	GEM	P55040	GADD45GIP1	Homo sapiens	Q8TAE8	Validated Y2H	32296183
Intra	GEM	P55040	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	GEM	P55040	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	GEM	P55040	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	GEM	P55040	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	GEM	P55040	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	GEM	P55040	MYOG	Homo sapiens	P15173	Y2H Array	32296183
Intra	GEM	P55040	MYOG	Homo sapiens	P15173	Y2H Prey Pooling	32296183
Intra	GEM	P55040	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	32296183
Intra	GEM	P55040	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	32296183
Intra	GEM	P55040	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	32296183
Intra	GEM	P55040	SPAG5	Homo sapiens	Q96R06	Validated Y2H	32296183
Intra	GEM	P55040	SPAG5	Homo sapiens	Q96R06	Y2H Prey Pooling	32296183
Intra	GEM	P55040	SPAG5	Homo sapiens	Q96R06	Y2H Array	32296183
Intra	GEM	P55040	ZNF688	Homo sapiens	P0C7X2	Y2H Array	32296183
Intra	GEM	P55040	ZNF688	Homo sapiens	P0C7X2	Y2H Prey Pooling	32296183
Intra	GEM	P55040	KCTD9	Homo sapiens	Q7L273	Y2H Prey Pooling	32296183
Intra	GEM	P55040	KCTD9	Homo sapiens	Q7L273	Validated Y2H	32296183
Intra	GEM	P55040	KCTD9	Homo sapiens	Q7L273	Y2H Array	25416956
Intra	GEM	P55040	KCTD9	Homo sapiens	Q7L273	Y2H Array	32296183
Intra	GEM	P55040	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Prey Pooling	32296183
Intra	GEM	P55040	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Array	32296183
Intra	GEM	P55040	BLOC1S2	Homo sapiens	Q6QNY1	Validated Y2H	32296183
Intra	GEM	P55040	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	GEM	P55040	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	GEM	P55040	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	GEM	P55040	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	GEM	P55040	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	GEM	P55040	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	GEM	P55040	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	GEM	P55040	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	GEM	P55040	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	GEM	P55040	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	GEM	P55040	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	GEM	P55040	MESD	Homo sapiens	Q14696	Validated Y2H	32296183
Intra	GEM	P55040	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Intra	GEM	P55040	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	GEM	P55040	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	GEM	P55040	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	GEM	P55040	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	GEM	P55040	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	GEM	P55040	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	GEM	P55040	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	GEM	P55040	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	GEM	P55040	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	GEM	P55040	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	GEM	P55040	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	GEM	P55040	KRT6A	Homo sapiens	P02538	Y2H Prey Pooling	32296183
Intra	GEM	P55040	KRT6A	Homo sapiens	P02538	Y2H Array	32296183
Intra	GEM	P55040	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	GEM	P55040	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	GEM	P55040	ECSIT	Homo sapiens	Q9BQ95	Y2H Prey Pooling	32296183
Intra	GEM	P55040	ECSIT	Homo sapiens	Q9BQ95	Validated Y2H	32296183
Intra	GEM	P55040	ECSIT	Homo sapiens	Q9BQ95	Y2H Array	32296183
Intra	GEM	P55040	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	32296183
Intra	GEM	P55040	KATNBL1	Homo sapiens	Q9H079	Validated Y2H	32296183
Intra	GEM	P55040	KATNBL1	Homo sapiens	Q9H079	Y2H Array	32296183
Intra	GEM	P55040	ZNF20	Homo sapiens	P17024	Y2H Array	32296183
Intra	GEM	P55040	ZNF20	Homo sapiens	P17024	Y2H Prey Pooling	32296183
Intra	GEM	P55040	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	GEM	P55040	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	GEM	P55040	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	GEM	P55040	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	GEM	P55040	COG8	Homo sapiens	Q96MW5	Y2H Prey Pooling	25416956
Intra	GEM	P55040	COG8	Homo sapiens	Q96MW5	Validated Y2H	25416956
Intra	GEM	P55040	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	GEM	P55040	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	GEM	P55040	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	GEM	P55040	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	GEM	P55040	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	GEM	P55040	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	GEM	P55040	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	GEM	P55040	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	GEM	P55040	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	GEM	P55040	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	GEM	P55040	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	GEM	P55040	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	GEM	P55040	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	GEM	P55040	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	GEM	P55040	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	GEM	P55040	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	GEM	P55040	BEGAIN	Homo sapiens	Q9BUH8	Y2H Prey Pooling	32296183
Intra	GEM	P55040	BEGAIN	Homo sapiens	Q9BUH8	Validated Y2H	32296183
Intra	GEM	P55040	BEGAIN	Homo sapiens	Q9BUH8	Y2H Array	32296183
Intra	GEM	P55040	TRIM32	Homo sapiens	Q13049	Y2H Prey Pooling	32296183
Intra	GEM	P55040	TRIM32	Homo sapiens	Q13049	Validated Y2H	32296183
Intra	GEM	P55040	TRIM32	Homo sapiens	Q13049	Y2H Array	32296183
Intra	GEM	P55040	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	GEM	P55040	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	GEM	P55040	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	GEM	P55040	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	25416956
Intra	GEM	P55040	RUNDC3A	Homo sapiens	Q59EK9	Y2H Prey Pooling	25416956
Intra	GEM	P55040	ZC4H2	Homo sapiens	Q9NQZ6	Validated Y2H	32296183
Intra	GEM	P55040	ZC4H2	Homo sapiens	Q9NQZ6	Y2H Prey Pooling	32296183
Intra	GEM	P55040	ZC4H2	Homo sapiens	Q9NQZ6	Y2H Array	32296183
Intra	GEM	P55040	DEUP1	Homo sapiens	Q05D60	Y2H Array	25416956
Intra	GEM	P55040	DEUP1	Homo sapiens	Q05D60	Y2H Prey Pooling	25416956
Intra	GEM	P55040	ZSCAN9	Homo sapiens	O15535	Y2H Prey Pooling	32296183
Intra	GEM	P55040	ZSCAN9	Homo sapiens	O15535	Y2H Array	32296183
Intra	GEM	P55040	INO80E	Homo sapiens	Q8NBZ0	Y2H Array	32296183
Intra	GEM	P55040	INO80E	Homo sapiens	Q8NBZ0	Y2H Prey Pooling	25416956
Intra	GEM	P55040	INO80E	Homo sapiens	Q8NBZ0	Y2H Prey Pooling	32296183
Intra	GEM	P55040	INO80E	Homo sapiens	Q8NBZ0	Validated Y2H	25416956
Intra	GEM	P55040	INO80E	Homo sapiens	Q8NBZ0	Validated Y2H	32296183
Intra	GEM	P55040	ZMAT5	Homo sapiens	Q9UDW3	Y2H Array	32296183
Intra	GEM	P55040	ZMAT5	Homo sapiens	Q9UDW3	Y2H Prey Pooling	32296183
Intra	GEM	P55040	ZMAT5	Homo sapiens	Q9UDW3	Validated Y2H	32296183
Intra	GEM	P55040	USH1G	Homo sapiens	Q495M9	Validated Y2H	32296183
Intra	GEM	P55040	USH1G	Homo sapiens	Q495M9	Y2H Array	32296183
Intra	GEM	P55040	USH1G	Homo sapiens	Q495M9	Y2H Prey Pooling	32296183
Intra	GEM	P55040	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	32296183
Intra	GEM	P55040	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	32296183
Intra	GEM	P55040	IHO1	Homo sapiens	Q8IYA8	Y2H Array	32296183
Intra	GEM	P55040	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	GEM	P55040	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	GEM	P55040	CACNB1	Homo sapiens	Q02641	Anti Tag CoIP	17052716
Intra	GEM	P55040	CACNB1	Homo sapiens	Q02641	Anti Tag CoIP	35122502
Intra	GEM	P55040	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	GEM	P55040	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	GEM	P55040	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	GEM	P55040	MORN3	Homo sapiens	Q6PF18	Validated Y2H	32296183
Intra	GEM	P55040	MORN3	Homo sapiens	Q6PF18	Y2H Array	32296183
Intra	GEM	P55040	MORN3	Homo sapiens	Q6PF18	Y2H Prey Pooling	32296183
Cross	GEM	P55040	CACNA1A	Oryctolagus cuniculus	P27884	Anti Tag CoIP	20679232
Cross	GEM	P55040	Cacnb3	Rattus norvegicus	P54287	Anti Tag CoIP	20679232

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-149906	Trecovirsen	Inhibitor	97.98%	Unkown
HY-149906C	Trecovirsen sodium	Inhibitor	96.55%	Unkown
HY-143411	GEM144		/	Unkown
HY-102020A	RG3039 hydrochloride		98.15%	Unkown
HY-185323	Gem-C12		99.48%	Unkown
HY-145314	TC113		/	Unkown
HY-145441	GEM–IB		/	Unkown
HY-146540	GEM-5		/	Unkown
HY-148827	GEM-231	Inhibitor	/	Unkown
HY-148827A	GEM-231 sodium	Inhibitor	/	Unkown
HY-148827C	GEM-231 sodium scrambled negative control	Inhibitor	/	Unkown
HY-148827D	FAM labled GEM-231 sodium		/	Unkown
HY-148827E	Cy3 labled GEM-231 sodium		/	Unkown
HY-149906A	FITC-Trecovirsen sodium	Inhibitor	/	Unkown
HY-154842	S-Gem		/	Unkown
HY-154843	C-Gem	Control	/	Unkown
HY-182898	Gal-dMor-Gem	Inducer	/	Unkown
HY-RS05366	GEM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05523	GMNN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16833	Gem Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23275	Gem Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GEM	MGD	MGI:99844
Bos taurus	GEM	VGNC	VGNC:29315
Rattus norvegicus	GEM	RGD	RGD:1307386
Canis familiaris	GEM	VGNC	VGNC:41172
Felis catus	GEM	VGNC	VGNC:62512
Others	GEM	NCBI