Antitumor agent-174
Antitumor agent-174 (Compound 10) directly engages the N-terminal site of Hsp90 and promotes the degradation of β-catenin, thereby suppressing the Wnt/β-catenin signaling. Antitumor agent-174 effectively inhibits proliferation, induce S and G2/M phases arrest and block the clonogenic ability in CRC cells. Antitumor agent-174 down-regulates CDK1, Cyclin D1, c-Myc, Cyclin B1, and Cyclin A2, and upregulaties P21 proteins. Antitumor agent-174 has significant anti-tumor efficacy against colorectal cancer (CRC) with excellent pharmacokinetics and low toxicity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C20H18Cl2N2
- Molecular Weight:357.28
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
CDK1/cyclinB1 |
HSP90 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
8.31 μM
Compound: 10
|
Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by MTT assay
|
[PMID: 39018921] |
| RKO | IC50 |
7.97 μM
Compound: 10
|
Antiproliferative activity against human RKO cells incubated for 24 hrs by MTT assay
Antiproliferative activity against human RKO cells incubated for 24 hrs by MTT assay
|
[PMID: 39018921] |
Chemical Information
-
Molecular Weight 357.28
-
Formel C20H18Cl2N2
-
SMILES
CC12C3=C(C(C=C(Cl)C=C4)=C4N3)CCN1CCC5=C2C=CC(Cl)=C5
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antitumor agent-174 Related Classifications
HY-161826 Related Classifications
Powered by Bioz