GRP - gastrin releasing peptide Gene
Also Known as BN; GRP-10; proGRP; preproGRP
Species: Homo sapiens
About GRP
This gene has 5 transcripts (splice variants), 103 orthologues and 1 paralogue. Low expression observed in reference dataset.
Summary
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal Hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
GRP Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001012512.3 | NP_001012530.1 | gastrin-releasing peptide isoform 2 precursor |
| NM_001012513.3 | NP_001012531.1 | gastrin-releasing peptide isoform 3 preproprotein |
| NM_002091.5 | NP_002082.2 | gastrin-releasing peptide isoform 1 preproprotein |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables neuropeptide hormone activity |
IDA
IDA: Inferred from direct assay
|
8756537 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| acts upstream of or within neuropeptide signaling pathway |
IDA
IDA: Inferred from direct assay
|
8756537 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
3211139 | GOA |
GRP Protein Structure
Bombesin: Bombesin-like peptide (41 - 54)
- 0
- 100
- 148 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
gastrin-releasing peptide |
|
GRP Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
GRP | P07492 | ALX1 | Homo sapiens | Q15699 | 32296183 | |
|
Intra
|
GRP | P07492 | ALX1 | Homo sapiens | Q15699 | 32296183 | |
|
Intra
|
GRP | P07492 | ALX1 | Homo sapiens | Q15699 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Duodenal Ulcer |
|
|
| Diffuse Pulmonary Fibrosis |
|
|
| Gastrinoma |
|
|
| Zollinger-Ellison Syndrome |
|
|
| Neuroendocrine Tumor |
|
|
| Neuroendocrine Carcinoma |
|
|
| Lambert-Eaton Myasthenic Syndrome |
|
|
| Splenic Tuberculosis |
|
|
| Small Cell Cancer Of The Lung |
|
|
| Agoraphobia |
|
|
| Lung Cancer |
|
|
| Lung Disease |
|
|
| Breast Cyst |
|
|
| Newborn Respiratory Distress Syndrome |
|
|
| Paraganglioma |
|
|
| Gastric Gastrinoma |
|
|
| Prostate Cancer |
|
|
| Lung Benign Neoplasm |
|
|
| Bronchus Cancer |
|
|
| Paraneoplastic Cerebellar Degeneration |
|
|
| Prostate Disease |
|
|
| Large Cell Carcinoma |
|
|
| Pancreatic Cancer |
|
|
| Anencephaly |
|
|
| Colon Adenocarcinoma |
|
|
| Pancreatic Ductal Carcinoma |
|
|
| Constipation |
|
|
| Colorectal Cancer |
|
|
| Diaphragmatic Hernia, Congenital |
|
|
| Vascular Disease |
|
|
| Small Cell Carcinoma |
|
|
| Ewing Sarcoma |
|
|
| Urinary Bladder Small Cell Neuroendocrine Carcinoma |
|
|
| Thyroid Carcinoma, Familial Medullary |
|
|
| Pulmonary Artery Leiomyosarcoma |
|
|
| Pheochromocytoma |
|
|
| Lung Large Cell Carcinoma |
|
|
| Achalasia |
|
|
| Esophageal Atresia |
|
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| Ovarian Cancer |
|
|
| Endobronchial Lipoma |
|
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| Subacute Leukemia |
|
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| Gastric Cancer |
|
|
| Gallbladder Small Cell Carcinoma |
|
|
| Breast Cancer |
|
|
| Interstitial Lung Disease 2 |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | GRP | VGNC | VGNC:53721 |
| Rattus norvegicus | GRP | RGD | RGD:621740 |
| Macaca mulatta | GRP | VGNC | VGNC:73294 |
| Bos taurus | GRP | VGNC | VGNC:29664 |
| Mus musculus | GRP | MGD | MGI:95833 |
| Others | GRP | NCBI |