Elevenostat
Based on 2 publication(s) in Google Scholar
Elevenostat (JB3-22) is a selective HDAC11 inhibitor with an IC50 of 0.235 µM. Elevenostat can induce apoptosis of multiple myeloma cells and has anti-tumor effect. In addition, Elevenostat inhibits the maturation of mouse oocytes.
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- Pureté: 95.07%
- CAS No.: 1454902-97-6
- Formule: C16H17N3O4
- Masse moléculaire:315.32
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) Elevenostat
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Activité biologique
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HDAC11 0.235 μM (IC50) |
Caspase-3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
139 nM
Compound: 1
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Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
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[PMID: 23009203] |
| Sf9 | IC50 |
265 nM
Compound: 1
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Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
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[PMID: 23009203] |
Elevenostat (10 μM; 4-16 h) inhibits the maturation of mouse oocytes, leading to spindle disintegration and chromosome dislocation[2].
Elevenostat (750 nM; 48 h) induces apoptosis in MM1.S cells, with about 31.4% of cells expressing activated caspase-3[3].
Elevenostat (10-8-10-4 M; 72 h) shows severe cytotoxicity to human multiple myeloma cells with an IC50 ranging from 0.803 to 3.410 μM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5TGM1/C57BL/KaLwRij mouse multiple myeloma model[3]
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Dosage:1 mg/kg and 10 mg/kg
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Administration:Intraperitoneal injection (i.p.); once daily for the first 10 days and every alternate day for the rest of the treatment period until mice reached disease endpoint.
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Result:Effectively inhibited tumor growth.
Decrease serum IgG2b level.
Significantly prolonged the survival period of tumor-bearing mice.
Was well-tolerated at these doses and dosing frequencies, supported by lack of changes in body weight.
Chemical Information
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CAS No. 1454902-97-6
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Appearance Solid
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Masse moléculaire 315.32
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Formule C16H17N3O4
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Color Off-white to pink
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SMILES
O=C(NO)C1=CC=C(CNC(NC2=CC=CC=C2OC)=O)C=C1
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Synonyms
JB3-22
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections. [Abstract]2026 Feb 11;34(2):245-262.e8. PMID: 41605216 -
Int J Biol Macromol
Hypoxia-mediated epigenetic silencing of YTHDF2 promotes endometriosis progression via the NFE2L1-NF-κB axis. [Abstract]2026 Jun:367:152621. PMID: 42162597
Solvant et solubilité
DMSO : 250 mg/mL (792.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (604 KB)
- English - EN (604 KB)
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- Deutsch - DE (604 KB)
- Norwegian - NO (604 KB)
- Español - ES (604 KB)
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- Italian - IT (604 KB)
- Korean - KR (604 KB)
- Portuguese - PT (604 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Huang J, et al. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep. 2017;7(1):8626. Published 2017 Aug 17. [Content Brief]
[3]. Mostofa A, et al. Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma. JCI Insight. 2021;6(24):e151713. Published 2021 Dec 22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1714 mL | 15.8569 mL | 31.7138 mL | 79.2845 mL |
| 5 mM | 0.6343 mL | 3.1714 mL | 6.3428 mL | 15.8569 mL | |
| 10 mM | 0.3171 mL | 1.5857 mL | 3.1714 mL | 7.9285 mL | |
| 15 mM | 0.2114 mL | 1.0571 mL | 2.1143 mL | 5.2856 mL | |
| 20 mM | 0.1586 mL | 0.7928 mL | 1.5857 mL | 3.9642 mL | |
| 25 mM | 0.1269 mL | 0.6343 mL | 1.2686 mL | 3.1714 mL | |
| 30 mM | 0.1057 mL | 0.5286 mL | 1.0571 mL | 2.6428 mL | |
| 40 mM | 0.0793 mL | 0.3964 mL | 0.7928 mL | 1.9821 mL | |
| 50 mM | 0.0634 mL | 0.3171 mL | 0.6343 mL | 1.5857 mL | |
| 60 mM | 0.0529 mL | 0.2643 mL | 0.5286 mL | 1.3214 mL | |
| 80 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9911 mL | |
| 100 mM | 0.0317 mL | 0.1586 mL | 0.3171 mL | 0.7928 mL |
Elevenostat Related Classifications
HY-145757 Related Classifications
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