MM129
MM129 is an anticancer agent. MM129 inhibits key oncogenic signaling molecules such as AKT, mTOR, and CDK2, and downregulates the expression of PD-L1. MM129 induces cell cycle arrest. MM129 induces Apoptosis. MM129 induces DNA damage. MM129 induces oxidative stress. MM129 exhibits chemosensitizing properties. MM129 restores the expression of E-cadherin. MM129 can be used in the research of colorectal cancer.
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- Formule: C17H17N9O5S
- Masse moléculaire:459.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
Description
IC50 & Target
[1]|
CDK2 |
In Vitro
MM129 (0.18 µM; 48 h) reduces the percentage of proliferating HCT-116 human colorectal cancer cells to 85.9% after 48 h[1].
MM129 (0.18 µM; 48 h) substantially reduces the percentage of proliferating HT-29 human colorectal cancer cells to 38.2% after 48 h[1].
MM129 (0.18 µM; 48 h) reduces Ki-67 proliferative marker abundance in HCT-116 human colorectal cancer cells to a median CTCF value of 111798 after 48 h[1].
MM129 (0.18 µM; 48 h) induces DNA double-strand breaks in HCT-116 human colorectal cancer cells, producing a median of 28 γH2AX foci per cell after 48 h[1].
MM129 (0.18 µM; 48 h) reduces Ki-67 proliferative marker abundance in HT-29 human colorectal cancer cells to a median CTCF value of 96482 after 48 h[1].
MM129 (0.18 µM; 48 h) induces DNA double-strand breaks in HCT-116 human colorectal cancer cells, producing a median tail DNA percentage of 4.1% after 48 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116 human colorectal cancer cells
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Concentration:0.18 µM
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Incubation Time:48 h (including 24 h BrdU exposure)
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Result:Produced 85.9% BrdU-positive proliferating cells.
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Cell Line:HT-29 human colorectal cancer cells
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Concentration:0.18 µM
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Incubation Time:48 h (including 24 h BrdU exposure)
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Result:Produced 38.2% BrdU-positive proliferating cells.
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Cell Line:HCT-116 human colorectal cancer cells
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Concentration:0.18 µM
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Incubation Time:48 h
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Result:Produced a median Ki-67 corrected total cell fluorescence (CTCF) value of 111798.\nProduced a median of 28 γH2AX foci per cell, indicating elevated levels of DNA double-strand breaks.
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Cell Line:HT-29 human colorectal cancer cells
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Concentration:0.18 µM
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Incubation Time:48 h
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Result:Produced a median Ki-67 corrected total cell fluorescence (CTCF) value of 96482.
Chemical Information
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Masse moléculaire 459.44
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Formule C17H17N9O5S
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SMILES
CC(C1=NC2=NN=NN2N=C31)=NN3C4=CC=C(S(=O)(N5C(C(OC)=O)CC(O)C5)=O)C=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MM129 Related Classifications
HY-189206 Related Classifications
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