Citronellol
Based on 2 publication(s) in Google Scholar
Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.
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- Pureza: 98.40%
- No. CAS: 106-22-9
- Fòrmula: C10H20O
- Peso molecular:156.27
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Citronellol
MoreVer todos los productos específicos de isoformas TNF Receptor
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Actividad biológica
IC50: 54.02，40.64，52.51，45.84，50.1 μg/mL (A549、NCI-H1299、NCI-H23、BT-20、PC3 cells) (Apoptosis)[6].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>100 μM
Compound: Citronellol
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Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
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[PMID: 25455494] |
| HEK293 | IC50 |
>100 μM
Compound: Citronellol
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Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
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[PMID: 25455494] |
| HEK293 | IC50 |
>100 μM
Compound: Citronellol
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Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
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[PMID: 25455494] |
| HEK293 | IC50 |
>100 μM
Compound: Citronellol
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Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
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[PMID: 25455494] |
Citronellol (50, 100 μg/mL, 72 h) can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways[2]. Citronellol can be used as a skin contact allergen after forming hydrogen peroxide through self oxidation[3]. Citronellol (0-100 μg/mL, 48 h) can induce necrotic apoptosis in human lung cancer cell line NCI-H1299 through the TNF-α pathway and accumulation of reactive oxygen species[6]. Citronellol (0-100 μg/mL, 48 h) exhibits cytotoxicity towards A549, NCI-H1299, NCI-H23, BT-20, and PC3 cells, with IC50 values of 54.02, 40.64, 52.51, 45.84, and 50.1 μg/mL, respectively[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH-SY5Y human neuroblastoma cells
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Concentration:50, 100 μg/mL
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Incubation Time:72 h
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Result:Improved the cell viability of SH-SY5Y cells treated with 6-OHDA, reaching levels of 96.25% and 97.56% at concentrations of 50 μ g/mL and 100 μg/mL, respectively.
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Cell Line:NSCLC cells A549, NCI-H23, NCI-H1299, BT-20, PC3 and MCF-10A
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Concentration:0-100 μg/mL
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Incubation Time:48 h
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Result:Showed toxic effects on 5 cancer cell lines, but had no effect on normal cells (MCF-10A).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat myocardial ischemia model established by intraperitoneal injection of DOX (2.5 mg/kg) (HY-15142A) 6 times every other day [1].
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Dosage:25, 50, 100 mg/kg
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Administration:Oral gavage (p.o.); once daily; 2 weeks
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Result:Reduced the production of cardiac antioxidant enzymes, pro-inflammatory cytokines, and lipid biomarkers, and increased the expression of anti-inflammatory cytokines.
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Animal Model:Chronic Rotenone (HY-B1756) PD rat model[4].
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Dosage:25 mg/kg
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Administration:Oral gavage (p.o.); once daily; 4 weeks
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Result:Inhibited Rotenone (HY-B1756) induced reactive oxygen species production, lipid peroxidation, and enhanced Nrf2 expression, catalase, glutathione peroxidase, and superoxide dismutase levels in the brain.
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Animal Model:A mouse model of rhabdomyolysis induced by a single intramuscular injection of 50% glycerol at a dose of 10 ml/kg [5].
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Dosage:50, 100 mg/kg
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Administration:Oral gavage (p.o.); once daily; 4 days
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Result:Reduced KIM-1 mRNA and myoglobin levels, as well as cleaved caspase-3 and BAX protein levels in renal tissue.
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Animal Model:NSCLC nude mouse model established by subcutaneous injection of NCI-H1299 cells into the posterior abdomen of 7-week-old BALB/c (nu/nu) nude mice[6].
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Dosage:12.5, 25, 50 mg/kg
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Administration:Intraperitoneal injection (i.p.); once daily; 20 days
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Result:Inhibited the growth of subcutaneous tumors.
Chemical Information
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No. CAS 106-22-9
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Appearance Liquid (Density: 0.857 g/cm3)
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Peso molecular 156.27
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Fòrmula C10H20O
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Color Colorless to light yellow
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SMILES
CC(CCC=C(C)C)CCO
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Synonyms
(±)-Citronellol; (±)-β-Citronellol
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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PLoS Biol
2024 Jun 27;22(6):e3002672. PMID: 38935621 -
bioRxiv
An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]2024 Apr 3:2023.06.02.542933. PMID: 37333363
Solvente y solubilidad
DMSO : ≥ 100 mg/mL (639.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.00 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.00 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 33.33 mg/mL (213.28 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (796 KB)
- English - EN (796 KB)
- Français - FR (796 KB)
- Deutsch - DE (796 KB)
- Norwegian - NO (796 KB)
- Español - ES (796 KB)
- Swedish - SV (796 KB)
- Italian - IT (796 KB)
- Korean - KR (796 KB)
- Portuguese - PT (796 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Munir S, et al. The Protective Effect of Citronellol against Doxorubicin-Induced Cardiotoxicity in Rats. Biomedicines. 2023 Oct 18;11(10):2820. [Content Brief]
[2]. Shao J, et al. Citronellol Prevents 6-OHDA-Induced Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Parkinson Disease Model of SH-SY5Y Cells via Modulating ROS-NO, MAPK/ERK, and PI3K/Akt Signaling Pathways. Neurotox Res. 2022 Dec;40(6):2221-2237. [Content Brief]
[3]. Sahli F, et al. Autoxidized citronellol: Free radicals as potential sparkles to ignite the fragrance induced skin sensitizing pathway. Food Chem Toxicol. 2022 Aug;166:113201. [Content Brief]
[4]. Jayaraj RL, et al. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson's disease. Heliyon. 2022 Nov 3;8(11):e11434. [Content Brief]
[5]. Mahmood YS, et al. Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice. J Med Life. 2023 Jul;16(7):1057-1061. [Content Brief]
[6]. Yu WN, et al. Citronellol Induces Necroptosis of Human Lung Cancer Cells via TNF-α Pathway and Reactive Oxygen Species Accumulation. In Vivo. 2019 Jul-Aug;33(4):1193-1201. [Content Brief]
[7]. Pereira Fde O, et al. Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against Trichophyton rubrum involves inhibition of ergosterol biosynthesis. Pharm Biol. 2015 Feb;53(2):228-34. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.3992 mL | 31.9959 mL | 63.9918 mL | 159.9795 mL |
| 5 mM | 1.2798 mL | 6.3992 mL | 12.7984 mL | 31.9959 mL | |
| 10 mM | 0.6399 mL | 3.1996 mL | 6.3992 mL | 15.9980 mL | |
| 15 mM | 0.4266 mL | 2.1331 mL | 4.2661 mL | 10.6653 mL | |
| 20 mM | 0.3200 mL | 1.5998 mL | 3.1996 mL | 7.9990 mL | |
| 25 mM | 0.2560 mL | 1.2798 mL | 2.5597 mL | 6.3992 mL | |
| 30 mM | 0.2133 mL | 1.0665 mL | 2.1331 mL | 5.3327 mL | |
| 40 mM | 0.1600 mL | 0.7999 mL | 1.5998 mL | 3.9995 mL | |
| 50 mM | 0.1280 mL | 0.6399 mL | 1.2798 mL | 3.1996 mL | |
| 60 mM | 0.1067 mL | 0.5333 mL | 1.0665 mL | 2.6663 mL | |
| 80 mM | 0.0800 mL | 0.3999 mL | 0.7999 mL | 1.9997 mL | |
| 100 mM | 0.0640 mL | 0.3200 mL | 0.6399 mL | 1.5998 mL |
Citronellol Related Classifications
HY-W010201 Related Classifications
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