CGA - glycoprotein hormones, alpha polypeptide Gene
Also Known as HCG; LHA; FSHA; GPA1; GPHa; TSHA; GPHA1; CG-ALPHA
Species: Homo sapiens
About CGA
This gene has 6 transcripts (splice variants) and 214 orthologues. Restricted expression toward placenta (RPKM 388.3).
Summary
The four human glycoprotein Hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these Hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein Hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
CGA Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_000735.4 | NP_000726.1 | glycoprotein hormones alpha chain isoform 2 precursor |
| NM_001252383.2 | NP_001239312.1 | glycoprotein hormones alpha chain isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables follicle-stimulating hormone activity |
IDA
IDA: Inferred from direct assay
|
2494176 | GOA |
| enables hormone activity |
IMP
IMP: Inferred from mutant phenotype
|
11207219 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
7922031 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in G protein-coupled receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
24692546 | GOA |
| involved in positive regulation of steroid biosynthetic process |
IDA
IDA: Inferred from direct assay
|
2494176 | GOA |
| involved in regulation of signaling receptor activity |
IDA
IDA: Inferred from direct assay
|
24692546 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
2494176 | GOA |
| part of follicle-stimulating hormone complex |
IDA
IDA: Inferred from direct assay
|
2494176 | GOA |
| part of follicle-stimulating hormone complex |
IPI
IPI: Inferred from physical interaction
|
11222739 | GOA |
| part of pituitary gonadotropin complex |
IPI
IPI: Inferred from physical interaction
|
7922031 | GOA |
CGA Protein Structure
Hormone_6: Glycoprotein hormone (28 - 116)
- 0
- 100
- 116 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
glycoprotein hormones alpha chain |
|
CGA Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CGA | P01215 | FSHB | Homo sapiens | P01225 | 11222739 | |
|
Intra
|
CGA | P01215 | CGB5 | Homo sapiens | P0DN86 | 31467278 | |
|
Intra
|
CGA | P01215 | CGB5 | Homo sapiens | P0DN86 | 7922031 |
Recombinant CGA Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7869 | CG alpha Protein, Human (HEK293, His) | P01215 (A25-S116) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7870 | CGA-CGB3 Heterodimer Protein, Human (HEK293, His) | P01215 (A25-S116)&P0DN86 (S21-Q165) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P70237 | FSH Protein, Human (HEK293, Flag-His) | P01215 (A25-S116)&P01225 (N19-E129) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P74133 | FSH Protein, Human (HEK293, Fc) | P01215 (A25-S116)&P01225 (N19-E129) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P75341 | CG alpha Protein, Human (HEK293, mFc) | P01215 (A25-S116) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P75342 | CG alpha Protein, Human (HEK293) | NP_000726.1 (A25-S116) | ≥ 90%, as determined by reducing SDS-PAGE. |
CGA Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P85956 | CGA/hCG alpha Antibody (YA5648) | IHC-P, WB, ICC/IF, ELISA | Human |
| HY-P86714 | CGA/hCG alpha Antibody (YA6406) | IHC-P, IHC-F, ICC/IF, ELISA | Human |
| HY-P86714A | CGA/hCG alpha Antibody (YA6406)(PBS only) | IHC-P, IHC-F, ICC/IF, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Ectopic Pregnancy |
|
|
| Ovarian Hyperstimulation Syndrome |
|
|
| Ovarian Disease |
|
|
| Germ Cell Cancer |
|
|
| Germinoma |
|
|
| Anovulation |
|
|
| Choriocarcinoma |
|
|
| Hydatidiform Mole, Recurrent, 1 |
|
|
| Polycystic Ovary Syndrome |
|
|
| Ovarian Mixed Germ Cell Neoplasm |
|
|
| Orofaciodigital Syndrome Viii |
|
|
| Teratoma |
|
|
| Hyperthyroidism |
|
|
| Gestational Trophoblastic Neoplasm |
|
|
| Trophoblastic Neoplasm |
|
|
| Gynecomastia |
|
|
| Androgen Insensitivity Syndrome |
|
|
| Seminoma |
|
|
| Testicular Cancer |
|
|
| Hypothyroidism |
|
|
| Hyperprolactinemia |
|
|
| Infertility |
|
|
| Varicocele |
|
|
| Complete Androgen Insensitivity Syndrome |
|
|
| Luteoma |
|
|
| Down Syndrome |
|
|
| Placenta Disease |
|
|
| Cataract 4, Multiple Types |
|
|
| Hydrocele |
|
|
| Endometriosis |
|
|
| Placental Insufficiency |
|
|
| Oligohydramnios |
|
|
| Patellofemoral Pain Syndrome |
|
|
| Glutaric Aciduria Iii |
|
|
| Penis Agenesis |
|
|
| Neuroendocrine Tumor |
|
|
| Pre-Eclampsia |
|
|
| Ovarian Cyst |
|
|
| Cryptorchidism, Unilateral Or Bilateral |
|
|
| Pituitary Gland Disease |
|
|
| Cystinosis |
|
|
| Hemophagocytic Lymphohistiocytosis, Familial, 3 |
|
|
| Placental Site Trophoblastic Tumor |
|
|
| Placental Abruption |
|
|
| Asperger Syndrome |
|
|
| Kallmann Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | CGA | MGD | MGI:88390 |
| Macaca mulatta | CGA | VGNC | VGNC:71021 |
| Canis familiaris | CGA | VGNC | VGNC:39181 |
| Rattus norvegicus | CGA | RGD | RGD:620436 |
| Bos taurus | CGA | VGNC | VGNC:27257 |
| Others | CGA | NCBI |