CGA - glycoprotein hormones, alpha polypeptide Gene

Also Known as HCG; LHA; FSHA; GPA1; GPHa; TSHA; GPHA1; CG-ALPHA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1081

About CGA

Cytogenetic location: 6q14.3 Genomic coordinates (GRCh38): 6:87,085,498-87,095,106 (from NCBI)

This gene has 6 transcripts (splice variants) and 214 orthologues. Restricted expression toward placenta (RPKM 388.3).

Summary

The four human glycoprotein Hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these Hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein Hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

CGA Products (2)

mRNA Protein Name
NM_000735.4 NP_000726.1 glycoprotein hormones alpha chain isoform 2 precursor
NM_001252383.2 NP_001239312.1 glycoprotein hormones alpha chain isoform 1 precursor
Molecular Function GO Annotation Evidence References Source
enables follicle-stimulating hormone activity IDA
IDA: Inferred from direct assay
2494176 GOA
enables hormone activity IMP
IMP: Inferred from mutant phenotype
11207219 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7922031 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
24692546 GOA
involved in positive regulation of steroid biosynthetic process IDA
IDA: Inferred from direct assay
2494176 GOA
involved in regulation of signaling receptor activity IDA
IDA: Inferred from direct assay
24692546 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
2494176 GOA
part of follicle-stimulating hormone complex IDA
IDA: Inferred from direct assay
2494176 GOA
part of follicle-stimulating hormone complex IPI
IPI: Inferred from physical interaction
11222739 GOA
part of pituitary gonadotropin complex IPI
IPI: Inferred from physical interaction
7922031 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CGA Protein Structure

Hormone_6

Hormone_6: Glycoprotein hormone (28 - 116)

  • 0
  • 100
  • 116 a.a.
Protein Preferred Names Protein Names

glycoprotein hormones alpha chain

  • FSH-alpha

CGA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CGA P01215 FSHB Homo sapiens P01225 11222739
Intra
CGA P01215 CGB5 Homo sapiens P0DN86
SLC
31467278
Intra
CGA P01215 CGB5 Homo sapiens P0DN86 7922031
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CGA Proteins

Cat. No. Product Name Accession Purity
HY-P7869 CG alpha Protein, Human (HEK293, His) P01215 (A25-S116) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7870 CGA-CGB3 Heterodimer Protein, Human (HEK293, His) P01215 (A25-S116)&P0DN86 (S21-Q165) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P70237 FSH Protein, Human (HEK293, Flag-His) P01215 (A25-S116)&P01225 (N19-E129) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74133 FSH Protein, Human (HEK293, Fc) P01215 (A25-S116)&P01225 (N19-E129) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75341 CG alpha Protein, Human (HEK293, mFc) P01215 (A25-S116) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75342 CG alpha Protein, Human (HEK293) NP_000726.1 (A25-S116) ≥ 90%, as determined by reducing SDS-PAGE.

CGA Antibodies

Cat. No. Product Name Application Reactivity
HY-P85956 CGA/hCG alpha Antibody (YA5648) IHC-P, WB, ICC/IF, ELISA Human
HY-P86714 CGA/hCG alpha Antibody (YA6406) IHC-P, IHC-F, ICC/IF, ELISA Human
HY-P86714A CGA/hCG alpha Antibody (YA6406)(PBS only) IHC-P, IHC-F, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Ectopic Pregnancy
  • Eccyesis

  • Pregnancy Ectopic

  • Pregnancy, Ectopic

  • Ectopic Pregnancies

  • Extrauterine Gestation Or Pregnancy

  • Extrauterine Pregnancy

  • Ep - [Ectopic Pregnancy]

  • Ectopic Mole

  • Aborted Ectopic Pregnancy

  • Ruptured Ectopic Pregnancy

Ovarian Hyperstimulation Syndrome
  • OHSS

  • Ovarian Hyperstimulation Syndrome, Familial Gestational Spontaneous

  • Secondary Meig'S Syndrome

  • Ohss - [Ovarian Hyperstimulation Syndrome]

  • Hyperstimulation Of Ovaries Nos

  • Hyperstimulation Of Ovaries Associated With Induced Ovulation

Ovarian Disease
  • Ovarian Dysfunction

  • Ovarian Diseases

  • Ovarian Disorders

  • Disorder Of Endocrine Ovary

Germ Cell Cancer
  • Malignant Germ Cell Tumor

  • Neoplasms, Germ Cell And Embryonal

  • Germ Cell Neoplasm

  • Germ Cell Tumour

  • Malignant Tumor Of The Germ Cell

  • Neoplasms Germ Cell

  • Malignant Germ Cell Neoplasm

Germinoma
Anovulation
Choriocarcinoma
  • Chorioepithelioma

Hydatidiform Mole, Recurrent, 1
  • Hydatidiform Mole

  • Gestational Trophoblastic Disease

  • Complete Hydatidiform Mole

  • Hydm

  • HYDM1

  • Chm

  • Molar Pregnancy

  • Hydatidiform Mole, Complete

  • Hydatid Mole

  • Complete Molar Pregnancy

  • Mole, Hydatidiform, Recurrent, Type 1

  • Gestational Trophoblastic Neoplasms

  • Hydatidiform Mole, Recurrent, 2

  • Classical Hydatidiform Mole

Polycystic Ovary Syndrome
  • Polycystic Ovarian Syndrome

  • Pcos

  • Polycystic Ovarian Disease

  • Polycystic Ovaries

  • Stein-Leventhal Syndrome

  • Multicystic Ovaries

  • Polycystic Ovary

  • Sclerocystic Ovaries

  • Sclerocystic Ovary Syndrome

  • Stein-Leventhal Synd.

  • Cystic Disease Of Ovaries

  • Cystic Disease Of Ovary

  • Pco

  • Pcod

  • Sclerocystic Ovarian Degeneration

  • Polycystic Ovary Syndrome, Susceptibility To

  • Pcos - [Polycystic Ovary Syndrome]

  • Polycystic Ovary Nos

  • Pco - [Polycystic Ovary]

Ovarian Mixed Germ Cell Neoplasm
  • Mixed Germ Cell Tumor Of Ovary

  • Ovarian Mixed Germ Cell Tumor

Orofaciodigital Syndrome Viii
  • Edwards Syndrome

  • Trisomy 18

  • Complete Trisomy 18 Syndrome

  • OFD8

  • Orofaciodigital Syndrome 8

  • Trisomy 18 Syndrome

  • Oral-Facial-Digital Syndrome With Hypoplastic Epiglottis

  • E3 Trisomy

  • Oral-Facial-Digital Syndrome Type 8

  • Orofaciodigital Syndrome Type 8

  • Ofds Viii

  • Oral-Facial-Digital Syndrome, Type Viii

  • Ofd Syndrome 8

  • Ofds 8

  • Oral Facial Digital Syndrome 8

  • Oral Facial Digital Syndrome Type 8

  • 18 Trisomy

  • Chromosome 18 Trisomy

  • Trisomy 16-18

  • Trisomy E

  • Trisomy E Syndrome

  • Chromosome 18 Duplication

  • Oral-Facial-Digital Syndrome, Edwards Type

  • Orofaciodigital Syndrome, Edwards Type

  • Chromosome 18, Trisomy

  • Cleft Lip/Palate With Abnormal Thumbs And Microcephaly

  • Trisomy 18 Chromosome

  • Abnormal Autosomes 18

Teratoma
  • Teratomas

Hyperthyroidism
  • Overactive Thyroid

Gestational Trophoblastic Neoplasm
  • Hydatidiform Mole

  • Molar Pregnancy

  • Gestational Trophoblastic Neoplasia

  • Gestational Trophoblastic Tumor

  • Gtn

  • Gestational Trophoblastic Disease

  • Gestational Trophoblastic Neoplasms

  • Hydatidiform Mole, Recurrent, 1

  • Hydatidiform Mole Benign

  • Trophoblastic Disease

  • Trophoblastic Disease Nos

  • Trophoblastic Disorder

  • Vesicular Mole Nos

  • Vesicular Mole

  • Hydatidiform Mole Nos

Trophoblastic Neoplasm
  • Trophoblastic Tumor

  • Trophoblastic Neoplasms

Gynecomastia
Androgen Insensitivity Syndrome
  • Androgen Resistance Syndrome

  • AIS

  • Testicular Feminization Syndrome

  • Androgen Receptor Deficiency

  • Dhtr Deficiency

  • Dihydrotestosterone Receptor Deficiency

  • Ar Deficiency

  • Testicular Feminization

  • Tfm

  • Androgen Insensitivity

  • Androgen-Insensitivity Syndrome

  • Goldberg-Maxwell Syndrome

  • Complete Androgen Insensitivity Syndrome

  • Cais

  • Feminisation - Testicular

  • Goldberg - Maxwell Syndrome

  • Androgen Insensitivity Syndrome, Complete

  • Morris Syndrome

  • Ary

  • AR

  • Insensitivity Syndrome, Androgen

  • Androgen Insensitivity Nos

Seminoma
  • Seminoma, Pure

Testicular Cancer
  • Testis Cancer

  • Testicular Carcinoma

  • Testicular Neoplasms

  • Malignant Neoplasm Of Testis

  • Childhood Neoplasm Of The Testis

  • Neoplasm Of Testis

  • Pediatric Testicular Neoplasm

  • Testicular Tumor

  • Testis Neoplasm

  • Testicular Tumors

  • Testicular Neoplasm

  • Testicular Malignant Germ Cell Tumor

  • Childhood Testicular Neoplasm

  • Carcinoma Of The Testis

  • Cancer Of Testis

  • Malignant Neoplasm Of Testis, Nos

  • Malignant Neoplasm Of Testis, Unspecified

  • Malignant Tumour Of Testis

  • Testicle Cancer

  • Primary Malignant Neoplasm Of Testis

Hypothyroidism
  • Thyroid Diseases

  • Thyroid Disease

  • Thyroid Deficiency

  • Thyroid Insufficiency

  • Dysfunction Thyroid

  • Thyroid Dysfunction

Hyperprolactinemia
  • Chiari-Frommel Syndrome

  • Hyperprolactinaemia

  • Familial Hyperprolactinemia

  • HPRL

  • Pregnancy-Related A-G Syndrome

  • Familial Isolated Prolactin Receptor Deficiency

Infertility
Varicocele
  • Scrotal Varices

  • Varicoceles

  • Varicocele Of Scrotum

  • Scrotal Varicocele

Complete Androgen Insensitivity Syndrome
  • Cais

  • Complete Androgen Resistance Syndrome

  • Androgen Insensitivity Syndrome Complete

  • Androgen Insensitivity, Complete

  • Androgen-Insensitivity Syndrome

  • Testicular Feminization

Luteoma
  • Leuteoma Of Pregnancy

  • Luteoma Of Pregnancy

Down Syndrome
  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21

Placenta Disease
  • Placenta Diseases

  • Placenta Disorder

  • Pregnancy Complications

  • Placenta Disorders

Cataract 4, Multiple Types
  • Cataract 4 Multiple Types

  • CTRCT4

  • Cca3

  • Pcc

  • Aculeiform Cataract

  • Cataract 4, Multiple Types, With Or Without Microcornea

  • Cataract, Crystalline Aculeiform

  • Caca

  • Cataract, Congenital, Cerulean Type, 3

  • Congenital Cataract Cerulean Type 3

  • Cataract Congenital Dominant Non Nuclear

  • Ccp

  • Cataract, Nonnuclear Polymorphic Congenital

  • Cataract, Punctate, Progressive Juvenile-Onset

  • Cataract 4 Multiple Types With Or Without Microcornea

  • Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

  • Cataract, Polymorphic Congenital

  • Congenital Cataract Blue Dot Type 3

  • Congenital Non-Nuclear Polymorphic Cataract

  • Crystalline Aculeiform Cataract

  • Punctate, Progressive Juvenile-Onset, Cataract

  • Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant

Hydrocele
  • Testicular Hydrocele

Endometriosis
  • Endometriosis, Site Unspecified

  • Endometrial Ectopia

Placental Insufficiency
  • Uteroplacental Vascular Insufficiency

Oligohydramnios
  • Oligohydramnios - Delivered

  • Antepartum Oligohydramnios

  • Delivered Oligohydramnios

  • Oligohydramnios, Antepartum Condition Or Complication

  • Deficient Liquor

  • Oligohydramnios, Unspecified Trimester

  • Reduced Liquor Volume

Patellofemoral Pain Syndrome
Glutaric Aciduria Iii
  • Glutaryl-Coa Oxidase Deficiency

  • Ga Iii

  • Glutaric Acidemia Type 3

  • GA3

  • Glutaric Aciduria Type 3

  • Glutaric Aciduria 3

  • Glutaric Acidemia Type Iii

  • Glutaric Aciduria Type Iii

Penis Agenesis
  • Micropenis

  • Agenesis Of The Penis

  • Penis Agenesia

Neuroendocrine Tumor
  • Neuroendocrine Neoplasm

  • Neuroendocrine Tumors

  • Carcinoma, Neuroendocrine

Pre-Eclampsia
  • Preeclampsia

  • Gestational Hypertension

  • Hypertension Induced By Pregnancy

  • Pre-Eclamptic Toxaemia

  • Pregnancy Associated Hypertension

  • Proteinuric Hypertension Of Pregnancy

  • Hypertension, Pregnancy-Induced, Susceptibility To

  • Preeclampsia/Eclampsia

  • Pregnancy Toxemia

  • Toxaemia Of Pregnancy

  • Gestational Proteinuric Hypertension

  • Pregnancy-Induced Hypertension

  • Toxemia Of Pregnancy

  • Preeclampsia, Susceptibility To

  • Transient Hypertension Of Pregnancy

  • Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

  • Gestational Hypertension Nos

  • Mild Proteinuric Hypertension Of Pregnancy

  • Pih - [Pregnancy-Induced Hypertension]

  • Pregnancy-Induced Hypertension Nos

  • Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

  • Pe - [Pre-Eclampsia]

  • Pre-Eclampsia Nos

  • Pre-Eclamptic Nos

  • Pregnancy Pre-Eclampsia

  • Puerperal Pre-Eclampsia

  • Pre-Eclampsia Toxaemia

  • Toxaemia In Pregnancy

  • Pet - [Pre-Eclamptic Toxaemia]

  • Maternal Toxaemia

Ovarian Cyst
  • Ovarian Cysts

Cryptorchidism, Unilateral Or Bilateral
  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes

Pituitary Gland Disease
  • Pituitary Diseases

  • Pituitary Dysfunction

  • Pituitary Disease

  • Pituitary Deficiency

  • Pituitary Disorders

Cystinosis
  • Cystine Storage Disease

  • Cystine Diathesis

  • Cystine Disease

  • Cystinoses

  • Protein Defect Of Cystin Transport

  • Cystin Transport, Protein Defect Of

  • Nephropathic Cystinosis

  • Protein Defect Of Cystine Transport

Hemophagocytic Lymphohistiocytosis, Familial, 3
  • Familial Hemophagocytic Lymphohistiocytosis 3

  • FHL3

  • Hplh3

  • Hlh3

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 3

Placental Site Trophoblastic Tumor
  • Trophoblastic Tumor Placental Site

  • Trophoblastic Tumor, Placental Site

  • Placental Site Trophoblastic Tumour

  • Placental-Site Gestational Trophoblastic Neoplasm

  • Placenta Neoplasm

  • Psst

  • Deciduoma

  • Placental Cancer

  • Primary Malignant Neoplasm Of Placenta

Placental Abruption
  • Abruptio Placentae

  • Abruptio Placenta

  • Abortion, Threatened

  • Threatened Miscarriage

  • Haemorrhage Specified As Due To Threatened Abortion

  • Spontaneous Threatened Abortion

Asperger Syndrome
  • Asperger Disorder

  • Asperger Syndrome, Susceptibility To

Kallmann Syndrome
  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus CGA MGD MGI:88390
Macaca mulatta CGA VGNC VGNC:71021
Canis familiaris CGA VGNC VGNC:39181
Rattus norvegicus CGA RGD RGD:620436
Bos taurus CGA VGNC VGNC:27257
Others CGA NCBI