Gne - glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Gene

Also Known as Uae1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114711

Summary

Enables N-acylmannosamine kinase activity and UDP-N-acetylglucosamine 2-epimerase activity. Predicted to be involved in N-acetylneuraminate biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in GNE myopathy and sialuria. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Gne Products (1)

mRNA Protein Name
NM_053765.3 NP_446217.1 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acylmannosamine kinase activity IDA
IDA: Inferred from direct assay
9305887 RGD
enables UDP-N-acetylglucosamine 2-epimerase activity IDA
IDA: Inferred from direct assay
9305887 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17118363 RGD
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
9305887 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

  • UDP-GlcNAc-2-epimerase/ManAc kinase

  • UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase

Gne Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Gne O35826 ZBTB16 Homo sapiens Q05516
Y2H
17118363
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-128850 N-Acetyl-D-mannosamine 99.99% Phase 2
HY-13246 Apitolisib 99.29% Phase 2

Pre-clinical Phase

Bioactive Molecules (90)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100742A (R)-GNE-140 Inhibitor 99.77% Unkown
HY-147214 GNE-7883 Inhibitor 99.54% Unkown
HY-108696 GNE-781 Inhibitor 98.51% Unkown
HY-100343 GNE-495 Inhibitor 99.49% Unkown
HY-12947 GNE-3511 Inhibitor 99.54% Unkown
HY-108435 GNE-049 Inhibitor 99.74% Unkown
HY-129937A GNE-987 Inhibitor 99.98% Unkown
HY-158113 CBPD-409 Degrader 99.38% Unkown
HY-100726 GNE-272 Inhibitor 99.60% Unkown
HY-15766 GNE-617 Inhibitor 99.58% Unkown
HY-107986 GNE-6776 Inhibitor 98.03% Unkown
HY-15796 GNE0877 Inhibitor 99.81% Unkown
HY-100742 GNE-140 racemate Inhibitor 99.25% Unkown
HY-12632 GNE 2861 Inhibitor 98.97% Unkown
HY-112937 GNE-6640 Inhibitor 99.91% Unkown
HY-18163 GNE-7915 Inhibitor 99.81% Unkown
HY-120028 GNE-207 Inhibitor 99.94% Unkown
HY-12763 GNE-317 Inhibitor 98.76% Unkown
HY-114332 GNE-8505 Inhibitor 99.53% Unkown
HY-149026 GNE-064 Inhibitor 99.65% Unkown
HY-107409 GNE 5729 Agonist 99.05% Unkown
HY-112803 GNE-371 98.06% Unkown
HY-19775 GNE-6468 Antagonist 98.02% Unkown
HY-10811 GNE-493 Inhibitor 99.81% Unkown
HY-12282 GNE-9605 Inhibitor 99.51% Unkown
HY-12410 GNE-9822 Inhibitor 98.47% Unkown
HY-129527 GNE-9278 Modulator 99.91% Unkown
HY-160821A N-Acetylmannosamine 6-phosphate sodium salt 95.0% Unkown
HY-100742B (S)-GNE-140 Inhibitor 99.30% Unkown
HY-11042 GNE-477 Inhibitor 98.75% Unkown
HY-145341 GNE-149 Antagonist 99.18% Unkown
HY-129939 BET-IN-31 Inhibitor 99.85% Unkown
HY-112279 GNE-131 Inhibitor 98.15% Unkown
HY-12628 GNE-618 Inhibitor 99.89% Unkown
HY-123824 GNE-0439 Inhibitor 99.80% Unkown
HY-129938 GNE-987 GSH linker-1 98.66% Unkown
HY-150289 GNE-235 98.86% Unkown
HY-15883 GNE-900 98.58% Unkown
HY-19774 GNE-0946 Inhibitor 98.11% Unkown
HY-18163A GNE-7915 tosylate Inhibitor 99.06% Unkown
HY-135892 GNE-1858 Inhibitor 99.23% Unkown
HY-123621 GNE-375 Inhibitor 99.93% Unkown
HY-10812 GNE-490 Inhibitor 96.79% Unkown
HY-134592 Piperidine-GNE-049-N-Boc 98.48% Unkown
HY-107498 GNE-8324 Modulator 98.88% Unkown
HY-117865 GNE-886 Inhibitor 99.81% Unkown
HY-149056 GNE-6893 Inhibitor 99.94% Unkown
HY-162553 GNE7599 99.19% Unkown
HY-108337 GNE-0723 Agonist 99.93% Unkown
HY-138634 GNE-987 GSH linker-2 Inhibitor 99.48% Unkown
HY-128585 GNE684 Inhibitor 99.08% Unkown
HY-142160 GNE-9815 Inhibitor 98.94% Unkown
HY-U00428A GNE 220 hydrochloride Inhibitor 98.22% Unkown
HY-107423 GNE 6901 Agonist 99.31% Unkown
HY-141551 GNE-274 Degrader 98.00% Unkown
HY-15766A GNE-617 hydrochloride Inhibitor 99.16% Unkown
HY-16983 GNE-3500 Antagonist 98.90% Unkown
HY-118241 GNE-140 Inhibitor 98.43% Unkown
HY-148238 GNE-2256 Inhibitor 99.14% Unkown
HY-149056A (3S,4R)-GNE-6893 Inhibitor 99.49% Unkown
HY-RS05551 GNE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00428 GNE 220 Inhibitor / Unkown
HY-126291 GNE-616 Inhibitor / Unkown
HY-132294 GNE-502 Inhibitor 99.73% Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-107409B (S,S)-GNE 5729 99.65% Unkown
HY-124153 GNE-431 Inhibitor / Unkown
HY-129937 (S)-GNE-987 Inhibitor / Unkown
HY-132294A (1S,3R)-GNE-502 Inhibitor / Unkown
HY-13847 GNE-555 Inhibitor / Unkown
HY-141551B (R)-GNE-274 / Unkown
HY-15882 GNE-783 / Unkown
HY-16984 GNE-4997 Inhibitor / Unkown
HY-174261 KRAS-IN-5 Inhibitor / Unkown
HY-175445 GNE-5472 / Unkown
HY-175447 GDC-0152-amide-PEG2-acid / Unkown
HY-175448 GNE-1567 / Unkown
HY-175449 XIAP ligand 5 Antagonist / Unkown
HY-175450 XIAP ligand-Linker Conjugate 2 Antagonist / Unkown
HY-176783 GNE-5152 Inhibitor / Unkown
HY-182458 GNE-203 Inhibitor / Unkown
HY-183817 GNE-781-COOH Ligand / Unkown
HY-100742AR (R)-GNE-140 (Standard) Inhibitor / Unkown
HY-100742BR (S)-GNE-140 (Standard) Inhibitor / Unkown
HY-100742R GNE-140 racemate (Standard) Inhibitor / Unkown
HY-12517 GNE-293 Inhibitor / Unkown
HY-182740 GSH linker-2 / Unkown
HY-185334 GNE-3565 Inhibitor / Unkown
HY-RS16774 Gne Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23214 Gne Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gne NCBI NCBI:10020