2. Gene
  3. Brd2 - bromodomain containing 2 Gene

Brd2 - bromodomain containing 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nat; Rnf3; Frg-1; Fsrg1; Ring3; Fsrg-1; mKIAA4005; D17H6S113E

Gene ID: 14312 | Gene type: protein coding

About Brd2

Chromosome 17: 34,330,997-34,341,608 reverse strand.GRCm39:CM001010.3

This gene has 19 transcripts (splice variants), 301 orthologues, 11 paralogues and is associated with 133 phenotypes. Ubiquitous expression in thymus adult (RPKM 36.3), adrenal adult (RPKM 32.4) and 28 other tissues.

Summary

Predicted to enable lysine-acetylated histone binding activity; nucleosomal histone binding activity; and protein serine/threonine kinase activity. Involved in regulation of gene expression. Acts upstream of or within neural tube closure. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; future brain; jaw; retina; and urinary system. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Brd2 Products(2)

mRNA Protein Name
NM_010238.3 NP_034368.2 bromodomain-containing protein 2
NM_001204973.1 NP_001191902.1 bromodomain-containing protein 2

Brd2 Protein Structure

Bromo_Brdt_I_like

Bromo_Brdt_I_like: cd05497 (72 - 178)

PHA03247

PHA03247: cl33720 (214 - 331)

Bromo_Brdt_II_like

Bromo_Brdt_II_like: cd05498 (347 - 448)

BET

BET: pfam17035 (638 - 700)

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  • 200
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  • 600
  • 798 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 2

female sterile homeotic-related gene 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
Pre-clinical Phase
Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100972 ARV-771 Inhibitor 99.87% Unkown
HY-136570 GSK778 Inhibitor 98.93% Unkown
HY-136571 GSK046 Inhibitor 99.65% Unkown
HY-101519 BETd-260 Inhibitor 99.59% Unkown
HY-141438 SIM1 Inhibitor 99.72% Unkown
HY-120000 MS402 Inhibitor 99.62% Unkown
HY-112429 HJB97 Inhibitor 98.24% Unkown
HY-114416 GS-626510 Inhibitor 99.80% Unkown
HY-114504 RVX-297 Inhibitor 96.59% Unkown
HY-112610 CF53 Inhibitor 99.78% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.91% Unkown
HY-146208 BRD4 Inhibitor-20 Inhibitor 99.00% Unkown
HY-145264 OARV-771 Inhibitor 98.33% Unkown
HY-142520 I-BET567 Inhibitor 99.49% Unkown
HY-138563 GSK973 Inhibitor 99.46% Unkown
HY-130612 PROTAC BRD2/BRD4 degrader-1 Inhibitor / Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-149098 SJ1461 Inhibitor / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-151972 BRD4 Inhibitor-25 Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-110215 XD14 Inhibitor 95.02% Unkown
HY-121738 TC AC 28 Inhibitor / Unkown
HY-162514 BBC0403 Inhibitor / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown
HY-160528 IBG3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brd2 NCBI NCBI:6046