Brd2 - bromodomain containing 2 Gene
Also Known as Nat; Rnf3; Frg-1; Fsrg1; Ring3; Fsrg-1; mKIAA4005; D17H6S113E
Species: Mus musculus
About Brd2
This gene has 19 transcripts (splice variants), 301 orthologues, 11 paralogues and is associated with 133 phenotypes. Ubiquitous expression in thymus adult (RPKM 36.3), adrenal adult (RPKM 32.4) and 28 other tissues.
Summary
Predicted to enable lysine-acetylated histone binding activity; nucleosomal histone binding activity; and protein serine/threonine kinase activity. Involved in regulation of gene expression. Acts upstream of or within neural tube closure. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; future brain; jaw; retina; and urinary system. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Brd2 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_010238.3 | NP_034368.2 | bromodomain-containing protein 2 |
| NM_001204973.1 | NP_001191902.1 | bromodomain-containing protein 2 |
Brd2 Protein Structure
Bromo_Brdt_I_like: cd05497 (72 - 178)
PHA03247: cl33720 (214 - 331)
Bromo_Brdt_II_like: cd05498 (347 - 448)
BET: pfam17035 (638 - 700)
- 0
- 200
- 400
- 600
- 798 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
bromodomain-containing protein 2 |
|
Related Agents
- Clinical Phase
- Pre-clinical Phase
Clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-100972 | ARV-771 | Degrader | 99.87% | Unkown |
| HY-78695 | JQ-1 carboxylic acid | Inhibitor | 99.69% | Unkown |
| HY-136570 | GSK778 | Inhibitor | 99.14% | Unkown |
| HY-162514 | BBC0403 | Inhibitor | 98.78% | Unkown |
| HY-136571 | GSK046 | Inhibitor | 99.70% | Unkown |
| HY-141438 | SIM1 | Degrader | 99.47% | Unkown |
| HY-160528 | IBG3 | Inhibitor | 98.53% | Unkown |
| HY-153385 | TMX1 | Degrader | 99.57% | Unkown |
| HY-153459 | IBG1 | Degrader | 99.88% | Unkown |
| HY-138563 | GSK973 | Inhibitor | 99.97% | Unkown |
| HY-101519 | BETd-260 | Inhibitor | 99.68% | Unkown |
| HY-112429 | HJB97 | Inhibitor | 99.12% | Unkown |
| HY-114504 | RVX-297 | Inhibitor | 95.00% | Unkown |
| HY-114416 | GS-626510 | Inhibitor | 99.46% | Unkown |
| HY-120000 | MS402 | Inhibitor | 98.36% | Unkown |
| HY-112610 | CF53 | Inhibitor | 99.81% | Unkown |
| HY-131061 | BET bromodomain inhibitor 1 | Inhibitor | 99.67% | Unkown |
| HY-146208 | BRD4 Inhibitor-20 | Inhibitor | 99.24% | Unkown |
| HY-145264 | OARV-771 | Inhibitor | 98.77% | Unkown |
| HY-110215 | XD14 | Inhibitor | 95.02% | Unkown |
| HY-142520 | I-BET567 | Inhibitor | 99.49% | Unkown |
| HY-130813 | BET-IN-6 | Inhibitor | / | Unkown |
| HY-126325 | BY27 | Inhibitor | / | Unkown |
| HY-184335 | PROTAC BET Degrader-18 | Degrader | / | Unkown |
| HY-181003 | GSK785 | Inhibitor | / | Unkown |
| HY-173062 | BRD4 Inhibitor-40 | Inhibitor | / | Unkown |
| HY-151972 | BRD4 Inhibitor-25 | Inhibitor | / | Unkown |
| HY-149098 | SJ1461 | Inhibitor | / | Unkown |
| HY-170900 | SJ44236 | Degrader | / | Unkown |
| HY-180804 | CZL-077 | Inhibitor | / | Unkown |
| HY-168634 | SJ46421 | Inhibitor | / | Unkown |
| HY-175678 | PROTAC BRD2 BD1 Degrader-1 | Degrader | / | Unkown |
| HY-176535 | KB-0118 | Inhibitor | / | Unkown |
| HY-181735 | BET-IN-30 | Inhibitor | / | Unkown |
| HY-181869 | PROTAC BET Degrader-17 | Degrader | / | Unkown |
| HY-170390 | AB3067 | Degrader | / | Unkown |
| HY-179589 | JQ-1 (carboxylic acid)-amine-PEG8-cyanogen | Degrader | / | Unkown |
| HY-169170 | PARP1/BRD4-IN-3 | Inhibitor | / | Unkown |
| HY-155680 | BET BD2-IN-1 | Inhibitor | / | Unkown |
| HY-121738 | TC AC 28 | Inhibitor | / | Unkown |
| HY-179588 | PROTAC BET Degrader-14 | Degrader | / | Unkown |
| HY-152213 | BET-IN-13 | Inhibitor | / | Unkown |
| HY-181729 | PROTAC BET Degrader-15 | Degrader | / | Unkown |
| HY-180831 | BRD4 D1-IN-3 | Inhibitor | / | Unkown |
| HY-181495 | RAJQ14 | Degrader | / | Unkown |
| HY-143471 | WNY0824 | Inhibitor | / | Unkown |
| HY-182801 | PROTAC BRD4 Degrader-46 | Degrader | / | Unkown |
| HY-182371 | BRD4 ligand 15 | Ligand | / | Unkown |
| HY-181867 | PROTAC BET Degrader-16 | Degrader | / | Unkown |
| HY-130612 | PROTAC BRD2/BRD4 degrader-1 | Inhibitor | / | Unkown |
| HY-175679 | BRD2 BD1 ligand-1 | Ligand | / | Unkown |
| HY-136570A | GSK778 hydrochloride | Inhibitor | / | Unkown |
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