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  2. Brd2 - bromodomain containing 2 Gene

Brd2 - bromodomain containing 2 Gene

Mus musculus

Also known as Nat; Rnf3; Frg-1; Fsrg1; Ring3; Fsrg-1; mKIAA4005; D17H6S113E

Gene ID: 14312 | Gene type: protein coding

About Brd2

Chromosome 17: 34,330,997-34,341,608 reverse strand.GRCm39:CM001010.3

This gene has 19 transcripts (splice variants), 301 orthologues, 11 paralogues and is associated with 133 phenotypes. Ubiquitous expression in thymus adult (RPKM 36.3), adrenal adult (RPKM 32.4) and 28 other tissues.

Summary

Predicted to enable lysine-acetylated histone binding activity; nucleosomal histone binding activity; and protein serine/threonine kinase activity. Involved in regulation of gene expression. Acts upstream of or within neural tube closure. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; future brain; jaw; retina; and urinary system. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Brd2 Products(2)

mRNA Protein Name
NM_010238.3 NP_034368.2 bromodomain-containing protein 2
NM_001204973.1 NP_001191902.1 bromodomain-containing protein 2

Brd2 Protein Structure

Bromo_Brdt_I_like

Bromo_Brdt_I_like: cd05497 (72 - 178)

PHA03247

PHA03247: cl33720 (214 - 331)

Bromo_Brdt_II_like

Bromo_Brdt_II_like: cd05498 (347 - 448)

BET

BET: pfam17035 (638 - 700)

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  • 798 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 2

female sterile homeotic-related gene 1

Orthologs Information

Species Symbol Source ID
Homo sapiens Brd2 NCBI NCBI:6046