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Cdk7 - cyclin-dependent kinase 7 Gene

Also Known as CAK; P39 Mo15

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 171150

About Cdk7

Primary_assembly 2: 31,840,558-31,865,383 reverse strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 214 orthologues, 24 paralogues and is associated with 2 phenotypes. Biased expression in Kidney (RPKM 187.4), Adrenal (RPKM 173.5) and 9 other tissues.

Summary

Enables cyclin-dependent protein serine/threonine kinase activity. Involved in protein phosphorylation and transcription by RNA polymerase II. Located in several cellular components, including cytoskeleton; cytosol; and nucleus. Part of transcription factor TFIIH holo complex. Orthologous to human CDK7 (cyclin dependent kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

Cdk7 Products (2)

mRNA	Protein	Name
NM_001398656.1	NP_001385585.1	cyclin-dependent kinase 7 isoform 1
NM_001398657.1	NP_001385586.1	cyclin-dependent kinase 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8906616	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	7885450	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8906616	RGD
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7553866	RGD

Cellular Component GO Annotation	Evidence	References	Source
part of transcription factor TFIIH holo complex	IDA IDA: Inferred from direct assay	7553866	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk7 Protein Structure

STKc_CDK7

0
100
200
300
346 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 7	39 protein kinase CDK-activating kinase 1 TFIIH basal transcription factor complex kinase subunit cell division protein kinase 7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes

Clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.51%	Phase 3
HY-112272	Lerociclib	Inhibitor	96.42%	Phase 3
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-X0009	Tambiciclib	Inhibitor	99.68%	Phase 2
HY-50940	AT7519	Inhibitor	99.69%	Phase 2
HY-137478	KB-0742	Inhibitor	99.63%	Phase 2
HY-137478A	KB-0742 dihydrochloride	Inhibitor	98.77%	Phase 2
HY-10424	Milciclib	Inhibitor	99.89%	Phase 2
HY-103712	Samuraciclib	Inhibitor	99.55%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.90%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.16%	Phase 2
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Phase 2
HY-161828A	(S)-JWZ-5-13	Degrader	99.62%	Phase 2
HY-50940A	AT7519 TFA	Inhibitor	99.75%	Phase 2
HY-X0009A	Tambiciclib dimaleate	Inhibitor	99.53%	Phase 2
HY-10008	SNS-032	Inhibitor	99.91%	Phase 1
HY-138293	SY-5609	Inhibitor	99.93%	Phase 1
HY-10012	AZD-5438	Inhibitor	99.91%	Phase 1
HY-128587	Mevociclib	Inhibitor	99.73%	Phase 1
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-11001	PHA-793887	Inhibitor	99.25%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.67%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.09%	Phase 1
HY-139342	CDK7-IN-4	Inhibitor	98.87%	Phase 1

Pre-clinical Phase

Bioactive Molecules (89)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-80013	THZ1	Inhibitor	99.84%	Unkown
HY-103618	THZ531	Inhibitor	99.86%	Unkown
HY-103248	Toyocamycin	Inhibitor	99.27%	Unkown
HY-101257	YKL-5-124	Inhibitor	99.53%	Unkown
HY-123954	BTX-A51	Inhibitor	98.58%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.52%	Unkown
HY-80013A	THZ1 Hydrochloride	Inhibitor	99.06%	Unkown
HY-13914	Roniciclib	Inhibitor	98.00%	Unkown
HY-144117	GFB-12811	Inhibitor	98.04%	Unkown
HY-11009	CGP60474	Inhibitor	98.90%	Unkown
HY-12445	Asnuciclib	Inhibitor	99.76%	Unkown
HY-X0150	JSH-150	Inhibitor	98.36%	Unkown
HY-N6954	Garcinone C	Inhibitor	99.51%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	99.37%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-112626	CDK12-IN-2	Inhibitor	99.36%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.93%	Unkown
HY-119940	MC180295	Inhibitor	98.07%	Unkown
HY-12653	LDC4297	Inhibitor	99.74%	Unkown
HY-18285	Longdaysin	Inhibitor	99.83%	Unkown
HY-12293	LY2857785	Inhibitor	99.21%	Unkown
HY-101257B	YKL-5-124 TFA	Inhibitor	99.74%	Unkown
HY-162706	BSJ-5-63	Degrader	99.97%	Unkown
HY-153278	Q901	Inhibitor	98.38%	Unkown
HY-112403	(S)-Roscovitine	Inhibitor	99.15%	Unkown
HY-153278A	Q901 TFA	Inhibitor	/	Unkown
HY-12653A	LDC4297 hydrochloride	Inhibitor	98.23%	Unkown
HY-151069	TMX-2039	Inhibitor	99.42%	Unkown
HY-139980	CDK9-IN-13	Inhibitor	99.94%	Unkown
HY-107419	NU6140	Inhibitor	99.53%	Unkown
HY-117203A	CDK12-IN-E9	Inhibitor	99.71%	Unkown
HY-116871	YKL-1-116	Inhibitor	98.67%	Unkown
HY-14372	BS-194	Inhibitor	99.13%	Unkown
HY-122665	HTH-01-091	Inhibitor	99.81%	Unkown
HY-161830	CDK7 ligand 2	Degrader	99.92%	Unkown
HY-100429	CAN508	Inhibitor	99.71%	Unkown
HY-155787	SHR5428	Inhibitor	99.80%	Unkown
HY-123955	Casein Kinase inhibitor A86	Inhibitor	99.26%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.88%	Unkown
HY-18969	LDC3140	Inhibitor	99.81%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-19988	THZ1-R	Inhibitor	98.06%	Unkown
HY-101257A	CDK7-IN-1	Inhibitor	98.91%	Unkown
HY-139011	IV-361	Inhibitor	99.60%	Unkown
HY-172194A	(S)-JNJ-3738	Inhibitor	/	Unkown
HY-164906	TMX-2138	Degrader	/	Unkown
HY-158170	CDK7-IN-28	Inhibitor	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-112450	Olomoucine II	Inhibitor	98.0%	Unkown
HY-110368	BS-181 dihydrochloride	Inhibitor	/	Unkown
HY-136711	CDK7-IN-2 hydrochloride hydrate	Inhibitor	/	Unkown
HY-145655	CDK7-IN-11	Inhibitor	/	Unkown
HY-139986	CDK7-IN-5	Inhibitor	/	Unkown
HY-181565	CDK7-IN-33	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-151898	CDK4/6-IN-14	Inhibitor	/	Unkown
HY-147600	CDK7-IN-15	Inhibitor	/	Unkown
HY-145389	SZ-015268	Inhibitor	/	Unkown
HY-180912	HS-36	Inhibitor	/	Unkown
HY-137478B	KB-0742 hydrochloride	Inhibitor	/	Unkown
HY-123034	CDKI-83	Inhibitor	/	Unkown
HY-182470	AG-012986 dihydrochloride	Inhibitor	/	Unkown
HY-162619	CDK9-IN-33	Inhibitor	/	Unkown
HY-180124	CDK8-IN-20	Inhibitor	/	Unkown
HY-183070	CXJ2080	Degrader	/	Unkown
HY-181528	JAK1/CDK7-IN-1	Inhibitor	/	Unkown
HY-183083	CDK7 ligand 3-CO-C5-COOH	Ligand	/	Unkown
HY-180355	SY-5102	Inhibitor	/	Unkown
HY-181645	CDK12-IN-9	Inhibitor	/	Unkown
HY-147601	CDK7-IN-16	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-150948	CDK12 ligand-2	Ligand	/	Unkown
HY-145408	CDK7/9-IN-1	Inhibitor	/	Unkown
HY-145394	CDK7-IN-6	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-170425	CDK7-IN-32	Inhibitor	/	Unkown
HY-162416	CDK7-IN-27	Inhibitor	/	Unkown
HY-145402	CDK7-IN-7	Inhibitor	/	Unkown
HY-169344	CDK7-IN-31	Inhibitor	/	Unkown
HY-156444	HDAC1/CDK7-IN-1	Inhibitor	/	Unkown
HY-145424	CDK7-IN-10	Inhibitor	/	Unkown
HY-183071	CDK7 ligand 3	Degrader	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-163721	CDK7-IN-29	Inhibitor	/	Unkown
HY-178112	CDK2-IN-47	Inhibitor	/	Unkown
HY-143586	CDK7-IN-8	Inhibitor	/	Unkown
HY-147409	Ulecaciclib	Inhibitor	/	Unkown
HY-182986	LS-Q2	Inhibitor	/	Unkown
HY-123826	CCT68127	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdk7	NCBI	NCBI:1022