CDK7 - cyclin dependent kinase 7 Gene

Also Known as CAK; CAK1; HCAK; MO15; STK1; CDKN7; p39MO15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1022

About CDK7

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:69,234,795-69,277,430 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 207 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 18.1), placenta (RPKM 14.9) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]

CDK7 Products (12)

mRNA	Protein	Name
NM_001324075.2	NP_001311004.1	cyclin-dependent kinase 7 isoform 4
NM_001324074.2	NP_001311003.1	cyclin-dependent kinase 7 isoform 4
NM_001324070.2	NP_001310999.1	cyclin-dependent kinase 7 isoform 3
NM_001324069.2	NP_001310998.1	cyclin-dependent kinase 7 isoform 2
NM_001324072.1	NP_001311001.1	cyclin-dependent kinase 7 isoform 4
NM_001324077.1	NP_001311006.1	cyclin-dependent kinase 7 isoform 4
XM_011543094.3	XP_011541396.1	cyclin-dependent kinase 7 isoform X2
NM_001324078.2	NP_001311007.1	cyclin-dependent kinase 7 isoform 4
NM_001324071.2	NP_001311000.1	cyclin-dependent kinase 7 isoform 5
NM_001799.4	NP_001790.1	cyclin-dependent kinase 7 isoform 1
XM_047416609.1	XP_047272565.1	cyclin-dependent kinase 7 isoform X1
NR_136690.2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP-dependent activity, acting on DNA	IDA IDA: Inferred from direct assay	9852112	GOA
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IDA IDA: Inferred from direct assay	9852112	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10801852	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9852112	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	23393140	GOA
involved in regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	23622515	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	7533895	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CAK-ERCC2 complex	IDA IDA: Inferred from direct assay	8692841	GOA
part of cyclin-dependent protein kinase holoenzyme complex	IDA IDA: Inferred from direct assay	23622515	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10958787	GOA
part of transcription factor TFIIH core complex	IDA IDA: Inferred from direct assay	8692841	GOA
part of transcription factor TFIIH holo complex	IDA IDA: Inferred from direct assay	9852112	GOA
part of transcription factor TFIIK complex	IDA IDA: Inferred from direct assay	8692841	GOA
part of transcription factor TFIIK complex	IMP IMP: Inferred from mutant phenotype	23393140	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK7 Protein Structure

Pkinase

0
100
200
300
346 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 7	39 KDa protein kinase CDK-activating kinase 1 TFIIH basal transcription factor complex kinase subunit cell division protein kinase 7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) homolog of Xenopus MO15 Cdk-activating kinase kinase subunit of CAK serine/threonine kinase stk1 serine/threonine protein kinase 1 serine/threonine protein kinase MO15

CDK7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDK7	P50613	CDK4	Homo sapiens	P11802	Protein Kinase Assay	16327805
Intra	CDK7	P50613	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	28514442
Intra	CDK7	P50613	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	CDK7	P50613	CDK2	Homo sapiens	P24941	Protein Kinase Assay	8521818
Intra	CDK7	P50613	CDK2	Homo sapiens	P24941	Protein Kinase Assay	16327805
Intra	CDK7	P50613	SRPK1	Homo sapiens	Q96SB4	Protein Kinase Assay	23602568
Intra	CDK7	P50613	SRPK1	Homo sapiens	Q96SB4	Pull Down	32707033
Intra	CDK7	P50613	SRPK2	Homo sapiens	P78362	Protein Kinase Assay	23602568
Intra	CDK7	P50613	SRPK2	Homo sapiens	P78362	Pull Down	32707033
Intra	CDK7	P50613	SUPT5H	Homo sapiens	O00267	Protein Kinase Assay	16327805

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDK7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75361	CDK7-CCNH-MNAT1 Protein, Human (Active, sf9, His)	P50613 (A2-F346)&P51946 (Y2-L323)&P51948 (D2-S309)	≥ 85%, as determined by reducing SDS-PAGE.

CDK7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80389	Cdk7 Antibody (YA3495)	WB	Human
HY-P811164	Phospho-CDK7 (Thr170) Antibody	WB, IHC-P	Human, Mouse

Related Diseases

Diseases	Alias
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Xeroderma Pigmentosum, Complementation Group D	Xeroderma Pigmentosum, Group D Xpdc Xeroderma Pigmentosum Iv XPD Xeroderma Pigmentosum Group D Xeroderma Pigmentosum Viii Xp Group D Xp Group H Xp4 Xp8 Xph Xp, Group D Xp4 Xeroderma Pigmentosum Viii, Formerly Xp8, Formerly Xp, Group H, Formerly Xph, Formerly Xeroderma Pigmentosum Complementation Group D XP-D Xp-D/Cs
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis De Sanctis-Cacchione Syndrome Xp Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes

Clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.51%	Phase 3
HY-X0009	Tambiciclib	Inhibitor	99.68%	Phase 2
HY-50940	AT7519	Inhibitor	99.69%	Phase 2
HY-137478	KB-0742	Inhibitor	99.63%	Phase 2
HY-13914	Roniciclib	Inhibitor	98.00%	Phase 2
HY-10424	Milciclib	Inhibitor	99.89%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.90%	Phase 2
HY-161828A	(S)-JWZ-5-13	Degrader	99.62%	Phase 2
HY-10008	SNS-032	Inhibitor	99.91%	Phase 1
HY-138293	SY-5609	Inhibitor	99.93%	Phase 1
HY-10012	AZD-5438	Inhibitor	99.91%	Phase 1
HY-123954	BTX-A51	Inhibitor	98.99%	Phase 1
HY-128587	Mevociclib	Inhibitor	99.73%	Phase 1
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.67%	Phase 1
HY-139342	CDK7-IN-4	Inhibitor	98.87%	Phase 1

Pre-clinical Phase

Bioactive Molecules (96)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-80013	THZ1	Inhibitor	99.84%	Unkown
HY-103618	THZ531	Inhibitor	99.86%	Unkown
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Unkown
HY-103248	Toyocamycin	Inhibitor	99.27%	Unkown
HY-101257	YKL-5-124	Inhibitor	99.53%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.52%	Unkown
HY-137478A	KB-0742 dihydrochloride	Inhibitor	98.77%	Unkown
HY-80013A	THZ1 Hydrochloride	Inhibitor	99.06%	Unkown
HY-144117	GFB-12811	Inhibitor	98.04%	Unkown
HY-11009	CGP60474	Inhibitor	98.90%	Unkown
HY-12445	Asnuciclib	Inhibitor	99.76%	Unkown
HY-X0150	JSH-150	Inhibitor	98.36%	Unkown
HY-N6954	Garcinone C	Inhibitor	99.51%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	99.37%	Unkown
HY-103712	Samuraciclib	Inhibitor	99.55%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-112626	CDK12-IN-2	Inhibitor	99.36%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.93%	Unkown
HY-119940	MC180295	Inhibitor	98.07%	Unkown
HY-112272	Lerociclib	Inhibitor	96.42%	Unkown
HY-12653	LDC4297	Inhibitor	99.74%	Unkown
HY-18285	Longdaysin	Inhibitor	99.83%	Unkown
HY-12293	LY2857785	Inhibitor	99.21%	Unkown
HY-101257B	YKL-5-124 TFA	Inhibitor	99.74%	Unkown
HY-162706	BSJ-5-63	Degrader	99.97%	Unkown
HY-153278	Q901	Inhibitor	98.38%	Unkown
HY-112403	(S)-Roscovitine	Inhibitor	99.15%	Unkown
HY-50943	AT7519 Hydrochloride	Inhibitor	99.16%	Unkown
HY-15504A	RGB-286638 free base	Inhibitor	98.09%	Unkown
HY-153278A	Q901 TFA	Inhibitor	/	Unkown
HY-12653A	LDC4297 hydrochloride	Inhibitor	98.23%	Unkown
HY-151069	TMX-2039	Inhibitor	99.42%	Unkown
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Unkown
HY-139980	CDK9-IN-13	Inhibitor	99.94%	Unkown
HY-107419	NU6140	Inhibitor	99.53%	Unkown
HY-117203A	CDK12-IN-E9	Inhibitor	99.71%	Unkown
HY-116871	YKL-1-116	Inhibitor	98.67%	Unkown
HY-14372	BS-194	Inhibitor	99.13%	Unkown
HY-122665	HTH-01-091	Inhibitor	99.81%	Unkown
HY-161830	CDK7 ligand 2	Degrader	99.92%	Unkown
HY-100429	CAN508	Inhibitor	99.71%	Unkown
HY-155787	SHR5428	Inhibitor	99.80%	Unkown
HY-123955	Casein Kinase inhibitor A86	Inhibitor	99.26%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.88%	Unkown
HY-50940A	AT7519 TFA	Inhibitor	99.75%	Unkown
HY-X0009A	Tambiciclib dimaleate	Inhibitor	99.53%	Unkown
HY-18969	LDC3140	Inhibitor	99.81%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-19988	THZ1-R	Inhibitor	98.06%	Unkown
HY-101257A	CDK7-IN-1	Inhibitor	98.91%	Unkown
HY-139011	IV-361	Inhibitor	99.60%	Unkown
HY-164906	TMX-2138	Degrader	98.99%	Unkown
HY-172194A	(S)-JNJ-3738	Inhibitor	/	Unkown
HY-158170	CDK7-IN-28	Inhibitor	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-112450	Olomoucine II	Inhibitor	98.0%	Unkown
HY-136711	CDK7-IN-2 hydrochloride hydrate	Inhibitor	/	Unkown
HY-110368	BS-181 dihydrochloride	Inhibitor	/	Unkown
HY-145655	CDK7-IN-11	Inhibitor	/	Unkown
HY-181565	CDK7-IN-33	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-151898	CDK4/6-IN-14	Inhibitor	/	Unkown
HY-147600	CDK7-IN-15	Inhibitor	/	Unkown
HY-145389	SZ-015268	Inhibitor	/	Unkown
HY-162416	CDK7-IN-27	Inhibitor	/	Unkown
HY-180912	HS-36	Inhibitor	/	Unkown
HY-123034	CDKI-83	Inhibitor	/	Unkown
HY-137478B	KB-0742 hydrochloride	Inhibitor	/	Unkown
HY-162619	CDK9-IN-33	Inhibitor	/	Unkown
HY-180124	CDK8-IN-20	Inhibitor	/	Unkown
HY-183070	CXJ2080	Degrader	/	Unkown
HY-180355	SY-5102	Inhibitor	/	Unkown
HY-181528	JAK1/CDK7-IN-1	Inhibitor	/	Unkown
HY-181645	CDK12-IN-9	Inhibitor	/	Unkown
HY-163721	CDK7-IN-29	Inhibitor	/	Unkown
HY-147601	CDK7-IN-16	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-150948	CDK12 ligand-2	Ligand	/	Unkown
HY-182986	LS-Q2	Inhibitor	/	Unkown
HY-145408	CDK7/9-IN-1	Inhibitor	/	Unkown
HY-145394	CDK7-IN-6	Inhibitor	/	Unkown
HY-139986	CDK7-IN-5	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-170425	CDK7-IN-32	Inhibitor	/	Unkown
HY-145402	CDK7-IN-7	Inhibitor	/	Unkown
HY-169344	CDK7-IN-31	Inhibitor	/	Unkown
HY-156444	HDAC1/CDK7-IN-1	Inhibitor	/	Unkown
HY-182470	AG-012986 dihydrochloride	Inhibitor	/	Unkown
HY-145424	CDK7-IN-10	Inhibitor	/	Unkown
HY-183071	CDK7 ligand 3	Degrader	/	Unkown
HY-178112	CDK2-IN-47	Inhibitor	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-143586	CDK7-IN-8	Inhibitor	/	Unkown
HY-183083	CDK7 ligand 3-CO-C5-COOH	Ligand	/	Unkown
HY-147409	Ulecaciclib	Inhibitor	/	Unkown
HY-123826	CCT68127	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDK7	MGD	MGI:102956
Canis familiaris	CDK7	VGNC	VGNC:39060
Felis catus	CDK7	VGNC	VGNC:60705
Macaca mulatta	CDK7	VGNC	VGNC:84288
Bos taurus	CDK7	VGNC	VGNC:27134
Rattus norvegicus	CDK7	RGD	RGD:621124
Others	CDK7	NCBI