2. Gene
  3. CDK7 - cyclin dependent kinase 7 Gene

CDK7 - cyclin dependent kinase 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAK; CAK1; HCAK; MO15; STK1; CDKN7; p39MO15

Gene ID: 1022 | Gene type: protein coding

About CDK7

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:69,234,795-69,277,430 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 207 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 18.1), placenta (RPKM 14.9) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]

CDK7 Products(12)

mRNA Protein Name
NM_001324075.2 NP_001311004.1 cyclin-dependent kinase 7 isoform 4
NM_001324074.2 NP_001311003.1 cyclin-dependent kinase 7 isoform 4
NM_001324070.2 NP_001310999.1 cyclin-dependent kinase 7 isoform 3
NM_001324069.2 NP_001310998.1 cyclin-dependent kinase 7 isoform 2
NM_001324072.1 NP_001311001.1 cyclin-dependent kinase 7 isoform 4
NM_001324077.1 NP_001311006.1 cyclin-dependent kinase 7 isoform 4
XM_011543094.3 XP_011541396.1 cyclin-dependent kinase 7 isoform X2
NM_001324078.2 NP_001311007.1 cyclin-dependent kinase 7 isoform 4
NM_001324071.2 NP_001311000.1 cyclin-dependent kinase 7 isoform 5
NM_001799.4 NP_001790.1 cyclin-dependent kinase 7 isoform 1
XM_047416609.1 XP_047272565.1 cyclin-dependent kinase 7 isoform X1
NR_136690.2

CDK7 Protein Structure

Pkinase

Pkinase: Protein kinase domain (12 - 295)

  • 0
  • 100
  • 200
  • 300
  • 346 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 7

39 KDa protein kinase

CDK-activating kinase 1

TFIIH basal transcription factor complex kinase subunit

cell division protein kinase 7

cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)

homolog of Xenopus MO15 Cdk-activating kinase

kinase subunit of CAK

serine/threonine kinase stk1

serine/threonine protein kinase 1

serine/threonine protein kinase MO15

Recombinant CDK7 Proteins

Cat. No. Product Name Accession Purity
HY-P75361 CDK7&CCNH&MNAT1 Protein, Human (sf9, His) P50613 (A2-F346)&P51946 (Y2-L323)&P51948 (D2-S309) ≥95%

Related Diseases

Diseases Alias
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Trichothiodystrophy

Ttd

Amish Brittle Hair Syndrome

Bids Syndrome

Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

Ibids

Pibids

Trichothiodystrophy Syndromes
Xeroderma Pigmentosum, Complementation Group D

Xeroderma Pigmentosum, Group D

Xpdc

Xeroderma Pigmentosum Iv

XPD

Xeroderma Pigmentosum Group D

Xeroderma Pigmentosum Viii

Xp Group D

Xp Group H

Xp4

Xp8

Xph

Xp, Group D

Xp4 Xeroderma Pigmentosum Viii, Formerly

Xp8, Formerly

Xp, Group H, Formerly

Xph, Formerly

Xeroderma Pigmentosum Complementation Group D

XP-D

Xp-D/Cs
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

De Sanctis-Cacchione Syndrome

Xp

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16297A Abemaciclib Inhibitor 99.96% Yes
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% Yes
Clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-10424 Milciclib Inhibitor 99.90% Phase 2
HY-13914 Roniciclib Inhibitor 98.03% Phase 2
HY-103712B Samuraciclib hydrochloride hydrate Inhibitor 99.08% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-112272 Lerociclib Inhibitor / Phase 2
HY-138293 SY-5609 Inhibitor 99.66% Phase 1
HY-10008 SNS-032 Inhibitor 99.51% Phase 1
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-128587 Mevociclib Inhibitor 99.27% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-15504 RGB-286638 Inhibitor 99.84% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
HY-139342 CDK7-IN-4 Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (54)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-80013 THZ1 Inhibitor 99.84% Unkown
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-103248 Toyocamycin Inhibitor 99.90% Unkown
HY-11009 CGP60474 Inhibitor 99.23% Unkown
HY-123954 Casein Kinase inhibitor A51 Inhibitor 98.58% Unkown
HY-10014 R547 Inhibitor 99.57% Unkown
HY-80013A THZ1 Hydrochloride Inhibitor 98.78% Unkown
HY-18340 (R)​-​CR8 Inhibitor 99.21% Unkown
HY-13266A BS-181 hydrochloride Inhibitor 99.80% Unkown
HY-12445 Asnuciclib Inhibitor 99.76% Unkown
HY-18340A (R)-CR8 trihydrochloride Inhibitor 98.95% Unkown
HY-12653 LDC4297 Inhibitor 98.25% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.44% Unkown
HY-12293 LY2857785 Inhibitor 99.92% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.97% Unkown
HY-119940 MC180295 Inhibitor 98.41% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-144117 GFB-12811 Inhibitor 98.00% Unkown
HY-101257B YKL-5-124 TFA Inhibitor 99.44% Unkown
HY-107419 NU6140 Inhibitor 99.07% Unkown
HY-15241 NVP-LCQ195 Inhibitor 98.91% Unkown
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% Unkown
HY-123955 Casein Kinase inhibitor A86 Inhibitor 98.47% Unkown
HY-18285 Longdaysin Inhibitor 99.87% Unkown
HY-N6954 Garcinone C Inhibitor 99.66% Unkown
HY-19988 THZ1-R Inhibitor 98.12% Unkown
HY-12653A LDC4297 hydrochloride Inhibitor 98.25% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.22% Unkown
HY-153278 CDK7-IN-21 Degrader 95.12% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-13266 BS-181 Inhibitor 98.10% Unkown
HY-139011 IV-361 Inhibitor 98.64% Unkown
HY-14372 BS-194 Inhibitor 99.36% Unkown
HY-136711 CDK7-IN-2 hydrochloride hydrate Inhibitor / Unkown
HY-103712 Samuraciclib Inhibitor / Unkown
HY-145655 CDK7-IN-11 Inhibitor / Unkown
HY-110368 BS-181 dihydrochloride Inhibitor / Unkown
HY-155787 SHR5428 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-145408 CDK7/9-IN-1 Inhibitor / Unkown
HY-145402 CDK7-IN-7 Inhibitor / Unkown
HY-147601 CDK7-IN-16 Inhibitor / Unkown
HY-143586 CDK7-IN-8 Inhibitor / Unkown
HY-116871 YKL-1-116 Inhibitor / Unkown
HY-145394 CDK7-IN-6 Inhibitor / Unkown
HY-145389 SZ-015268 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-156444 HDAC1/CDK7-IN-1 Inhibitor / Unkown
HY-139986 CDK7-IN-5 Inhibitor / Unkown
HY-145424 CDK7-IN-10 Inhibitor / Unkown
HY-147409 Ulecaciclib Inhibitor / Unkown
HY-162416 CDK7-IN-27 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-151898 CDK4/6-IN-14 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CDK7 MGD MGI:102956
Canis familiaris CDK7 VGNC VGNC:39060
Felis catus CDK7 VGNC VGNC:60705
Macaca mulatta CDK7 VGNC VGNC:84288
Bos taurus CDK7 VGNC VGNC:27134
Rattus norvegicus CDK7 RGD RGD:621124
Others CDK7 NCBI