NOTCH2NLA - notch 2 N-terminal like A Gene

Homo sapiens

Also known as N2N; NOTCH2NL

Gene ID: 388677 | Gene type: protein coding

About NOTCH2NLA

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:146,148,865-146,229,021 (from NCBI)

This gene has 9 transcripts (splice variants), 121 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 12.1), skin (RPKM 6.6) and 25 other tissues.

Summary

Enables Notch binding activity. Involved in cerebral cortex development and positive regulation of Notch signaling pathway. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

NOTCH2NLA Products(4)

mRNA	Protein	Name
NM_001364006.2	NP_001350935.1	notch homolog 2 N-terminal-like protein A isoform 2
NM_001395231.1	NP_001382160.1	notch homolog 2 N-terminal-like protein A isoform 3
NM_001395232.1	NP_001382161.1	notch homolog 2 N-terminal-like protein A isoform 4
NM_203458.6	NP_982283.2	notch homolog 2 N-terminal-like protein A isoform 1

NOTCH2NLA Protein Structure

EGF

EGF_CA

0
100
200
236 a.a.

Protein Preferred Names

Protein Names

notch homolog 2 N-terminal-like protein A

Notch homolog 2 N-terminal like protein

Recombinant NOTCH2NLA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77107	NOTCH2NL Protein, Human (HEK293, Fc)	Q7Z3S9 (M1-N236)	≥95%

Related Diseases

Diseases

Alias

Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome	Fragile X Tremor/Ataxia Syndrome
Fxtas

Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy	Bafme
Benign Adult Familial Myoclonic Epilepsy	Fame
Familial Cortical Myoclonic Tremor And Epilepsy	Fcmte
Adcme	Autosomal Dominant Cortical Myoclonus And Epilepsy
Fam	Epilepsy, Myoclonic, Familial Adult
Epilepsy, Myoclonic, Benign Adult Familial, Type 2

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09449	NOTCH2NLA Human Pre-designed siRNA Set A		/	Unkown

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