LPA - lipoprotein(a) Gene

Also Known as LP; AK38; APOA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4018

About LPA

Cytogenetic location: 6q25.3-q26 Genomic coordinates (GRCh38): 6:160,531,482-160,664,275 (from NCBI)

This gene has 3 transcripts (splice variants), 26 orthologues, 1 paralogue and is associated with 1 phenotype. Restricted expression toward liver (RPKM 48.1).

Summary

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

LPA Products (1)

mRNA	Protein	Name
NM_005577.4	NP_005568.2	apolipoprotein(a) precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables apolipoprotein binding	IPI IPI: Inferred from physical interaction	9269765	GOA
enables fibronectin binding	IPI IPI: Inferred from physical interaction	2531657	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2531657	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	2531657	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of plasma lipoprotein particle	IDA IDA: Inferred from direct assay	2531657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPA Protein Structure

Kringle

Trypsin

0
400
800
1200
1600
2040 a.a.

Protein Preferred Names	Protein Names
apolipoprotein(a)	antiangiogenic AK38 protein

LPA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LPA	P08519	FN1	Homo sapiens	P02751	ELISA	2531657
Intra	LPA	P08519	FN1	Homo sapiens	P02751	Y2H	9269765
Intra	LPA	P08519	APOH	Homo sapiens	P02749	Y2H	9269765
Intra	LPA	P08519	APOH	Homo sapiens	P02749	Anti Bait CoIP	9269765
Intra	LPA	P08519	APOH	Homo sapiens	P02749	ELISA	9269765

Cross: Cross-species interaction Intra: Intraspecies interaction

LPA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82987	ApoA Antibody (YA2732)	WB	Human
HY-P84010	LPA Antibody (YA3707)	IHC-P, ICC/IF, ELISA	Human
HY-P84010A	LPA Antibody (YA3707)(PBS only)	IHC-P, ICC/IF, ELISA	Human
HY-P85037	ApoA Antibody (YA4729)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Carotid Artery Disease	Carotid Artery Diseases Disorder Of Carotid Artery
Hyperlipoproteinemia, Type Iii	Hyperlipoproteinemia Type Iii Broad-Betalipoproteinemia Floating-Betalipoproteinemia Familial Type 3 Hyperlipoproteinemia Broad Beta Disease Familial Hyperbeta- And Prebetalipoproteinemia Familial Hypercholesterolemia With Hyperlipemia Hyperlipemia With Familial Hypercholesterolemic Xanthomatosis Coronary Artery Disease, Severe, Susceptibility To Coronary Artery Disease, Severe Hyperlipidemia Type 3 Familial Dysbetalipoproteinemia Hyperlipoproteinemia Type 3 Coronary Artery Disease Apolipoprotein E, Deficiency Or Defect Of Dysbetalipoproteinemia Due To Defect In Apolipoprotein E-D Carbohydrate Induced Hyperlipemia Familial Hypercholesterolaemia With Hyperlipaemia Remnant Hyperlipidemia Remnant Removal Disease Dysbetalipoproteinemia Broad-Beta Disease Familial Dyslipidemia Type 3 Hlp Type 3 Remnant Hyperlipoproteinemia Familial Hyperlipoproteinemia Type Iii CAD Hyperlipoproteinemia 3 HLPP3 Deficiency Or Defect Of Apolipoprotein E Dysbetalipoproteinemia Due To Defect In Apolipoprotein E Coronary Arteriosclerosis Coronary Heart Disease
Peripheral Vascular Disease	Peripheral Arterial Disease Arterial Occlusive Disease Arterial Occlusive Diseases Pad Peripheral Vascular Diseases Peripheral Occlusive Disease Peripheral Arterial Diseases Helicobacter Infections
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Tangier Disease	Analphalipoproteinemia High Density Lipoprotein Deficiency, Tangier Type TGD High Density Lipoprotein Deficiency, Type 1 Hdldt1 Familial High Density Lipoprotein Deficiency A-Alphalipoprotein Neuropathy Alpha High Density Lipoprotein Deficiency Disease Cholesterol Thesaurismosis Familial High Density Lipoprotein Deficiency Disease Hdl Lipoprotein Deficiency Disease Tangier Disease Neuropathy Familial Alpha-Lipoprotein Deficiency Familial High-Density Lipoprotein Deficiency 1 Primary Hypoalphalipoproteinemia 1 Analphalipo-Proteinemia Familial Hypoalphalipo-Proteinemia Familial Hypoalphalipoproteinemia Lipoprotein Deficiency Disease, Hdl, Familial Tangier Hereditary Neuropathy Atp-Binding Cassette Transporter A1 Deficiency Hdld1 High Density Lipoprotein Deficiency 1 Tangier Disease, Variant Hypoalphalipoproteinemia, Familial Familial Hdl Deficiency
Upper Lip Cancer
Xanthomatosis	Xanthomatosis, Susceptibility To Xanthelasmatosis
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Childhood Testicular Germ Cell Tumor	Paediatric Testicular Germ Cell Neoplasm Paediatric Testicular Germ Cell Tumour Pediatric Testicular Germ Cell Neoplasm Pediatric Testicular Germ Cell Tumor Testicular Germ Cell Tumor, Pediatric
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Arteriosclerosis	Arteriosclerotic Vascular Disease
Carotid Stenosis	Carotid Artery Stenosis Stenosis, Carotid Artery
Hypoalphalipoproteinemia, Primary, 2	Apolipoprotein A-I Deficiency Hypoalphalipoproteinemia, Primary, 2, Autosomal Recessive Primary Hypoalphalipoproteinemia 2 High Density Lipoprotein Deficiency Apoa-I Deficiency Familial Apoa-I Deficiency Familial Hypoalphalipoproteinemia FHA2 Apolipoprotein A-I
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Hyperhomocysteinemia
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Acute Myocardial Infarction	Cardiac Attack Heart Attack
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Lecithin:Cholesterol Acyltransferase Deficiency	Norum Disease Lcat Deficiency Familial Lcat Deficiency Fld Lecithin Acyltransferase Deficiency Complete Lcat Deficiency Lecithin Cholesterol Acyltransferase Deficiency Lecithin-Cholesterol Acyltransferase Deficiency Familial Lecithin-Cholesterol Acyltransferase Deficiency Norum'S Disease LCATD Deficiency, Lecithin:Cholesterol Acyltransferase
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Amyloidosis, Familial Visceral	Ostertag Type Amyloidosis German Type Amyloidosis Familial Renal Amyloidosis Amyloidosis Viii Amyloidosis, 3 Or More Types Familial Visceral Amyloidosis Familial Amyloid Nephropathy Hereditary Amyloid Nephropathy Amyloidosis, Familial Renal Amyloidosis, Systemic Nonneuropathic Amyloidosis Familial Visceral Amyloidosis 8 Amyloidosis, Ostertag Type Hereditary Amyloidosis With Primary Renal Involvement Hereditary Renal Amyloidosis Renal Amyloidosis Amyloidosis, Renal Systemic Nonneuropathic Amyloidosis Amyloidosis Familial Renal Amyloidosis Systemic Nonneuropathic Hereditary Amyloidosis With Primary Renal Involement AMYL8 Systemic Non-Neuropathic Amyloidosis Amyloid Nephropathy
Hepatic Flexure Cancer	Ca Hepatic Flexure - Colon Malignant Neoplasm Of Hepatic Flexure Malignant Tumor Of Hepatic Flexure Carcinoma Of Hepatic Flexure Malignant Neoplasm Of Hepatic Flexure Of Colon
Hypobetalipoproteinemia, Familial, 1	Hypobetalipoproteinemia Familial Hypobetalipoproteinemia 1 Familial Hypobetalipoproteinemia FHBL1 Hypobetalipoproteinemia, Familial Fhbl Acanthocytosis With Hypobetalipoproteinemia Hypobetalipoproteinemias Hypobetalipoproteinemia, Normotriglyceridemic Hypo-Beta-Lipoproteinemia Hypobetalipoprotéinemia, Familial Normotriglyceridemic Hypobetalipoproteinemia Hypobetalipoproteinemia, Familial, Type 1
Coronary Heart Disease 1	Coronary Heart Disease Coronary Heart Disease, Susceptibility To, 1 Chds1 Coronary Heart Disease, Susceptibility To CHD Heart, Coronary, Disease, Susceptibility To, Type 1 Coronary Arteriosclerosis Coronary Artery Disease
Hypoalphalipoproteinemia, Primary, 1	Familial Hdl Deficiency Fha High Density Lipoprotein Deficiency Familial Hypoalphalipoproteinemia Hypoalphalipoproteinemia, Familial Hdld Fhd Hdl Deficiency, Type 2 Primary Hypoalphalipoproteinemia 1 Hdl Cholesterol, Low Serum Hdlc Hdl Deficiency, Familial, 1 Hypoalphalipoproteinemia, Primary Low Serum Hdl Cholesterol Primary Hypoalphalipoproteinemia FHA1 Hdld2 High Density Lipoprotein Deficiency 2 Hypoalphalipoproteinemias Apolipoprotein A-I Deficiency
Arcus Corneae	Arcus Senilis Corneal Arcus Arcus Of Cornea
Diabetes Mellitus	Diabetes
Hypolipoproteinemia	Hypolipoproteinaemia Lipoprotein Deficiencies Lipoprotein Disorder Hypolipoproteinemias Lipoprotein Lipoprotein Deficiency Hypolipidaemia Lipoprotein Deficiency Disorder High-Density Lipoid Deficiency High-Density Lipoprotein Deficiency Dyslipidaemia, Depressed Hdl Cholesterol
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Hypercholesterolemia, Familial, 1	Hypercholesterolemia FHCL1 Fhc Fh Hyperlipoproteinemia, Type Ii Hyperlipoproteinemia, Type Iia Hyper-Low-Density-Lipoproteinemia Hypercholesterolemic Xanthomatosis, Familial Ldl Receptor Disorder Hypercholesterolemia, Susceptibility To Hypercholesterolemia, Familial, Modifier Of Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of Ldl Cholesterol Level Qtl2 Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial, Type 1 High Cholesterol Increased Cholesterol Low-Density-Lipoid-Type Hyperlipoproteinemia Pure Hypercholesterolaemia Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia Group A Hyperlipidaemia Pure Hypercholesterinaemia Cholesterolaemia Essential Cholesterolaemia Essential Hypercholesterolaemia Group A Hyperlipemia Increased Low Density Lipoprotein Low-Density-Lipoprotein-Type Low-Density-Lipoprotein-Type Hyperlipoproteinemia
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Cerebral Atherosclerosis	Intracranial Arteriosclerosis
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Aortic Valve Disease 2	Aortic Valve Stenosis Aortic Stenosis Rheumatic Aortic Stenosis AOVD2 Bicuspid Aortic Valve Rheumatic Aortic Valve Stenosis Valvular Aortic Stenosis Aortic Valve Disease, Type 2 Aortic Valve Stricture Aortic Valve Obstruction Obstructed Aorta Valve Rheumatic Aortic Obstruction Rheumatic Aortic Valve Obstruction Rheumatic Aortic Stricture Aortic Valve Regurgitation Aortic Insufficiency With Stenosis Rheumatic Aortic Valve Stenosis With Insufficiency Rheumatic Aortic Stenosis With Incompetence Rheumatic Aortic Stenosis With Regurgitation
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-10341	Fasudil Hydrochloride	99.97%	Yes
HY-10341A	Fasudil	99.98%	Yes
HY-10341C	Fasudil dihydrochloride	99.98%	Yes
HY-10341B	Fasudil hydrochloride semihydrate	/	Unkown

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-139853	BMS-986278	Antagonist	99.95%	Phase 3
HY-152857	Muvalaplin	Inhibitor	99.96%	Phase 3
HY-153492A	Olpasiran sodium	Inhibitor	98.82%	Phase 3
HY-177640	Lepodisiran	Inhibitor	91.95%	Phase 3
HY-100619	BMS-986020	Antagonist	99.83%	Phase 2
HY-120797	CRT0273750		98.87%	Phase 2
HY-145561	Cudetaxestat	Inhibitor	98.32%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991310	Lpathomab	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (103)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107614	1-Oleoyl lysophosphatidic acid sodium	Inducer	99.96%	Unkown
HY-137862	1-Oleoyl lysophosphatidic acid	Activator	99.96%	Unkown
HY-13285	Ki16425		99.30%	Unkown
HY-132222	SET2	Antagonist	99.78%	Unkown
HY-16040	AM095 free acid	Inhibitor	99.02%	Unkown
HY-15277	AM966	Antagonist	98.91%	Unkown
HY-16039	AM095	Antagonist	99.72%	Unkown
HY-107616	H2L5186303		98.50%	Unkown
HY-114379	AS2717638	Antagonist	99.85%	Unkown
HY-117779	DBIBB		98.07%	Unkown
HY-15706	H2L 5765834	Antagonist	98.66%	Unkown
HY-145344	ONO-8430506	Inhibitor	99.90%	Unkown
HY-150204	ONO-0740556	Agonist	99.78%	Unkown
HY-107501	(Rac)-1-Oleoyl lysophosphatidic acid sodium		98.0%	Unkown
HY-100619A	BMS-986020 sodium	Inhibitor	99.88%	Yes
HY-124772	BI-2545	Inhibitor	98.85%	Unkown
HY-107615	TC LPA5 4	Antagonist	99.69%	Unkown
HY-18075	LPA2 antagonist 1	Inhibitor	98.63%	Unkown
HY-117444	ONO-9780307	Inhibitor	99.94%	Unkown
HY-120967	(2S)-OMPT triethylamine, in ethanol:chloroform (1:1), 98%		99.0%	Unkown
HY-W127502	1-Hexadecyl lysophosphatidic acid		99.89%	Unkown
HY-117959	TAK-615	Inhibitor	98.07%	Unkown
HY-100676	GRI977143		99.29%	Unkown
HY-114380	Radioprotectin-1	Agonist	99.49%	Unkown
HY-138453	ACT-1016-0707	Antagonist	98.28%	Unkown
HY-100882	ONO-7300243	Antagonist	98.11%	Unkown
HY-120478	ASP6432	Antagonist	99.92%	Unkown
HY-175646	AGPAT4-IN-1		99.04%	Unkown
HY-18641	Ki16198	Antagonist	98.17%	Unkown
HY-116100A	HA155	Inhibitor	98.50%	Unkown
HY-151391	LPA5 antagonist 1		98.91%	Unkown
HY-18076	LPA1 receptor antagonist 1	Antagonist	99.13%	Unkown
HY-128127	NAEPA	Agonist	≥99.0%	Unkown
HY-115450	ONO-0300302	Antagonist	98.02%	Unkown
HY-103267	S32826 disodium	Inhibitor	98.85%	Unkown
HY-124072	HL001		98.90%	Unkown
HY-124535	TGX-115	Inhibitor	99.31%	Unkown
HY-146945S	Arachidonoyl LPA-d5		95%	Unkown
HY-146956S	Oleoyl LPA-d5		98.0%	Unkown
HY-157693	C18:1 Cyclic LPA		99%	Unkown
HY-W923661	1-Octadecyl lysophosphatidic acid	Activator	95%	Unkown
HY-113973	LPA2 antagonist 2	Antagonist	95.0%	Unkown
HY-120967A	(2S)-OMPT		/	Unkown
HY-139061	Palmitoyl 3-carbacyclic phosphatidic acid	Inhibitor	99.9%	Unkown
HY-145486	1-Arachidonoyl-sn-glycerol 3-phosphate ammonium		/	Unkown
HY-146955S	Linoleoyl LPA-d5		95%	Unkown
HY-151392	LPA5 antagonist 2	Antagonist	99.62%	Unkown
HY-167862A	UCM-05194 ammonium	Agonist	/	Unkown
HY-167862	UCM-05194		90.0%	Unkown
HY-184076	Ibrilparant		/	Unkown
HY-184986	PIPE-791		/	Unkown
HY-103267A	S32826	Inhibitor	/	Unkown
HY-107614G	1-Oleoyl lysophosphatidic acid sodium (GMP)	Activator	/	Unkown
HY-118539	NSC12404	Agonist	/	Unkown
HY-119013	VPC32183		/	Unkown
HY-119601	GRI918013	Inhibitor	/	Unkown
HY-123522	PAT-048	Inhibitor	/	Unkown
HY-126230	PAT-494		/	Unkown
HY-126230A	(Rac)-PAT-494		/	Unkown
HY-126233A	PAT-347 sodium	Inhibitor	/	Unkown
HY-129808	VPC12249	Antagonist	/	Unkown
HY-130011	CCG-232964	Inhibitor	/	Unkown
HY-137862A	(Rac)-1-Oleoyl lysophosphatidic acid	Control	/	Unkown
HY-148291	BrP-LPA sodium		/	Unkown
HY-157617	16:0 Cyclic LPA ammonium		/	Unkown
HY-157669	1-Oleoyl-sn-glycero-2,3-cyclic-phosphate ammonium		/	Unkown
HY-160616	LPA5 antagonist 3	Antagonist	/	Unkown
HY-160823	2ccPA sodium	Inhibitor	/	Unkown
HY-171464A	Lp(a)-IN-5 hydrochloride	Inhibitor	99.70%	Unkown
HY-171465	Lp(a)-IN-6		/	Unkown
HY-171806	BMT-136088	Ligand	/	Unkown
HY-171906A	1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA sodium	Inhibitor	/	Unkown
HY-173322	Lp(a)-IN-8	Inhibitor	/	Unkown
HY-173323	Lp(a)-IN-7	Inhibitor	/	Unkown
HY-173324	LPA2 antagonist 5	Antagonist	/	Unkown
HY-173325	LPA2 antagonist 6	Antagonist	/	Unkown
HY-173509	ATX inhibitor 27	Inhibitor	/	Unkown
HY-174267S	ATX-IN-2	Inhibitor	/	Unkown
HY-175084	1-Hexadecyl lysophosphatidic acid sodium	Activator	/	Unkown
HY-178845	Decyl phosphate	Modulator	/	Unkown
HY-179580	EL244		99.55%	Unkown
HY-181452	1-Arachidoyl-2-hydroxy-sn-glycero-3-PA sodium		/	Unkown
HY-182787	LPA1 receptor antagonist-7	Antagonist	/	Unkown
HY-404647	FK3453	Inhibitor	99.98%	Unkown
HY-N15794	AzoLPA ammonium	Activator	/	Unkown
HY-N15931	18:1 1,3-Cyclic LPA ammonium		/	Unkown
HY-N16000	12:0 Biotinyl LPA ammonium		/	Unkown
HY-RS07745	LPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W040175	L-NASPA ammonium	Inhibitor	/	Unkown
HY-W040176	N-PTyrosine PA ammonium	Modulator	/	Unkown
HY-W725737	BrP-LPA		/	Unkown
HY-W783254	C18 LPA		/	Unkown
HY-10341D	Fasudil mesylate		/	Unkown
HY-139133	L-NASPA	Inhibitor	/	Unkown
HY-160003	PPARγ agonist 9	Agonist	/	Unkown
HY-160173	LPA receptor antagonist-1	Antagonist	/	Unkown
HY-171464	Lp(a)-IN-5	Inhibitor	/	Unkown
HY-171906	1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA	Inhibitor	/	Unkown
HY-172566	1-Myristyl-2-hydroxy-sn-glycero-3-PA	Activator	/	Unkown
HY-181456	1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate sodium		/	Unkown
HY-N16077	C16 Cyclic LPA ammonium		/	Unkown
HY-N16110	17:0 Cyclic LPA ammonium		/	Unkown
HY-W725317	C16 LPA ammonium		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992262	Anti-LPA/Lysophosphatidic acid Antibody (504B3)		/	Unkown