2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Bcl-2 Family Caspase PARP
  4. (-)-β-Peltatin

(-)-β-Peltatin  (Synonyms: β-Peltatin)

Cat. No.: HY-125135 Purity: 99.45%
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(-)-β-Peltatin is an aryltetrahydronaphthalene lignan. (-)-β-Peltatin exhibits antitumor activity and cytotoxicity against pancreatic cancer cells. (-)-β-Peltatin induces G2/M cell cycle arrest and apoptosis in pancreatic cancer cells. (-)-β-Peltatin inhibits the growth of subcutaneous xenografts of pancreatic cancer cells in nude mice. (-)-β-Peltatin can be used in pancreatic cancer-related research.

For research use only. We do not sell to patients.

(-)-β-Peltatin

(-)-β-Peltatin Chemical Structure

CAS No. : 518-29-6

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(-)-β-Peltatin Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

(-)-β-Peltatin is an aryltetrahydronaphthalene lignan. (-)-β-Peltatin exhibits antitumor activity and cytotoxicity against pancreatic cancer cells. (-)-β-Peltatin induces G2/M cell cycle arrest and apoptosis in pancreatic cancer cells. (-)-β-Peltatin inhibits the growth of subcutaneous xenografts of pancreatic cancer cells in nude mice. (-)-β-Peltatin can be used in pancreatic cancer-related research[1][2].

Cellular Effect
Cell Line Type Value Description References
BXPC-3 GI50
0.0012 μg/mL
Compound: 3
Growth inhibition of human BxPC3 cells measured after 48 hrs by sulforhodamine B assay
Growth inhibition of human BxPC3 cells measured after 48 hrs by sulforhodamine B assay
[PMID: 26938998]
DU-145 GI50
0.0021 μg/mL
Compound: 3
Growth inhibition of human DU145 cells measured after 48 hrs by sulforhodamine B assay
Growth inhibition of human DU145 cells measured after 48 hrs by sulforhodamine B assay
[PMID: 26938998]
HL-60 IC50
0.0052 μg/mL
Compound: 11
Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay
[PMID: 10514313]
HT-29 IC50
2.5 ng/mL
Compound: beta-peltatin A
Growth inhibition of human HT29 cells
Growth inhibition of human HT29 cells
[PMID: 15332833]
KM-20L2 GI50
0.0076 μg/mL
Compound: 3
Growth inhibition of human KM20L2 cells measured after 48 hrs by sulforhodamine B assay
Growth inhibition of human KM20L2 cells measured after 48 hrs by sulforhodamine B assay
[PMID: 26938998]
MCF7 GI50
0.00055 μg/mL
Compound: 3
Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay
Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay
[PMID: 26938998]
NCI-H460 GI50
0.00077 μg/mL
Compound: 3
Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay
[PMID: 26938998]
P388 ED50
0.0031 μg/mL
Compound: 3
Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay
Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay
[PMID: 26938998]
P388 IC50
2.5 ng/mL
Compound: beta-peltatin A
Growth inhibition of mouse P388 cells
Growth inhibition of mouse P388 cells
[PMID: 15332833]
SF-268 GI50
0.0004 μg/mL
Compound: 3
Growth inhibition of human SF268 cells measured after 48 hrs by sulforhodamine B assay
Growth inhibition of human SF268 cells measured after 48 hrs by sulforhodamine B assay
[PMID: 26938998]
In Vitro

(-)-β-Peltatin (0-8 nM, 24-72 h) inhibits the viability of MIA PaCa-2 and BxPC-3 cells, with IC50 values of 2.09 nM and 1.49 nM, respectively[2].
(-)-β-Peltatin (0-4 nM, 12 h) induces G2/M phase arrest and apoptosis in PAC cells[2].
(-)-β-Peltatin (0-4 nM, 12 h) downregulates the expression levels of CDC25C, phosphorylated CDC25C (Ser216) and phosphorylated CDK1 (Tyr15), upregulates the protein expression level of cyclin B1, downregulates the expression of the anti-apoptotic protein Bcl-2, and activates caspase 3, caspase 9 and PARP[2] in MIA PaCa-2 and BxPC-3 cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-β-Peltatin Related Antibodies

Cell Viability Assay[2]

Cell Line: PaCa-2, BxPC-3 cells
Concentration: 0, 1, 2, 4, 8 nM
Incubation Time: 24, 48, 72 h
Result: Inhibited the viability of MIA PaCa-2 and BxPC-3 cells, with IC50 values of 2.09 nM and 1.49 nM, respectively.
In Vivo

(-)-β-Peltatin (15 mg/kg; i.p.; once weekly) exerts potent in vivo anti-pancreatic cancer activity, suppressing subcutaneous BxPC-3 xenograft growth, reducing tumor cell proliferation, inducing apoptosis, and prolonging mouse survival by 65.85% with minimal observed toxicity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (female, 6 weeks of age)[2]
Dosage: 15 mg/kg
Administration: i.p.; once weekly
Result: Significantly suppressed subcutaneous tumor growth relative to vehicle control.
Prolonged mouse survival time by 65.85% (34 days) compared to control mice (21 days).
Showed no notable alterations in mouse body weight or gross anatomy of primary organs relative to control.
Reduced Ki-67 positive cell percentage from ~100% relative in control to ~30% relative in treated tumors.
Increased cleaved caspase 3 positive cell percentage from ~0% in control to ~50% in treated tumors.
Increased p-Histone H3 (Ser10) positive cell percentage from ~1% in control to ~4% in treated tumors.
Molecular Weight

414.41

Formula

C22H22O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@]2([H])[C@H](C3=CC(OC)=C(C(OC)=C3)OC)C4=CC(OCO5)=C5C(O)=C4C[C@@]2([H])CO1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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(-)-β-Peltatin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-β-Peltatin518-29-6β-PeltatinApoptosisBcl-2 FamilyCaspasePARPpoly ADP ribose polymerasepancreatic cancer cellsnude miceBxPC-3Pulsatillae chinensisPodophyllum peltatumapoptosisPodophyllum hexandrumBALB/c micedesoxypodophyllotoxinG2/M phase cell cycle arrestInhibitorinhibitorinhibit

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