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Cat. No.: HY-125135

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(-)-β-Peltatin

(Synonyms: β-Peltatin)

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(-)-β-Peltatin is an aryltetrahydronaphthalene lignan. (-)-β-Peltatin exhibits antitumor activity and cytotoxicity against pancreatic cancer cells. (-)-β-Peltatin induces G2/M cell cycle arrest and apoptosis in pancreatic cancer cells. (-)-β-Peltatin inhibits the growth of subcutaneous xenografts of pancreatic cancer cells in nude mice. (-)-β-Peltatin can be used in pancreatic cancer-related research.

For research use only. We do not sell to patients.

Purity: 99.45%
CAS No.: 518-29-6
Formula: C₂₂H₂₂O₈
Molecular Weight:414.41

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

(-)-β-Peltatin Chemical Structure

CAS No.: 518-29-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Bcl-2 Family Isoforms :

All Caspase Isoforms :

All PARP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	GI₅₀	0.0012 μg/mL Compound: 3	Growth inhibition of human BxPC3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human BxPC3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
DU-145	GI₅₀	0.0021 μg/mL Compound: 3	Growth inhibition of human DU145 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human DU145 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
HL-60	IC₅₀	0.0052 μg/mL Compound: 11	Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay	[PMID: 10514313]
HT-29	IC₅₀	2.5 ng/mL Compound: beta-peltatin A	Growth inhibition of human HT29 cells Growth inhibition of human HT29 cells	[PMID: 15332833]
KM-20L2	GI₅₀	0.0076 μg/mL Compound: 3	Growth inhibition of human KM20L2 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human KM20L2 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
MCF7	GI₅₀	0.00055 μg/mL Compound: 3	Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
MCF7	GI₅₀	0.55 ng/mL Compound: 3	Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
NCI-H460	GI₅₀	0.00077 μg/mL Compound: 3	Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
NCI-H460	GI₅₀	0.77 ng/mL Compound: 3	Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
P388	IC₅₀	2.5 ng/mL Compound: beta-peltatin A	Growth inhibition of mouse P388 cells Growth inhibition of mouse P388 cells	[PMID: 15332833]
P388	ED₅₀	0.0031 μg/mL Compound: 3	Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
SF-268	GI₅₀	0.0004 μg/mL Compound: 3	Growth inhibition of human SF268 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF268 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
SF-268	GI₅₀	0.4 ng/mL Compound: 3	Growth inhibition of human SF268 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF268 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]

In Vitro

(-)-β-Peltatin (0-8 nM, 24-72 h) inhibits the viability of MIA PaCa-2 and BxPC-3 cells, with IC₅₀ values of 2.09 nM and 1.49 nM, respectively^[2].
(-)-β-Peltatin (0-4 nM, 12 h) induces G2/M phase arrest and apoptosis in PAC cells^[2].
(-)-β-Peltatin (0-4 nM, 12 h) downregulates the expression levels of CDC25C, phosphorylated CDC25C (Ser216) and phosphorylated CDK1 (Tyr15), upregulates the protein expression level of cyclin B1, downregulates the expression of the anti-apoptotic protein Bcl-2, and activates caspase 3, caspase 9 and PARP^[2] in MIA PaCa-2 and BxPC-3 cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

PaCa-2, BxPC-3 cells
Concentration:

0, 1, 2, 4, 8 nM
Incubation Time:

24, 48, 72 h
Result:

Inhibited the viability of MIA PaCa-2 and BxPC-3 cells, with IC50 values of 2.09 nM and 1.49 nM, respectively.

In Vivo

(-)-β-Peltatin (15 mg/kg; i.p.; once weekly) exerts potent in vivo anti-pancreatic cancer activity, suppressing subcutaneous BxPC-3 xenograft growth, reducing tumor cell proliferation, inducing apoptosis, and prolonging mouse survival by 65.85% with minimal observed toxicity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude (female, 6 weeks of age)^[2]
Dosage:

15 mg/kg
Administration:

i.p.; once weekly
Result:

Significantly suppressed subcutaneous tumor growth relative to vehicle control.
Prolonged mouse survival time by 65.85% (34 days) compared to control mice (21 days).
Showed no notable alterations in mouse body weight or gross anatomy of primary organs relative to control.
Reduced Ki-67 positive cell percentage from ~100% relative in control to ~30% relative in treated tumors.
Increased cleaved caspase 3 positive cell percentage from ~0% in control to ~50% in treated tumors.
Increased p-Histone H3 (Ser10) positive cell percentage from ~1% in control to ~4% in treated tumors.

Chemical Information

CAS No. 518-29-6
Appearance Solid
Molecular Weight 414.41
Formula C₂₂H₂₂O₈
Color White to off-white
SMILES

O=C1[C@]2([H])[C@H](C3=CC(OC)=C(C(OC)=C3)OC)C4=CC(OCO5)=C5C(O)=C4C[C@@]2([H])CO1
Synonyms

β-Peltatin
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. WIDAD M. KAMIL, et al. BIOSYNTHESIS OF THE LIGNANS cx-AND /3-PELTATIN. Phytochemistry, Vol. 25, No. 9, pp. 2089-2092, 1986.

[2]. Wu R, et al. Pulsatilla Decoction and its bioactive component β-peltatin induce G2/M cell cycle arrest and apoptosis in pancreatic cancer. Chin Med. 2023;18(1):61. Published 2023 May 28. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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(-)-β-Peltatin

All Bcl-2 Family Isoforms

All Caspase Isoforms

All PARP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(-)-β-Peltatin Related Classifications

HY-125135 Related Classifications